32 results on '"Xiao, Roy"'
Search Results
2. Practice Patterns of Surgical Approaches for Pituitary Tumors across Otolaryngologists and Neurosurgeons between 2010 and 2018.
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Miller, Lauren, Xiao, Roy, Wasserman, Isaac, Lin, Derrick, and Gray, Stacey
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PITUITARY tumors , *OTOLARYNGOLOGISTS , *NEUROSURGEONS - Published
- 2023
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3. Suction mitigation of airborne particulate generated during sinonasal drilling and cautery.
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Workman, Alan D., Xiao, Roy, Feng, Allen, Gadkaree, Shekhar K., Quesnel, Alicia M., Bleier, Benjamin S., and Scangas, George A.
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COVID-19 , *NASAL septum , *MAXILLECTOMY , *CAUTERY , *BEAKS - Abstract
Background: Coronavirus disease 2019 (COVID‐19) has significantly impacted endonasal surgery, and recent experimentation has demonstrated that sinonasal drilling and cautery have significant propensity for airborne particulate generation immediately adjacent to the surgical field. In the present investigation, we assessed nasopharyngeal suctioning as a mitigation strategy to decrease particulate spread during simulated endonasal surgical activity. Methods: Airborne particulate generation in the 1‐µm to 10‐µm range was quantified with an optical particle sizer in real‐time during cadaveric‐simulated anterior and posterior endonasal drilling and cautery conditions. To test suction mitigation, experiments were performed both with and without a rigid suction placed in the contralateral nostril, terminating in the nasopharynx. Results: Both anterior (medial maxillary wall and nasal septum) and posterior (sphenoid rostrum) drilling produced significant particulate generation in the 1‐µm to 10‐µm range throughout the duration of drilling (p < 0.001) without the use of suction, whereas nasopharyngeal suction use eliminated the detection of generated airborne particulate. A similar effect was seen with nasal cautery, with significant particle generation (p < 0.001) that was reduced to undetectable levels with the use of nasopharyngeal suction. Conclusion: The use of nasopharyngeal suctioning via the contralateral nostril minimizes airborne particulate spread during simulated sinonasal drilling and cautery. In the era of COVID‐19, this technique offers an immediately available measure that may increase surgical safety. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Solitary Fibrous Tumor of the Nasal Cavity: A Case Report and Review of the Literature.
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Marcus, Kathryn S., Wasserman, Isaac, Xiao, Roy, Ayoub, Noel, Gray, Stacey T., and Holbrook, Eric H.
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PLEURA , *NASAL cavity , *NASAL tumors , *LITERATURE reviews , *INTERNAL carotid artery , *MAXILLARY artery - Abstract
This article, published in the Journal of Neurological Surgery, discusses a rare case of a solitary fibrous tumor in the nasal cavity. Solitary fibrous tumors are uncommon neoplasms that can arise in various parts of the body, including the head and neck region. Although these tumors are slow-growing, they can potentially spread and invade nearby structures, leading to life-threatening complications. The article highlights the importance of early identification and surgical resection in managing these tumors. The case presented in the article describes the successful removal of the tumor through endoscopic surgical resection after embolization. The article emphasizes the need for prompt diagnosis and treatment due to the potential risks associated with these tumors. [Extracted from the article]
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- 2024
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5. Price Transparency for COVID-19 Testing Among Top US Hospitals.
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Xiao, Roy and Rathi, Vinay K.
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COVID-19 testing , *HOSPITALS , *HOSPITAL charges , *SPOT prices , *COVID-19 pandemic - Abstract
On March 27, 2020, Congress passed the Coronavirus Aid, Relief, and Economic Security (CARES) Act in response to the COVID-19 pandemic and its economic repercussions.[1] Under the CARES Act, private insurers are required to cover in vitro diagnostic testing for COVID-19 without patient cost sharing or other barriers during the public health emergency. For hospitals that disclosed both cash prices and hospital charges, we estimated the corresponding out-of-network bill balance (defined as the difference between hospital charge minus the cash price) for each type of test offered. [Extracted from the article]
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- 2021
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6. Increased pathologic upstaging with rising time to treatment initiation for head and neck cancer: A mechanism for increased mortality.
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Xiao, Roy, Ward, Matthew C., Yang, Kailin, Adelstein, David J., Koyfman, Shlomo A., Prendes, Brandon L., and Burkey, Brian B.
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SQUAMOUS cell carcinoma , *HYPOPHARYNGEAL cancer , *HYPOPHARYNX , *REGRESSION analysis , *PATHOLOGY , *TUMORS - Abstract
Background: Time to treatment initiation (TTI) is increasing and is associated with worsening survival. In the current study, the authors sought to identify a mechanism for this relationship by assessing the effect of TTI on clinical-to-pathologic upstaging in patients with head and neck squamous cell carcinoma (HNSCC).Methods: Using the National Cancer Data Base, the authors analyzed patients receiving definitive surgery for SCC of the oral cavity, oropharynx, larynx, and hypopharynx from 2005 through 2014. The primary outcome was T, N, or stage group upstaging, defined as higher pathologic stage than clinical stage. TTI was defined as the time between diagnosis and surgery. Multivariable logistic and Cox proportional hazards regression modeled upstaging and survival, respectively.Results: Cohorts of 60,194 patients, 51,380 patients, and 52,980 patients, respectively, with complete T, N, and stage group data were included. N upstaging was most common (18.6%), followed by stage group (17.4%) and T (12.1%) upstaging; all types were predicted by TTI. Compared with a TTI of 1 to 6 days, TTIs as short as 7 to 13 days (odds ratio, 1.20; P = .038) or ≥ 70 days (odds ratio, 2.04; P < .001) were found to predict T upstaging, a finding that is consistent for N and stage group upstaging. Using restricted cubic splines, relative odds of T and stage group upstaging escalated to 2.25 and 1.93, respectively, at a TTI of 365 days. In survival analyses, T (hazard ratio [HR], 1.53), N (HR, 1.88), and stage group (HR, 1.69) upstaging all predicted mortality (P < .001), whereas TTI only predicted mortality after 70 days (HR, 1.11; P = .023).Conclusions: Tumor progression, measured by clinical-to-pathologic upstaging, increases mortality for patients with HNSCC experiencing treatment delays. Cancer 2018;124:1400-14. © 2018 American Cancer Society. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. Quality of life outcomes following cervical decompression for coexisting Parkinson's disease and cervical spondylotic myelopathy.
