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Through the study of the geological conditions of potash deposits in China from recent years, a new understanding of potash theories has arisen that appropriate Chinese geological features. Important progress and substantial breakthroughs have been gained in the direction and management of potash prospecting: (1) Important breakthroughs in continental potassium prospecting: The “Quaternary gravel type deep potassium rich brine metallogenic model in western Qaidam” ensures Quaternary deep potassium rich brine prospecting will grow new KCl resources by 350 Mt, providing a resource guarantee for meeting the Chinese demand for sylvite. (2) The Marine facies potash prospecting shows good prospects: the determination of the new type of Triassic polyhalite potash ore deposits in Sichuan provide an important scientific basis for the establishment of exploration planning and the selection of exploration target areas for polyhalite minerals in the Sichuan Basin; The “two-storey potash deposits model” in southwestern Yunnan has been confirmed, which indicates prospects for the exploration of potash in the deeper Marine facies in southwestern Yunnan are likely to be successful. The discovery of a high concentration of rich bromite salt and potash salt in the Paleogene of the Kuqa depression and the southwestern Tarim region provides strong support for the likelihood large-scale potash deposits exist in these regions.

Based on the high-throughput first-principles calculations with structural recognition, we have ystematically investigated the structural stabilities and optical properties of SixGeyHz nanocrystals(H-SiGeNCs), including various sizes, shapes and compositions. The total energies of H-SiGeNCs can be simply estimated by the bond energy model in high accuracy, where the error of test set is less than 0.5 meV per atom. According to the energy difference of Si/Ge in various bonding environments, we have determined the ground state structures by the geometry analysis, as is confirmed the convex hulls of formation enthalpy from the first-principles calculations. In addition, the energy gaps of H-SiGeNCs are modulated by the atomic distributions, as well as the vibrations of Si-H and Ge-H bonds at room temperature which is revealed by ab initio molecular dynamics simulations.

SVC is a dynamic reactive compensator based on switching type HV electrical and electronic devices, well recognized as an effective means of resolving power quality problems. SVC is complex in structure, consisting of TCR valve sets, FC filter channel, etc. In particular, TCR valve set adopts thyristor serial connecting technology, and over 100 thyristors are adopted, which requires real-time status of devices in SVC to be monitored and uploaded, and even failures to be recorded. Therefore, the monitoring software becomes an important part in ensuring SVC safe operation. Combined with actual cases, this paper introduces a technology of using C++ Builder and Inter Base to design the static reactive compensator monitoring software. The user interface is elegant, with short development period, highly transplantable, and easily modified.

The paper establishes a three-dimensional solid model of the frame, and simplifies the frame model according to the simplification rules of finite element. Use Pro/MECHANICA module of Pro/ENGINEER software to carry out static and modal analysis of the frame, and to conduct sensitivity analysis of geometric parameters having a great impact on the frame characteristics, thus the most sensitive size parameters of the frame performance are gotten. By optimization design function of Pro/MECHANICA module, specifying goals of optimized design and ranges of size sensitive parameters, the frame structure is optimized.

This paper studies and designs the gems feeding manipulator, makes a detailed analysis of the overall structure and working principle of the manipulator, and establishes the three-dimensional model of the manipulator. The virtual prototype model of the manipulator is built in ADAMS software. Use simulation analysis functions of ADAMS to carry out kinematics and dynamics simulation analysis on manipulator, obtaining parameter curves of the manipulator such as position, speed and torque, which verifies it feasible to use manipulator to unload and load gems, achieving the design requirements.

