1. Melatonin or its analogs as premedication to prevent emergence agitation in children: a systematic review and meta-analysis
- Author
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Dongni Zhang, Xiaotong Jia, Duomao Lin, and Jun Ma
- Subjects
Emergence agitation ,Melatonin ,Pediatrics ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Background Emergence agitation (EA) is a prevalent complication in children following general anesthesia. Several studies have assessed the relationship between melatonin or its analogs and the incidence of pediatric EA, yielding conflicting results. This meta-analysis aims to assess the effects of premedication with melatonin or its analogs on preventing EA in children after general anesthesia. Methods PubMed, EMBASE, the Cochrane Library, ProQuest Dissertations & Theses Global, Web of Science, CNKI, Wanfang Data, clinicaltrials.gov, and WHO International Clinical Trials Registry Platform were searched until 25 November 2022. We included randomized controlled trials that assessed EA in patients less than 18 years old who underwent general anesthesia. We excluded studies that did not use a specific evaluation to assess EA. Results Nine studies (951 participants) were included in this systematic review. Melatonin significantly reduced the incidence of EA compared with placebos (risk ratio 0.40, 95% CI 0.26 to 0.61, P
- Published
- 2023
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