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Xiao, Roy, Miller, Jacob A., Lubelski, Daniel, Alberts, Jay L., Mroz, Thomas E., Benzel, Edward C., Krishnaney, Ajit A., and Machado, Andre G.
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SPINAL surgery , *CERVICAL spondylotic myelopathy , *PARKINSON'S disease patients , *QUALITY of life , *AGE factors in disease , *TERTIARY care , *PATIENTS , *CERVICAL vertebrae , *LONGITUDINAL method , *PARKINSON'S disease , *QUESTIONNAIRES , *SPINAL cord diseases , *TREATMENT effectiveness , *SURGICAL decompression , *SPONDYLOSIS , *DISEASE complications , *SURGERY - Abstract
Background Context: Coexisting Parkinson's disease (PD) and cervical spondylotic myelopathy (CSM) presents a diagnostic and therapeutic challenge due to symptomatic similarities between the diseases. Whereas CSM patients are routinely treated with surgery, PD patients face poorer outcomes following spine surgery. No studies have investigated the quality of life (QOL) outcomes following decompression in coexisting PD and CSM.Purpose: The purpose of the present study was to characterize QOL outcomes for patients with coexisting PD and CSM following cervical decompression.Study Design/setting: This is a matched cohort study at a single tertiary-care center.Patient Sample: Patients with coexisting PD and CSM undergoing cervical decompression between June 2009 and December 2014 were included. These patients were matched to controls with CSM alone by age, gender, American Society of Anesthesiologists classification, Modified Japanese Orthopaedic Association scores, and operative parameters.Outcome Measures: The primary outcome measure was QOL outcomes assessed by change in the EuroQol 5-Dimensions (EQ-5D), Pain Disability Questionnaire (PDQ), and Patient Health Questionnaire-9 (PHQ-9) at last follow-up (LFU). Change in QOL exceeding the minimal clinically important difference (MCID) was secondary.Methods: QOL data were collected using the institutional prospectively collected database of patient-reported health status measures. Simple and multivariable regressions were used to assess the impact of PD upon change in QOL.Results: Eleven PD patients were matched to 44 controls. Control patients experienced QOL improvement across all three measures, whereas PD patients only improved with respect to PDQ(89.9-80.7, p=.03). Despite no significant differences in preoperative QOL, PD patients experienced poorer QOL at LFU in EQ-5D (0.526 vs. 0.707, p=.01) and PDQ (80.7 vs. 51.4, p=.03), and less frequently achieved an EQ-5D MCID (18% vs. 57%, p=.04). However, no differences in the achievement of an MCID in PDQ or PHQ-9 were observed between cohorts. Multivariable regression identified PD as a significant independent predictor of poorer improvement in EQ-5D (β=-0.09, p<.01) and failure to achieve an EQ-5D MCID (odds ratio: 0.08, p<.01).Conclusions: This is the first study to characterize QOL outcomes following cervical decompression for patients with coexisting PD and CSM. Although myelopathy may have been less severe among PD patients, a significant reduction in pain-related disability was observed following decompression. However, PD predicted diminished improvement in overall QOL measured by the EQ-5D. [ABSTRACT FROM AUTHOR]- Published
- 2016
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8. Radiographic progression of vertebral fractures in patients with multiple myeloma.
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Xiao, Roy, Miller, Jacob A., Margetis, Konstantinos, Lubelski, Daniel, Lieberman, Isador H., Benzel, Edward C., and Mroz, Thomas E.
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MULTIPLE myeloma diagnosis , *MULTIPLE myeloma treatment , *RADIOGRAPHY , *DIPHOSPHONATES , *CANCER invasiveness , *MULTIPLE myeloma , *PATIENTS , *BONE fractures , *SPINAL injuries , *STATURE , *DISEASE progression , *DISEASE complications - Abstract
Background Context: Nearly 70% of patients with multiple myeloma (MM) experience vertebral fracture. As a consequence, these patients suffer significantly poorer quality of life. However, no studies have characterized the natural progression of these fractures.Purpose: The purpose of this study was to characterize the progression of MM-associated vertebral fractures.Study Design/setting: A consecutive retrospective chart review at a single tertiary-care center was carried out.Patient Sample: Patients with MM and pathologic vertebral fracture with at least one follow-up between January 2007 and December 2013 were included. Radiographic measurements were recorded until last follow-up (LFU) or until surgical intervention or patient death. Patients with a history of vertebral fracture not associated with MM were excluded.Outcome Measures: The primary outcome measure was change in height of the fractured vertebrae. Fractures were characterized by Genant grade and morphology.Methods: At baseline and each follow-up, anterior, middle, and posterior vertebral body heights were measured from midline sagittal T1-weighted magnetic resonance imaging. Student t tests and Fisher exact tests were performed to identify variables associated with fracture progression.Results: Among 33 patients, 67 fractures were followed. Sixty-four percent of patients were female, with a mean age of 66. Baseline mean anterior, middle, and posterior vertebral body height losses were 30%, 36%, and 15%, respectively. Forty-three percent of fractures were Genant grade 3, and 57% were biconcave. Mean time to LFU was 40 months. At LFU, mean anterior, middle, and posterior vertebral body height losses increased to 47% (p<.01), 49% (p<.01), and 28% (p<.01), respectively. More fractures became Genant grade 3 (75%, p<.01) and wedge (54%, p=.03). On average, patients lost 0.83% in vertebral body height per month, with initial Genant grade 1 fractures progressing most rapidly (1.69%/month, p<.01). Patients treated with bisphosphonates suffered less additional height loss compared with untreated patients (14% vs. 24%, p=.07).Conclusions: We observed significant fracture progression despite high utilization of bisphosphonates. Patients lost nearly 1% of additional vertebral body height per month, with the least severe presenting fractures progressing most rapidly, highlighting the necessity for early referral to spine specialists and evidence-based guidelines for surveillance and treatment in the myeloma population. [ABSTRACT FROM AUTHOR]- Published
- 2016
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9. Predicting the progression of vertebral fractures in patients with multiple myeloma.
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Xiao, Roy, Miller, Jacob A., Margetis, Konstantinos, Lubelski, Daniel, Lieberman, Isador H., Benzel, Edward C., and Mroz, Thomas E.
