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The real-time identification of inflow aerodynamic parameters such as the flow separation situation, angle of attack, and inflow velocity is challenging. In this paper, a new data-driven strategy i...

The interturbine burner (ITB) engine, which is introduced between high and low pressure turbines (LPTs), is a relatively new concept for increasing specific thrust and lowering high altitude specific fuel consumption (SFC) than engine with afterburner (AB). Although ITB engines have outstanding performance improvements, they also present a challenge to the design of control laws for ITB engines under unknown matching mechanisms and multiple constraints. This study proposes a self-scheduling control law design method for ITB engine mode transition that considers ITB ignition and flameout characteristics, as well as cooling air volume. This method derives the control law based on the global optimal algorithm and shapley additive explanation (SHAP)-value analysis method, which avoids manual analysis and reduces the number of adjustment of variable geometric components. An ITB transient model is established to verify the control laws under the transition of ignition and flameout modes. During the mode transition process of opening and closing the ITB, the flow fluctuation of the precritical point and rear-critical point does not exceed 2%, and the comprehensive thrust fluctuation index composed of three typical state points does not exceed 5%. Through simulation analysis with constrained constraints, at most one variable geometry component is adjusted.

Endogenous hypochlorous acid (HOCl), an ROS of particular interest, is like a double-edged sword, which has dual influence on both the maintenance of normal physiological functions and the occurrence of many diseases. Methods to track minimal changes of biological HOCl in both multi-modes and real time are essential for precisely tracking this biomolecule with high oxidation activity. However, the methods are still limited due to the difficulty in combining the two functions into one. To resolve this issue, we herein introduced a small-sized fluorescence probe KSQT with two sites which are sensitive to HOCl at nanomolar and micromolar concentrations. With this novel design, our probe achieved real-time and distinct detection of both physiological and pathogenic concentrations of HOCl via turn-on and ratiometric responses in turn, which enables it to effectively avoid the fluorescence cross-talk through simultaneous use of multiple probes and to solve the problem of transmembrane trafficking of previous dual-mode HOCl probes with large size or high positive charges. Together with its marvelous response to HOCl, high biomembrane permeability and biocompatibility, the real-time and dual-mode fluorescence imaging of endogenous HOCl in living HepG2 cells and living zebrafish were accomplished.

Biological hypochlorous acid (HOCl), a reactive oxygen species (ROS) with high activity, plays a crucial role in normal biochemical functions and abnormal pathological processes related to oxidative stress. However, “eco-friendly” tools to unambiguously monitor subtle changes of mitochondrial HOCl in vivo are limited. Herein, a novel mitochondria-specific and “eco-friendly” fluorescent probe (NM1) using triphenylphosphonium as the targeting group is designed for the detection of biological HOCl by a HOCl-promoted triazolopyridine formation strategy. This HOCl-promoted triazolopyridine formation reaction is fast and does not release additional substances except H2O. Therefore, NM1 is not only an “eco-friendly” HOCl probe, but also can target mitochondria to monitor biological HOCl in situ and in real time. Better still, our probe NM1 is capable to image endogenous HOCl in living HepG2 cells and zebrafish.