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2. Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Author

Chen, Qian, Perales, Celia, Soria, María Eugenia, García-Cehic, Damir, Gregori, Josep, Rodríguez-Frías, Francisco, Buti, María, Crespo, Javier, Calleja, José Luis, Tabernero, David, Vila, Marta, Lázaro, Fernando, Rando-Segura, Ariadna, Nieto-Aponte, Leonardo, Llorens-Revull, Meritxell, Cortese, Maria Francesca, Fernandez-Alonso, Irati, Castellote, José, Niubó, Jordi, Imaz, Arkaitz, Xiol, Xavier, Castells, Lluís, Riveiro-Barciela, Mar, Llaneras, Jordi, Navarro, Jordi, Vargas-Blasco, Víctor, Augustin, Salvador, Conde, Isabel, Rubín, Ángel, Prieto, Martín, Torras, Xavier, Margall, Nuria, Forns, Xavier, Mariño, Zoe, Lens, Sabela, Bonacci, Martin, Pérez-del-Pulgar, Sofía, Londoño, Maria Carlota, García-Buey, María Luisa, Sanz-Cameno, Paloma, Morillas, Rosa, Martró, Elisa, Saludes, Verónica, Masnou-Ridaura, Helena, Salmerón, Javier, Quíles, Rosa, Carrión, José Antonio, Forné, Montserrat, Rosinach, Mercè, Fernández, Inmaculada, García-Samaniego, Javier, Madejón, Antonio, Castillo-Grau, Pilar, López-Núñez, Carme, Ferri, María José, Durández, Rosa, Sáez-Royuela, Federico, Diago, Moisés, Gimeno, Concepción, Medina, Rafael, Buenestado, Juan, Bernet, Albert, Turnes, Juan, Trigo-Daporta, Matilde, Hernández-Guerra, Manuel, Delgado-Blanco, Manuel, Cañizares, Angelina, Arenas, Juan Ignacio, Gomez-Alonso, Maria Juana, Rodríguez, Manuel, Deig, Elisabet, Olivé, Gemma, Río, Oscar del, Cabezas, Joaquín, Quiñones, Ildefonso, Roget, Mercè, Montoliu, Silvia, García-Costa, Juan, Force, Lluís, Blanch, Silvia, Miralbés, Miguel, López-de-Goicoechea, María José, García-Flores, Angels, Saumoy, María, Casanovas, Teresa, Baliellas, Carme, Gilabert, Pau, Martin-Cardona, Albert, Roca, Rosa, Barenys, Mercè, Villaverde, Joana, Salord, Silvia, Camps, Blau, Silvan di Yacovo, María, Ocaña, Imma, Sauleda, Silvia, Bes, Marta, Carbonell, Judit, Vargas-Accarino, Elena, Ruzo, Sofía P., Guerrero-Murillo, Mercedes, Von Massow, Georg, Costafreda, María Isabel, López, Rosa Maria, González-Moreno, Leticia, Real, Yolanda, Acero-Fernández, Doroteo, Viroles, Silvia, Pamplona, Xavier, Cairó, Mireia, Ocete, María Dolores, Macías-Sánchez, José Francisco, Estébanez, Angel, Quer, Joan Carles, Mena-de-Cea, Álvaro, Otero, Alejandra, Castro-Iglesias, Ángeles, Suárez, Francisco, Vázquez, Ángeles, Vieito, David, López-Calvo, Soledad, Vázquez-Rodríguez, Pilar, Martínez-Cerezo, Francisco José, Rodríguez, Raúl, Macenlle, Ramiro, Cachero, Alba, Mereish, Gasshan, Mora-Moruny, Carme, Fábregas, Silvia, Sacristán, Begoña, Albillos, Agustín, Sánchez-Ruano, Juan José, Baluja-Pino, Raquel, Fernández-Fernández, Javier, González-Portela, Carlos, García-Martin, Carmen, Sánchez-Antolín, Gloria, Andrade, Raúl Jesús, Simón, Miguel Angel, Pascasio, Juan Manuel, Romero-Gómez, Manolo, Antonio del-Campo, José, Domingo, Esteban, Esteban, Rafael, Esteban, Juan Ignacio, and Quer, Josep

Published
2020
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5. Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial

