10 results on '"Xie, Sheling"'
Search Results
2. Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol for a randomized controlled trial
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Xie, Sheling, Yan, Peng, Yao, Chen, Yan, Xiaoyan, Huo, Yuliang, Zhang, Junhua, Liu, Si, Feng, Zhiqiao, Shang, Hongcai, and Xie, Lixin
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- 2019
- Full Text
- View/download PDF
3. Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses
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He, Wanxue, primary, Xiao, Kun, additional, Xu, Jiaruo, additional, Guan, Wei, additional, Xie, Sheling, additional, Wang, Kaifei, additional, Yan, Peng, additional, Fang, Min, additional, and Xie, Lixin, additional
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- 2021
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4. Diagnostic value of Candida mannan antigen and anti‐mannan IgG and IgM antibodies for Candida infection
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Wang, Kaifei, primary, Luo, Yanping, additional, Zhang, Wei, additional, Xie, Sheling, additional, Yan, Peng, additional, Liu, Yang, additional, Li, Yanqin, additional, Ma, Xiuqing, additional, Xiao, Kun, additional, Fu, Han, additional, Cai, Jinyu, additional, and Xie, Lixin, additional
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- 2019
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5. Effect of ambient air quality on exacerbation of COPD in patients and its potential mechanism
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Yan, Peng, Liu, Pengfei, Lin, Rong, Xiao, Kun, Xie, Sheling, Wang, Kaifei, Zhang, Yuhan, He, Xanxue, Zhao, Shifeng, Zhang, Xingang, Liu, Martin, and Xie, Lixin
- Subjects
Male ,Time Factors ,air pollution ,Apoptosis ,Bronchi ,International Journal of Chronic Obstructive Pulmonary Disease ,Risk Assessment ,chronic obstructive pulmonary disease ,Cell Line ,Pulmonary Disease, Chronic Obstructive ,Risk Factors ,Smoke ,Humans ,Lung ,Original Research ,Aged ,Aged, 80 and over ,Inhalation Exposure ,apoptosis of airway epithelial cells ,Urban Health ,lung function ,Epithelial Cells ,Middle Aged ,Beijing ,Disease Progression ,Female ,Particulate Matter ,Seasons ,temporary migration - Abstract
Peng Yan,1 Pengfei Liu,2 Rong Lin,3 Kun Xiao,2 Sheling Xie,2 Kaifei Wang,2 Yuhan Zhang,2 Xanxue He,2 Shifeng Zhao,1 Xingang Zhang,1 Martin Liu,4 Lixin Xie11Pulmonary and Critical Care Medicine, The General Hospital of PLA, Beijing 100853, People’s Republic of China; 2Medical School of Chinese PLA, Beijing 100853, People’s Republic of China; 3Department of Respiratory Disease, The Sanya People’s Hospital, Sanya 572000, People’s Republic of China; 4Pulmonary, Critical Care, Sleep and Allergy, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USABackground: Chronic obstructive pulmonary disease (COPD) is a disease of continuous progress and environmental factors may affect the progress. COPD patients’ activity tolerance and quality of life are associated with air quality. COPD exacerbation from the perspective of geographical air quality has not been reported.Objectives: To explore environmental effect of two different geographical places on COPD exacerbation and the effect of cigarette smoke extract and carbon particles on bronchial epithelial cell viability.Methods: Total 139 COPD patients, who lived in Beijing during summer and temporarily migrated to Sanya city in winter, have been enrolled. Respiratory symptoms and lung function data were collected when they were living in Beijing or Sanya, respectively. Effect of cigarette smoke extract plus ultrafine carbon particles on airway epithelial cells were studied.Measurements and main results: Air pollution as measured by air quality index (AQI) in Beijing summer (113.1±14.2) was significantly worse than that in Sanya winter (49.4±8.9, p
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- 2019
6. Effect of ambient air quality on exacerbation of COPD in patients and its potential mechanism
- Author
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Yan,Peng, Liu,Pengfei, Lin,Rong, Xiao,Kun, Xie,Sheling, Wang,Kaifei, Zhang,Yuhan, He,Xanxue, Zhao,Shifeng, Zhang,Xingang, Liu,Martin, Xie,Lixin, Yan,Peng, Liu,Pengfei, Lin,Rong, Xiao,Kun, Xie,Sheling, Wang,Kaifei, Zhang,Yuhan, He,Xanxue, Zhao,Shifeng, Zhang,Xingang, Liu,Martin, and Xie,Lixin
- Abstract