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SPINAL injury treatment , *MULTIPLE myeloma treatment , *DISEASE progression , *DISEASE complications , *QUALITY of life , *MEDICAL radiography , *BONE fractures , *MAGNETIC resonance imaging , *MULTIPLE myeloma , *RADIOGRAPHY , *SPINE , *SPINAL injuries , *COMORBIDITY , *RETROSPECTIVE studies , *KAPLAN-Meier estimator - Abstract
Background Context: Patients with multiple myeloma (MM) incur significant degradation in quality of life because of progressive osteolytic vertebral fractures. No studies have investigated predictors of fracture progression, and limited data are available for predicting the development of future fractures.Purpose: The purpose of this study was to identify independent predictors of vertebral fracture progression and the development of future vertebral fracture.Study Design/setting: This is a consecutive retrospective chart review at a single tertiary-care center.Patient Sample: Patients with MM and pathologic vertebral fracture with radiographic follow-up between January 2007 and December 2013 were included. Radiographic measurements were recorded at presentation with fracture and first follow-up (FFU) after at least three months. Patients with a history of vertebral fracture not associated with MM were excluded.Outcome Measures: The primary outcome measure was the rate of vertebral body height loss. The development of future vertebral fracture was secondary.Methods: Anterior, middle, and posterior vertebral body heights were measured from midline sagittal T1-weighted magnetic resonance imaging (MRI). Future fracture-free survival was calculated using Kaplan-Meier analysis. Multivariable regression was used to identify independent predictors of the rate of vertebral height loss. Multivariable Cox proportional hazards modeling was used to identify predictors of developing future vertebral fracture.Results: Thirty-three patients with 67 fractures were followed for a median of 10.8 months to FFU. Sixty-four percent of the patients were female and the median age was 66. The median additional vertebral height loss between presentation and FFU was 15%, whereas the median rate of vertebral height loss was 1.01%/month. More rapid vertebral height loss was predicted by dyslipidemia (β=0.36, p=.05), previous non-vertebral pathologic fracture related to MM (β=0.51, p=.01), and Durie-Salmon Stage III (β=0.66, p=.06). The median time to future fracture was 25.1 months; the 5-year future fracture-free survival rate was 34%. Osteopenia/osteoporosis (hazard ratio [HR]: 9.28, p<.01), serum light chains (HR: 1.37, p=.06), and serum calcium (HR: 1.62, p=.05) predicted the development of future vertebral fracture.Conclusions: We observed significant fracture progression over a short follow-up period. Several comorbidities and laboratory measures predicted more rapid vertebral height loss and the development of future fracture. Identifying risk factors for increased fracture burden may allow spine specialists to pursue earlier and appropriate intervention to optimize function and minimize morbidity. [ABSTRACT FROM AUTHOR]- Published
- 2016
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10. Surprise Billing in Health Care.
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Miller, Lauren E., Xiao, Roy, and Rathi, Vinay K.
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HEALTH care industry billing , *HEALTH care industry laws , *HEALTH facilities , *MEDICAL care , *HEALTH insurance - Published
- 2021
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11. Payer-Negotiated Prices in the Diagnosis and Management of Thyroid Cancer in 2021.
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Xiao, Roy, Rathi, Vinay K., Gross, Cary P., Ross, Joseph S., and Sethi, Rosh K. V.
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THYROID cancer , *MEDICAL care costs , *HOSPITAL costs , *MEDICAL fees - Abstract
This study examines price availability and variation for thyroid cancer care at National Cancer Institute (NCI)–Designated Cancer Centers following a 2021 CMS policy reform requiring hospitals to disclose commercial payer-specific negotiated prices for all items and services. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Long-Term Outcome of Patients with Sinonasal Adenoid Cystic Carcinoma and Adenocarcinoma.
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Wasserman, Isaac, Miller, Lauren E., Xiao, Roy, Shah, Anjay P., Gray, Stacey T., and Lin, Derrick T.
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ADENOID cystic carcinoma , *PARANASAL sinuses , *ADENOCARCINOMA - Published
- 2023
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13. Spending and Utilization on Drugs Prescribed by Otolaryngologists to Medicare Beneficiaries, 2013 to 2017.
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Shah, Shivani A., Miller, Lauren E., Xiao, Roy, Workman, Alan, Xu, Lucy, and Rathi, Vinay K.
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CROSS-sectional method , *MEDICAL care costs , *RETROSPECTIVE studies , *DRUG therapy , *GENERIC drugs , *DESCRIPTIVE statistics , *DRUG utilization , *OTOLARYNGOLOGY , *MEDICARE - Abstract
Objectives: The significant and rising cost of prescription drugs is a pressing concern for patients and payers. However, little is known about spending on and utilization of drugs prescribed by otolaryngologists. Methods: Utilizing publicly available Medicare Part D Prescriber Public Use data, we conducted a retrospective crosssectional analysis of 34 small-molecule drugs commonly prescribed by otolaryngologists (defined as 2017 Medicare Part D spending =$500 000) to Medicare beneficiaries. Prescription data was characterized by drug type (brand name vs generic). Primary outcomes for each prescription drug included the total annual cost and the total annual number of days supplied. Results: From 2013 to 2017, spending on drugs prescribed by otolaryngologists to Medicare beneficiaries decreased by $32.1 million ($131.7-$99.5 million; relative decrease 24.4%; compound annual growth rate [CAGR] -5.4%), while total utilization increased by 24.9 million days supplied (74.6-99.5 million; relative increase 33.3%; CAGR 5.9%). For brand name drugs, there was a decrease in spending ($71.1-$26.7 million; relative decrease -62.4%; CAGR -17.8%) and utilization (11.2-3.1 million days supplied; relative decrease -72.5%; CAGR -22.8%). In contrast, generic drugs demonstrated increased spending ($60.6-$72.8 million; relative increase 20.2%; CAGR 3.7%) and utilization (63.5-96.4 million days supplied; relative increase 51.9%; CAGR 8.7%). Conclusions: Spending on drugs prescribed by otolaryngologists to Medicare Part D beneficiaries declined between 2013 and 2017 in part due to a transition from brand name drugs to lower-cost generic equivalents. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Private payer‐negotiated prices for FDA‐approved biologic treatments for allergic diseases.
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Wang, Annette A., Rathi, Vinay K., Xiao, Roy, Holbrook, Eric H., Scangas, George A., Workman, Alan D., and Gray, Stacey T.
