1. Decreased left amygdala functional connectivity by cognitive-coping therapy in obsessive-compulsive disorder
- Author
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Ping Huang, Hengfen Li, Hong-Zeng Zhao, Shao-Jie Kou, Chang-Hong Wang, Xunan Wang, Zhi-Rong Li, De-En Sang, Xian-Zhang Hu, Zongya Zhao, Xiao-Wen Shan, Li-Jing Shi, Hong-Kai Lian, and Jian-Dong Ma
- Subjects
0301 basic medicine ,medicine.medical_specialty ,genetic structures ,medicine.diagnostic_test ,business.industry ,Left amygdala ,Parietal lobe ,Posterior parietal cortex ,Amygdala ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Psychiatry and Mental health ,030104 developmental biology ,0302 clinical medicine ,Text mining ,Pharmacotherapy ,medicine.anatomical_structure ,Internal medicine ,medicine ,Cardiology ,business ,Functional magnetic resonance imaging ,Molecular Biology ,030217 neurology & neurosurgery ,Anterior cingulate cortex - Abstract
It is of great clinical importance to explore more efficacious treatments for OCD. Recently, cognitive-coping therapy (CCT), mainly focusing on recognizing and coping with a fear of negative events, has been reported as an efficacious psychotherapy. However, the underlying neurophysiological mechanism remains unknown. This study of 79 OCD patients collected Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and resting-state functional magnetic resonance imaging (rs-fMRI) scans before and after four weeks of CCT, pharmacotherapy plus CCT (pCCT), or pharmacotherapy. Amygdala seed-based functional connectivity (FC) analysis was performed. Compared post- to pretreatment, pCCT-treated patients showed decreased left amygdala (LA) FC with the right anterior cingulate gyrus (cluster 1) and with the left paracentral lobule/the parietal lobe (cluster 2), while CCT-treated patients showed decreased LA-FC with the left middle occipital gyrus/the left superior parietal/left inferior parietal (cluster 3). The z-values of LA-FC with the three clusters were significantly lower after pCCT or CCT than pretreatment in comparisons of covert vs. overt and of non-remission vs. remission patients, except the z-value of cluster 2 in covert OCD. CCT and pCCT significantly reduced the Y-BOCS score. The reduction in the Y-BOCS score was positively correlated with the z-value of cluster 1. Our findings demonstrate that both pCCT and CCT with large effect sizes lowered LA-FC, indicating that FCs were involved in OCD. Additionally, decreased LA-FC with the anterior cingulate cortex (ACC) or paracentral/parietal cortex may be a marker for pCCT response or a marker for distinguishing OCD subtypes. Decreased LA-FC with the parietal region may be a common pathway of pCCT and CCT. Trial registration: ChiCTR-IPC-15005969.
- Published
- 2021