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29. Increased Plasma Homocysteine Levels Are Associated with Left Ventricular Hypertrophy in Hypertensive Patients with Normal Renal Function.

Author

Zhang, Lingyu, Wang, Tingjun, Shen, Yihua, Luo, Li, Xu, Guoyan, and Xie, Liangdi

Subjects
LEFT ventricular hypertrophy, HYPERTENSION, KIDNEY physiology, HOMOCYSTEINE, GLOMERULAR filtration rate
Abstract

Introduction: Renal function has an important bearing on plasma homocysteine levels. Plasma homocysteine is related to left ventricular hypertrophy (LVH). However, it remains unclear whether the association between plasma homocysteine levels and LVH is influenced by renal function. This study aimed to investigate relationships among left ventricular mass index (LVMI), plasma homocysteine levels, and renal function in a population from southern China. Methods: A cross-sectional study was performed in 2,464 patients from June 2016 to July 2021. Patients were divided into three groups based on gender-specific tertiles of homocysteine levels. LVMI ≥115 g/m2 for man or ≥95 g/m2 for woman was defined as LVH. Results: LVMI and the percentage of LVH were increased, while estimated glomerular filtration rate (eGFR) was decreased with the increase in homocysteine levels, both significantly. Multivariate stepwise regression analysis showed that eGFR and homocysteine were independently associated with LVMI in patients with hypertension. No correlation was observed between homocysteine and LVMI in patients without hypertension. Stratified by eGFR, further analysis confirmed homocysteine was independently associated with LVMI (β = 0.126, t = 4.333, p < 0.001) only in hypertensive patients with eGFR ≥90 mL/(min·1.73 m2), not with 60≤ eGFR <90 mL/(min·1.73 m2). Multivariate logistic regression indicated that in hypertensive patients with eGFR ≥90 mL/(min·1.73 m2), the patients in high tertile of homocysteine levels had a nearly twofold increased risk of occurring LVH compared with those in low tertile (high tertile: OR = 2.780, 95% CI: 1.945–3.975, p < 0.001). Conclusion: Plasma homocysteine levels were independently associated with LVMI in hypertensive patients with normal eGFR. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Trends in cause-related comorbidities in hospitalized patients with secondary hypertension in China from 2013 to 2016: a retrospective analysis of hospital quality monitoring system data

Author

Zhang, Long, primary, Li, Jianping, additional, Li, Nanfang, additional, Sun, Ningling, additional, Xie, Liangdi, additional, Han, Qinghua, additional, Li, Yong, additional, Lu, Xin Zheng, additional, Sun, Pengfei, additional, Li, Yuxi, additional, Shi, Ying, additional, Wang, Haibo, additional, Zhang, Yan, additional, Chen, Hu, additional, and Huo, Yong, additional

Published
2021
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32. Additional file 5 of Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Author

Xiao, Genfa, Lian, Guili, Wang, Tingjun, Chen, Weixiao, Zhuang, Wei, Luo, Li, Wang, Huajun, and Xie, Liangdi

Abstract

Additional file 4: Figure S4. Identification of protein kinases involved in hypoxia-prolonged CREB phosphorylation. a The effect of ERK1/2, CAMK and PKC on CREB phosphorylation in hypoxia-treated PASMCs. Serum-starved PASMCs were pretreated with ERK1/2 inhibitor PD98059 (20 μM), CaMK inhibitor KN62 (10 μM) and PKC inhibitor chelerythrine chloride (CHE, 10 µM) for 24 h in the present of hypoxia, respectively. Then cells then were stimulated by 10% fetal bovine serum (FBS) for 1 h in the present of hypoxia and protein kinase inhibitors. n=5, 6 and 5. b The effect of P38MAPK, PI3K and PKA on CREB phosphorylation in hypoxia-treated PASMCs. Serum-starved PASMCs were pretreated with P38MAPK inhibitor SB203580 (20 μM), PI3K inhibitor LY294002 (50 μM) and PKA inhibitor H89 (10 μM) for 24h in the present of hypoxia, respectively. Then cells were stimulated by 10% FBS for 1 h in the present of hypoxia and protein kinase inhibitors. n=5, 5 and 5. c The effect of staurosporine (Sto, 10 nM) on CREB phosphorylation in hypoxia-pretreated PASMCs. The PASMCs were starved with serum-free DMEM/F12 and exposed to hypoxia for 24h, then, the cells were simultaneously stimulated by 10% FBS and Sto for 1 h in the present of hypoxia. n=6. *p

