713 results on '"Xiao Li Liu"'
Search Results
2. Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
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Zhi Qiang Yang, Xiao Teng Ma, Qiao Yu Shao, Qiu Xuan Li, Yu Fei Wang, Jing Liang, Hua Shen, Xiao Li Liu, Dong Mei Shi, Yu Jie Zhou, Zhe Fang, and Zhi Jian Wang
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free triiodothyronine ,acute coronary syndrome ,percutaneous coronary intervention ,adverse cardiovascular events ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Homeostasis of thyroid hormones has significant effects on the cardiovascular system. The aim of this study was to investigate the association between free triiodothyronine (FT3) and adverse cardiovascular events in patients with acute coronary syndrome (ACS) who were undergoing percutaneous coronary intervention (PCI). Methods: A total of 1701 patients with ACS undergoing PCI were included in this study. All patients were divided into three groups according to the tertiles of FT3 level: the lowest tertile (FT3
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- 2022
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3. Facile Synthesis of Manganese Cobalt Oxide/Nickel Cobalt Oxide Composites for High-Performance Supercapacitors
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Wang Chen Huo, Xiao Li Liu, Yun Song Yuan, Nan Li, Tian Lan, Xiao Ying Liu, and Yu Xin Zhang
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transition metal oxides ,spinel structure ,composites ,supercapacitor ,MnCo2O4.5@NiCo2O4 nanowire ,Chemistry ,QD1-999 - Abstract
Transition metal oxides (TMOs) with spinel structures have a promising potential as the electrode materials for supercapacitors application owning to its outstanding theoretical capacity, good redox activity, and eco-friendly feature. In this work, MnCo2O4.5@NiCo2O4 nanowire composites for supercapacitors has been successfully fabricated by using a mild hydrothermal approach without any surfactant. The morphology and physicochemical properties of the prepared products can be well-controlled by adjusting experimental parameters of preparation. The double spinel composite exhibits a high specific capacitance of 325 F g−1 (146 C g−1) and 70.5% capacitance retention after 3,000 cycling tests at 1 A g−1.
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- 2019
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4. Identification and Genetic Analysis of a Factor IX Gene Intron 3 Mutation in a Hemophilia B Pedigree in China
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Dong Hua Cao, Xiao Li Liu, Kai Mu, Xiang Wei Ma, Jing Li Sun, Xiao Zhong Bai, Chang Kun Lin, and Chun Lian Jin
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hemophilia b ,factor ix ,mutation ,intron 3 ,mrna splice site ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
OBJECTIVE: Hemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. A wide range of mutations, showing extensive molecular heterogeneity, have been described in hemophilia B patients. Our study was aimed at genetic analysis and prenatal diagnosis of hemophilia B in order to further elucidate the pathogenesis of the hemophilia B pedigree in China. METHODS: Polymerase chain reaction amplification and direct sequencing of all the coding regions was conducted in hemophilia B patients and carriers. Prenatal diagnosis of the proband was conducted at 20 weeks. RESULTS: We identified the novel point mutation 10.389 A>G, located upstream of the intron 3 acceptor site in hemophilia B patients. The fetus of the proband's cousin was identified as a carrier. CONCLUSION: Our identification of a novel mutation in the F9 gene associated with hemophilia B provides novel insight into the pathogenesis of this genetically inherited disorder and also represents the basis of prenatal diagnosis.
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- 2014
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5. Contemporary management and attainment of cholesterol targets for patients with dyslipidemia in China.
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Fei Gao, Yu Jie Zhou, Da Yi Hu, Ying Xin Zhao, Yu Yang Liu, Zhi Jian Wang, Shi Wei Yang, and Xiao Li Liu
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Medicine ,Science - Abstract
It is well-established that lipid disorder is an important cardiovascular risk factor, and failure to reach optimal lipid levels significantly contributes to the residual cardiovascular risks. However, limited information is available on the management and the attainment of recommended cholesterol targets in real-world practice in China.A nationally representative sample of 12,040 patients with dyslipidemia from 19 provinces and 84 hospitals across China were consecutively enrolled in this survey. Risk stratification and individual cholesterol target was established for all participants. This survey identified a high-risk cohort, with over 50% of patients had hypertension, 37.5% had coronary artery disease, and more than 30% had peripheral artery disease. Thirty-nine percent of all participants received lipid lowering medications. And the majority of them (94.5%) had statins (42.5% with atorvastatin, 29.0% with simvastatin, and 15.2% with rosuvastatin). However, the overall attainment for low-density lipoprotein cholesterol (LDL-C) target is low (25.8%), especially, in female (22.2%), and in patients with increased body mass index (BMI) (38.3% for BMI
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- 2013
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6. An Improved Genetic Algorithm Based Annulus-Sector Clustering Routing Protocol for Wireless Sensor Networks
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Chu-hang, Wang, Xiao-li, Liu, You-jia, Han, Huang-shui, Hu, and Sha-sha, Wu
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- 2022
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7. An Improved Genetic Algorithm Based Annulus-Sector Clustering Routing Protocol for Wireless Sensor Networks.
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Chuhang Wang, Xiao-li Liu, Youjia Han, Huangshui Hu, and Shasha Wu
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- 2022
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8. Enhancement on antioxidant, anti-hyperglycemic and antibacterial activities of blackberry anthocyanins by processes optimization involving extraction and purification
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Han Wu, Qing-Ru Di, Liang Zhong, Jian-Zhong Zhou, Cheng-Jun Shan, Xiao-Li Liu, and Ai-Min Ma
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blackberry anthocyanin ,enrichment ,UPLC-QTOF-MS ,bioactivity ,nutraceutical supplement ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This research aimed to recover anthocyanin-rich extracts from blackberry (Rubus spp. Hull cultivar) by optimizing the processing conditions, and to characterize anthocyanin individuals and determine influences of optimization on enhancement of antioxidant and anti-hyperglycemic activities of anthocyanins as natural supplements. The ethanol concentration of 69.87%, HCl dosage of 0.53%, solid-to-liquid ratio of 1:19.06 at 47.68°C for 17.04 h were optimal to obtain the highest extraction yield of anthocyanins at 0.72 mg/g. By using AB-8 macroporous resins, the anthocyanin concentration of 3.0 mg/mL, ethanol concentration of 90%, and elution rate of 2.0 mL/min were selected to boost the anthocyanin purity up to be 60.11%. Moreover, the purified anthocyanin extracts from blackberry contained nine main pigments which could be divided into three aglycone-based forms, and cyanidin-3-O-glucoside was the most abundant among them. Due to the successive processes of extraction and purification, the blackberry purified anthocyanin extracts (BA-PAE) showed much higher bioactive capacities than the blackberry crude anthocyanin extracts (BA-CAE) and blackberry fruit slurry extracts (BA-FSE), e.g., DPPH and ABTS radical scavenging activities (EC50 = 0.08 and 0.04, 0.32 and 0.24, and 1.31 and 0.41 mg/mL), oxygen radical absorbance capacity (1.60, 0.59, and 0.15 mmol TEAC/g), cytoprotective effects against oxidative stress in PC12 cells (1.69-, 1.58-, and 1.50-fold cell viability compared to oxidative group), α-amylase and α-glucosidase inhibitory activities (IC50 = 0.10 and 0.06, 0.56 and 0.32, and 3.98 and 2.16 mg/mL), and antibacterial activity (93.23, 40.85, and 80.42% reduced biofilm).
