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In order to find an appropriate thermodynamic model of rectisol process, the SRKH model of low-temperature methanol absorption was established and parameter regression was used to abtain all binary interaction parameters of the NRTL equation for rectisol system. The correctness of the arguments was verified by the vapor-liquid equilibrium calculations. An industrial absorber in China was simulated and the CO2, and H2S concentration distribution in the absorber was obtained. The results show that the SRKH model is suitable for rectisol system. The effects of operating conditions on rectisol system were investigated and the concentration variations of CO2 and H2S in purified gas caused by the changes of operating conditions were obtained. The acidic gas concentration in purified gas decreases along with the increase of pure methanol flow or/and the decrease of methanol temperature and the concentration of H2S can be reduced to less than 0.1x106 quickly. Therefore, qualified gas with different CO2 concentrations can be produced by changing the flow of pure methanol or methanol temperature. The effect of crude gas flow on pure methanol flow was also investigated when the concentration requirements of acidic gases in purufied gas of coal gasification methanol synthesis process were meet; and results show that the flow of pure methanol increased with the augment of crude gas flow and the extent of growth decreases gradually, which indicates that it is beneficial to enlarge the scale so as to reduce operating cost in advanced coal chemical industry. [ABSTRACT FROM AUTHOR]

Ubiquitination is a crucial post-translational modification of proteins that mediates the degradation or functional regulation of specific proteins. This process participates in various biological processes such as cell growth, development, and signal transduction. E3 ubiquitin ligases play both positive and negative regulatory roles in osteogenesis and differentiation by ubiquitination-mediated degradation or stabilization of transcription factors, signaling molecules, and cytoskeletal proteins. These activities affect the proliferation, differentiation, survival, and bone formation of osteoblasts (OBs). In recent years, advances in genomics, transcriptomics, and proteomics have led to a deeper understanding of the classification, function, and mechanisms of action of E3 ubiquitin ligases. This understanding provides new insights and approaches for revealing the molecular regulatory mechanisms of bone formation and identifying therapeutic targets for bone metabolic diseases. This review discusses the research progress and significance of the positive and negative regulatory roles and mechanisms of E3 ubiquitin ligases in the process of osteogenic differentiation. Additionally, the review highlights the role of E3 ubiquitin ligases in bone-related diseases. A thorough understanding of the role and mechanisms of E3 ubiquitin ligases in osteogenic differentiation could provide promising therapeutic targets for bone tissue engineering based on stem cells., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhang, Wang, Xiao, Yang, Xu, Huang, Wang and He.)