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15 results on '"Xie, Xiao-Yang"'

6. Sigma-2 Receptor as a Potential Drug Target

Author

Ma Wen-Hui, Xie Xiao-Yang, Huang Yun-Sheng, and Chen Ai-Fang

Subjects
Sigma-2 receptor, medicine.disease_cause, 01 natural sciences, Biochemistry, Neuroprotection, 03 medical and health sciences, Alzheimer Disease, Drug Discovery, medicine, Humans, Receptors, sigma, 0101 mathematics, Receptor, Protein kinase C, PI3K/AKT/mTOR pathway, 030304 developmental biology, Pharmacology, 0303 health sciences, Amyloid beta-Peptides, Chemistry, Organic Chemistry, Autophagy, Brain, 010101 applied mathematics, Pharmaceutical Preparations, Cancer research, Molecular Medicine, Signal transduction, Oxidative stress
Abstract

Sigma-2 receptor plays key roles in promoting tumor cell apoptosis, enhancing efficacy of anti-tumor drugs, blocking signal transduction controlled by Aβ oligomers, regulating Ca2+ homeostasis and protecting nerve cells. Studies indicated that sigma-2 receptor may be closely coupled with ROS, LDL, mTOR, RAS, PLC/PKC, lysosomal autophagy and mitochondrial super oxidative stress. In addition, the high expression of this receptor in proliferating cells and nerve cells indicates that sigma-2 receptor is an ideal molecular target for imaging and therapeutic development for cancer, Alzheimer's disease, schizophrenia and traumatic brain injury. Various sigma-2 agonists have shown promising anticancer activities, while sigma-2 antagonists have displayed neuroprotection and inhibition of Aβ oligomers in the brain of Alzheimer's disease patients. Thus, both sigma-2 agonists and antagonists are potentially useful therapeutics for the management of cancer and neurodegenerative disorders.

Published
2021
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15. [Geochemical Background and Baseline Value of Soil Chemical Elements in Hebei Province].

Author

Zhang LT, Cheng HX, Xie WM, Qi QQ, Xie XY, Yu WL, and Wang JD

Abstract

Geochemical background and baseline values are important parameters for understanding the geochemical characteristics of soil elements, but the research degree of these two parameters is lacking in Hebei Province. Therefore, data from the multi-purpose regional geochemical survey and land quality geochemical assessment in Hebei Province from 2004 to 2018 were collected, covering approximately 71% of the land area of the whole province. Based on the data of surface soil and deep soil, scientific and robust methods including median value and median absolute deviation were used to calculate the geochemical background values, geochemical baseline values, as well as variation ranges of 54 indexes (Ag, Al 2 O 3 , As, Au, B, Ba, Be, Bi, Br, CaO, Cd, Ce, Cl, Co, Cr, Cu, F, Fe 2 O 3 , Ga, Ge, Hg, I, K 2 O, La, Li, MgO, Mn, Mo, N, Na 2 O, Nb, Ni, P, Pb, pH, Rb, S, Sb, Sc, Se, SiO 2 , Sn, Sr, Th, Ti, Tl, U, V, W, Y, Zn, Zr, total carbon (TC), and organic carbon (C org )) in Hebei Province and 11 prefecture-level cities. The change rate in geochemical background for each index was also calculated. The results showed that the geochemical background and baseline values of most soil chemical elements in Hebei Province were lower than those nationwide, but the values of Ba, Br, Cl, MgO, Na 2 O, P, pH, S, Sr, and TC were higher, with CaO being the highest. Compared with those in north China, there was no significant difference in the geochemical background and baseline values for the 54 indexes, with the ratios of 0.83-1.17 and 0.79-1.19, respectively. Significant changes in the geochemical background for C org , Hg, N, P, S, and Se were observed in Hebei Province, indicating that these indexes were greatly influenced by human factors. Preliminary analysis suggests that coal burning emissions and agricultural chemical use were two very important inducing factors.

Published
2023
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