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To investigate oral infections in patients suffering in-stent restenosis (ISR) and non-ISR and analyze the possible correlation between the oral infection and triglyceride-glucose (TyG) index, a clinical surrogate indicator of insulin resistance (IR).A cross-sectional design was used, in which 586 patients with acute coronary syndrome who underwent coronary angiography 6-24 months after coronary stent implantation were recruited. The modified total dental index (TDI) was used to evaluate the status of oral inflammation.In both univariate analyses, TDI scores [3 (1.5, 4.5) vs. 2.5 (1.5, 4.0), p 0.01] and a multivariate regression model (OR = 1.202, 95% CI = 1.085-1.333, p 0.01), the TDI significantly correlated with ISR. The TyG index was positively associated with ISR (OR = 1.766, 95% CI = 1.055-2.957, p 0.05). Correlation analysis showed that TDI was positively correlated with TyG index (r = 0.190, p 0.01). Using linear regression analysis, higher TDI scores were significantly associated with IR (95% CI = 0.029-0.063, p 0.01).Oral infections and TyG index were independently and positively correlated with ISR in patients with acute coronary syndrome. Oral inflammatory burden assessed by TDI score was associated with IR.

The Single Prolonged Stress protocol is considered a model for PTSD, as it induces long lasting changes in rat behaviour and endocrine regulation. Previous work demonstrated that some of these changes can be prevented by treatment with the glucocorticoid receptor antagonist RU486, administered a week after the stressor. The current study evaluated the effects of an earlier intervention with RU486, as evaluated 1 week after SPS-exposure. Most RU486 effects occurred independent of prior stress, except for the reversal of a stress-induced increase in locomotor behaviour. The accompanying changes in gene expression depended on gene, brain region, and time. DNA methylation of the robustly down-regulated Fkbp5 gene was dissociated of changes in mRNA expression. The findings reinforce the long term effects of GR antagonist treatment, but also emphasize the need to evaluate changes over time to allow the identification of robust correlates between gene expression and behavioural/endocrine outcome of stressful experiences.

Studies from postmortem and animal models have revealed altered synapse morphology and function in the brain of posttraumatic stress disorder (PTSD). And the effects of PTSD on dendrites and spines have been reported, however, the effection on axon include microtubule (MT) and synaptic vesicles of presynaptic elements remains unknown. Hippocampus is involved in abnormal memory in PTSD. In the present study, we used the single prolonged stress (SPS) model to mimic PTSD. Quantitative real-time polymerase chain reaction (RT-qPCR) and high-throughput sequencing (GSE153081) were utilized to analyze differentially expressed genes (DEGs) in the hippocampus of control and SPS rats. Immunofluorescence and western blotting were performed to examine change in axon-related proteins. Synaptic function was evaluated by measuring miniature excitatory postsynaptic currents (mEPSCs). RNA-sequencing analysis revealed 230 significantly DEGs between the control and SPS groups. Gene Ontology analysis revealed upregulation in axonemal assembly, MT formation, or movement, but downregulation in axon initial segment and synaptic vesicles fusion in the hippocampus of SPS rats. Increased expression in tau, β-tubulin MAP1B, KIF9, CCDC40, DNAH12 and decreased expression in p-tau, stathmin suggested SPS induced axon extension. Increased protein expression in VAMP, STX1A, Munc18-1 and decreased expression in synaptotagmin-1 suggested SPS induced more SNARE complex formation but decreased ability in synaptic vesicle fusion to presynaptic active zone membrane in the hippocampus of SPS rats. Further, low mEPSC frequency in SPS rats indicated dysfunction in presynaptic membrane. These results suggest that axon extension and synaptic vesicles fusion abnormality are involved in dysfunction of PTSD.

