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38. Preparation and optimization of silicon nitride slurries for digital light processing.

Author

Sha, Qi, Xie, Jianjun, Duan, Yesen, Tang, Wenyu, and Zhang, Jingxian

Subjects
*REFRACTIVE index, *SLURRY, *LIGHT absorption, *SILICON surfaces, *THREE-dimensional printing, *SILICON nitride
Abstract

Digital light processing (DLP) three‐dimensional printing has the advantages of both high printing resolution and efficiency and has been used to manufacture high‐precision, small, and complex shaped ceramic parts. One of the challenges of DLP is to develop photosensitive ceramic slurries with high solid content and low viscosity, especially for non‐oxide ceramics such as silicon nitride due to the dispersion and light absorption problem. This study mainly explores the dispersibility of silicon nitride in ultraviolet (UV)‐cured resins and the photocured properties of the slurry. Rheological measurements were utilized to characterize and screen different dispersants in the resin. It was found that DISPERMP is an effective dispersant. In order to improve the curing depth of Si3N4 photosensitive paste, the surface of silicon nitride powder was treated by oxidation, and organic compounds with different refractive indices were also introduced to increase the light penetration depth. It was found that glycerol with a refractive index of 1.474 resulted in the greatest improvement in the curing depth of Si3N4 photosensitive paste. Finally, a proposed slurry composition was developed to successfully print silicon nitride ceramics through UV‐curing molding technology. [ABSTRACT FROM AUTHOR]

Published
2025
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42. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1

Author

Lin, Lehang, Huang, Moli, Shi, Xianping, Mayakonda, Anand, Hu, Kaishun, Jiang, Yan-Yi, Guo, Xiao, Chen, Li, Pang, Brendan, Doan, Ngan, Said, Jonathan W, Xie, Jianjun, Gery, Sigal, Cheng, Xu, Lin, Zhaoyu, Li, Jinsong, Berman, Benjamin P, Yin, Dong, Lin, De-Chen, and Koeffler, H Phillip

Subjects
Biotechnology, Pediatric Cancer, Genetics, Pediatric, Pediatric Research Initiative, Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Apoptosis, Cell Line, Tumor, Cell Proliferation, Enhancer Elements, Genetic, Gene Expression Regulation, Neoplastic, Humans, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Myeloid Ecotropic Viral Integration Site 1 Protein, Nucleotide Motifs, Oncogene Proteins, Fusion, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Sarcoma, Ewing, Signal Transduction, Transcription, Genetic, Environmental Sciences, Biological Sciences, Information and Computing Sciences, Developmental Biology
Abstract

As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize the transcription dysregulation in this cancer, focusing on the investigation of super-enhancer and its associated transcriptional regulatory mechanisms. We demonstrate that super-enhancer-associated transcripts are significantly enriched in EWS-FLI1 target genes, contribute to the aberrant transcriptional network of the disease, and mediate the exceptional sensitivity of Ewing sarcoma to transcriptional inhibition. Through integrative analysis, we identify MEIS1 as a super-enhancer-driven oncogene, which co-operates with EWS-FLI1 in transcriptional regulation, and plays a key pro-survival role in Ewing sarcoma. Moreover, APCDD1, another super-enhancer-associated gene, acting as a downstream target of both MEIS1 and EWS-FLI1, is also characterized as a novel tumor-promoting factor in this malignancy. These data delineate super-enhancer-mediated transcriptional deregulation in Ewing sarcoma, and uncover numerous candidate oncogenes which can be exploited for further understanding of the molecular pathogenesis for this disease.

Published
2019

46. Circadian clock cryptochrome proteins regulate autoimmunity

Author

Cao, Qi, Zhao, Xuan, Bai, Jingwen, Gery, Sigal, Sun, Haibo, Lin, De-Chen, Chen, Qi, Chen, Zhengshan, Mack, Lauren, Yang, Henry, Deng, Ruishu, Shi, Xianping, Chong, Ling-Wa, Cho, Han, Xie, Jianjun, Li, Quan-Zhen, Müschen, Markus, Atkins, Annette R, Liddle, Christopher, Yu, Ruth T, Alkan, Serhan, Said, Jonathan W, Zheng, Ye, Downes, Michael, Evans, Ronald M, and Koeffler, H Phillip

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Lupus, Autoimmune Disease, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Inflammatory and immune system, Animals, Antibodies, Antinuclear, Autoimmune Diseases, Autoimmunity, B-Lymphocytes, Circadian Clocks, Complement C1q, Cryptochromes, Gene Expression Profiling, Gene Expression Regulation, Kidney, Lung, Lymphocyte Activation, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Antigen, B-Cell, Signal Transduction, Spleen, cryptochrome, autoimmune, B cell receptor
Abstract

The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations, serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli and massive infiltration of leukocytes into the lungs and kidneys. Flow cytometry of lymphoid organs revealed decreased pre-B cell numbers and a higher percentage of mature recirculating B cells in the bone marrow, as well as increased numbers of B2 B cells in the peritoneal cavity of Cry DKO mice. The B cell receptor (BCR) proximal signaling pathway plays a critical role in autoimmunity regulation. Activation of Cry DKO splenic B cells elicited markedly enhanced tyrosine phosphorylation of cellular proteins compared with cells from control mice, suggesting that overactivation of the BCR-signaling pathway may contribute to the autoimmunity phenotype in the Cry DKO mice. In addition, the expression of C1q, the deficiency of which contributes to the pathogenesis of systemic lupus erythematosus, was significantly down-regulated in Cry DKO B cells. Our results suggest that B cell development, the BCR-signaling pathway, and C1q expression are regulated by circadian clock CRY proteins and that their dysregulation through loss of CRY contributes to autoimmunity.

Published
2017

49. Mini Percutaneous Nephrolithotomy Is a Noninferior Modality to Standard Percutaneous Nephrolithotomy for the Management of 20–40 mm Renal Calculi: A Multicenter Randomized Controlled Trial

Author

Zeng, Guohua, Cai, Chao, Duan, Xianzhong, Xu, Xun, Mao, Houping, Li, Xuedong, Nie, Yong, Xie, Jianjun, Li, Jiongming, Lu, Jun, Zou, Xiaofeng, Mo, Jianfeng, Li, Chengyang, Li, Jianzhong, Wang, Weiguo, Yu, Yonggang, Fei, Xiang, Gu, Xianen, Chen, Jianhui, Kong, Xiangbo, Pang, Jian, Zhu, Wei, Zhao, Zhijian, Wu, Wenqi, Sun, Hongling, Liu, Yongda, and la Rosette, Jean de

Published
2021
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50. Early Warning System for Financial Risks in the Real Estate Market of China on the Basis of BP Neural Network

Author

Xie, Jianjun, Zeng, Yue, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Abawajy, Jemal H., editor, Choo, Kim-Kwang Raymond, editor, Islam, Rafiqul, editor, Xu, Zheng, editor, and Atiquzzaman, Mohammed, editor

Published
2020
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