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20 results on '"Xie, Lin-Ying"'

3. A methylation study of long-term depression risk

Author

Clark, Shaunna L., Hattab, Mohammad W., Chan, Robin F., Shabalin, Andrey A., Han, Laura K. M., Zhao, Min, Smit, Johannes H., Jansen, Rick, Milaneschi, Yuri, Xie, Lin Ying, van Grootheest, Gerard, Penninx, Brenda W. J. H., Aberg, Karolina A., and van den Oord, Edwin J. C. G.

Published
2020
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8. Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA)

Author

Han, Laura, Verhoeven, Josine, Aghajani, Moji, Clark, Shaunna, Hattab, Mohammad, Shabalin, Andrey, Zhao, Min, Kumar, Gaurav, Chan, Robin, Xie, Lin Ying, Milaneschi, Yuri, Jansen, Rick, Aberg, Karolina, van den Oord, Edwin, Penninx, Brenda, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience, Amsterdam Neuroscience - Complex Trait Genetics, and APH - Digital Health

Published
2018

9. A methylation study of long-term depression risk

Author

Clark, Shaunna L., primary, Hattab, Mohammad W., additional, Chan, Robin F., additional, Shabalin, Andrey A., additional, Han, Laura K. M., additional, Zhao, Min, additional, Smit, Johannes H., additional, Jansen, Rick, additional, Milaneschi, Yuri, additional, Xie, Lin Ying, additional, van Grootheest, Gerard, additional, Penninx, Brenda W. J. H., additional, Aberg, Karolina A., additional, and van den Oord, Edwin J. C. G., additional

Published
2019
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11. Epigenetic Aging in Major Depressive Disorder

Author

Han, Laura K.M., primary, Aghajani, Moji, additional, Clark, Shaunna L., additional, Chan, Robin F., additional, Hattab, Mohammad W., additional, Shabalin, Andrey A., additional, Zhao, Min, additional, Kumar, Gaurav, additional, Xie, Lin Ying, additional, Jansen, Rick, additional, Milaneschi, Yuri, additional, Dean, Brian, additional, Aberg, Karolina A., additional, van den Oord, Edwin J.C.G., additional, and Penninx, Brenda W.J.H., additional

Published
2018
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12. 41. Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA)

Author

Han, Laura, primary, Verhoeven, Josine, additional, Aghajani, Moji, additional, Clark, Shaunna, additional, Hattab, Mohammad, additional, Shabalin, Andrey, additional, Zhao, Min, additional, Kumar, Gaurav, additional, Chan, Robin, additional, Xie, Lin Ying, additional, Milaneschi, Yuri, additional, Jansen, Rick, additional, Aberg, Karolina, additional, van den Oord, Edwin, additional, and Penninx, Brenda, additional

Published
2018
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13. Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies

Author

Hattab, Mohammad W., primary, Shabalin, Andrey A., additional, Clark, Shaunna L., additional, Zhao, Min, additional, Kumar, Gaurav, additional, Chan, Robin F., additional, Xie, Lin Ying, additional, Jansen, Rick, additional, Han, Laura K. M., additional, Magnusson, Patrik K. E., additional, van Grootheest, Gerard, additional, Hultman, Christina M., additional, Penninx, Brenda W. J. H., additional, Aberg, Karolina A., additional, and van den Oord, Edwin J. C. G., additional

Published
2017
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19. Myc activates telomerase

Author

Wang, Jing, primary, Xie, Lin Ying, additional, Allan, Susan, additional, Beach, David, additional, and Hannon, Gregory J., additional

Published
1998
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20. A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.

Author

van den Oord EJ, Clark SL, Xie LY, Shabalin AA, Dozmorov MG, Kumar G, Vladimirov VI, Magnusson PK, and Aberg KA

Subjects
Adult, Aged, Autopsy, Biomarkers blood, Biomarkers metabolism, Case-Control Studies, Female, Humans, Male, Microfilament Proteins genetics, Middle Aged, Neuropeptides genetics, Nuclear Proteins genetics, Polymorphism, Single Nucleotide, Psychotic Disorders blood, Psychotic Disorders genetics, Schizophrenia blood, Schizophrenia genetics, Brain metabolism, CpG Islands genetics, DNA Methylation genetics, Genome-Wide Association Study, Psychotic Disorders metabolism, Schizophrenia metabolism
Abstract

Mutated CpG sites (CpG-SNPs) are potential hotspots for human diseases because in addition to the sequence variation they may show individual differences in DNA methylation. We performed methylome-wide association studies (MWAS) to test whether methylation differences at those sites were associated with schizophrenia. We assayed all common CpG-SNPs with methyl-CpG binding domain protein-enriched genome sequencing (MBD-seq) using DNA extracted from 1408 blood samples and 66 postmortem brain samples (BA10) of schizophrenia cases and controls. Seven CpG-SNPs passed our FDR threshold of 0.1 in the blood MWAS. Of the CpG-SNPs methylated in brain, 94% were also methylated in blood. This significantly exceeded the 46.2% overlap expected by chance (P-value < 1.0×10(-8)) and justified replicating findings from blood in brain tissue. CpG-SNP rs3796293 in IL1RAP replicated (P-value = .003) with the same direction of effects. This site was further validated through targeted bisulfite pyrosequencing in 736 independent case-control blood samples (P-value < 9.5×10(-4)). Our top result in the brain MWAS (P-value = 8.8×10(-7)) was CpG-SNP rs16872141 located in the potential promoter of ENC1. Overall, our results suggested that CpG-SNP methylation may reflect effects of environmental insults and can provide biomarkers in blood that could potentially improve disease management., (© The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2016
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