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11. Mixed germ cell tumor of the endometrium: a case report and literature review

Author

Zhang Heping, Liu Fangyun, Wei Jianguo, Xue Debin, Xie Zhengxin, and Xu Chunwei

Subjects
mixed gcts, extragonadal, yolk sac tumor, endometrium, Medicine
Abstract

Germ cell tumors (GCTs) localized extragonadally are rare, with only 14 reported cases of a yolk sac tumor in the endometrium. Here we report a case of mixed endometrium GCTs in a 65-year-old postmenopausal woman with abnormal vaginal bleeding. An ultrasound examination showed an oval-shaped mass in the patient’s uterine cavity. Biochemical examination revealed elevated serum α-fetoprotein (AFP) at 359 ng/mL, whereas the tumor markers CA-125, CA-199, and CEA were all within normal range. Total hysterectomy and bilateral salpingo-oophorectomy were performed;. a histological examination revealed that the malignant components contained a yolk sac tumor, embryonal carcinoma, and focal immature teratoma. Immunohistochemical staining showed that AFPs were diffusively distributed in both the yolk sac tumor and embryonal carcinoma. The stem cell marker OCT3/4 was positive in the embryonal carcinoma component and that the pan-cytokeratin AE1/AE3 staining was positive in glandular areas. GFAPs (Glial Fibrillary Acidic Proteins) were positive in neuroectodermal tubules; the Ki-67 protein was positive in 90% of the tumor cells, whereas CD117 and placental alkaline phosphatase (PLAP) were negative. The cumulative evidence indicated mixed GCTs of endometrium as the final histopathological diagnosis. The patient received three courses of adjunct chemotherapy that provided good therapeutic efficacy as evidenced by the decreased serum AFP level. Our report on this rare case of mixed GCTs of the endometrium, supported by associated histological patterns and immunophenotypes and successful adjunct chemotherapy after surgery, could provide insight on future treatment of this rare but lethal disease.

Published
2020
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17. Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

Author

Zhou, Hanying, primary, Wang, Meng, additional, Zhang, Yixi, additional, Su, Qingqing, additional, Xie, Zhengxin, additional, Chen, Xiangyan, additional, Yan, Ran, additional, Li, Ping, additional, Li, Tingting, additional, Qin, Xiang, additional, Yang, Hong, additional, Wu, Chunhui, additional, You, Fengming, additional, Li, Shun, additional, and Liu, Yiyao, additional

Published
2022
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38. Effects of dissolved organic matter, feeding, and water flow on the bioconcentration of diclofenac in crucian carp (<italic>Carassius auratus</italic>).

Author

Lu, Guanghua, Xie, Zhengxin, and Zhang, Zhenghua

Subjects
GOLDFISH, DISSOLVED organic matter, HYDRAULICS, DISSOLVED oxygen in water, BIOCONCENTRATION
Abstract

Diclofenac (DCF), a prevalent anti-inflammatory drug, is frequently detected in aquatic organisms. However, little is known about the environmental factors that affect the bioconcentration of DCF in aquatic environments. Here, we firstly investigated the bioconcentration of DCF by crucian carp (Carassius auratus) following aqueous exposure (3.57, 14.5, and 71.8 μg L−1) for 21 days. DCF can accumulate in crucian carp, and the maximum bioconcentration factors (BCFs) of 121 L kg−1 in the liver, 52.3 L kg−1 in the gills, and 46.8 L kg−1 in the muscle were always found at 3.57 μg L−1 after 14 days of exposure. Secondly, the influences of dissolved organic matter (DOM), feeding, and water flow on the bioconcentration of DCF were determined at the nominal concentration of 4 μg L−1 for 14 days. The BCFs of DCF in various fish tissues decreased by 0.5-85% with the increasing DOM concentrations. Feeding also led to lower body burden of DCF in fish tissues (6-55%) with the increasing food amount. In hydrodynamic experiment, the BCFs of DCF decreased by15-57% at most in various fish tissues. Collectively, our results demonstrated the bioconcentration of DCF in fish can be influenced by various environmental factors, which should be considered in the risk assessment of pharmaceuticals. [ABSTRACT FROM AUTHOR]

Published
2018
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