Author

Solà, Elsa, Solé, Cristina, Simón-Talero, Macarena, Martín-Llahí, Marta, Castellote, José, Garcia-Martínez, Rita, Moreira, Rebeca, Torrens, Maria, Márquez, Francisca, Fabrellas, Núria, de Prada, Gloria, Huelin, Patrícia, Lopez Benaiges, Eva, Ventura, Meritxell, Manríquez, Marcela, Nazar, André, Ariza, Xavier, Suñé, Pilar, Graupera, Isabel, Pose, Elisa, Colmenero, Jordi, Pavesi, Marco, Guevara, Mónica, Navasa, Miquel, Xiol, Xavier, Córdoba, Joan, Vargas, Victor, and Ginès, Pere

Published
2018
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6. Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation

Author

Pascasio, Juan Manuel, Vinaixa, Carmen, Ferrer, María Teresa, Colmenero, Jordi, Rubin, Angel, Castells, Lluis, Manzano, María Luisa, Lorente, Sara, Testillano, Milagros, Xiol, Xavier, Molina, Esther, González-Diéguez, Luisa, Otón, Elena, Pascual, Sonia, Santos, Begoña, Herrero, José Ignacio, Salcedo, Magdalena, Montero, José Luis, Sánchez-Antolín, Gloria, Narváez, Isidoro, Nogueras, Flor, Giráldez, Álvaro, Prieto, Martín, Forns, Xavier, and Londoño, María-Carlota

Published
2017
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9. Efficacy and Safety of Therapy With Simeprevir and Sofosbuvir in Liver Transplant Recipients Infected by Hepatitis C Virus Genotype 4: Cohort Spanish Society of Liver Transplantation Cohort

Author

Xiol, Xavier, Gonzalez Dieguez, Maria Luisa, Cristobal, Mario Romero, Pons Miñano, Jose Antonio, Bartolome, Sonia Pascual, Montero, Jose Luis, Arencibia, Ana, Lorente, Sara, Molina, Esther, Espinosa, Maria Dolores, Cuervas-Mons, Valentin, Garcia, Emilio Fabrega, Sanchez Antolin, G., Testillano, M., Pascasio, J.M., Narvaez Rodriguez, I., Prieto, M., Otero, A., Herrero, J.I., Londoño, M., Fernandez Vazquez, I., and Castells, L.

Published
2016
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10. Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study

Author

Castells, Lluis, Rimola, Antoni, Manzardo, Christian, Valdivieso, Andrés, Montero, José Luis, Barcena, Rafael, Abradelo, Manuel, Xiol, Xavier, Aguilera, Victoria, Salcedo, Magdalena, Rodriguez, Manuel, Bernal, Carmen, Suarez, Francisco, Antela, Antonio, Olivares, Sergio, del Campo, Santos, Laguno, Montserrat, Fernandez, José R., de la Rosa, Gloria, Agüero, Fernando, Perez, Iñaki, González-García, Juan, Esteban-Mur, Juan I., and Miro, Jose M.

Published
2015
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13. Effectiveness and safety of ombitasvir, paritaprevir, ritonavir ± dasabuvir ± ribavirin: An early access programme for Spanish patients with genotype 1/4 chronic hepatitis C virus infection

Author

Perelló, C., Carrión, J. A., Ruiz‐Antorán, B., Crespo, J., Turnes, J., Llaneras, J., Lens, S., Delgado, M., García‐Samaniego, J., García‐Paredes, F., Fernández, I., Morillas, R. M., Rincón, D., Porres, J. C., Prieto, M., Lázaro Ríos, M., Fernández‐Rodríguez, C., Hermo, J. A., Rodríguez, M., Herrero, J. I., Ruiz, P., Fernández, J. R., Macías, M., Pascasio, J. M., Moreno, J. M., Serra, M. Á., Arenas, J., Real, Y., Jorquera, F., Calleja, J. L., Rayuela, Federico Sáez, Simón, Miguel Ángel, González, José Manuel, Muñoz, Eduardo, González, Marta, Jiménez, Miguel, Moran, Senador, Vergara‐Gómez, Mercè, Jiménez, Felipe, García, Rosa, Albujar, Alicia Hernández, Navarro, José María, Antón, María Dolores, Vilella, Àngels, Hijona, Lander, Gil, Fernando, Quiñones, Ildefonso, Montero, Jose Luis, Ceña, Gloria, de la Vega, Juan, Torras, Xavier, Diago, Moisés, Ampuero, Javier, Pascual, Sonia, Zaragoza, Natividad, Xiol, Xavier, Devesa, Maria José, Garay, Carmen, Bellot, Pablo, Moreno, Javier, Roget, Mercè, Alonso, Maria Rosario González, Gómez‐Rubio, Mariano, Valbuena, Marta, Piqueras, Belén, Monton, Cristina, Cortés, Luis, Comas, Carmen, Puertas, Manuel, Sansó, Andrés, García‐Herola, Antonio, Primo, Ximo, Garcia‐Pardo, Pilar Griño, Pamplona, Javier, and de Artaza, Tomás

