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534 results on '"Xie, Biao"'

3. Ultrashort vertical-channel MoS2 transistor using a self-aligned contact.

Author

Liu, Liting, Chen, Yang, Chen, Long, Xie, Biao, Li, Guoli, Kong, Lingan, Tao, Quanyang, Li, Zhiwei, Yang, Xiaokun, Lu, Zheyi, Ma, Likuan, Lu, Donglin, Yang, Xiangdong, and Liu, Yuan

Abstract

Two-dimensional (2D) semiconductors hold great promises for ultra-scaled transistors. In particular, the gate length of MoS2 transistor has been scaled to 1 nm and 0.3 nm using single wall carbon nanotube and graphene, respectively. However, simultaneously scaling the channel length of these short-gate transistor is still challenging, and could be largely attributed to the processing difficulties to precisely align source-drain contact with gate electrode. Here, we report a self-alignment process for realizing ultra-scaled 2D transistors. By mechanically folding a graphene/BN/MoS2 heterostructure, source-drain metals could be precisely aligned around the folded edge, and the channel length is only dictated by heterostructure thickness. Together, we could realize sub-1 nm gate length and sub-50 nm channel length for vertical MoS2 transistor simultaneously. The self-aligned device exhibits on-off ratio over 105 and on-state current of 250 μA/μm at 4 V bias, which is over 40 times higher compared to control sample without self-alignment process.

Published
2024

45. Designing the next generation of proton-exchange membrane fuel cells

Author

Jiao, Kui, Xuan, Jin, Du, Qing, Bao, Zhiming, Xie, Biao, Wang, Bowen, Zhao, Yan, Fan, Linhao, Wang, Huizhi, Hou, Zhongjun, Huo, Sen, Brandon, Nigel P., Yin, Yan, and Guiver, Michael D.

Subjects
Market trend/market analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

With the rapid growth and development of proton-exchange membrane fuel cell (PEMFC) technology, there has been increasing demand for clean and sustainable global energy applications. Of the many device-level and infrastructure challenges that need to be overcome before wide commercialization can be realized, one of the most critical ones is increasing the PEMFC power density, and ambitious goals have been proposed globally. For example, the short- and long-term power density goals of Japan's New Energy and Industrial Technology Development Organization are 6 kilowatts per litre by 2030 and 9 kilowatts per litre by 2040, respectively. To this end, here we propose technical development directions for next-generation high-power-density PEMFCs. We present the latest ideas for improvements in the membrane electrode assembly and its components with regard to water and thermal management and materials. These concepts are expected to be implemented in next-generation PEMFCs to achieve high power density. This Perspective reviews the recent technical developments in the components of the fuel cell stack in proton-exchange membrane fuel cell vehicles and outlines the road towards large-scale commercialization of such vehicles., Author(s): Kui Jiao [sup.1] , Jin Xuan [sup.2] , Qing Du [sup.1] , Zhiming Bao [sup.1] , Biao Xie [sup.1] , Bowen Wang [sup.1] , Yan Zhao [sup.3] , Linhao [...]

Published
2021
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50. Identification and Validation of Tumor Microenvironment-Associated Signature in Clear-Cell Renal Cell Carcinoma through Integration of DNA Methylation and Gene Expression.

Author

Ye, Zijian, Xu, Jialiang, Zhang, Xin, Zhang, Yifan, Ivanova, Deyana, Lu, Weiyu, Zhang, Jianning, Li, Fangfang, Chen, Xuemei, Wang, Yingxiong, Wang, Meijiao, and Xie, Biao

Subjects
RENAL cell carcinoma, DNA methylation, GENE expression, TREATMENT effectiveness, DISEASE risk factors, METHYLGUANINE
Abstract

The tumor microenvironment (TME) is crucial in tumor development, metastasis, and response to immunotherapy. DNA methylation can regulate the TME without altering the DNA sequence. However, research on the methylation-driven TME in clear-cell renal cell carcinoma (ccRCC) is still lacking. In this study, integrated DNA methylation and RNA-seq data were used to explore methylation-driven genes (MDGs). Immune scores were calculated using the ESTIMATE, which was employed to identify TME-related genes. A new signature connected with methylation-regulated TME using univariate, multivariate Cox regression and LASSO regression analyses was developed. This signature consists of four TME-MDGs, including AJAP1, HOXB9, MYH14, and SLC6A19, which exhibit high methylation and low expression in tumors. Validation was performed using qRT-PCR which confirmed their downregulation in ccRCC clinical samples. Additionally, the signature demonstrated stable predictive performance in different subtypes of ccRCC. Risk scores are positively correlated with TMN stages, immune cell infiltration, tumor mutation burden, and adverse outcomes of immunotherapy. Interestingly, the expression of four TME-MDGs are highly correlated with the sensitivity of first-line drugs in ccRCC treatment, especially pazopanib. Molecular docking indicates a high affinity binding between the proteins and pazopanib. In summary, our study elucidates the comprehensive role of methylation-driven TME in ccRCC, aiding in identifying patients sensitive to immunotherapy and targeted therapy, and providing new therapeutic targets for ccRCC treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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