1. Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus
- Author
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Xiaoyi Qian, Wenwen Wu, Boyang Chen, Simin Zhang, Chunmei Xiao, Long Chen, Jun Chen, Lingli Ke, Meian He, and Xiulou Li
- Subjects
type 2 diabetes mellitus ,body mass index ,triglyceride glucose body mass index ,nonalcoholic fatty liver disease ,receiver operating characteristic curve ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundThere is limited data on the association between TyG-BMI and NAFLD in patients with Type 2 Diabetes Mellitus (T2DM). The magnitude of risk prediction and predictive efficacy of TyG-BMI for T2DM with NAFLD remains unclear.ObjectiveTo examine the association of TyG-BMI with NAFLD in T2DM patients and assess the effectiveness of screening using the TyG-BMI index.MethodsWe conducted a retrospective analysis of clinical data from 602 T2DM patients at an enterprise health lodge from September 2021 to November 2022. Patients were categorized into two groups: T2DM alone (n=250) and T2DM with NAFLD (n=352). The Mann-Whitney U test was used for comparing non-normally distributed continuous data between groups, while the Chi-square test was used for categorical data. Logistic regression analysis was performed to evaluate the effect of BMI, TyG index, and TyG-BMI index on NAFLD. The ROC curve was used to assess the predictive efficacy of the TyG-BMI index for NAFLD in T2DM patients.ResultsBMI predicted the development of NAFLD in T2DM patients with an area under the receiver operating characteristic (ROC) curve of 0.792 (95% CI 0.757-0.828), and the optimal cutoff value was 25.22, with 72.2% sensitivity and 71.6% specificity; The area under the receiver operating characteristic (ROC) curve of the TyG index to predict the development of NAFLD in patients with T2DM was 0.755 (95% CI 0.716-0.794), and the optimal cutoff value was 8. 945, with a sensitivity of 80.1% and a specificity of 59.2%; The area under the receiver operating characteristic (ROC) curve of TyG-BMI index to predict the development of NAFLD in T2DM patients was 0.852, (95% CI 0.822-0.882), and the optimal cutoff value was 227.385, with a sensitivity and specificity of 80.1% and 59.2%, respectively.ConclusionsThe TyG-BMI index is a significant predictor of comorbid NAFLD in T2DM patients and provides better screening performance than BMI alone. The TyG-BMI index shows promise as an early screening tool for NAFLD in T2DM patients.
- Published
- 2025
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