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- 2022
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9. Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X
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Dong-Hong Zhang, Chen Yuan, Bei-Bei Wang, Xin-Jiang Dong, Shu-Ping Lv, Fei-Hong Li, Zhen-Xiu Hou, Xiao-Li Liu, and Kang Chen
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Helicobacter pylori infection ,Cardiac syndrome X ,cytotoxin-associated gene A ,meta-analysis ,systematic review ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
PurposeCardiac syndrome X (CSX) is a condition with normal coronary angiography but angina pectoris. Chronic inflammation caused by Helicobacter pylori (H. pylori) infection may play a pathogenic role in CSX. Therefore, we conducted a meta-analysis to explore the relationship between H. pylori infection and risk of CSX.MethodsA systematic search in the Web of Science, Medline, Embase and Chinese databases (CNKI and Wanfang) was conducted up to October 2021. Articles on the association between H. pylori infection and the risk of CSX were included and were analyzed by R software (version 4.1.0).ResultsTen case-control studies involving 703 CSX patients and 731 healthy controls were included. H. pylori infection was associated with an increased risk of CSX (OR: 8.29, 95% CI: 4.64–14.82). We also found a significant association in those 25–40 years of age (OR: 1.34, 95% CI: 1.04–1.72), those 40–50 years of age (OR: 11.27, 95% CI: 4.29–29.61), those over 50 years of age (OR: 7.18, 95% CI: 3.59–14.36), those in developing countries [Iran (OR: 12.99, 95% CI: 8.61–19.60) and China (OR: 5.14, 95% CI: 3.09–8.56)]. However, this association was not apparent in a developed country [Italy (OR: 0.93, 95% CI: 0.37–2.33)].ConclusionsOur study suggested a possible association between H. pylori infection and the risk of CSX. Its pathogenicity is stronger in middle-aged individuals and some developing countries. However, more studies are needed to further investigate whether early eradication of H. pylori can reduce the incidence rate of CSX, especially in middle-aged individuals and some developing countries.
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- 2022
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10. Choroidal thickness in primary angle-closure disease
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Shao-Fan Zhu, Dan-Yan Liu, Shuang Liang, Xiao-Li Liu, and Bin Zhang
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primary angle-closure disease ,macular choroidal thickness ,peripapillary choroidal thickness ,enhanced depth imaging spectral-domain optical coherence tomography ,a prospective clinical study ,Ophthalmology ,RE1-994 - Abstract
AIM:To measure the macular and peripapillary choroidal thickness(CT)in primary angle-closure disease(PACD)with enhanced depth imaging optical coherence tomography(EDI-OCT). To explore the characteristics of CT in each subtypes of PACD and to evaluate its role in the pathogenesis of PACD.METHODS: This was a prospective clinical study. A total of 155 PACD eyes(82 patients)were enrolled in the study, including 24 PACS eyes(24 patients), 35 APAC eyes(28 patients), 38 CPAC eyes(30 patients), 58 eyes PACG(38 patients). 87 normal eyes(87 patients)were set up as control. The EDI-OCT was used to measure the macular and peripapillary choroidal thickness in all study patients. RESULTS: PACD eyes exhibited thicker choroid than the control eyes at all macular locations(P0.05).CONCLUSION: In PACD and controls groups, the CT of subfoveal location was the thickest with decreasing thickness when moving eccentrically from the fovea. The thicker CT might be another anatomic characteristic of PACD. Increased CT in macular location might be a contributing factor of acute attacks. There was no characteristic distinction in the peripapillary CT of PACD when compared with normal controls.
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- 2021
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11. The impact of female sex hormones on cardiovascular disease: from mechanisms to hormone therapy.
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Yi KAN, Yu-Lu PENG, Ze-Hao ZHAO, Shu-Tong DONG, Yin-Xiao XU, Xiao-Teng MA, Xiao-Li LIU, Yu-Yang LIU, and Yu-Jie ZHOU
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CARDIOVASCULAR disease related mortality ,SEX hormones ,PROGESTERONE ,WOMEN ,GENOMICS ,SEX distribution ,MENOPAUSE ,HYPERTENSION ,CARDIOVASCULAR diseases risk factors ,ESTROGEN ,HEART failure ,HORMONE therapy ,PREECLAMPSIA ,MENSTRUATION disorders - Abstract
Cardiovascular disease remains the leading cause of mortality in women, yet it has not raised the awareness from the public. The pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex hormones. Estrogen and progestogen impact cardiovascular system through genomic and non-genomic effects. Before menopause, cardiovascular protective effects of estrogens have been well described. Progestogens were often used in combination with estrogens in hormone therapy. Fluctuations in sex hormone levels, particularly estrogen deficiency, were considered the specific risk factor in women's cardiovascular disease. However, considerable heterogeneity in the impact of hormone therapy was observed in clinical trials. The heterogeneity is likely closely associated with factors such as the initial time, administration route, dosage, and formulation of hormone therapy. This review will delve into the pathogenesis and hormone therapy, summarizing the effect of female sex hormones on hypertension, pre-eclampsia, coronary heart disease, heart failure with preserved ejection fraction, and cardiovascular risk factors specific to women. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Hulless Black Barley as a Carrier of Probiotics and a Supplement Rich in Phenolics Targeting Against H2O2-Induced Oxidative Injuries in Human Hepatocarcinoma Cells
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Han Wu, Hao-Nan Liu, Chun-Quan Liu, Jian-Zhong Zhou, Xiao-Li Liu, and Hong-Zhi Zhang
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black barley ,lactic acid bacteria ,phenolic transformation ,antioxidant activity ,human hepatocarcinoma cells ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Lactic acid bacteria can provide benefits to human beings and transform phenolic substances to improve their potential functionality. It was of interest to develop black barley as a carrier of probiotics and nutraceutical supplement rich in more antioxidants. Due to fermentation, bacterial counting and free phenolic content in black barley increased to 9.54 ± 0.22 log cfu/mL and 5.61 ± 0.02 mg GAE/mL, respectively. Eleven phenolic compounds, including nine isoflavones and two nitrogenous compounds were characterized using UPLC-QTOF-MS, among which epicatechin, hordatine, and pelargonidin aglycone were largely enriched. Moreover, free phenolic extracts from fermented barley (F-BPE) played a greater role in scavenging DPPH radicals, reducing Fe3+ to Fe2+, and increasing oxygen radical absorbance capacity, compared phenolic extracts from unfermented barley [UF-BPE (1.94-, 1.71-, and 1.35-fold at maximum for F-BPE vs. UF-BPE, respectively)]. In hepatocarcinoma cells, F-BPE also better inhibited ROS production and improved cell viability, cell membrane integrity, SOD activity, and non-enzymatic antioxidant GSH redox status (2.85-, 3.28-, 2.05-, 6.42-, and 3.99-fold at maximum for F-BPE vs. UF-BPE, respectively).
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- 2022
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13. Clinicopathologic characterization and abnormal autophagy of CSF1R-related leukoencephalopathy
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Wo-Tu Tian, Fei-Xia Zhan, Qing Liu, Xing-Hua Luan, Chao Zhang, Liang Shang, Ben-Yan Zhang, Si-Jian Pan, Fei Miao, Jiong Hu, Ping Zhong, Shi-Hua Liu, Ze-Yu Zhu, Hai-Yan Zhou, Suya Sun, Xiao-Li Liu, Xiao-Jun Huang, Jing-Wen Jiang, Jian-Fang Ma, Ying Wang, Shu-Fen Chen, Hui-Dong Tang, Sheng-Di Chen, and Li Cao
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Hereditary diffuse leukoencephalopathy with spheroids ,CSF1R ,Autophagy ,Haploinsufficiency ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background CSF1R-related leukoencephalopathy, also known as hereditary diffuse leukoencephalopathy with spheroids (HDLS), is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to colony-stimulating factor 1 receptor (CSF1R) gene mutation. Few of CSF1R mutations have been functionally testified and the pathogenesis remains unknown. Methods In order to investigate clinical and pathological characteristics of patients with CSF1R-related leukoencephalopathy and explore the potential impact of CSF1R mutations, we analyzed clinical manifestations of 15 patients from 10 unrelated families and performed brain biopsy in 2 cases. Next generation sequencing was conducted for 10 probands to confirm the diagnosis. Sanger sequencing, segregation analysis and phenotypic reevaluation were utilized to substantiate findings. Functional examination of identified mutations was further explored. Results Clinical and neuroimaging characteristics were summarized. The average age at onset was 35.9 ± 6.4 years (range 24–46 years old). Younger age of onset was observed in female than male (34.2 vs. 39.2 years). The most common initial symptoms were speech dysfunction, cognitive decline and parkinsonian symptoms. One patient also had marked peripheral neuropathy. Brain biopsy of two cases showed typical pathological changes, including myelin loss, axonal spheroids, phosphorylated neurofilament and activated macrophages. Electron microscopy disclosed increased mitochondrial vacuolation and disorganized neurofilaments in ballooned axons. A total of 7 pathogenic variants (4 novel, 3 documented) were identified with autophosphorylation deficiency, among which c.2342C > T remained partial function of autophosphorylation. Western blotting disclosed the significantly lower level of c.2026C > T (p.R676*) than wild type. The level of microtubule associated protein 1 light chain 3-II (LC3-II), a classical marker of autophagy, was significantly lower in mutants expressed cells than wild type group by western blotting and immunofluorescence staining. Conclusions Our findings support the loss-of-function and haploinsufficiency hypothesis in pathogenesis. Autophagy abnormality may play a role in the disease. Repairing or promoting the phosphorylation level of mutant CSF1R may shed light on therapeutic targets in the future. However, whether peripheral polyneuropathy potentially belongs to CSF1R-related spectrum deserves further study with longer follow-up and more patients enrolled. Trial registration ChiCTR, ChiCTR1800015295. Registered 21 March 2018.
