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Seven chlorinated phenolic sesquiterpenoids, together with one prenylated 2-pyridyl ketone alkaloid (9) and two monophenols (10 and 11), were isolated from the fungus Nectria sp. B-13 obtained from an Arctic soil sample. Their chemical structures were elucidated using a combination of spectroscopic data (ESI-MS, 1H, and 13C NMR) and comparisons with the published data. This is the first report on the isolation of compounds from pole-derived Nectria sp. B-13. The chemotaxonomic significance of these compounds is discussed.

Phytochemical investigation of the roots of Scrophularia buergeriana Miq. (Scrophulariaceae), resulted in the isolation of a new iridoid derivative named as buergerinin (1). Its structure was elucidated as rel-(1R, 5R, 6R)-(2-oxa-bicyclo[3.3.0]oct-7-en-6, 7-diyl)dimethoxypropane based mainly on MS and 1D and 2D NMR spectroscopic analyses.

Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.