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Antimicrobial modification of poly(ethylene terephthalate) (PET) is effective in preventing the adhesion and growth of microorganisms on its surface. However, few methods are available to modify PET directly at its backbone to impart the antimicrobial effect. Herein, menthoxytriazine-modified PET (PMETM) based on the stereochemical antimicrobial strategy was reported. This novel PET was prepared by inserting menthoxytriazine into the PET backbone. The antibacterial adhesion test and the antifungal landing test were employed to confirm the antiadhesion ability of PMETM. PMETM could effectively inhibit the adhesion of bacteria, with inhibition ratios of 99.9 and 99.7% against Escherichia coli(Gram-negative) and Bacillus subtilis(Gram-positive), respectively. In addition, PMETM exhibited excellent resistance to Aspergillus niger(fungal) contamination for more than 30 days. Cytotoxicity assays indicated that PMETM was a noncytotoxic material. These results suggested that the insertion of menthoxytriazine in the PET backbone was a promising strategy to confer antimicrobial properties to PET.

Modification of fabrics by stereochemical antiadhesion strategies is an emerging approach to antimicrobial fabric finishing. However, a purely antiadhesive fabric cannot avoid the passive adhesion of pathogenic microorganisms. To address this issue, borneol 4-formylbenzoate (BF) with a stereochemical structure is introduced into a cationic polymer PEI-modified PET fabric by a simple two-step method. The obtained fabric exhibits remarkable features of high bactericidal activity, excellent resistance to bacterial adhesion, desirable fungal repellent performance, and low cytotoxicity. More impressively, this modified fabric not only effectively reduces microbial contamination during food preservation but also plays a role in avoiding infection and accelerating wound healing in the mouse wound model. The dual coordination between stereochemistry and cations is validated as a viable “attack and defense” antimicrobial strategy, providing an effective guide for diversiform antimicrobial designs.