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- 2019
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14. Nutritional Risk Index Improves the GRACE Score Prediction of Clinical Outcomes in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
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Xiao-Teng Ma, Qiao-Yu Shao, Qiu-Xuan Li, Zhi-Qiang Yang, Kang-Ning Han, Jing Liang, Hua Shen, Xiao-Li Liu, Yu-Jie Zhou, and Zhi-Jian Wang
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nutritional risk index (NRI) ,GRACE score ,acute coronary syndrome (ACS) ,percutaneous coronary intervention ,diabetes ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Malnutrition has been shown to be associated with adverse cardiovascular outcomes in many patient populations.Aims: To investigate the prognostic significance of malnutrition as defined by nutritional risk index (NRI) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and whether NRI could improve the GRACE score based prognostic models.Methods: This study applied NRI among 1,718 patients with ACS undergoing PCI. Patients were divided into three nutritional risk groups according to their baseline NRI: no nutritional risk (NRI ≥ 100), mild nutritional risk (97.5 ≤ NRI
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- 2021
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15. Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L. and Its Components for Ischemic Stroke: A Systematic Review and Meta-Analysis
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Yan Li, Miao Cai, Gen-Xiang Mao, Qin-Fen Shu, Xiao-Bei Liu, and Xiao-Li Liu
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Rhodiola rosea L ,traditional medicine ,ischemia stroke ,possible mechanisms ,preclinical evidence ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background:Rhodiola rosea L. has long been used as traditional medicines in Europe and Asia to treat a variety of common conditions and diseases including Alzheimer’s disease, cardiovascular disease, cognitive dysfunctions, cancer, and stroke. Previous studies reported that Rhodiola rosea L. and its components (RRC) improve ischemia stroke in animal models. Here, we conducted a systematic review and meta-analysis for preclinical studies to evaluate the effects of RRC and the probable neuroprotective mechanisms in ischemic stroke.Methods: Studies of RRC on ischemic stroke animal models were searched in seven databases from inception to Oct 2021. The primary measured outcomes included the neural functional deficit score (NFS), infarct volume (IV), brain water content, cell viability, apoptotic cells, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells, B-cell lymphoma-2 (Bcl-2) level and tumor necrosis factor-α (TNF-α) level. The secondary outcome measures were possible mechanisms of RRC for ischemic stroke. All the data were analyzed via RevMan version 5.3.Results: 15 studies involving 345 animals were identified. Methodological quality for each included studies was accessed according to the CAMARADES 10-item checklist. The quality score of studies range from 1 to 7, and the median was 5.53. Pooled preclinical data showed that compared with the controls, RRC could improve NFS (Zea Longa (p < 0.01), modified neurological severity score (mNSS) (p < 0.01), rotarod tests (p < 0.01), IV (p < 0.01), as well as brain edema (p < 0.01). It also can increase cell viability (p < 0.01), Bcl-2 level (p < 0.01) and reduce TNF-α level (p < 0.01), TUNEL-positive cells (p < 0.01), apoptotic cells (p < 0.01).Conclusion: The findings suggested that RRC can improve ischemia stroke. The possible mechanisms of RRC are largely through antioxidant, anti-apoptosis activities, anti-inflammatory, repressing lipid peroxidation, antigliosis, and alleviating the pathological blood brain barrier damage.
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- 2021
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16. A case of Quebec platelet disorder with interstitial pneumonia
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Yong-Jing Wang, Jian-Qiang Liu, Ya-Nan Guo, Xiao-Li Liu, Yang Jiang, De-Xiao Kong, Ying-Xue Wang, Cheng-Yun Zheng, Ai-Xia Dou, and Pei-Fang Wei
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Medicine - Published
- 2020
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17. Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation
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Yao-Wu Liu, Xiao-Li Liu, Li Kong, Meng-Ya Zhang, Ya-Jing Chen, Xia Zhu, and Yun-Chao Hao
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Glyoxalase 1 ,Quercetin ,Nrf2/ARE pathway ,High glucose ,Central neurons ,Protein kinases ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Although dietary flavonoid quercetin alleviates diabetes-associated cognitive decline in rodents, the mechanisms are not clearly clarified. This study was designed to investigate whether quercetin showed neuroprotection on central neurons against chronic high glucose through the enhancement of Nrf2/ARE/glyoxalase 1 (Glo-1) pathway. SH-SY5Y cells were divided into 8 groups: normal glucose, high glucose (HG), osmotic pressure control, solvent control, HG plus low, middle, high concentrations of quercetin, or Nrf2 activator (sulforaphane). After treatment for 72 h, the associated parameters were measured. We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG. Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of γ-glutamycysteine synthase (γ-GCS), a known target gene of Nrf2/ARE signaling. Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3β inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3β activation pretreatment reversed the effects of quercetin on the protein expression of γ-GCS in the HG condition. In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3β inhibition may involve in the activation of Nrf2/ARE pathway.
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- 2019
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18. The GC2 haplotype of the vitamin D binding protein is a risk factor for a low plasma 25-hydroxyvitamin D concentration in a Han Chinese population
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Ji-Chang Zhou, Yumei Zhu, Chunmei Gong, Xiongshun Liang, Xiaoying Zhou, Yuanfei Xu, Deliang Lyu, Junluan Mo, Jian Xu, Jinping Song, Xiaoling Che, Shiqiang Sun, Changhua Huang, and Xiao-Li Liu
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Vitamin D binding protein ,Single nucleotide polymorphism ,Circulating 25-hydroxyvitamin D ,Glucose ,Lipids ,Han Chinese ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background The GC haplotype of the vitamin D binding protein (encoded by the GC gene) might be a risk factor to the vitamin D (VD) nutritional status for many populations, while evidences from the Chinese Han population are sparse. We test the association between vitamin D binding protein genotypes and VD status as well as the metabolic parameters of glucose and lipids in a Han Chinese population. Methods In a cross-sectional study conducted at a health examination centre (registered in ClinicalTrials.gov as QLS2013), 2641 adults were included and grouped according to their plasma 25-hydroxyvitamin D (25OHD) concentrations as VD deficient (VDD), insufficient (VDI), or sufficient (VDS). The rs7041 and rs4588 genotypes were analysed with a molecular beacon-based qPCR method using blood samples. Results Plasma 25OHD concentrations were lower in the GC2/2, rs7041T/T, and rs4588A/A genotypes than the GC1f/1s, rs7041G/T, and rs4588C/C genotypes (P 0.05). Conclusions In a Han Chinese population, the GC2 haplotype or more exactly rs4588A is a risk factor for low VD status but is not associated with glucose and lipid metabolic disorders, which are inversely correlated with the circulating 25OHD concentration in males. Trial registration The study was retrospectively registered in January 2018 as NCT03406234 in the ClinicalTrials.gov online system.