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THERAPEUTICS , *ALLERGIES , *NASAL polyps , *RATINGS of hospitals , *PRICE markup , *SURGICAL clinics , *THYROID cancer - Abstract
Keywords: allergic rhinitis; asthma; chronic rhinosinusitis EN allergic rhinitis asthma chronic rhinosinusitis 798 801 4 04/28/22 20220501 NES 220501 INTRODUCTION Novel biologic agents have recently emerged as treatments for allergic disease. Payer-negotiated prices were consistently higher than ASPs for the drugs in our sample (Figure 1), with median price markups ranging from +101.4% (omalizumab) to +149.4% (reslizumab) in excess of ASP. 1 TABLEPrivate payer-negotiated prices of monoclonal antibodies for treatment of allergic diseases HT
ht 1 Abbreviations: HCPCS, Healthcare Common Procedure Coding System; IQR, interquartile range; SD, standard deviation. [Extracted from the article]Biologic (dose) HCPCS Code N Centers (%) Median payer-negotiated price (IQR) ($)0002 Mean payer-negotiated price (SD) ($)0002 Minimum median payer-negotiated price ($)0002 Maximum median payer-negotiated price ($)0002 Across-center price ratio0003 Median within-center price ratio (IQR)0004 Omalizumab (150 mg/ml) J2357 19 (38%) 2160 [1465-3101] 2337 [896] 1077 3802 3 1.7 [1.5-2.3] Mepolizumab (100 mg/ml) J2182 14 (28%) 5732 [4435-7468] 5832 [1878] 2929 8857 2.4 1.7 [1.4-2.3] Reslizumab (100 mg/10 ml) J2786 11 (22%) 2342 [1476-2755] 2176 [820] 1013 3355 3.4 1.5 [1.3-2.2] Benralizumab (30 mg/ml) J0517 11 (22%) 10,636 [8648-12,487] 10,092 [2692] 5604 13,428 2.1 1.7 [1.4-2.3] - Published
- 2022
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15. Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer.
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Xiao, Roy, Patel, Priya, Chen, Zhong, Van Waes, Carter, Tran, Linda, Park, So-Jin, Allen, Clint T., and Schmitt, Nicole C.
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SQUAMOUS cell carcinoma , *RADIOTHERAPY - Abstract
Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in cell death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor of Apoptosis Proteins 1/2 (cIAP1/2), critical components of the Tumor Necrosis Factor (TNF) Receptor signaling pathways. ASTX660 is a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP under evaluation in a clinical trial for advanced solid tumors and lymphomas. Herein, we show that ASTX660, at nanomolar concentrations, sensitized Murine Oral Cancer (MOC1) cells to TNFα. Using syngeneic mouse models, ASTX660 showed additive anti-tumor activity with radiation therapy (XRT), cisplatin chemotherapy, and PD-1 blockade to significantly delay or eradicate MOC1 tumors. These combinations significantly increased CD8 + T cells and dendritic cells, as well as T cell activity. ASTX660 stimulated cytotoxic T lymphocyte (CTL) killing of MOC1 cells expressing ovalbumin. Early stages of CTL killing were predominantly mediated by perforin/granzyme B, whereas later stages were mediated by death ligands TNFα, TRAIL, and FasL. Correspondingly, depletion of CD8 + T cells and NK cells in vivo revealed both types of immune cells to be important components of the complete anti-tumor response enhanced by ASTX660+XRT. These findings serve to inform future studies of IAP inhibitors and support the potential for future clinical trials investigating ASTX660 with XRT and immunotherapies like PD-1/PD-L1 blockade in HNSCC. [ABSTRACT FROM AUTHOR]
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- 2018
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16. Airborne aerosol olfactory deposition contributes to anosmia in COVID-19.
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Workman, Alan D., Jafari, Aria, Xiao, Roy, and Bleier, Benjamin S.
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COVID-19 , *AEROSOLS , *AIRBORNE infection , *MICROBIOLOGICAL aerosols , *OLFACTORY receptors , *SMELL disorders , *METHACHOLINE chloride , *SARS-CoV-2 - Abstract
Introduction: Olfactory dysfunction (OD) affects a majority of COVID-19 patients, is atypical in duration and recovery, and is associated with focal opacification and inflammation of the olfactory epithelium. Given recent increased emphasis on airborne transmission of SARS-CoV-2, the purpose of the present study was to experimentally characterize aerosol dispersion within olfactory epithelium (OE) and respiratory epithelium (RE) in human subjects, to determine if small (sub 5μm) airborne aerosols selectively deposit in the OE. Methods: Healthy adult volunteers inhaled fluorescein-labeled nebulized 0.5–5μm airborne aerosol or atomized larger aerosolized droplets (30–100μm). Particulate deposition in the OE and RE was assessed by blue-light filter modified rigid endoscopic evaluation with subsequent image randomization, processing and quantification by a blinded reviewer. Results: 0.5–5μm airborne aerosol deposition, as assessed by fluorescence gray value, was significantly higher in the OE than the RE bilaterally, with minimal to no deposition observed in the RE (maximum fluorescence: OE 19.5(IQR 22.5), RE 1(IQR 3.2), p<0.001; average fluorescence: OE 2.3(IQR 4.5), RE 0.1(IQR 0.2), p<0.01). Conversely, larger 30–100μm aerosolized droplet deposition was significantly greater in the RE than the OE (maximum fluorescence: OE 13(IQR 14.3), RE 38(IQR 45.5), p<0.01; average fluorescence: OE 1.9(IQR 2.1), RE 5.9(IQR 5.9), p<0.01). Conclusions: Our data experimentally confirm that despite bypassing the majority of the upper airway, small-sized (0.5–5μm) airborne aerosols differentially deposit in significant concentrations within the olfactory epithelium. This provides a compelling aerodynamic mechanism to explain atypical OD in COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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17. Impact of Home Health Care on Health Care Resource Utilization Following Hospital Discharge: A Cohort Study.
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Xiao, Roy, Miller, Jacob A., Zafirau, William J., Gorodeski, Eiran Z., and Young, James B.