Entecavir rescue therapy is frequently used in patients with lamivudine-resistant hepatitis B virus (HBV) strains. The aim of this study was to investigate evolutionary patterns of HBV quasispecies during entecavir rescue therapy and evaluate their impacts on therapeutic efficacy. We enrolled 21 chronic hepatitis B patients who failed to respond to lamivudine therapy and were switched to entecavir treatment. Measurement of serum HBV DNA and sequence analysis of HBV reverse transcriptase were done up to 144 weeks. Four patients of this series showed a reversion to wild-type HBV after entecavir treatment and in three of them, a complete viral response (

In this study, we investigated the pharmacokinetics parameters of SPIO-shRNA dual functional molecular probe and observed the main organ distribution by MRI in vivo. Eighteen New Zealand white rabbits were randomly divided into three groups and injected intravenously with different doses of SPIO-shRNA molecular probe, respectively. The blood samples were collected to analyze the pharmacokinetic parameters by measuring the iron content at 30 minutes before and after the injection. Twenty-four Kun Ming (KM) mice were randomly divided into 4 groups: the control group was injected intravenously with physiological saline 200 µL per mouse via the tail vein, the other 3 groups were injected intravenously with different doses of SPIO-shRNA molecular probe. MRI observation was performed in 24 hours, and the liver, spleen, kidney, brain and muscle were collected for iron quantification with Prussian blue staining to determine distribution of the SPIO-shRNA molecular probe in the main organ in vivo. Our results suggest that the molecular probe blood half-life is more than 3 hours. The data of MRI suggest the probe was distributed in liver and spleen, and the MRI signal was reduced with the increase in probe's doses (P0.05). The results of Prussian blue staining confirmed the results of MRI. Most of the probe could escape the phagocytosis of mononuclear phagocyte system. Our data provide the pharmacokinetic and distribution of SPIO-shRNA molecular probe in organs. Meanwhile, it suggests the choice of the time and dose of probe for MR imaging of tumor in vivo.

According to the rock burst features occurred in the coal mass of roadway rib in one mine, the mechanics model of coal mass and roof structure system along the edge of goaf was founded to analyze the stress of roof rock layer, so the subside curve of roof rock layer was deduced. Furthermore, the stability of coal and rock system were analyzed, the critical load and critical resistance zone were used to judge the danger degree of rock burst occurrence. The influence of coal mass strength, brittleness degree, coal seam thickness, roof thickness, suspending length, equivalent shear module on the critical load, critical resistance zone was confirmed. So the rock burst occurrence conditions of coal mass in roadway rib mainly depend on mining depth, coal seam thickness and hard roof and floor, which are decided by the above studies, and successfully applied in prediction and prevention of rock burst in this mine.

To explore the effects of superparamagnetic iron oxide-short hairpin RNA (SPIO-ShRNA) dual functional molecular probes of different concentrations on morphology and biological behavior of ovarian cancer SKOV3 cells in vitro.The dual functional molecular probes at an iron concentration of 5, 15, 30, 45, 75, and 100 mg/L were transfected into SKOV3 cells. The transfection rate of the probe was observed by fluorescence microscope. The distribution and content of iron particles in SKOV3 cells were determined by Prussian blue staining, atomic adsorption spectrometer and electron microscopy. Cell viability was observed by cell counting kit-8 (CCK-8).The apoptosis was detected by flow cytometry. The expression of protein within the cells was detected by Western blot. The changes of the signal intensity were measured by magnetic resonance imaging (MRI).The SPIO-ShRNA dual functional molecular probe was uptaken in aconcentration-dependence manner within a certain range (5-30 mg/L). When the concentration of the probe was 45 mg/L, the labeling rate of the cell was close to 100%; With the increase of the concentration of probe, the cell survival rate decreased gradually. The cell survival rate of each experimental group were 94.626%±1.050%, 93.373%±1.180%, 91.700%±3.122%, 75.100%±4.362%, 72.983%±3.233%, 71.010%±2.910%,5, 15, 30 mg/L cell survival rate was not significantly decreased, the difference was not statistically significant (P=0.226, P=0.068, P=0.475); When the concentration of the probe was greater than or equal to 45 mg/L,the survival rate decreased obviously (P0.001); Group of 45 mg/L protein expression rate was 68.905%±3.510%, When the concentration of the probe was greater than or equal to 45 mg/L, the inhibition rate of the protein expression level of epidermal growth factor receptor was obviously higher than those of 5, 15, and 30 mg/L groups, the difference was statistically significant (P0.001, P=0.001, P=0.003, all P0.01); the MRI displayed that the signal intensity was decreased with increasing concentrations of the probe. The signal intensity of 45 mg/L group was 165.55±4.92, compared with the blank control group(same volume of phosphate buffer saline), normal group (unlabeled ovarian cancer SKOV3 cells), 5, 15, and 30 mg/L groups , the signal intensity of 45 mg/L group decreased significantly (all P0.001).The dual functional molecular probe can effectively transfect and specifically inhibit the expression of SKOV3 cell lines at the iron concentration of 45 mg/L, and can also be detected by MRI. The role of diagnosis and treatment of the dual functional molecular probe has been initially confirmed.