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- 2019
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19. FeCo-N encapsuled in nitrogen-doped carbon nanotubes as bifunctional electrocatalysts with a high stability for zinc air batteries
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Xiao-Gang Wu, Rui Wang, Fei Ma, Xiao-Li Liu, Da-Li Jia, Hong-Cen Yang, Yan-Peng Liu, Zhi-Xia Wang, Han-Zhen Zheng, Ya-Nan Zhang, Juan Hou, Juan-Juan Huang, and Shang-Long Peng
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Materials Chemistry ,Metals and Alloys ,Physical and Theoretical Chemistry ,Condensed Matter Physics - Published
- 2023
20. 3D Models to Educated Museum Interactive Exhibition with Computing Techniques.
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Hao Jiang, Xiao-Li Liu 0008, Xiang Peng, Ming-Xi Tang, Dong He, Hai-Long Chen, Kai-Bing Xiang, and Bo Man
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- 2017
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21. Correlation between Insulin Resistance and Cardiopulmonary Function during Physical Exams for Male Patients
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Bin-Bin Liu, Zi-Ru Niu, Xiao-Jiao Jia, Xiao-Li Liu, and Qiang Lu
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Health (social science) ,Social Psychology ,Public Health, Environmental and Occupational Health - Abstract
Objective: In this study, we investigated the correlation between insulin resistance (IR) and cardiopulmonary function during physical exams for male patients. Methods: We selected 124 healthy male participants in the physical examination center of our hospital. They were divided into 3 groups according to the homeostasis model assessment of insulin resistance values. The oxygen uptake, peak oxygen uptake (VO2/kg), heart rate, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured by a cardiopulmonary exercise function tester. We analyzed the correlation between the index of IR and cardiopulmonary function. Results: There were statistically significant differences in body mass index, waist circumference, fasting insulin level, anaerobic threshold SBP, maximum VO2/kg and maximum SBP among the 3 groups (p.05). The anaerobic threshold SBP, maximum VO2/kg and maximum SBP were all negatively correlated with the IR index. Conclusion: Our results indicate that IR is associated with cardiopulmonary function and that there are different correlations between the various cardiopulmonary function indexes and IR.
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- 2022
22. Development of a texture evaluation system for winter jujube (Ziziphus jujuba ‘Dongzao’)
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Xia-bing KONG, Min XU, Hao-liang WAN, Ling-xi HAN, Xiao-li LIU, Qing-jun LI, Bian-qing HAO, Shao-jun ZHANG, Xiao-ming LI, Yi-hui LIU, and Ji-yun NIE
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Food Animals ,Ecology ,Animal Science and Zoology ,Plant Science ,Agronomy and Crop Science ,Biochemistry ,Food Science - Published
- 2022
23. Adult‐onset neuronal nuclear inclusion disease presenting with mental and behavioral disorders: A case report and literature review
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Yue Lou, Jing‐Ying Yu, Zhi‐Feng Shuai, Ting Zhao, Yan‐Wen Wang, and Xiao‐Li Liu
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Aging ,Geriatrics and Gerontology - Published
- 2022
24. Regulation of Stainless Steel Electrode Characteristics through Thermal Oxidation at Various Temperatures Induces Different Microbial Electrochemical Performances
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Yi-Ran Wang, Wen-Qiang Li, Yi-Xuan Wang, Ke-Wan Li, Xiao-Li Liu, and Yang Mu
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General Medicine - Published
- 2022
25. Genetic polymorphisms of superoxide dismutase 1 are associated with the serum lipid profiles of Han Chinese adults in a sexually dimorphic manner.
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Ping Xu, Yumei Zhu, Xiongshun Liang, Chunmei Gong, Yuanfei Xu, Changhua Huang, Xiao-Li Liu, and Ji-Chang Zhou
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Medicine ,Science - Abstract
Inspired by the mechanistic correlations between superoxide dismutase 1 (SOD1) and lipid metabolism, the associations of SOD1 single nucleotide polymorphisms (SNPs) with circulating lipid levels were explored. In 2621 Chinese Han adults, randomly recruited from a health examination center without organic diseases, cancers, and pregnancy, three tag SNPs, rs4998557, rs1041740, and rs17880487 selected by Haploview software were genotyped with a probe-based real-time quantitative PCR method. In both genders, most parameters of the dyslipidemia adults were inferior (P < 0.001) to those of the non-dyslipidemia adults, and genotype frequencies of rs4998557 and rs17880487 were significantly different (P < 0.05) between the normal and abnormal subgroups of total cholesterol (TC) or high-density lipoprotein cholesterol (HDLC). Adjusted for confounding factors, logistic regression analyses revealed that in males rs4998557A, rs1041740T, and rs17880487T reduced the risk of high TC and/or LDLC (P < 0.05), and rs4998557A and rs17880487T increased the risk of low HDLC (P < 0.05); but in females, none of the SNPs had associations with any of the lipid parameters (P > 0.05). Conclusively, characterized by a sexual dimorphism, the SOD1 polymorphisms were associated with the lipid disorders in the adult males but not females of the Chinese Han population.
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- 2020
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26. A review of the development and current status of wound ostomy continence nurses in the mainland of China
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Xiao-li Liu and Ling Wang
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Nursing ,RT1-120 - Abstract
Wound ostomy continence nurses (WOC nurses), developed as an important part of clinical nurse specialists play an indispensable role in the management of ostomy, all kinds of chronic wounds and incontinent dermatitis. However, there exists a gap compared with developed countries and regions. This paper provides an overview of WOC nurses in China including origin and development, training and accreditation system, roles, values and management, in order to provide references for the development of WOC nurses in China. Keywords: Clinical nurse specialists, Wound ostomy continence, Training, Management
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- 2018
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27. Comparison of vaginal flora in patients with spontaneous abortion and women with normal first-trimester
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Xiao-Li Liu, Yi Xiao, Hong Zhang, and Li-Juan Wu
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Bacterial Vaginosis ,Pregnancy ,Spontaneous Abortion ,Vaginal Infection ,Vulvovaginal Candidiasis ,Immunologic diseases. Allergy ,RC581-607 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Objective: The effect of alterations in vaginal flora during pregnancy remains uncertain. We compared the flora distribution in women with spontaneous abortion (SA) and those in normal condition. Methods: Samples of vaginal discharge were obtained from 3,233 women attending the Gynecological and Public Health Centre of our hospital from January 2010 to December 2013. Pathogen culture testing was performed by the Microbiological Diagnostic Centre of our hospital, including SA group (n = 1,513), normal first-trimester group (NP group, n = 908), and nonpregnant women (control group, n = 812). Results: Of 3,233 vaginal discharge samples, 425 samples (13.15%) were positive for pathogen. The pathogen detection rate was 19.96% (302/1,513), 7.93% (72/908), and 6.28% (51/812) in the SA, NP, and control groups, respectively. The five most common bacteria were Enterococcus faecalis, Candida albicans, Escherichia coli, group B Streptococcus (GBS), and Ureaplasma urealyticum (Uu) in the SA group; Uu, C. albicans, Candida tropicalis, GBS, and E. faecalis in the NP group; and Candida glabrata, Uu, E. coli, Gardnerella vaginalis, and C. albicans in the control group. Conclusions: In the SA group, the pathogen detection rate was markedly elevated. An infection of Candida sp. in pregnant women was relatively common. In routine antenatal care, overtreatment is not recommended in asymptomatic candidiasis. There was no significant difference in the detection rate of Uu between the SA group and the other two groups, suggesting that it does not cause SA.
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- 2018
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28. An Enhanced Identity Authentication Security Access Control Model Based on 802.1x Protocol.
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Hanying Chen and Xiao-Li Liu
- Published
- 2016
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29. An Interactive Model of Creative Design Behavior with 3D Optical Technology.
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Hao Jiang, Xiao-Li Liu 0008, Xiang Peng, and Ming-Xi Tang
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- 2016
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30. Extract seismic deformation field using Chinese optical satellites.
