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31 results on '"Xie, Jianlei"'

9. Temperature regulates Rab3a and mast cell‐derived exosomal FcεRI to inhibit mast cell activation

Author

Liao, Wenjing, primary, Chen, Gui, additional, Song, Lijuan, additional, Xu, Meiqian, additional, Li, Hao, additional, Wang, Yiyan, additional, Wang, Xiaofen, additional, Ye, Jinfeng, additional, Ren, Mei, additional, Kuang, Xiaoxuan, additional, Tang, Yaqiang, additional, Yang, Saixuan, additional, Ning, Xiaoping, additional, Xie, Jianlei, additional, Yang, Zhaowei, additional, and Zhang, Xiaowen, additional

Published
2023
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10. Genetic Predisposition to Allergic Rhinitis May Be a Causal Risk Factor for Bipolar Disorder and Major Depressive Disorder

Author

Liao, Wenjing, primary, Song, Lijuan, additional, Xie, Junyang, additional, Chen, Gui, additional, Liang, Tianhao, additional, Li, Ang, additional, Zhang, Chunyi, additional, Xu, Meiqian, additional, Li, Hao, additional, Xie, Jianlei, additional, Yang, Pingchang, additional, Han, Deming, additional, Zhong, Nanshan, additional, and Zhang, Xiaowen, additional

Published
2022
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14. Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Author

Xie, Jianlei, primary, Wang, Yingwei, additional, Choi, Wonseok, additional, Jangili, Paramesh, additional, Ge, Yanqi, additional, Xu, Yunjie, additional, Kang, Jianlong, additional, Liu, Liping, additional, Zhang, Bin, additional, Xie, Zhongjian, additional, He, Jun, additional, Xie, Ni, additional, Nie, Guohui, additional, Zhang, Han, additional, and Kim, Jong Seung, additional

Published
2021
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15. Emetine‐Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation

Author

Xie, Jianlei, primary, Fan, Taojian, additional, Kim, Ji Hyeon, additional, Xu, Yunjie, additional, Wang, Yingwei, additional, Liang, Weiyuan, additional, Qiao, Lijun, additional, Wu, Zongze, additional, Liu, Quan, additional, Hu, Weibin, additional, Yin, Na, additional, Yang, Ling, additional, Liu, Liping, additional, Kim, Jong Seung, additional, and Zhang, Han, additional

Published
2020
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16. Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy

Author

Wang, Yingwei, primary, Xie, Jianlei, additional, Kang, Jianlong, additional, Choi, Wonseok, additional, Jangili, Paramesh, additional, Zhang, Bin, additional, Xie, Ni, additional, Nie, Guohui, additional, He, Jun, additional, Zhang, Han, additional, Liu, Liping, additional, and Kim, Jong Seung, additional

Published
2020
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19. Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine

Author

Liu, Quan, primary, Fan, Taojian, additional, Zheng, Yuanyuan, additional, Yang, Sheng-li, additional, Yu, Zhiqiang, additional, Duo, Yanhong, additional, Zhang, Yuhua, additional, Adah, Dickson, additional, Shi, Lulin, additional, Sun, Zhe, additional, Wang, Dou, additional, Xie, Jianlei, additional, Wu, Hong, additional, Wu, Zongze, additional, Ge, Chenchen, additional, Qiao, Lijun, additional, Wei, Chaoying, additional, Huang, Luodan, additional, Yan, Qiaoting, additional, Yang, Qinhe, additional, Bao, Shiyun, additional, Liu, Li-Ping, additional, and Zhang, Han, additional

Published
2020
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23. A C-terminally truncated form of β-catenin acts as a novel regulator of Wnt/β-catenin signaling in planarians

Author

Su, Hanxia, Sureda Gómez, Miquel, Rabaneda Lombarte, Neus, Gelabert, Maria, Xie, Jianlei, Wu, Wei, Adell i Creixell, Teresa, and Universitat de Barcelona