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HOME care services , *HOSPITAL admission & discharge - Abstract
Background: As healthcare costs rise, home health care represents an opportunity to reduce preventable adverse events and costs following hospital discharge. No studies have investigated the utility of home health care within the context of a large and diverse patient population.Methods: A retrospective cohort study was conducted between 1/1/2013 and 6/30/2015 at a single tertiary care institution to assess healthcare utilization after discharge with home health care. Control patients discharged with "self-care" were matched by propensity score to home health care patients. The primary outcome was total healthcare costs in the 365-day post-discharge period. Secondary outcomes included follow-up readmission and death. Multivariable linear and Cox proportional hazards regression were used to adjust for covariates.Results: Among 64,541 total patients, 11,266 controls were matched to 6,363 home health care patients across 11 disease-based Institutes. During the 365-day post-discharge period, home health care was associated with a mean unadjusted savings of $15,233 per patient, or $6,433 after adjusting for covariates (p < 0.0001). Home health care independently decreased the hazard of follow-up readmission (HR 0.82, p < 0.0001) and death (HR 0.80, p < 0.0001). Subgroup analyses revealed that home health care most benefited patients discharged from the Digestive Disease (death HR 0.72, p < 0.01), Heart & Vascular (adjusted savings of $11,453, p < 0.0001), Medicine (readmission HR 0.71, p < 0.0001), and Neurological (readmission HR 0.67, p < 0.0001) Institutes.Conclusions: Discharge with home health care was associated with significant reduction in healthcare utilization and decreased hazard of readmission and death. These data inform development of value-based care plans. [ABSTRACT FROM AUTHOR]- Published
- 2018
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18. Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer.
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Park, So-Jin, Ye, Wenda, Xiao, Roy, Silvin, Christopher, Padget, Michelle, Hodge, James W., Van Waes, Carter, and Schmitt, Nicole C.
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CISPLATIN , *HEAD & neck cancer , *OXALIPLATIN , *IMMUNOCOMPETENT cells , *T helper cells , *THERAPEUTICS - Abstract
Objectives: Prior studies suggest that oxaliplatin is unique among platinum chemotherapy drugs in its ability to enhance anti-tumor immunity, but the immune mechanisms of different platinum chemotherapy drugs have not been previously compared in preclinical models of head and neck squamous cell carcinoma (HNSCC).Materials and Methods: Human HNSCC cell lines were treated with cisplatin or oxaliplatin, then assessed for markers associated with immunogenic cell death (ICD) and antigen processing. A syngeneic mouse model of oral cancer was then used to compare the effects of cisplatin vs. oxaliplatin, alone or in combination with anti-PD-1 immunotherapy, on tumor growth and survival. A subset of spleens and tumors were analyzed for ICD markers and immune cell infiltrates by flow cytometry.Results: Cisplatin and oxaliplatin both increased cell surface levels of calreticulin, HSP70, MHC class I and PD-L1 in multiple cell lines. Inoculation of immunocompetent mice with cells killed in vitro by either drug resulted in failure of subsequently-injected live tumor cells to establish and grow in a small proportion of animals. Systemic cisplatin and oxaliplatin induced similar tumor growth delay when combined with anti-PD-1 therapy.Conclusions: Treatment of HNSCC cells with platinum chemotherapy appears to induce some features of anti-tumor immunity, which may be enhanced by anti-PD-1 therapy. Cisplatin, the standard drug for HNSCC, appears to affect anti-tumor immunity in a similar fashion to oxaliplatin in these preclinical models. [ABSTRACT FROM AUTHOR]- Published
- 2019
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19. P136 - Quality of Life Outcomes following Surgical Management of Coexistent Parkinson's Disease and Cervical Spondylotic Myelopathy.
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Xiao, Roy, Miller, Jacob, Lubelski, Daniel, Mroz, Thomas E., Benzel, Edward C., Krishnaney, Ajit A., and Machado, Andre
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TREATMENT of spinal muscular atrophy , *PARKINSON'S disease treatment , *QUALITY of life , *SURGERY , *HEALTH outcome assessment , *PHYSIOLOGY , *MANAGEMENT - Published
- 2016
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20. 80 - Clinical Outcomes following Lumbar Fusion Using the O-Arm: A Propensity-Matched Analysis.
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Xiao, Roy, Miller, Jacob, Sharma, Akshay, Alentado, Vincent J., Lubelski, Daniel, Healy, Andrew T., Mroz, Thomas E., and Benzel, Edward C.
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LUMBAR vertebrae surgery , *LUMBAR vertebrae diseases , *HISTORY of medicine , *TERTIARY care , *HEALTH outcome assessment , *THERAPEUTICS - Published
- 2016
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21. 62 - Clinical Outcomes following Surgical Management of Coexistent Parkinson's Disease and Cervical Spondylotic Myelopathy.
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Xiao, Roy, Miller, Jacob, Sharma, Akshay, Lubelski, Daniel, Mroz, Thomas E., Benzel, Edward C., Krishnaney, Ajit A., and Machado, Andre
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PARKINSON'S disease , *CERVICAL spondylotic myelopathy , *DECOMPRESSION (Physiology) , *SPINAL surgery , *ORTHOPEDICS - Published
- 2016
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22. Patient-reported allergies predict postoperative outcomes and psychosomatic markers after spine surgery.
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Xiong, David D., Ye, Wenda, Xiao, Roy, Miller, Jacob A., Mroz, Thomas E., Steinmetz, Michael P., Nagel, Sean J., and Machado, Andre G.
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SPINAL surgery , *LUMBAR vertebrae , *SIMULATED patients , *LOGISTIC regression analysis , *ALLERGIES - Abstract
Background Context: Prior studies have shown that patient-reported allergies can be prognostic of poorer postoperative outcomes.Purpose: The objective of this study was to investigate the correlation between self-reported allergies and outcomes after cervical or lumbar spine surgery.Study Design/setting: This is a retrospective cohort study at a single tertiary care institution.Patient Sample: The patient sample included all patients undergoing cervical or lumbar spine surgery from 2009 to 2014.Outcome Measures: The primary outcome measure was change in the EuroQol-5 Dimensions (EQ-5D) after surgery. Secondary outcomes included changes in the Pain Disability Questionnaire (PDQ) and in the Patient Health Questionnaire-9 (PHQ-9), achievement of the minimal clinically important difference (MCID) in these measures, and cost of admission.Methods: Before and after surgery, EQ-5D, PDQ, and PHQ-9 were recorded for patients with available data. Paired Student t tests were used to compare changes in these measures after surgery. Multivariable linear and logistic regressions were used to assess the relationship between the log transformation of the total number of allergies and outcomes.Results: A total of 592 cervical patients and 4,465 lumbar patients were included. The median number of reported allergies was two. The EQ-5D index increased from 0.539 to 0.703 for cervical patients and from 0.530 to 0.676 for lumbar patients (p<.01 for both). Patients experienced significant pain improvement by the PDQ (80.1-58.2 for cervical patients and 79.4-58.1 for lumbar patients, p<.01). Using multivariable logistic regression, the log transformation of the number of allergies predicted significantly higher odds of achieving the PDQ MCID (odds ratio [OR]=2.09, 95% confidence interval [CI] 1.05-4.15, p=.02, for cervical patients; OR=1.30, 95% CI 1.03-1.68, p=.03, for lumbar patients). However, this relationship was not durable for patients with follow-up exceeding 1 year. The log transformation of the number of allergies for lumbar patients predicted a significantly increased cost of admission (β=$3,597, p<.01) and trended toward significance among cervical patients (β=$1,842, p=.10).Conclusions: Patient-reported allergies correlate with subjective improvement in pain and disability after spine surgery and may serve as a marker of postoperative outcomes. The relationship between allergies and PDQ improvement may be secondary to the short-term expectation-actuality discrepancy, as this relationship was not durable beyond 1 year. [ABSTRACT FROM AUTHOR]- Published
- 2019
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23. Radiologic Progression of Vertebral Fractures in Patients with Multiple Myeloma.