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Xue Li, Xiao-li Liu, Qing Wang, Yong-hua Jiang 0001, and Liang Li
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- 2016
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31. The effects of childhood maltreatment on adolescent non-suicidal self-injury behavior: mediating role of impulsivity
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Xi Li, Xiao-Li Liu, Yu-Jing Wang, Dong-Sheng Zhou, and Ti-Fei Yuan
- Subjects
Psychiatry and Mental health - Abstract
BackgroundNon-suicidal self-injury (NSSI) severely challenges mental health in adolescents. Childhood maltreatment experience acts as high-risk factor for adolescents to engage in NSSI behaviors. On the other hand, impulsivity or loss of control sets the threshold for NSSI execution. Here we examined the effects of childhood maltreatment on adolescent NSSI-related clinical outcomes and the potential role of impulsivity.MethodsWe assessed the clinical data of 160 hospitalized NSSI adolescents and recruited 64 age-matched healthy subjects as a control group. The clinical symptoms of NSSI are expressed by the NSSI frequency, depression, and anxiety measured by the Ottawa Self-Injury Inventory, the Beck Depression Inventory, and the Beck Anxiety Inventory. Childhood maltreatment and impulsivity were assessed with Childhood Trauma Questionnaire and Barratt Impulsiveness Scale.ResultsThe results showed that when compared to HC group, NSSI group is more likely to experience childhood maltreatment. Notably, NSSI group with Childhood maltreatment accompanies higher trait impulsivity and exacerbated clinical outcomes, such as NSSI frequency, depression and anxiety symptoms. Mediation analyses indicated that the association between childhood maltreatment and NSSI-related clinical outcomes was partially explained by impulsivity.ConclusionWe found that NSSI adolescents have a higher proportion of childhood maltreatment. Impulsivity plays a mediating role between childhood maltreatment and NSSI behaviors.
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- 2023
32. Imatinib compared with second‐generation tyrosine kinase‐inhibitors in persons with chronic myeloid leukemia presenting in accelerated phase
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Sen Yang, Xiaoshuai Zhang, Robert Peter Gale, Xin Du, Chun‐yan Chen, Jian‐yu Weng, Jian Huang, Fei Li, Yun Zeng, Zhen Xiao, Jian‐da Hu, Li‐jie Yang, Zhuo‐gang Liu, Guo‐hui Li, Xiu‐li Sun, Wei Yang, Ru Feng, Yan‐qiu Han, Yu Jing, Na Xu, Xiao‐li Liu, Zhen‐fang Liu, Xiao‐dong Wang, Shi‐xin Wu, Rong Liang, Yan‐li Zhang, Yun‐fan Yang, Huan‐ling Zhu, Ling Pan, Li Meng, Yan‐hong Zhao, Hai Yi, Yi‐lan Liu, Wei‐hua Zhang, Yuan‐jun Zheng, Ze‐ping Zhou, Su‐ning Chen, Hui‐ying Qiu, Wei‐ming Li, Zhi‐lin Jia, Yan‐liang Bai, Li‐e Lin, Bing‐cheng Liu, Chun‐shui Liu, Jian‐min Luo, Jun‐xia Meng, Zhi‐qiang Sun, Yan‐qing Zhang, Xiao‐jun Huang, and Qian Jiang
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Hematology - Published
- 2023
33. Wider geographic distribution and higher diversity of hexaploids than tetraploids in Carassius species complex reveal recurrent polyploidy effects on adaptive evolution
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Xiao-Li Liu, Fang-Fang Jiang, Zhong-Wei Wang, Xi-Yin Li, Zhi Li, Xiao-Juan Zhang, Fan Chen, Jian-Feng Mao, Li Zhou, and Jian-Fang Gui
- Subjects
Medicine ,Science - Abstract
Abstract Polyploidy roles on adaptive evolution and ecological novelty have been extensively studied in plants but remained unclear in vertebrates owing to the rare polyploidy incidences. Here, a huge number of 3105 specimens in Carassius species complex including 2211 hexaploids and 894 tetraploids were sampled from 34 locations through mainland China. And hexaploids had wider geographic distribution than tetraploids especially in the areas with high altitude, high latitude and low annual precipitation. Then, an approximate 1050 bp transferrin (tf) fragments were amplified from all the samples, and 526 tf alleles were identified from a total of 37260 sequences at last. Intriguingly, higher nucleotide diversity of tf alleles in hexaploids than in tetraploids was revealed. Moreover, via phylogenetic analysis of tf alleles, potential origin center of Carassius species complex was deduced to be Yangtze River basin and hexaploids should undergo multiple independent polyploidy origins from sympatric tetraploids. These findings indicate that the hexaploids might possess stronger environmental adaptation and ecological novelty than the tetraploids, which provide an association paradigm of recurrent polyploidy and ecological context in polyploid vertebrates.
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- 2017
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34. The Risk Model Based on the Three Oxidative Stress-Related Genes Evaluates the Prognosis of LAC Patients
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Qiang Guo, Xiao-Li Liu, Hua-Song Liu, Xiang-Yu Luo, Ye Yuan, Yan-Mei Ji, Tao Liu, Jia-Long Guo, and Jun Zhang
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Oxidative Stress ,Aging ,Lung Neoplasms ,Article Subject ,Carcinogenesis ,Cell Cycle ,Humans ,bacteria ,Adenocarcinoma of Lung ,Cell Biology ,General Medicine ,Biochemistry - Abstract
Background. Oxidative stress plays a role in carcinogenesis. This study explores the roles of oxidative stress-related genes (OSRGs) in lung adenocarcinoma (LAC). Besides, we construct a risk score model of OSRGs that evaluates the prognosis of LAC patients. Methods. OSRGs were downloaded from the Gene Set Enrichment Analysis (GSEA) website. The expression levels of OSRGs were confirmed in LAC tissues of the TCGA database. GO and KEGG analyses were used to evaluate the roles and mechanisms of oxidative stress-related differentially expressed genes (DEGs). Survival, ROC, Cox analysis, and AIC method were used to screen the prognostic DEGs in LAC patients. Subsequently, we constructed a risk score model of OSRGs and a nomogram. Further, this work investigated the values of the risk score model in LAC progression and the relationship between the risk score model and immune infiltration. Results. We discovered 163 oxidative stress-related DEGs in LAC, involving cellular response to oxidative stress and reactive oxygen species. Besides, the areas under the curve of CCNA2, CDC25C, ERO1A, CDK1, PLK1, ITGB4, and GJB2 were 0.970, 0.984, 0.984, 0.945, 0.984, 0.771, and 0.959, respectively. This indicates that these OSRGs have diagnosis values of LAC and are significantly related to the overall survival of LAC patients. ERO1A, CDC25C, and ITGB4 overexpressions were independent risk factors for the poor prognosis of LAC patients and were associated with risk scores in the risk model. High-risk score levels affected the poor prognosis of LAC patients. Notably, a high-risk score may be implicated in LAC progression via cell cycle, DNA replication, mismatch repair, and other mechanisms. Further, ERO1A, CDC25C, and ITGB4 expression levels were related to the immune infiltrating cells of LAC, including mast cells, NK cells, and CD8 T cells. Conclusion. In summary, ERO1A, CDC25C, and ITGB4 of OSRGs are associated with poor prognosis of LAC patients. We confirmed that the risk model based on the ERO1A, CDC25C, and ITGB4 is expected to assess the prognosis of LAC patients.