Subjects
Photoreceptors, Pigments, Sensory Receptors, Flatworms, Social Sciences, Biochemistry, RNA interference, Cell Signaling, Animal Cells, Medicine and Health Sciences, Homeostasis, Psychology, Wnt Signaling Pathway, beta Catenin, WNT Signaling Cascade, Neurons, Eukaryota, Signaling Cascades, Nucleic acids, Genetic interference, Physical Sciences, Photoreceptor Cells, Invertebrate, Epigenetics, Sensory Perception, Anatomy, Cellular Types, TCF Transcription Factors, Research Article, Signal Transduction, Signal Inhibition, lcsh:QH426-470, Cèl·lules, Cells, Materials Science, Models, Biological, Evolution, Molecular, Ocular System, Genetics, Animals, Regeneration, Protein Interaction Domains and Motifs, Materials by Attribute, Armadillo Domain Proteins, Transactivation, Organisms, Biology and Life Sciences, Afferent Neurons, Proteins, Planarians, Cell Biology, Invertebrates, Peptide Fragments, lcsh:Genetics, Cellular Neuroscience, Eyes, RNA, gamma Catenin, Gene expression, Head, Proteïnes, Neuroscience
Abstract

β-Catenin, the core element of the Wnt/β-catenin pathway, is a multifunctional and evolutionarily conserved protein which performs essential roles in a variety of developmental and homeostatic processes. Despite its crucial roles, the mechanisms that control its context-specific functions in time and space remain largely unknown. The Wnt/β-catenin pathway has been extensively studied in planarians, flatworms with the ability to regenerate and remodel the whole body, providing a ‘whole animal’ developmental framework to approach this question. Here we identify a C-terminally truncated β-catenin (β-catenin4), generated by gene duplication, that is required for planarian photoreceptor cell specification. Our results indicate that the role of β-catenin4 is to modulate the activity of β-catenin1, the planarian β-catenin involved in Wnt signal transduction in the nucleus, mediated by the transcription factor TCF-2. This inhibitory form of β-catenin, expressed in specific cell types, would provide a novel mechanism to modulate nuclear β-catenin signaling levels. Genomic searches and in vitro analysis suggest that the existence of a C-terminally truncated form of β-catenin could be an evolutionarily conserved mechanism to achieve a fine-tuned regulation of Wnt/β-catenin signaling in specific cellular contexts., Author summary The Wnt signaling pathway is essential for proper intercellular communication in every developmental process since it controls basic cellular events as cell fate or proliferation. The key element of the Wnt signaling is β-catenin, which controls the transcription of multiple genes in the Wnt receiving cell. A main level of regulation of the Wnt/β-catenin signaling occurs in the cytoplasm, where β-catenin protein levels depend on the activity of the β-catenin destruction complex. However, once it reaches the nucleus, β-catenin transcriptional activity requires a fine-tuned regulation to enable the multiple context-specific responses that it performs. These nuclear mechanisms that regulate the Wnt/β-catenin signaling remain poorly understood. Here we report the existence of C-terminal truncated forms of β-catenin in planarians (β-cat3 and 4), which, in vitro, do not show transactivation activity and compete with the canonical planarian β-catenin (β-cat1), thus acting as competitor inhibitors. Functional analyses in planarians indicate that β-cat4 acts as a negative regulator of β-cat1 during planarian eye photoreceptor specification. We provide evidence to suggest that this novel mechanism for the regulation of nuclear β-catenin activity could be conserved across animal evolution.

Published
2017

26. Ultrathin boron nanosheets as an emerging two-dimensional photoluminescence material for bioimagingElectronic supplementary information (ESI) available. See DOI: 10.1039/c9nh00698b

Author

MaD. Ma, Dingtao, Zhao, J., work., J. Xie contributed equally to this, Zhao, Jinlai, Xie, Jianlei, Zhang, Feng, Wang, Rui, Wu, Leiming, Liang, Weiyuan, Li, Delong, Ge, Yanqi, Li, Jianqing, Zhang, Yupeng, and Zhang, Han