Synapse impairment is associated with post-traumatic stress disorder (PTSD), which is characterized by enhanced apoptosis in the hippocampus, amygdala, and other brain regions. However, there are no detailed studies on the relationship between apoptosis and synaptic connectivity in PTSD. In this review, we discuss results from various studies describing the synaptic changes observed in the PTSD brain. A decreased number of dendrites/spines or increased number of immature spines in the hippocampus, medial prefrontal cortex, and other brain regions has been reported. Studies on axon guidance, myelination, and the cytoskeleton suggest that PTSD may involve axon overgrowth and overbranching. Apoptosis affects synapse formation; low levels of caspase maintain the balance between growth cone attraction and repulsion and inhibit axon elongation. PTSD enhances neuronal apoptosis through caspase activation, which disrupts the balance between growth cone attraction and repulsion and alters growth cone trajectory, leading to axon mistargeting. Meanwhile, caspase activation induces dendritic pruning and dendrite degeneration. These events contribute to the formation of fewer and aberrant synapses, which is associated with enhanced apoptosis in PTSD.

Background Stressors activate a wide spectrum of interacting hormonal and neuronal systems resulting in behavioral and physiological responses, with consequences for the development of psychopathology. Several recent studies demonstrated that treatment with the glucocorticoid receptor (GR) antagonist RU486 during adulthood normalized effects of early life stress. We aimed to evaluate the potential of RU486 to reverse stress-induced changes in an animal model of adult stress. Method We employed the single-prolonged stress (SPS) model as a multimodal stress exposure protocol in male rats. SPS rats and unstressed controls were treated with RU486 on days 8, 9, 10 after stress exposure and the effects of treatment were evaluated after another 4 days. We determined body weight gain, corticosterone levels, behavioral reactivity in anxiety tests, and brain gene expression of c-fos, corticosteroid receptors, drivers of the stress response and genes (epi-)genitally linked to PTSD. Results RU486 affected body weight gain, corticosterone levels and open field behavior only in SPS rats. RU486 had history-independent effects in reducing fear in the elevated plus maze and fear conditioning behavior. Gene expression analysis showed a diversity of in- and interdependent effects of stress and RU486. Conclusion The effects of RU486 applied 1 week after stress and measured 4 days after treatment demonstrate that in the state of post-SPS the GR-dependence of homeostatic processes has changed. This suggests that GR-mediated processes are part of allostatic regulation after adult stress. The normalization of a number of SPS-effects after RU486 treatment reinforces the potential of targeting GR for treatment of stress-related psychopathologies.

A new method based on interpolation using band-limited signal restoration method was proposed for enhancing the resolution of the nearfield acoustic holography. According to the band-limited property of the pressure on the hologram surface, a band-limited signal restoration method named Papoulis-Gerchberg algorithm was used to realize the interpolation of acoustic pressure. Therefore acoustic pressure data on the hologram surface were increased, the sampling interval was reduced, the information on evanescent waves which was lost because of the large sampling interval was partially recovered, and the resolution of nearfield acoustic holography image was improved. The experimental result shows that the method can enhance the resolution of the nearfield acoustic holography image efficiently.

Research on the acoustic design sensitivity is significant for its ability to provide the optimized orientation for low noise design of radiating structures. In this paper, the wave superposition approach (WSA) is employed to calculate acoustic design sensitivity. The sensitivity formulations based on the wave superposition are presented in a direct differentiation way, by which the sensitivity of acoustic quantities with respect to the design variables such as structural parameters or physical properties can be obtained. This method is suitable for both shape and sizing sensitivity analysis of arbitrary shaped sources. Compared with the conventional direct differentiation boundary element method, the proposed method has improved accuracy and speed of computation, and has no inherent problem of singular integration which will make numerical processing more complicated. Numerical experiments are demonstrated to show the validity and feasibility of the proposed method.

A technique for separating sound fields using two closely spaced parallel measurement surfaces and based on equivalent source method is proposed. The method can separate wave components crossing two measurement surfaces in opposite directions, which makes nearfield acoustic holography (NAH) applications in a field where there exist sources on the two sides of the hologram surface, in a reverberant field or in a scattered field, possible. The method is flexible in applications, simple in computation, and very easy to implement. The measurement surfaces can be arbitrarily shaped, and they are not restricted to be regular as in the traditional field separation technique. And, because the method performs field separation calculations directly in the spatial domain-not in the wave number domain--it avoids the errors and limitations (the window effects, etc.) associated with the traditional field separation technique based on the spatial Fourier transform method. In the paper, a theoretical description is first given, and the performance of the proposed field separation technique and its application in NAH are then evaluated through experiments.