Published
2017
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27. Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series

Author

Castellote José, Solà Ricard, Forné Montserrat, Guarner Carlos, Mas Antoni, Buti Maria, Xiol Xavier, Vidal Xavier, Pérez Eulàlia, Ibáñez Luisa, Sabaté Mònica, Rigau Joaquim, and Laporte Joan-Ramon

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses of paracetamol. An assessment of the causality role of paracetamol was performed in each case. Methods Based on the evaluation of prospectively gathered cases of ALI with detailed clinical information, thirty-two cases of ALI in non-alcoholic patients exposed to therapeutic doses of paracetamol were identified. Two authors assessed all drug exposures by using the CIOMS/RUCAM scale. Each case was classified into one of five categories based on the causality score for paracetamol. Results In four cases the role of paracetamol was judged to be unrelated, in two unlikely, and these were excluded from evaluation. In seven of the remaining 26 cases, the RUCAM score associated with paracetamol was higher than that associated with other concomitant medications. The estimated incidence of ALI related to the use of paracetamol in therapeutic dosages was 0.4 per million inhabitants older than 15 years of age and per year (99%CI, 0.2-0.8) and of 10 per million paracetamol users-year (95% CI 4.3-19.4). Conclusions Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.

Published
2011
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33. Análisis de 500 trasplantes hepáticos en el Hospital de Bellvitge

Author

Jaurrieta, Eduardo, Casais, Luis, Figueras, Juan, Ramos, Emilio, Lama, Carmen, Rafecas, Antonio, Casanovas Taltavull, Teresa, Fabregat, Juan, Xiol, Xavier, Torras, Jaume, Baliellas, Carmen, Sabaté, Antonio, Rufí, Gabriel, Benasco, Carmen, Casanovas, Teodoro, Serrano, Teresa, Gil-Vernet, Salvador, Sabaté, Isabel, and Busquets, Juli

Published
2000
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35. Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study

Author

Manzardo, Christian, primary, Londoño, Maria C., additional, Castells, LLuís, additional, Testillano, Milagros, additional, Luis Montero, José, additional, Peñafiel, Judit, additional, Subirana, Marta, additional, Moreno, Ana, additional, Aguilera, Victoria, additional, Luisa González-Diéguez, María, additional, Calvo-Pulido, Jorge, additional, Xiol, Xavier, additional, Salcedo, Magdalena, additional, Cuervas-Mons, Valentin, additional, Manuel Sousa, José, additional, Suarez, Francisco, additional, Serrano, Trinidad, additional, Ignacio Herrero, Jose, additional, Jiménez, Miguel, additional, Fernandez, José R., additional, Giménez, Carlos, additional, del Campo, Santos, additional, Esteban-Mur, Juan I., additional, Crespo, Gonzalo, additional, Moreno, Asunción, additional, de la Rosa, Gloria, additional, Rimola, Antoni, additional, and Miro, Jose M., additional

Published
2018
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36. Usefulness and complications of thoracentesis in cirrhotic patients

Author

Xiol, Xavier, Castellote, Jose, Cortes-Bent, Ricart, Delgado, Mercedes, and Guardiola, Jordi

Subjects
Chest -- Paracentesis, Liver cirrhosis -- Complications, Pleural effusions -- Diagnosis, Ascites -- Causes of, Health, Health care industry
Published
2001

39. Efficacy and Safety of Therapy With Simeprevir and Sofosbuvir in Liver Transplant Recipients Infected by Hepatitis C Virus Genotype 4: Cohort Spanish Society of Liver Transplantation Cohort

Author

Sanchez Antolin, G., primary, Testillano, M., additional, Pascasio, J.M., additional, Narvaez Rodriguez, I., additional, Prieto, M., additional, Otero, A., additional, Herrero, J.I., additional, Londoño, M., additional, Fernandez Vazquez, I., additional, Castells, L., additional, Xiol, Xavier, additional, Gonzalez Dieguez, Maria Luisa, additional, Cristobal, Mario Romero, additional, Pons Miñano, Jose Antonio, additional, Bartolome, Sonia Pascual, additional, Montero, Jose Luis, additional, Arencibia, Ana, additional, Lorente, Sara, additional, Molina, Esther, additional, Espinosa, Maria Dolores, additional, Cuervas-Mons, Valentin, additional, and Garcia, Emilio Fabrega, additional