Peng Yan,1 Pengfei Liu,2 Rong Lin,3 Kun Xiao,2 Sheling Xie,2 Kaifei Wang,2 Yuhan Zhang,2 Xanxue He,2 Shifeng Zhao,1 Xingang Zhang,1 Martin Liu,4 Lixin Xie11Pulmonary and Critical Care Medicine, The General Hospital of PLA, Beijing 100853, People’s Republic of China; 2Medical School of Chinese PLA, Beijing 100853, People’s Republic of China; 3Department of Respiratory Disease, The Sanya People’s Hospital, Sanya 572000, People’s Republic of China; 4Pulmonary, Critical Care, Sleep and Allergy, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USABackground: Chronic obstructive pulmonary disease (COPD) is a disease of continuous progress and environmental factors may affect the progress. COPD patients’ activity tolerance and quality of life are associated with air quality. COPD exacerbation from the perspective of geographical air quality has not been reported.Objectives: To explore environmental effect of two different geographical places on COPD exacerbation and the effect of cigarette smoke extract and carbon particles on bronchial epithelial cell viability.Methods: Total 139 COPD patients, who lived in Beijing during summer and temporarily migrated to Sanya city in winter, have been enrolled. Respiratory symptoms and lung function data were collected when they were living in Beijing or Sanya, respectively. Effect of cigarette smoke extract plus ultrafine carbon particles on airway epithelial cells were studied.Measurements and main results: Air pollution as measured by air quality index (AQI) in Beijing summer (113.1±14.2) was significantly worse than that in Sanya winter (49.4±8.9, p<0.001). The COPD Assessment Test (CAT) score was significantly higher in Beijing (26.4±7.1) than that in Sanya (20.0±8.0, p=0.019). Modified Medical Research Council dyspnea scale was also significantly higher in Beijing (2.9±0.9) t
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- 2019
7. Biomarkers of Sepsis-Induced Acute Kidney Injury
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Wang, Kaifei, Xie, Sheling, Xiao, Kun, Yan, Peng, He, Wanxue, and Xie, Lixin
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Article Subject ,urogenital system ,urologic and male genital diseases - Abstract
Sepsis, an infection-induced systemic disease, leads to pathological, physiological, and biochemical abnormalities in the body. Organ dysfunction is caused by a dysregulated host response to infection during sepsis which is a major contributing factor to acute kidney injury (AKI) and the mortality rate for sepsis doubles due to coincidence of AKI. Sepsis-induced AKI is strongly associated with increased mortality and other adverse outcomes. More timely diagnosis would allow for earlier intervention and could improve patient outcomes. Sepsis-induced AKI is characterized by a distinct pathophysiology compared with other diseases and may also have unique patterns of plasma and urinary biomarkers. This concise review summarizes properties and perspectives of the biomarkers for their individual clinical utilization.
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- 2018
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8. Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses.
- Author
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He, Wanxue, Xiao, Kun, Xu, Jiaruo, Guan, Wei, Xie, Sheling, Wang, Kaifei, Yan, Peng, Fang, Min, and Xie, Lixin
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T cells ,SUPPRESSOR cells ,SEPSIS ,IMMUNE response ,INFLUENZA - Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. It is a disease with a high incidence, mortality, and recurrence rate and frequently results in its survivors requiring readmission into hospitals. The readmission is mainly due to recurrent sepsis. Patients with recurrent sepsis are more susceptible to secondary infections partly due to immune dysfunction, leading to a higher mortality in the long term. However, there remains a gap in the understanding of immunological characteristics and underlying mechanisms of recurrent sepsis. In this study, we used mouse models of acute and recurrent sepsis to investigate their different immunological characteristics. And then we subjected the two mouse models to a secondary influenza A virus (H1N1) infection and characterized the different immune responses. Here, we demonstrated that CD4
+ T cells present an exacerbated exhaustion phenotype in response to recurrent sepsis as illustrated by the decreased frequency of CD4+ T cells, reduced co-stimulatory CD28 and increased inhibitory PD-1 and Tim-3 expression on CD4+ T cells, increased frequency of regulatory T cells, and reduced MHC-II expression on antigen-presenting cells. Moreover, we showed that antiviral immune responses decrease in the recurrent sepsis mouse model subjected to a secondary infection as illustrated by the reduced pathogen clearance and inflammatory response. This may be a consequence of the exacerbated CD4+ T cell exhaustion. In summary, recurrent sepsis exacerbates CD4+ T cell exhaustion and decreases antiviral immune responses, contributing to significant morbidity, increased late mortality, and increased health care burden in recurrent sepsis patients. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