In a semi-free field, the acoustic field is composed of two components: the direct sound and the reflected sound. Because it is difficult to separate the direct sound from the acoustic field, conventional nearfield acoustic holography (NAH) methods cannot reconstruct an acoustic source and predict the acoustic field directly. Through utilization of the distributed source boundary point method (DSBPM)-based NAH, a treatment method for a semi-free field is proposed. In the method, the source in a semi-free field can be reconstructed correctly, and the acoustic field can be predicted and separated. An experiment on a speaker in a semi-anechoic chamber is carried out to verify the proposed method. By comparing the reconstructed and predicted results in DSBPM-based NAH with and without the proposed method, the proposed method is validated. The disadvantages of NAH without any treatment method in a semi-free field are demonstrated.

On the basis of the distributed source boundary point method (DSBPM)-based nearfield acoustic holography (NAH), Landweber iterative regularization method is proposed to stabilize the NAH reconstruction process, control the influence of measurement errors on the reconstructed results and ensure the validity of the reconstructed results. And a new method, the auxiliary surface method, is proposed to determine the optimal iterative number for optimizing the regularization effect. Here, the optimal number is determined by minimizing the relative error between the calculated pressure on the auxiliary surface corresponding to each iterative number and the measured pressure. An experiment on a speaker is investigated to demonstrate the high sensitivity of the reconstructed results to measurement errors and to validate the chosen method of the optimal iterative number and the Landweber iterative regularization method for controlling the influence of measurement errors on the reconstructed results.

In the light of the concept of spherical wave source, the theoretical model of nearfield acoustic holography (NAH) based on the spherical wave superposition method (SWSM), including reconstruction of expansion coefficients, prediction of acoustic field, error sensitivity analysis, regularization method and a searching method with dual measurement surfaces for determining the optimal number of expansion terms, is established. Subsequently, the spherical wave source boundary point method (SWSBPM) and its application in the NAH are introduced briefly. Considering the similarity of the SWSM and the SWSBPM for realizing the NAH, they are compared. The similarities and differences of the two methods are illuminated by a rigorous mathematical justification and two experiments on a single source and two coherent sources in the semi-free acoustic field. And, the superiority of the NAH based on the SWSBPM is demonstrated.

When solving acoustic radiation problem in the routine boundary point method (BPM), the inverse of the particular solution matrix of surface normal velocities is needed and the matrix must be full rank and reversible. However, the type of the particular solution sources is single and the sources are not linear independent, so the locations of the particular solution sources inside the vibrating body must be selected carefully. But, in the routine BPM, the locations are determined by an experiential formula, so the method may be invalid for a complicated vibrating body. In this paper, the construction method of the particular solution sources is improved first, and the singular value decomposition (SVD) technique and the Moore-Penrose pseudoinverse are adopted to realize the inversion. As a consequence, the particular solution matrix of surface normal velocities can be non-full rank and the locations of the particular sources can be determined easily. On the basis of the improved BPM, the spherical wave sources of different orders are proposed to be the particular solution sources. Here, all particular solution sources are located on only one point inside the vibrating body, so the problem of the locations of the particular solution sources is thoroughly solved, and such particular solution sources that are useless for the calculation results are discarded. The theoretical model is established at first, and then the proposed method is used to realize the nearfield acoustic holography (NAH). Subsequently, an experiment is investigated to validate the feasibility and correctness of the proposed method and its application to acoustic holography.

In this paper, the conditions for the complete dynamic balance of rotor inertial forces in the rotary piston vacuum pump with single cylinder are determined based on motion analysis. The experiment results show that the pump vibration can be depressed obviously by improving the rotor structure according to the balance conditions. It is proved that the rotor inertial forces can not be balanced completely even by means of the Triplex balance technique of the rotary piston pump with three cylinders.