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- 2022
35. Data from SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence
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Wei-Jun Yang, Yi-Ding Chen, Jiao-Jiao Zhou, Yue-Hong Wang, Guo-Ping Ding, Sheng-Nan Jia, Jin-Shu Yang, Xue-Ting Huang, Qian-Yun Lu, Yao-Shun Yang, Sun-Li Cai, Qian Zhu, Jing-Yi Feng, Xiao-Li Liu, Wen-Huan Jia, Yan-Fu Ding, and Sen Ye
- Abstract
Quiescent cancer stem cells (CSC) play important roles in tumorigenesis, relapse, and resistance to chemoradiotherapy. However, the determinants of CSC quiescence and how they sustain themselves to generate tumors and relapse beyond resistance to chemoradiotherapy remains unclear. Here, we found that SET domain–containing protein 4 (SETD4) epigenetically controls breast CSC (BCSC) quiescence by facilitating heterochromatin formation via H4K20me3 catalysis. H4K20me3 localized to the promoter regions and regulated the expression of a set of genes in quiescent BCSCs (qBCSC). SETD4-defined qBCSCs were resistant to chemoradiotherapy and promoted tumor relapse in a mouse model. Upon activation, a SETD4-defined qBCSC sustained itself in a quiescent state by asymmetric division and concurrently produced an active daughter cell that proliferated to produce a cancer cell population. Single-cell sequence analysis indicated that SETD4+ qBCSCs clustered together as a distinct cell type within the heterogeneous BCSC population. SETD4-defined quiescent CSCs were present in multiple cancer types including gastric, cervical, ovarian, liver, and lung cancers and were resistant to chemotherapy. SETD4-defined qBCSCs had a high tumorigenesis potential and correlated with malignancy and chemotherapy resistance in clinical breast cancer patients. Taken together, the results from our previous study and current study on six cancer types reveal an evolutionarily conserved mechanism of cellular quiescence epigenetically controlled by SETD4. Our findings provide insights into the mechanism of tumorigenesis and relapse promoted by SETD4-defined quiescent CSCs and have broad implications for clinical therapies.Significance:These findings advance our knowledge on the epigenetic determinants of quiescence in cancer stem cell populations and pave the way for future pharmacologic developments aimed at targeting drug-resistant quiescent stem cells.
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- 2023
36. Supplementary Data from SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence
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Wei-Jun Yang, Yi-Ding Chen, Jiao-Jiao Zhou, Yue-Hong Wang, Guo-Ping Ding, Sheng-Nan Jia, Jin-Shu Yang, Xue-Ting Huang, Qian-Yun Lu, Yao-Shun Yang, Sun-Li Cai, Qian Zhu, Jing-Yi Feng, Xiao-Li Liu, Wen-Huan Jia, Yan-Fu Ding, and Sen Ye
- Abstract
Supplementary Table S1 and Supplementary Figure S1 to S11
- Published
- 2023
37. Observation on the short-term efficacy of inverse moxibustion at the Baihui point and Dazhui point in preventing post-stroke depression
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Chuan-Wei Xu, Tian-Tian Wang, Li-Ping Chen, Xiao-Li Liu, Zhou Yang, De-Ren Chen, Fang-Fang Zhou, and Dan Zhao
- Subjects
Complementary and alternative medicine ,Chiropractics ,General Nursing ,Analysis - Published
- 2023
38. Components and composition of active volatiles attract on Diorhabda tarsalis (Coleoptera: Chrysomelidae) from Glycyrrhiza uralensis (Rosales: Leguminoseae)
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Hong-hao Chen, Rong Zhang, Shu-qian Tan, Yan Wang, Xiao-li Liu, and Wang-peng Shi
- Subjects
Ecology ,Ecology, Evolution, Behavior and Systematics - Abstract
IntroductionPerennial Chinese licorice, Glycyrrhiza uralensis, is an important medicinal plant. Diorhabda tarsalis, a leaf beetle, is a serious insect pest on the plant and cause serious yield losses every year and is attracted to healthy and pest-damaged licorice by plant volatiles.AimThe biologically active components of the volatiles released from G. uralensis have not been reported; the components of the volatiles that attract D. tarsalis need to be identified. Such compounds could potentially be used for monitoring and mass-trapping pests.MethodsGC-EAD, GC-MS, EAG, Y-shaped olfactometer behavioral bioassays, and field trials were performed to identify the components and composition of active volatiles.ResultsMale and virgin female adults were generally attracted to volatiles from licorice, and volatiles from pest-infested plants were more attractive. Four compounds from licorice elicited a significant electrophysiological response (EAD) and were confirmed by EAG, including hexanal, (Z)-3-hexenal, (Z)-3-hexen-1-ol, and (E)-2-hexenal. With the exception of the (E)-2-hexenal, these molecules significantly attracted adults in individual behavioral bioassays, and a proportional mixture corresponding to beetle-damaged licorice of hexanal, (Z)-3-hexenal, (Z)-3-hexen-1-ol, and (E)-2-hexenal (8.78:15.26:57.24:18.72) was most effective for attracting D. tarsalis in the field, attracted a mean of 26 ± 7.19 beetles per trap.DiscussionD. tarsalis was attracted to volatiles from healthy and herbivore-induced G. uralensis under both laboratory and field conditions. The aforementioned compounds show considerable potential for commercial application to monitor and control D. tarsalis populations.
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- 2023
39. Quantitative Analysis of Acoustic Black Hole Property by the Catastrophe Theory
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Jiamin Niu, Jiu Hui Wu, Xiao Li Liu, Meng Qi Yuan, and Libo Wang
- Published
- 2023
40. Interference with orco gene expression affects host recognition in Diorhabda tarsalis
- Author
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Hong-Hao Chen, Youssef Dewer, Yan Wang, Shu-Qian Tan, Xiao-Li Liu, and Wang-Peng Shi
- Subjects
Physiology ,Physiology (medical) - Abstract
Introduction:Diorhabda tarsalis Weise is an important insect pest of the Chinese licorice Glycyrrhiza uralensis Fisch. Behavior of the beetle, including host location, oviposition site selection, self-defense, and aggregation, were regulated by plant volatiles or insect pheromones.Aim: In this study, Identification of ORs and function research on orco were carried out, these could lead to the development of understand for olfaction mechanism in D. tarsalis.Methods: ORs were identified by PacBio RS II platform to sequence the antennas of adult D. tarsalis, the function of orco was explored by dsRNA interference.Results: 29 odorant receptor candidate genes of D. tarsalis were obtained, which code for 130–479 amino acids. Phylogenetic trees of olfactory receptors were constructed with 243 ORs from eight Coleoptera species. DtarORco, DtarOR7 and DtarOR26 are specifically expressed in the antenna, and the expression levels were significantly higher than other DtarORs in antenna, there were no differential expression between male and female beetles. An odorant coreceptor gene (DtarORco) has characteristics of an odorant receptor family member, the encoded mature protein has a predicted molecular weight of 53.898 kDa, dsRNA L4440 expression vectors were constructed and successfully transformed into ribonuclease III-deficient Escherichia coli strain HT115 DE3. After interference treatment, the relative expression level of DtarORco in D. tarsalis antennae significantly decreased and electrophysiological responses to host localization odor signals significantly decreased. At the same time, beetles lost the ability to locate hosts.Discussion: The research on its mechanism of olfaction may lead to the development of new control measures that are environmentally friendly.
- Published
- 2022
41. Hypomagnesemia is associated with increased mortality in the short-term but not the long-term in community-acquired pneumonia patients with type 2 diabetes
- Author
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Xiao-Li, Liu, Si-Qiong, Wang, Mei-Jing, Ji, Xiao-Ming, Wang, Jing, Sun, Meng-Meng, Zhang, and Chun-Ming, Ma
- Subjects
Adult ,Community-Acquired Infections ,Diabetes Mellitus, Type 2 ,Risk Factors ,Humans ,Magnesium ,Pneumonia ,Retrospective Studies - Abstract
The present study explored the relationship between hypomagnesemia and outcome in community-acquired pneumonia (CAP) patients with type 2 diabetes mellitus (T2DM).The study was a retrospective cohort study, conducted on adult CAP patients with T2DM at The First Hospital of Qinhuangdao between January 2015 and December 2018. The primary outcome was all-cause deaths.In total, 480 CAP inpatients with T2DM were enrolled, and 71 patients (14.8%) had hypomagnesemia on admission. After one month and three months of follow-up, the hypomagnesemia group had a higher mortality rate than the normal magnesium group (plt;0.05). After six months of follow-up, the mortality rate remained higher in the hypomagnesemia group, however, this was not statistically significant (χ²=2.799, p=0.094). After 12 months and 24 months of follow-up, the mortality rates were similar between the hypomagnesemia and normal magnesium groups (plt;0.05). Based on multiple logistic regression analysis, hypomagnesemia was an independent risk factor for one-monthmortality(OR=3.858,95% CI: 1.637~9.088, p=0.002), three-month mortality (OR=3.083, 95% CI: 1.434~6.627, p=0.004) and six-month mortality (OR=2.551, 95% CI: 1.209~5.383, p=0.014).Hypomagnesemia is common in CAP inpatients with T2DM. Moreover, in these patients, hypomagnesemia at admission is associated with increased mortality in the short-term but not the long-term.