Abstract

Two-dimensional (2D) metal-free sheets with atomic thickness have been highly considered as promising candidates for fluorescent probes, due to their intriguing characteristics. In this work, 2D ultrathin boron nanosheets (B NSs) with a surface defect nanolayer can be effectively prepared by modified liquid phase exfoliation. The as-prepared ultrathin B NSs show blue fluorescence characteristics even with a quantum yield efficiency of up to 10.6%. Such luminescent behavior originates from the quantum confinement effect and the existence of a surface defect layer. In light of the advantages of being environmentally friendly, having high photostability and good biocompatibility, for the first time we have shown that ultrathin B NSs can be used as an emerging fluorescent probe for application in cellular bioimaging. It is believed that this work will open new avenues for ultrathin B NSs in biomedical fields, and it will also inspire the development of other elemental 2D nanomaterials.

Published
2020
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30. Assessing C/N and δ13C as indicators of Holocene sea level and freshwater discharge changes in the subaqueous Yangtze delta, China.

Author

Zhan, Qing, Wang, Zhanghua, Xie, Yan, Xie, Jianlei, and He, Zhongfa

Subjects
STABLE isotopes, HOLOCENE Epoch, ESTUARINE ecology, MARINE algae, MARINE phytoplankton
Abstract

To examine the applicability of C/N and organic carbon stable isotope (δ13C) in studies of the Holocene sea level and freshwater discharge in the large river mouth of Yangtze, we observed the distribution of carbon, nitrogen and δ13C in a late-Quaternary core (ZK9) collected from the present subaqueous delta. We also collected published data of the two proxies for the suspended particulate matter (SPM) and surficial sediments from the lower Yangtze River to the adjacent East China Sea. The results show that the estuarine front is an important boundary for terrestrial and marine contribution of the organic component in the modern sedimentary environment. In the core ZK9, sediments deposited during c. 13–9 cal. ka BP are characterized by high values of TOC (0.54–1.16%), CaCO3 (0.35% on average), and C/N (>12), which reflect an inner tidal estuarine environment dominated by C3 terrestrial organic carbon input. During c. 9–0.7 cal. ka BP, both TOC content (0.57% on average) and C/N ratio (<10) decrease remarkably while TN increases, indicating a lower estuarine or shallow marine environment. An abrupt sea level rise from c. 9 cal. ka BP resulted in a deeper water environment and reduced terrestrial input at the core location. The low δ13C values (−24.23‰ on average) before c. 6 cal. ka BP reflect a dominantly terrestrial source of organic matter associated with increased freshwater discharge into the estuary during that time. The sediments since c. 6 cal. ka BP are characterized by increasing δ13C up to −24.1 to −23.39‰, reflecting more contribution from marine algae as freshwater discharge fell. We suggest that in the Yangtze River mouth the C/N ratio indicates an abrupt sea level rise at c. 9 cal. ka BP, while δ13C is more useful in reflecting freshwater discharge. [ABSTRACT FROM AUTHOR]

Published
2012
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31. 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

Author

Xu, Yunjie, Wang, Yingwei, An, Jusung, Sedgwick, Adam C., Li, Mingle, Xie, Jianlei, Hu, Weibin, Kang, Jianlong, Sen, Sajal, Steinbrueck, Axel, Zhang, Bin, Qiao, Lijun, Wageh, Swelm, Arambula, Jonathan F., Liu, Liping, Zhang, Han, Sessler, Jonathan L., and Kim, Jong Seung

Abstract

An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities. We report here a dual-therapeutic prodrug, DOXjade, that allows for iron chelation chemo-photothermal cancer therapy. This prodrug takes advantage of the clinically approved iron chelator deferasirox (ExJade®) and the topoisomerase 2 inhibitor, doxorubicin (DOX). Loading DOXjadeonto ultrathin 2D Ti3C2MXene nanosheets produces a construct, Ti3C2-PVP@DOXjade, that allows the iron chelation and chemotherapeutic functions of DOXjadeto be photo-activated at the tumor sites, while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%. Antitumor mechanistic investigations reveal that upon activation, Ti3C2-PVP@DOXjadeserves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor (TfR). A tumor pH-responsive iron chelation/PTT/chemotherapy antitumor effect was achieved both in vitroand in vivo. The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.

Published
2021
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