9. Diagnostic value of Candida mannan antigen and anti‐mannan IgG and IgM antibodies for Candida infection.
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Wang, Kaifei, Luo, Yanping, Zhang, Wei, Xie, Sheling, Yan, Peng, Liu, Yang, Li, Yanqin, Ma, Xiuqing, Xiao, Kun, Fu, Han, Cai, Jinyu, and Xie, Lixin
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IMMUNOGLOBULIN M ,CANDIDIASIS ,RECEIVER operating characteristic curves ,CANDIDA ,IMMUNOGLOBULINS ,ANTIGENS - Abstract
Summary: Objective: To assess the diagnostic value of serum Candida mannan antigen (MN) and anti‐mannan IgG and IgM antibodies for candidiasis. Methods: This study was a prospective cohort study. Clinical data and venous blood samples from 23 medical centres in Beijing, China were collected between 1 January 2017 and 31 December 2018. All collected specimens were tested within one week for serum Candida MN and IgG and IgM antibodies using an ELISA kit. Results: A total of 452 patients were enrolled, including 188 patients in the Candida exposure groups (56 patients with Candida bloodstream infection, 69 patients with Candida‐positive tracheal aspirate cultures and 63 patients with Candida‐positive urine cultures) and 264 patients in the control groups (212 healthy controls and 52 patients with bacteraemia). The receiver operating characteristic (ROC) curve of the 56 patients with Candida bloodstream infection and 212 healthy controls showed that serum MN and IgG had good diagnostic value. The area under the ROC curve (AUC) values were 0.812 (95% CI, 0.750‐0.873) and 0.866 (95% CI, 0.808‐0.924), respectively, wherein the MN specificity and sensitivity were 86.79% and 60.71%, and the IgG were 84.43% and 80.36%, respectively. The AUC of the combination of serum MN and IgG was 0.871(95% CI, 0.813‐0.929), and the specificity and sensitivity were 93.87% and 57.14%. Conclusions: The serum levels of Candida MN and its IgG antibody have diagnostic value for Candida bloodstream infection, and combination of MN and IgG can improve diagnostic specificity and may provide a new approach for diagnosis of candidaemia. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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10. Recurrent Sepsis Exacerbates CD4 + T Cell Exhaustion and Decreases Antiviral Immune Responses.
- Author
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He W, Xiao K, Xu J, Guan W, Xie S, Wang K, Yan P, Fang M, and Xie L
- Subjects
- Animals, Cells, Cultured, Disease Models, Animal, Disease Progression, Female, Humans, Immunity, Mice, Mice, Inbred BALB C, Recurrence, CD4-Positive T-Lymphocytes immunology, Influenza A Virus, H1N1 Subtype physiology, Influenza, Human immunology, Orthomyxoviridae Infections immunology, Sepsis immunology
- Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. It is a disease with a high incidence, mortality, and recurrence rate and frequently results in its survivors requiring readmission into hospitals. The readmission is mainly due to recurrent sepsis. Patients with recurrent sepsis are more susceptible to secondary infections partly due to immune dysfunction, leading to a higher mortality in the long term. However, there remains a gap in the understanding of immunological characteristics and underlying mechanisms of recurrent sepsis. In this study, we used mouse models of acute and recurrent sepsis to investigate their different immunological characteristics. And then we subjected the two mouse models to a secondary influenza A virus (H1N1) infection and characterized the different immune responses. Here, we demonstrated that CD4
+ T cells present an exacerbated exhaustion phenotype in response to recurrent sepsis as illustrated by the decreased frequency of CD4+ T cells, reduced co-stimulatory CD28 and increased inhibitory PD-1 and Tim-3 expression on CD4+ T cells, increased frequency of regulatory T cells, and reduced MHC-II expression on antigen-presenting cells. Moreover, we showed that antiviral immune responses decrease in the recurrent sepsis mouse model subjected to a secondary infection as illustrated by the reduced pathogen clearance and inflammatory response. This may be a consequence of the exacerbated CD4+ T cell exhaustion. In summary, recurrent sepsis exacerbates CD4+ T cell exhaustion and decreases antiviral immune responses, contributing to significant morbidity, increased late mortality, and increased health care burden in recurrent sepsis patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 He, Xiao, Xu, Guan, Xie, Wang, Yan, Fang and Xie.)- Published
- 2021
- Full Text
- View/download PDF
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