1. Can left ventricular entropy by cardiac magnetic resonance late gadolinium enhancement be a prognostic predictor in patients with left ventricular non-compaction?
- Author
-
Yun-Ting Ma, Lu-Jing Wang, Xiao-Ying Zhao, Yue Zheng, Li-Hui Sha, and Xin-Xiang Zhao
- Subjects
left ventricular non-compaction ,cardiac magnetic resonance ,entropy ,major adverse cardiovascular events ,prognosis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
PURPOSELeft ventricular non-compaction (LVNC) is considered rare; however, the use of cardiac magnetic resonance (CMR) has shown that its incidence is not uncommon, and its clinical presentation remains variable, with an uncertain prognosis. Risk stratification of major adverse cardiac events (MACE) in patients with LVNC remains complex. Therefore, this study aims to determine whether tissue heterogeneity from late gadolinium enhancement-derived entropy is associated with MACE in patients with LVNC.METHODSThis study was registered in the Clinical Trial Registry (CTR2200062045). Consecutive patients who underwent CMR imaging and were diagnosed with LVNC were followed up for MACE, which was defined by heart failure, arrhythmias, systemic embolism, and cardiac death. The patients were divided into MACE and non-MACE groups. The CMR parameters included left ventricular (LV) entropy, LV ejection fraction (LVEF), LV end-diastolic volume, LV end-systolic volume (LVESV), and LV mass (LVM).RESULTSEighty-six patients (age: 45.48 ± 16.64 years; female: 62.7%; LVEF: 42.58 ± 17.20%) were followed up for a median of 18 months and experienced 30 MACE events (34.9%). The MACE group showed higher LV entropy, LVESV, and LVM and lower LVEF than the non-MACE group. LV entropy [hazard ratio (HR): 1.710, 95% confidence interval (CI): 1.078–2.714, P = 0.023] and LVEF (HR: 0.961, 95% CI: 0.936–0.988, P = 0.004) were independent predictors of MACE (P
- Published
- 2023
- Full Text
- View/download PDF