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Xiao, Roy, Miller, Jacob, Featherall, Joseph, Margetis, Konstantinos, Lubelski, Daniel, Lieberman, Isador H., Benzel, Edward C., and Mroz, Thomas E.
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SPINE radiography , *DISEASE progression , *SPINAL injuries , *COMPRESSION fractures , *MULTIPLE myeloma , *MEDICAL care , *PATIENTS - Published
- 2015
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24. Association Between Radiation Necrosis and Tumor Biology After Stereotactic Radiosurgery for Brain Metastasis.
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Miller, Jacob A., Bennett, Elizabeth E., Xiao, Roy, Kotecha, Rupesh, Chao, Samuel T., Vogelbaum, Michael A., Barnett, Gene H., Angelov, Lilyana, Murphy, Erin S., Yu, Jennifer S., Ahluwalia, Manmeet S., Suh, John H., and Mohammadi, Alireza M.
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BRAIN metastasis , *STEREOTACTIC radiosurgery , *TOXICITY testing , *NEUROLOGY , *HISTOLOGY , *THERAPEUTICS , *ADENOCARCINOMA , *BRAIN , *BRAIN tumors , *BREAST tumors , *GENE amplification , *GENES , *LUNG cancer , *LUNG tumors , *MELANOMA , *MULTIVARIATE analysis , *NECROSIS , *RADIATION injuries , *RADIOSURGERY , *REGRESSION analysis , *SQUAMOUS cell carcinoma , *TRANSFERASES , *RETROSPECTIVE studies , *DISEASE complications - Abstract
Background: The primary dose-limiting toxicity of stereotactic radiosurgery (SRS) is radiation necrosis (RN), which occurs after approximately 5% to 10% of treatments. This adverse event may worsen neurologic deficits, increase the frequency and cost of imaging, and necessitate prolonged treatment with steroids or antiangiogenic agents. Previous investigations have primarily identified lesion size and dosimetric constraints as risk factors for RN in small populations. We hypothesized that disease histology, receptor status, and mutational status are associated with RN.Methods and Materials: All patients presenting with brain metastasis between 1997 and 2015 who underwent SRS and subsequent radiographic follow-up at a single tertiary-care institution were eligible for inclusion. The primary outcome was the cumulative incidence of radiographic RN. Multivariate competing risks regression was used to identify biological risk factors for RN.Results: 1939 patients (5747 lesions) were eligible for inclusion; 285 patients (15%) experienced radiographic RN after the treatment of 427 (7%) lesions. After SRS, the median time to RN was 7.6 months. After multivariate analysis, graded prognostic assessment, renal pathology, lesion diameter, and the heterogeneity index remained independently predictive of RN in the pooled cohort. In subset analyses of individual pathologies, HER2-amplified status (hazard ratio [HR] 2.05, P=.02), BRAF V600+ mutational status (HR 0.33, P=.04), lung adenocarcinoma histology (HR 1.89, P=.04), and ALK rearrangement (HR 6.36, P<.01) were also associated with RN.Conclusions: In the present investigation constituting the largest series of RN, several novel risk factors were identified, including renal histology, lung adenocarcinoma histology, HER2 amplification, and ALK/BRAF mutational status. These risk factors may be used to guide clinical trial design incorporating biological risk stratification or dose escalation. Future studies determining the optimal timing of targeted therapies are warranted to further define the risk of RN. [ABSTRACT FROM AUTHOR]- Published
- 2016
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25. Out‐of‐pocket costs of biologic treatments for chronic rhinosinusitis with nasal polyposis in the Medicare population.
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Rathi, Vinay K., Scangas, George A., Metson, Ralph B., Xiao, Roy, Nshuti, Leonce, and Dusetzina, Stacie B.
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NASAL polyps , *NASAL tumors , *SINUSITIS , *MEDICARE , *MEDICARE Part D , *MEDICARE Part B , *COST - Abstract
Keywords: chronic rhinosinusitis; dupilumab; Medicare Part D; mepolizumab; nasal polyposis; omalizumab; out-of-pocket EN chronic rhinosinusitis dupilumab Medicare Part D mepolizumab nasal polyposis omalizumab out-of-pocket 1295 1298 4 09/30/22 20221001 NES 221001 In June 2019, dupilumab became the first biologic therapy to receive US Food and Drug Administration (FDA) approval for add-on maintenance treatment of adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP). First, we did not include the costs of concomitantly prescribed medications (eg, inhaled corticosteroids, oral antibiotics, or short-acting beta-2 agonists) and thus underestimate annual out-of-pocket drug costs for patients receiving biologic treatments for CRSwNP. Given that Medicare patients have a median annual income of $26,500 and mean annual out-of-pocket health-care costs of $2150 (excluding premiums and long-term care facility fees),10 biologic treatments could thus impose considerable financial burden. We estimated patient first fill, catastrophic coverage, and annual out-of-pocket costs using the mean spending per claim for each biologic listed within the 2019 Medicare Part D Spending Dashboard. [Extracted from the article]
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- 2022
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26. The impact of diabetes upon quality of life outcomes after lumbar decompression.
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Silverstein, Michael P., Miller, Jacob A., Xiao, Roy, Lubelski, Daniel, Benzel, Edward C., and Mroz, Thomas E.