Patch near field acoustic holography (PNAH) based on sound pressure measurements makes it possible to reconstruct the source field near a source by measuring the sound pressure at positions on a surface. that is comparable in size to the source region of concern. Particle velocity is an alternative input quantity for NAH, and the advantage of using the normal component of the particle velocity rather than the sound pressure as the input of conventional spatial Fourier transform based NAH and as the input of the statistically optimized variant of NAH has recently been demonstrated. This paper examines the use of particle velocity as the input of PNAH. Because the particle velocity decays faster toward the edges of the measurement aperture than the pressure does and because the wave number ratio that enters into the inverse propagator from pressure to velocity amplifies high spatial frequencies, PNAH based on particle velocity measurements can give better results than the pressure-based PNAH with a reduced number of iterations. A simulation study, as well as an experiment carried out with a pressure-velocity sound intensity probe, demonstrates these findings.

Study on a multi-source hybrid acoustic field is very important for nearfield acoustic holography (NAH) to be applied in the practical engineering field. In this paper, two methods based on the distributed source boundary point method (DSBPM) for holographic reconstruction and prediction of multi-source hybrid acoustic field, namely combination method with single surface measurement and combination method with multi-surface measurement, are proposed. Then, an experiment on two coherent speakers is carried out. By comparison of the reconstructed and predicted, results and the actual measured results, the validity of the two methods and the superiority of the combination method with multi-surface measurement are proved. Considering the high sensitivity of the reconstructed results to measurement errors the Tikhonov regularization method is proposed to stabilize the reconstruction procedure and restrict the influence of errors. And then, the optimal reconstructed results can be obtained and the reliability of holographic reconstruction and prediction is assured.

On the basis of the nearfield acoustic holography (NAH) based on the distributed source boundary point method (DSBPM), a novel NAH based on the equivalent source method (ESM) is proposed. The theoretical model of the proposed method is established at first. And then, the error sensitivity and the reconstruction problems of a multi-source acoustic field and a semi-free acoustic field are analyzed, and the corresponding treatment methods are proposed. Subsequently, an experiment on a speaker is investigated to validate the feasibility and correctness of the method. In the method, no discretization is needed on the boundary of the vibrating body. The acoustic field is predicted directly by a set of weighted equivalent sources located inside the vibrating body. Therefore, the variable interpolation, the treatments of singular integrals and non-uniqueness of solutions in the characteristic wave number are avoided. Additionally, the method is adapted to arbitrary-shaped source, so it is really a meshless method. Furthermore, there are such merits as the simple principle, the high calculation efficiency and precision. It is valuabe for the NAH to be applied in the practical engineering field.

A robust technique has been proposed for reconstructing sound field for all wave-numbers, which is suitable for the radiation analysis on an arbitrarily-shaped body. According to the wave superposition formulation, the spatial sound field of an actual radiator can be represented equivalently by superposing the fields generated by some fictitious sources interior to the actual radiator. Meanwhile, the strength density on the fictitious sources can be obtained by matching the sound pressures of a finite number of field points. Once the strength density is calculated, the acoustic information at any field point can be obtained subsequently. Finally, some typical numerical examples are given to validate the theoretical analysis, and some investigations are made to analyze the influence of sound frequency and the fictitious source position on the reconstruction precision, which are helpful to the application of the proposed technique to real industrial measurements.

In a multi-source acoustic field, the actual measured pressure is a scalar sum of pressures from all the sources. The pressure belonging to every source cannot be separated out with the existing techniques. Consequently, routine formulas cannot be used to reconstruct the acoustic source and predict the acoustic field directly. In this paper, a novel theoretical model of reconstruction and prediction of multi-source acoustic field in the distributed source boundary point method (DSBPM) based nearfield acoustic holography (NAH) is established. Three different methods, namely combination method with single surface measurement, combination method with multi-surface measurement and elimination method with multi-surface measurement, are proposed to realize the holographic reconstruction of sources. With these methods, the problem of reconstruction and prediction of acoustic field existing multiple coherent sources synchronously is solved effectively. Using the particular solutions constructed by the DSBPM to establish the vibro-acoustic transfer matrix, the calculation time, calculation precision and calculation stability are improved. These methods are valuable in localizing acoustic source and predicting acoustic field in engineering field.