To explore the transfection rate of SPIO-shRNA dual functional molecular probe into ovarian carcinoma SKOV3 cells in external magnetic field.Dual functional molecular probe at an iron concentration of 45 mg/L was transfected into SKOV3 cells. The cells with coexisting probe and magnetic fields were set as the intervention group,the probe-transfected cells as negative control group, and normally cultured SKOV3 without any transfection as blank control group. The transfection rate was detected by flow cytometry. Cell viability was observed by CCK-8 assay. Epidermal growth factor receptor (EGFR) expression level in SKOV3 cells was determined by real-time quantitative PCR and Western blot analysis. The signal intensity was measured by magnetic resonance imaging (MRI).The transfection rate of the intervention group was (79.20 ± 3.31)%, which was significantly higher than that of negative control group (P=0.001). Compared with the negative control group,the cell viability of the intervention group significantly decreased (P=0.011), protein and mRNA expression levels of EGFR in the intervention group were significantly decreased (both P0.05). The signal intensity on T2(*)WI in the intervention group also significantly decreased (P=0.0004).The external magnetic field can improve the transfection efficiency SPIO-shRNA dual functional molecular probe into ovarian carcinoma SKOV3 cells.

To explore the efficacy and safety of vitamin D (VD) in the treatment of idiopathic oligoasthenozoospermia.This study included 86 infertile men with idiopathic oligoasthenozoospermia, who were randomized to a VD and a control group of equal number, the former given oral VD 200 IU/d and calcium 600 mg/d,qd, while the latter administered oral vitamin E 100 mg and vitamin C 100 mg, tid. After 3 months of medication, we compared the semen parameters, adverse reactions, and pregnancy rate between the two groups.After medication, the count of progressively motile sperm per ejaculate was increased from (9.82 ± 3.72) x 10(6) to (21.47 ± 6.52) x 10(6) ( P0.05) and the proportion of progressively motile sperm from (18.41 ± 9.82)% to (28.27 ± 4.47)% (P0.05) in the VD group. In comparison, the count of progressively motile sperm per ejaculate was elevated from (9.51 ± 6.31) x 10(6) to (12.36 ± 4.43) x 10(6) (P0.05) and the proportion of progressively motile sperm from (17.79 ± 5.25)% to (21.35 ± 2.41)% (P0.05) in the control group. Pregnancy was achieved in 7 cases (16.3%) in the VD group, but only lease (2.3%) in the control (P0.05). No adverse reactions were observed in either of the groups.Vitamin D, as a safe option for the treatment of idiopathic oligoasthenozoospermia, can effectively improve the semen quality, especially the progressive sperm motility of the patient.

Cost controlling is key behavior of getting more profits in an enterprise, but the cost of construction material cover 40-60 percent or more. So, reduce its cost as less possible as on the premise of insuring material quality is very important. The article starts from this, and gives some suggestions about controlling of the cost of construction material.