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SPINAL surgery , *DIABETES , *QUALITY of life , *SURGICAL decompression , *COHORT analysis , *DIABETES complications , *FUNCTIONAL assessment , *QUESTIONNAIRES , *SURGICAL complications , *TREATMENT effectiveness , *RETROSPECTIVE studies - Abstract
Background Context: Patients with comorbid disease may experience suboptimal quality of life (QOL) improvement following decompression spinal surgery. Prior studies have suggested the deleterious effect of diabetes upon postoperative QOL; however, these studies have not used minimal clinically important differences (MCIDs) or multivariable statistical techniques.Purpose: The purpose of this study was to assess the effect of preoperative diabetes upon postoperative change in QOL.Study Design/setting: A retrospective cohort study at a single tertiary-care center was carried out.Patient Sample: Patients who underwent lumbar decompression between 2008 and 2014 were included in the study. Inclusion necessitated a minimum follow-up of 6 months.Outcomes Measures: Postoperative changes in the EuroQol 5-Dimensions (EQ-5D), Pain Disability Questionnaire (PDQ), and Patient Health Questionnaire 9 (PHQ-9) at last follow-up were the primary outcome measures. The secondary outcome variable was postoperative change in QOL measures exceeding the MCID.Methods: Quality of life data were collected using the institutional prospectively collected database of patient-reported health status measures. Simple and multivariable logistic regressions were used to assess the impact of diabetes upon normalized change in QOL and improvement exceeding the MCID.Results: There were 212 patients who met inclusion criteria. Whereas non-diabetics experienced significant improvements in EQ-5D, PDQ, and PHQ-9 (p<.01), diabetics experienced no significant changes in any measures. More non-diabetics achieved the EQ-5D MCID compared with diabetics (55% vs. 23%, p<.01). Following multivariable regression, chronic kidney disease (CKD, β=-0.15, p=.04) and diabetes (β=-0.05, p=.04) were identified as significant independent predictors of diminished improvement in EQ-5D postoperatively. Furthermore, diabetes was also identified as a significant independent predictor of failure to achieve an EQ-5D MCID (OR 0.20, p<.01), whereas CKD trended toward predicting diminished improvement (OR<0.01, p=.09).Conclusion: The burden of comorbidities may impact the QOL benefit of decompression spine surgery. In the present study, diabetes was found to independently predict diminished improvement in QOL after lumbar decompression. [ABSTRACT FROM AUTHOR]- Published
- 2016
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27. Payer-Negotiated Prices for Telemedicine Services.
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Wu, Shannon S., Rathi, Vinay K., Ross, Joseph S., Sethi, Rosh K.V., and Xiao, Roy
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NEGOTIATION , *MEDICAL care costs , *TELEMEDICINE - Abstract
Online digital encounter, payer-negotiated price, telemedicine, telephone encounter, virtual check-in, price transparency Keywords: online digital encounter; payer-negotiated price; price transparency; telemedicine; telephone encounter; virtual check-in EN online digital encounter payer-negotiated price price transparency telemedicine telephone encounter virtual check-in 3495 3497 3 10/12/22 20221001 NES 221001 INTRODUCTION Amid the COVID-19 pandemic, insurers broadened eligibility for telemedicine.[1] Correspondingly, hospitals expanded telemedicine availability, and utilization is expected to persist.[2] While attention has been paid to statutory Medicare payment rates for telemedicine services, less is known about private payer prices negotiated with healthcare delivery organizations. We restricted analysis to each state's top-ranking hospital disclosing telemedicine pricing given their anticipated resources to comply with price disclosure requirements and offer telemedicine services, as well as in-state requirements to deliver telemedicine. [Extracted from the article]
- Published
- 2022
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28. Circumferential fusion: a comparative analysis between anterior lumbar interbody fusion with posterior pedicle screw fixation and transforaminal lumbar interbody fusion for L5-S1 isthmic spondylolisthesis.
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Tye, Erik Y., Tanenbaum, Joseph E., Alonso, Andrea S., Xiao, Roy, Steinmetz, Michael P., Mroz, Thomas E., and Savage, Jason W.
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SPINAL fusion , *SPONDYLOLISTHESIS , *QUALITY of life , *HEALTH outcome assessment , *QUESTIONNAIRES - Abstract
Background Context: Transforaminal lumbar interbody fusion (TLIF) or anterior lumbar interbody fusion with percutaneous pedicle screws (ALIFPS) offer significantly higher radiographic fusion rates than other fusion techniques for L5-S1 isthmic spondylolisthesis (IS). As it stands, there is a relative paucity of comparative data of the two techniques.Purpose: To define the clinical, radiographic, and financial differences between TLIF and ALIFPS for L5-S1 IS.Design/setting: A retrospective cohort study conducted at a single tertiary care center.Patient Sample: Sixty-six patients who underwent either TLIF or ALIPFS for L5-S1 IS at a single tertiary care center between 2009 and 2014.Outcome Measures: Quality of life outcome scores including the EuroQol-5 Dimensions (EQ-5D), Pain Disability Questionnaire (PDQ), and Patient Health Questionnaire-9 (PHQ-9). Sagittal balance parameters including: pelvic incidence, pelvic tilt, sacral slope, segmental lordosis, total lordosis, degree of slip, disc height, and L1-axis S1 distance (LASD). Cost measures included in-hospital charges, hospital length of stay (LOS), and post-admission costs accrued over 1 year.Methods: Quality of life (QoL) outcome scores, radiographic data, and financial data were collected with a minimum of 1-year follow-up. Clinical results were investigated using the PDQ, PHQ-9, and EQ-5D. Radiographic measurements included lumbar lordosis, segmental lordosis, pelvic tilt, pelvic incidence, height of disc, L-1 axis S-1 distance, and the degree of slip. Cost data were generated based on patient-level resource utilization. Comparative data were presented as median with interquartile range (IQR). Continuous variables were compared using either independent Student t tests assuming unequal variance or Mann-Whitney U tests for parametric and nonparametric variables, respectively. The minimally clinical important difference (MCID) used for each questionnaire was as follows: PDQ (26), PHQ-9 (5), and EQ-5D (0.4).Results: A total of 66 patients met inclusion criteria. In the ALIFPS cohort, PDQ scores improved from 69 [47, 82] to 26 [18.2, 79.7], p=.02. In the TLIF cohort, PDQ scores improved from 73 [46, 85] to 48.5 [23, 67.5], p=.01. Both groups also showed a significant improvement in EQ-5D scores at 1 year, but the ALIFPS group showed a significantly greater improvement in EQ-5D scores at 1 year (0.1 [0,0.2] vs. 0.2 [0.1, 0.4], p=.02). Furthermore, only the ALIFPS cohort showed a significant improvement in segmental lordosis. The ALIFPS cohort showed a significantly greater improvement in disc height than did TLIF (3.5 [2, 5.5] vs. 6.7 [4.1, 10], p=.01). No significant differences were found in the direct costs of both procedures.Conclusions: Our findings suggest that anterior lumbar interbody fusion with percutaneous pedicle screws can achieve better clinical outcomes compared with TLIF for the treatment of IS. We believe the superior radiographic outcomes achieved through ALIFPS, namely a greater restoration of segmental lordosis and disc height, may have contributed to the improved clinical outcomes presented in the current study. [ABSTRACT FROM AUTHOR]- Published
- 2018
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29. Emergency department visits after lumbar spine surgery are associated with lower Hospital Consumer Assessment of Healthcare Providers and Systems scores.
