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3 results on '"Xiao, Sheng-Nan"'

2. Simulation of Multi-stage Flash（MSF）Desalination Process

Author

Xiao Sheng-nan, Wu Lian-ying, and Gao Cong-jie

Subjects
Multi stage, Brine, Fresh water, business.industry, Seawater desalination, General Engineering, Environmental science, Seawater, Process simulation, Process engineering, business, Desalination, Effect factor
Abstract

MSF seawater desalination has become an important technology to solve the scarce of fresh water resources in the world. But the high energy cost is the bottle-neck of extendibility and application. In this paper, the principle of MSF is analyzed and the single flash stage is divided into several elementary unit operations. The Aspen Plus is adopted to simulate MSF desalination process. The effect factor of MSF system, such as the feed seawater temperature, the top brine temperature（TBT） and the stage number, is investigated and the optimum operation condition is obtained.

Published
2012

3. Semi-synthesis and anti-tumor activity of novel 25-OCH 3 -PPD derivatives incorporating aromatic moiety.

Author

Qu FZ, Xiao SN, Wang XD, Zhang Y, Su GY, and Zhao YQ

Subjects
Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Ginsenosides chemical synthesis, Ginsenosides chemistry, Hep G2 Cells, Humans, MCF-7 Cells, Molecular Structure, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Ginsenosides pharmacology
Abstract

Previously we have reported that 25-OCH 3 -PPD could suppress the reproduction of cancer cells and cause apoptosis without obvious toxicity. Herein, we aimed to enhance its bioactivity by introducing aromatic groups to its dammarane-type skeleton. These synthesized derivatives were tested for their inhibitory activities against five cancer cell lines. Of them, compounds 3a, 14a and 18a had the strongest antiproliferative activities against tumor cells (IC 50  < 15 µM, 5-fold to 10-fold increases than 25-OCH 3 -PPD). Especially compound 14a displayed the most potent activity against DU145, MCF-7 and HepG2 cells (IC 50  = 6.7 ± 0.8, 4.3 ± 0.8 and 5.8 ± 0.6 µM, respectively). Structure-activity relationships demonstrated that having aromatic ester at the C3 position could improve the bioactivity. The data provided new insights into exploring novel antiproliferative lead compounds., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2019
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