- Published
- 2022
42. Spatiotemporal Pattern of Ecosystem Respiration in China Estimated by Integration of Machine Learning With Ecological Understanding
- Author
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Lang Han, Gui‐Rui Yu, Zhi Chen, Xian‐Jin Zhu, Wei‐Kang Zhang, Tie‐Jun Wang, Li Xu, Shi‐Ping Chen, Shao‐Min Liu, Hui‐Min Wang, Jun‐Hua Yan, Jun‐Lei Tan, Fa‐Wei Zhang, Feng‐Hua Zhao, Ying‐Nian Li, Yi‐Ping Zhang, Li‐Qing Sha, Qing‐Hai Song, Pei‐Li Shi, Jiao‐Jun Zhu, Jia‐Bing Wu, Zhong‐Hui Zhao, Yan‐Bin Hao, Xi‐Bin Ji, Liang Zhao, Yu‐Cui Zhang, Shi‐Cheng Jiang, Feng‐Xue Gu, Zhi‐Xiang Wu, Yang‐Jian Zhang, Li Zhou, Ya‐Kun Tang, Bing‐Rui Jia, Gang Dong, Yan‐Hong Gao, Zheng‐De Jiang, Dan Sun, Jian‐Lin Wang, Qi‐Hua He, Xin‐Hu Li, Fei Wang, Wen‐Xue Wei, Zheng‐Miao Deng, Xiang‐Xiang Hao, Xiao‐Li Liu, Xi‐Feng Zhang, Xing‐Guo Mo, Yong‐Tao He, Xin‐Wei Liu, Hu Du, and Zhi‐Lin Zhu
- Subjects
Atmospheric Science ,Global and Planetary Change ,Environmental Chemistry ,General Environmental Science - Published
- 2022
43. [Clinical Study of miRNAs Derived from Serum Exosomes in Multiple Myeloma]
- Author
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Lin, Zhou, Xiao-Li, Liu, Yu-Wu, Li, Liang, Wu, Guang-Zhou, Wang, Zheng-Fang, Wang, Li, Ma, Jun, Guan, and Chong-Xu, Han
- Subjects
MicroRNAs ,Creatinine ,Humans ,Calcium ,Cystatin C ,Exosomes ,Multiple Myeloma - Abstract
To investigate the expression level and prognostic value of miR-21, miR-18a, miR-146a, and Let-7b derived from serum exosomes in patients with multiple myeloma (MM).Serum exosomes were extracted from 57 MM patients and 20 healthy persons using ExoQuick exosome precipitation solution kit, and the relative expression level of miR-21, miR-18a, miR-146a, and Let-7b derived from serum exosomes was measured by RT-qPCR. Correlations of the expression levels of all miRNAs mentioned above with routine laboratory parameters were analyzed by Spearman correlation analysis. The relationship between the expression level of miR-21, miR-18a, miR-146a, and Let-7b derived from serum exosomes and overall survival of patients with MM was analyzed using the Kaplan-Meier survival curve.The expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes in patients with MM were significantly lower than those in the normal control group (P0.001), while the expression level of miR-146a between the two groups was not significantly different (P0.05). The expression level of miR-21 was strongly negatively correlated with serum βAberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.血清外泌体来源的miRNAs在多发性骨髓瘤中的临床研究.研究血清外泌体来源的miR-21、miR-18a、miR-146a、Let-7b在多发性骨髓瘤(MM)患者中的表达水平及其在预后评估中的价值。.采用ExoQuick试剂盒提取57例MM患者和20例健康体检者血清外泌体,用RT-qPCR检测血清外泌体中miR-21、miR-18a、miR-146a、Let-7b的相对表达水平,采用Spearman相关性分析研究miR-21、miR-18a、miR-146a、Let-7b表达水平与常规实验室指标之间的相关性,Kaplan-Meier生存曲线分析miR-21、miR-18a、miR-146a、Let-7b的表达水平与MM患者总体生存的关系。.MM患者血清外泌体来源的miR-21、miR-18a、Let-7b的表达水平均显著低于正常对照组(P0.001),而miR-146a在两组之间的表达水平无显著性差异(P0.05)。miR-21的表达水平与血清β血清外泌体来源的miR-21、miR-18a、Let-7b在MM患者中存在异常低表达,且与MM患者的总体生存率下降存在关联。.
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- 2022
44. Integrating peripheral blood and brain transcriptomics to identify immunological features associated with Alzheimer’s disease in mild cognitive impairment patients
- Author
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Xiao-Hang, Qian, Xiao-Li, Liu, Sheng-di, Chen, and Hui-Dong, Tang
- Subjects
Alzheimer Disease ,Caspase 3 ,Immunology ,NF-kappa B ,Brain ,Humans ,Immunology and Allergy ,Cognitive Dysfunction ,Amyloid Precursor Protein Secretases ,Transcriptome - Abstract
BackgroundImmune system dysfunction has been proven to be an important pathological event in Alzheimer’s disease (AD). Mild cognitive impairment (MCI), as a transitional stage between normal cognitive function and AD, was an important research object for the screening of early diagnostic markers and therapeutic targets for AD. However, systematic assessment of peripheral immune system changes in MCI patients and consistent analysis with that in the CNS were still lacking.MethodsPeripheral blood transcriptome data from the AddNeuroMed Cohort (n = 711) was used as a training dataset to assess the abundance of 24 immune cells through ImmuCellAI and to identify MCI-related immune signaling pathways and hub genes. The expression level of the immune hub gene was validated in peripheral blood (n = 587) and brain tissue (78 entorhinal cortex, 140 hippocampi, 91 temporal cortex, and 232 frontal cortex) validation datasets. Finally, reliable immune hub genes were applied for Gene Set Enrichment Analysis and correlation analysis of AD pathological characteristics.ResultsMCI patients have early changes in the abundance of various types of immune cells in peripheral blood, accompanied by significant changes in NF-kB, TNF, JAK-STAT, and MAPK signaling pathways. Five hub immune-related differentially expressed genes (NFKBIA, CD4, RELA, CASP3, and HSP90AA1) were screened by the cytoHubba plugin in Cytoscape and the least absolute shrinkage and selection operator (LASSO) regression. Their expression levels were significantly correlated with infiltration score and the abundance of monocytes, natural killer cells, Th2 T cells, T follicular helper cells, and cytotoxic T cells. After validation with independent datasets derived from peripheral blood and brain, RELA and HSP90AA1 were identified as two reliable immune hub genes in MCI patients and had consistent changes in AD. The Gene Set Enrichment Analysis (GSEA) showed that their expression levels were closely associated with Alzheimer’s disease, JAK-STAT, calcium signaling pathway, etc. In addition, the expression level of RELA was positively correlated with β- and γ-secretase activity and Braak stage. The expression level of HSP90AA1 was negatively correlated with α- and β-secretase activity.ConclusionImmune system dysfunction was an early event in AD. It provides a new target for the early diagnosis and treatment of AD.