Based on ab initio molecular dynamic simulations, we have theoretically investigated the structural stabilities and electronic properties of X22H28 (X=C, Si, and Ge) nanocrystals, as a function of temperature with consideration of vibrational entropy effects. To compare the relative stabilities of X22H28 isomers, the vibration free energies are obtained according to the calculated phonon spectrum, where the typical modes are shown to be dominant to the structural stabilities. In addition, there is a significant gap reduction as the temperature increases from 0 K to 300 K, where the decrements are 0.2 /0.5 /0.6eV for C/Si/Ge nanocrystals, respectively. The dependence of energy gap on the variance of bond length is also analyzed according to the corresponding atomic attributions to the HOMO and LUMO levels.

Uroflowmetry is the most widely used non-invasive urodynamic tool for most patients with suspected lower urinary tract dysfunction. Home uroflowmetry can produce multiple representative flow readings in adequate privacy condition when patients feel a normal desire. Because of its advantages of decreasing variability, describing circadian rhythms and combating problems inherent to clinic-based measurements, it can improve diagnostic accuracy and predictive value. Further studies are required to confirm quantitative data of patient's preferences and to measure cost-benefit of home uroflowmetry.

To design a new portable home electronic uroflowmeter and compare it with traditional methods.The system consists of collectors, urine conducting apparatus, intelligent cell phone, wireless network communication technology, computer analysis and drawing, and data storage technology, etc., and can automatically collect voiding information from patients with lower urinary tract symptoms(LUTS) Through Bluetooth, the voiding information was sent to the patient's intelligent cell phone from the collector, then stored directly by intelligent cell phone and wirelessly transmitted to the workstation in hospital. The system was primarily tested with regard to accuracy of measurement of the voided volume. Multiple doses with known volume were introduced in the system and Laborie uroflowmeter. Furthermore, 38 outpatients who had LUTS were tested simultaneously with the system and Laborie uroflowmeter. The statistical method for assessing agreement between the two methods of clinical measurement was Bland-Altman analysis. Among the subjects, there were 22 male patients and 16 female patients, ranging from 21 to 37 years old, with an average age of 25.5 years, of whom, 19 were tested once and 19 patients twice, equaling to 57 tests.The system could accurately collect and analyze voiding time, uroflowmetry, voided volume, and automatically provide uroflowmetry parameters. The measurement error of 100, 200, 300, 500 and 800 mL is less than 5%. 12.28%, 5.26% and 3.51% of the Qmax, Qave and voided volume points were beyond the 95% limits of agreement. The maximum absolute values of the Qmax, Qave and voided volume difference were 0.38 mL/s, 0.70 mL/s and 2.90 mL, respectively.They agreed with the recommendation of Standardization International Continence Society.The new portable home electronic uroflowmeter has good agreement with Laborie uroflowmeter,and is a new LUTS monitoring system integrated with correct, reliable, real-time, convenient and easy-managing advantages. It is as noninvasive and reliable as traditional methods, and its portable feature facilitates application out of hospitals. It can also record voiding diaries.

To investigate the effect of light-emitting diode (LED) light curing unit (LCU) and quartz-tungsten (QTH) LCU on the polymerization-shrinkage of different resin composites.Three composites Z100, Z250, AP-X were irradiated by QTH LCU and LED LCU. Polymerization-shrinkage of 50s and 400s after the composites curing were measured by 3D-profile measuring apparatus by phase-shifted projected grating.The polymerization-shrinkage of LED and QTH curing composites were analysed by SPSS12.0 software package of one-way ANOVA.At 50s curing and 400s curing period, the polymerization- shrinkage of Z100, Z250 resin was different by QTH LCU and LED LCU curing, the polymerization-shrinkage by LED LCU curing was less than that by QTH LCU (P0.05); the polymerization-shrinkage of AP-X was not statistically different by QTH LCU and LED LCU curing (P0.05). CONCLUSUINS: The polymerization-shrinkage of Z100,Z250 resin is statistically less cured by LED LCU than QTH; the polymerization-shrinkage of AP-X resin is not statistically different cured by QTH LCU and LED LCU. Supported by Research Fund of Science and Technology Commission of Shanghai Municipality (08DZ2271100).