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Levin, Jay M., Winkelman, Robert D., Smith, Gabriel A., Tanenbaum, Joseph E., Xiao, Roy, Mroz, Thomas E., and Steinmetz, Michael P.
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LUMBAR vertebrae surgery , *HOSPITAL emergency services , *VISITATION in hospitals , *MEDICAL personnel , *HEALTH reimbursement accounts - Abstract
Background: Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys are used to assess the quality of the patient experience following an inpatient stay. Hospital Consumer Assessment of Healthcare Providers and Systems scores are used to determine reimbursement for hospital systems and incentivize spine surgeons nationwide. There are conflicting data detailing whether early readmission or other postdischarge complications are associated with patient responses on the HCAHPS survey. Currently, the association between postdischarge emergency department (ED) visits and HCAHPS scores following lumbar spine surgery is unknown.Purpose: To determine whether ED visits within 30 days of discharge are associated with HCAHPS scores for patients who underwent lumbar spine surgery.Study Design: Retrospective cohort study.Patient Sample: A total of 453 patients who underwent lumbar spine surgery who completed the HCAHPS survey between 2013 and 2015 at a single tertiary care center.Outcome Measures: The HCAHPS survey-the Centers for Medicare and Medicaid Services' official measure of patient experience-results for each patient were analyzed as the primary outcome of this study.Methods: All patients undergoing lumbar spine surgery between 2013 and 2015 who completed an HCAHPS survey were studied. Patients were excluded from the study if they had been diagnosed with spinal malignancy or scoliosis. Patients who had an ED visit at our institution within 30 days of discharge were included in the ED visit cohort. The primary outcomes of this study include 21 measures of patient experience on the HCAHPS survey. Statistical analysis included Pearson chi-square for categorical variables, Student t test for normally distributed continuous variables, and Mann-Whitney U test for nonparametric variables. Additionally, log-binomial regression models were used to analyze the association between ED visits within 30 days after discharge and odds of top-box HCAHPS scores. No funds were received in support of this study, and the authors report no conflict of interest-associated biases.Results: After adjusting for patient-level covariates using log-binomial regression models, we found postdischarge ED visits were independently associated with lower likelihood of top-box score for several individual questions on HCAHPS. Emergency department visits within 30 days of discharge were negatively associated with perceiving your doctor as "always" treating you with courtesy and respect (risk ratio [RR] 0.26, p<.001), as well as perceiving your doctor as "always" listeningcarefully to you (RR 0.40, p=.003). Also, patients with an ED visit were less likely to feel as if their preferences were taken into account when leaving the hospital (RR 0.61, p=.008), less likely to recommend the hospital to family or friends (RR 0.46, p=.020), and less likely to rate the hospital as a 9 or a 10 out of 10, the top-box score (RR 0.43, p=.005).Conclusions: Our results demonstrate a strong association between postdischarge ED visits and low HCAHPS scores for doctor communication, discharge information, and global measures of hospital satisfaction in a lumbar spine surgery population. [ABSTRACT FROM AUTHOR]- Published
- 2018
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30. P203 - Correlation of Patient-Reported Allergies with Postoperative Outcomes and Cost of Admission for Cervical and Lumbar Spinal Surgery.
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Xiong, David, Ye, Wenda, Xiao, Roy, Miller, Jacob, Nagel, Sea J., and Machado, Andre
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LUMBAR vertebrae surgery , *CERVICAL vertebrae , *POSTOPERATIVE period , *MEDICAL care costs , *QUALITY of life , *SURGERY - Published
- 2017
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31. Use of Payer as a Proxy for Health Insurance Status on Admission Results in Misclassification of Insurance Status among Pediatric Trauma Patients.
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CARTER, ELIZABETH A., WATERHOUSE, LAUREN J., ROY XIAO, BURD, RANDALL S., and Xiao, Roy
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CHILDREN'S injuries , *HEALTH insurance , *HOSPITAL admission & discharge , *EMERGENCY medical services , *CHILD mortality , *INSURANCE statistics , *WOUNDS & injuries , *HEALTH insurance statistics , *CHILDREN'S hospitals , *COMPARATIVE studies , *HOSPITAL emergency services , *INSURANCE , *RESEARCH methodology , *MEDICAL cooperation , *PATIENTS , *RESEARCH , *TRAUMA centers , *LOGISTIC regression analysis , *EVALUATION research , *RETROSPECTIVE studies , *ECONOMICS - Abstract
The purpose of this study was to quantify health insurance misclassification among children treated at a pediatric trauma center and to determine factors associated with misclassification. Demographic, medical, and financial information were collected for patients at our institution between 2008 and 2010. Two health insurance variables were created: true (insurance on hospital admission) and payer (source of payment). Multivariable logistic regression was used to determine which factors were independently associated with health insurance misclassification. The two values of health insurance status were abstracted from the hospital financial database, the trauma registry, and the patient medical record. Among 3630 patients, 123 (3.4%) had incorrect health insurance designation. Misclassification was highest in patients who died: 13.9 per cent among all deaths and 30.8 per cent among emergency department deaths. The adjusted odds of misclassification were 6.7 (95% confidence interval: 1.7, 26.6) among patients who died and 16.1 (95% confidence interval: 3.2, 80.77) among patients who died in the emergency department. Using payer as a proxy for health insurance results in misclassification. Approaches are needed to accurately ascertain true health insurance status when studying the impact of insurance on treatment outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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32. P191 - Comparative Effectiveness between Primary and Revision Foraminotomy for the Treatment of Lumbar Foraminal Stenosis.
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Hu, Emily, Shao, Jianning, Gould, Heath, Xiao, Roy, Haines, Colin M., Moore, Don K., Mroz, Thomas E., and Steinmetz, Michael P.
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SPINAL stenosis , *SPINE diseases , *SPINAL surgery , *QUALITY of life , *PATIENTS - Published
- 2017
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