Published
2021
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33. Additional file 4 of Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Author

Xiao, Genfa, Lian, Guili, Wang, Tingjun, Chen, Weixiao, Zhuang, Wei, Luo, Li, Wang, Huajun, and Xie, Liangdi

Abstract

Additional file 3: Figure S3. Enhanced and prolonged serum-induced CREB phosphorylation in hypoxia-pretreated PASMCs. a Enhanced serum-induced CREB phosphorylation in hypoxia-pretreated PASMCs. The PASMCs were starved with serum-free DMEM/F12 and simultaneously exposed to hypoxia for 24h and then, the cells were stimulated by 10% fetal bovine serum (FBS) for 1 h in the present of hypoxia. n=3. b Prolonged serum-induced CREB phosphorylation in hypoxia-pretreated PASMCs. The PASMCs were starved with serum-free DMEM/F12 medium and simultaneously exposed to hypoxia for 24h, the cells were then stimulated by 10% fetal bovine serum for 1, 3, 6 and 24h in the present of hypoxia. n=5. Ctr, control; MCTW1, MCTW2, MCTW3 and MCTW4 represent MCT treatment for 1, 2, 3 and 4 weeks, respectively. *p

Published
2021
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34. Additional file 8 of Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Author

Xiao, Genfa, Lian, Guili, Wang, Tingjun, Chen, Weixiao, Zhuang, Wei, Luo, Li, Wang, Huajun, and Xie, Liangdi

Abstract

Additional file 7: Figure S6. Plasmid profile of pGL4.20-TH and ZIP12 expression in MCT- and hypoxia+su5416-induced PH. a The TH promoter (-4490~+10) was linked to a luciferase reporter, pGL4.20 to make pGL4.20-TH (TH-promoter reporter). b Elevated expression of ZIP12 mRNA in rat lung tissues. n=6. c Elevated expression of ZIP12 mRNA in isolated PH-PASMCs, n= 5. *p

Published
2021
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35. Additional file 7 of Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Author

Xiao, Genfa, Lian, Guili, Wang, Tingjun, Chen, Weixiao, Zhuang, Wei, Luo, Li, Wang, Huajun, and Xie, Liangdi

Abstract

Additional file 6: Figure S5. Profiling of phosphatases associated with CREB phosphorylation in hypoxia- and hypoxia+su5416-induced PH. Rows in the heatmap represent gene expression levels and columns represent each sample. The data were downloaded and extracted from gene expression omnibus repository with an accession number GSE8078.

Published
2021
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36. Additional file 3 of Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Author

Xiao, Genfa, Lian, Guili, Wang, Tingjun, Chen, Weixiao, Zhuang, Wei, Luo, Li, Wang, Huajun, and Xie, Liangdi

Abstract

Additional file 2: Figure S2. Total and phosphorylated CREB in hypoxia-treated PASMCs. a The levels of phosphorylated and total CREB in hypoxia-treated PASMCs. PASMCs were starved with serum-free DMEM/F12 for 24 h and then treated with hypoxia (2% O2) for 0min, 20min, 1h, 3h, 6h and 24h. n=12. b Serum-induced CREB phosphorylation and expression in PASMCs, PASMCs were starved with serum-free DMEM/F12 for 24 h and then treated with 10% fetal bovine serum (FBS) for 0min, 5min, 15min, 30min, 1h and 24h. n=4. c The levels of phosphorylated and total CREB in PASMCs treated with hypoxia. The PASMCs cultured in 10% FBS were exposed to 2% O2 for 0min, 20min, 1h, 3h, 6h and 24h. n=8. *p

Published
2021
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