- Published
- 2022
45. LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway
- Author
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Yi-Pin CAI, Yu HUANG, Jie ZHANG, Xiao-Li LIU, Fang ZHAO, Kuan ZHANG, Song-Yuan XU, Yan YANG, Hai-Wei HUANG, and Yu GAO
- Subjects
Cancer Research ,Oncology - Abstract
LncRNA carbonyl reductase antisense RNA 1 (CBR3-AS1) is increased in cervical cancer and predicts poor prognosis. This study aims to investigate the underlying mechanism of lncRNA CBR3-AS1 in cervical cancer. LncRNA CBR3-AS1 and LASP1 expressions were significantly elevated in cervical cancer tissue and cells, whereas miR-3163 expression was significantly decreased in cervical cancer tissue and cells. High lncRNA CBR3-AS1 expression and LASP1 expression showed a lower overall survival rate, whereas high miR-3163 expression showed a higher overall survival rate. Correlation between clinicopathological parameters of cervical cancer patients and lncRNA CBR3-AS1, miR-3163, LASP1 expressions indicated that the expressions of lncRNA CBR3-AS1, miR-3163, and LASP1 were closely related with distant metastasis and lymphatic metastasis of cervical cancer. LncRNA CBR3-AS1 knockdown suppressed cervical cancer cell viability and inhibited cancer stem cell-like properties. Besides, we identified that lncRNA CBR3-AS1 interacted with miR-3163, and miR-3163 targeted to LASP1. Moreover, the correlation between lncRNA CBR3-AS1 and miR-3163, as well as the correlation between miR-3163 and LASP1 was confirmed. Finally, lncRNA CBR3-AS1 knockdown inhibited tumor growth and suppressed cancer stem cell-like properties of cervical cancer in vivo. Taken together, high expression of lncRNA CBR3-AS1 predicts poor prognosis in cervical cancer, and the lncRNA CBR3-AS1/miR-3163/LASP1 pathway plays a vital function in the modulation of cervical cancer cell proliferation and cancer stem cell-like properties.
- Published
- 2022
46. Decreased APOC1 expression inhibited cancer progression and was associated with better prognosis and immune microenvironment in esophageal cancer
- Author
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Qiang, Guo, Xiao-Li, Liu, Ni, Jiang, Wen-Jun, Zhang, Shao-Wen, Guo, Heng, Yang, Yan-Mei, Ji, Jun, Zhou, Jia-Long, Guo, Jun, Zhang, and Hua-Song, Liu
- Abstract
Several studies have demonstrated the involvement of apolipoprotein C1 (APOC1) in multiple cancers. However, the role of APOC1 in esophageal cancer (ESCA) has not been elucidated. Hence, we examined the expression of APOC1 in ESCA tissues acquired from The Cancer Genome Atlas (TCGA) database and clinical samples from our hospital. An investigation of the association of APOC1 with the clinicopathological characteristics, prognosis, and diagnosis of ESCA was carried out on the basis of survival, receiver operating characteristics, and correlation analyses. Gene ontology, KEGG analysis, and protein-protein interaction network showed that co-expressed APOC1 genes were involved in the functions, mechanisms, and action network. The effects of APOC1 expression on ESCA cells were explored using CCK-8, migration and invasion assays. The relationship between APOC1 expression and ESCA immune-infiltrating cells and cell markers were examined using correlation analysis. We found that APOC1 was overexpressed in TCGA ESCA tissues and the same was validated in clinical ESCA tissues, with the area under the curve for APOC1 being 0.887. Overexpression of APOC1 was associated with short overall survival, disease-specific survival, progression-free interval, T stage, pathological stage, body mass index, and histological grade. Inhibition of APOC1 expression significantly reduced the proliferation, migration, and invasion of ESCA cells. Furthermore, APOC1 expression positively correlated with the ESTIMATE, immune, and stromal scores in ESCA. Overexpression of APOC1 correlated with the tumor purity, B cells, T helper cells, natural killer cells, cytotoxic cells, and other immune cells. Moreover, APOC1 was involved in ESCA progression via T cell receptor, B cell receptor, and other immune signaling pathways. Thus, APOC1 overexpression is expected to be a biomarker for dismal prognosis and diagnosis of ESCA. Inhibition of APOC1 expression significantly reduced the proliferation, migration, and invasion of ESCA cells. Overexpression of APOC1 was associated with the immune microenvironment in ESCA. Thus, APOC1 may be an efficient biomarker for proper prognosis and diagnosis of ESCA.
- Published
- 2022
47. Prognostic significance of multiple triglycerides-derived metabolic indices in patients with acute coronary syndrome
- Author
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Qiao-Yu, Shao, Xiao-Teng, Ma, Zhi-Qiang, Yang, Qiu-Xuan, Li, Yu-Fei, Wang, Jing, Liang, Hua, Shen, Xiao-Li, Liu, Yu-Jie, Zhou, Dong-Mei, Shi, and Zhi-Jian, Wang
- Abstract
Triglyceride (TG) and its related metabolic indices, all recognized as surrogates of insulin resistance, have been demonstrated to be relevant to clinical prognosis. However, the relative value of these TG-related indices for predicting cardiovascular events among patients with acute coronary syndrome (ACS) has not been examined.The TG, the triglyceride-glucose (TyG) index, the atherogenic index of plasma, TG to high-density lipoprotein cholesterol ratio, and the lipoprotein combine index were assessed in 1694 ACS patients undergoing percutaneous coronary intervention. The primary endpoint was major adverse cardiovascular event (MACE), which was the composite of all-cause mortality, stroke, myocardial infarction, or unplanned repeat revascularization.During a median follow-up of 31 months, 345 patients (20.4%) had MACE. The risk of the MACE was increased with higher TG and the four TG-derived metabolic indices [TG-adjusted hazard ratio (HR) = 1.002, 95% CI: 1.001-1.003; TyG index-adjusted HR = 1.736, 95% CI: 1.398-2.156; atherogenic index of plasma-adjusted HR = 2.513, 95% CI: 1.562-4.043; TG to high-density lipoprotein cholesterol ratio-adjusted HR = 1.148, 95% CI: 1.048-1.258; and lipoprotein combine index-adjusted HR = 1.009, 95% CI: 1.004-1.014;TG and TG-derived metabolic indices were all strongly associated with MACE among ACS patients undergoing percutaneous coronary intervention. Among all the indices, TyG index showed the best ability to predict the risk of MACE.
- Published
- 2022
48. Real-time perception of rock–machine interaction information in TBM tunnelling using muck image analysis
- Author
-
Wei-Qiang Xie, Xiao-Ping Zhang, Xiao-Li Liu, Chen-Yu Xu, Xin-Fang Li, Dan-Qing Song, Qing Ma, and Nan Hu
- Subjects
Building and Construction ,Geotechnical Engineering and Engineering Geology - Published
- 2023
49. Preserving Porcine Genetics: A Simple and Effective Method for On-Site Cryopreservation of Ear Tissue Using Direct Cover Vitrification
- Author
-
Xia Zhang, Xin Liu, Xiao-Li Liu, Dan-Ya Wu, Kai Zhou, Zhi-Sheng Yu, Cheng-Li Dou, Tian Xu, Mei Yu, and Yi-Liang Miao
- Subjects
Inorganic Chemistry ,pig ,vitrification ,genetic conservation ,ear tissue ,Organic Chemistry ,General Medicine ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy ,Catalysis ,Computer Science Applications - Abstract
Cell cryopreservation is widely used for porcine genetic conservation; however, isolating and freezing primary cells in farms without adequate experimental equipment and environment poses a significant challenge. Therefore, it is necessary to establish a quick and simple method to freeze tissues on-site, which can be used for deriving primary fibroblasts when needed to achieve porcine genetic conservation. In this study, we explored a suitable approach for porcine ear tissue cryopreservation. The porcine ear tissues were cut into strips and frozen by direct cover vitrification (DCV) in the cryoprotectant solution with 15% EG, 15% DMSO and 0.1 M trehalose. Histological analysis and ultrastructural evaluation revealed that thawed tissues had normal tissue structure. More importantly, viable fibroblasts could be derived from these tissues frozen in liquid nitrogen for up to 6 months. Cells derived from thawed tissues did not show any cell apoptosis, had normal karyotypes and could be used for nuclear transfer. These results suggest that this quick and simple ear tissue cryopreservation method can be applied for porcine genetic conservation, especially in the face of a deadly emerging disease in pigs.
- Published
- 2023
50. Hypertriglyceridemic waist phenotype, hypertriglyceridemic waist-to-height ratio phenotype and abnormal glucose metabolism in adolescents
- Author
-
Na Lu, Gang Cheng, Chun-Ming Ma, and Xiao-Li Liu
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Published
- 2023
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