Published
2016
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42. Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study

Author

Universitat Rovira i Virgili, Castells, Lluis; Rimola, Antoni; Manzardo, Christian; Valdivieso, Andres; Luis Montero, Jose; Barcena, Rafael; Abradelo, Manuel; Xiol, Xavier; Aguilera, Victoria; Salcedo, Magdalena; Rodriguez, Manuel; Bernal, Carmen; Suarez, Francisco; Antela, Antonio; Olivares, Sergio; del Campo, Santos; Laguno, Montserrat; Fernandez, Jose R.; de la Rosa, Gloria; Agueero, Fernando; Perez, Inaki; Gonzalez-Garcia, Juan; Esteban-Mur, Juan I.; Miro, Jose M.;FIPSE LT-HIV Investigators, Universitat Rovira i Virgili, and Castells, Lluis; Rimola, Antoni; Manzardo, Christian; Valdivieso, Andres; Luis Montero, Jose; Barcena, Rafael; Abradelo, Manuel; Xiol, Xavier; Aguilera, Victoria; Salcedo, Magdalena; Rodriguez, Manuel; Bernal, Carmen; Suarez, Francisco; Antela, Antonio; Olivares, Sergio; del Campo, Santos; Laguno, Montserrat; Fernandez, Jose R.; de la Rosa, Gloria; Agueero, Fernando; Perez, Inaki; Gonzalez-Garcia, Juan; Esteban-Mur, Juan I.; Miro, Jose M.;FIPSE LT-HIV Investigators

Abstract

Background & Aims: The aim of this study was to evaluate the results of treatment with pegylated interferon and ribavirin for the recurrence of hepatitis C after liver transplantation in HCV/ HIV-coinfected patients. Methods: This was a prospective, multicentre cohort study, including 78 HCV/HIV-coinfected liver transplant patients who received treatment for recurrent hepatitis C. For comparison, we included 176 matched HCV-monoinfected patients who underwent liver transplantation during the same period of time at the same centres and were treated for recurrent hepatitis C. Results: Antiviral therapy was discontinued prematurely in 56% and 39% (p = 0.016), mainly because of toxicity (22% and 11%, respectively; p = 0.034). Sustained virological response (SVR) was achieved in 21% of the coinfected patients and in 36% of monoinfected patients (p = 0.013). For genotype 1, SVR rates were 10% and 33% (p = 0.002), respectively; no significant differences were observed for the other genotypes. A multivariate analysis based on the whole series identified HIV-coinfection as an independent predictor of lack of SVR (OR, 0.17; 95% CI, 0.06-0.42). Other predictors of SVR were donor age, pretreatment HCV viral load, HCV genotype, and early virological response. SVR was associated with a significant improvement in survival: 5-year survival after antiviral treatment was 79% for HCV/HIV-coinfected patients with SVR vs. 43% for those without (p = 0.02) and 92% vs. 60% in HCV-monoinfected patients (p < 0.001), respectively. Conclusions: The response to pegylated interferon and ribavirin was poorer in HCV/HIV-coinfected liver recipients, particularly those with genotype 1. However, when SVR was achieved, survival of coinfected patients increased significantly. (C) 2014 European Association

Published
2015

44. Document de consens per a la coinfecció pel Virus de la Immunodeficiència Humana i els Virus de les Hepatitis a Catalunya

Author

Ballesteros, A., Fuster, D., Domingo, Pere, Jaen, Ángeles, Laguno, M., Mallolas, J., Miró, Josep M., Pahissa, Albert, Planas-Vilà, Ramon, Rafecas, Antoni, Ribera, Esteve, Rimola, Antoni, Rufí, G., Sánchez-Tapias, José M., Tural, Cristina, Vargas, Víctor, Xiol, Xavier, [Ballesteros A, Fuster D] Unitat Clínica del VIH, Servei de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Domingo P] Unitat de Malalties Infeccioses, Servei de Medicina Interna, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Jaén A] Centre d’Estudis Epidemiològics sobre la Sida de Catalunya (CEESCAT), Departament de Salut, Badalona, Spain. [Laguno M, Mallolas J, Sánchez-Tapias JM] Serveis d’Infeccions i d’Hepatologia, Hospital Clínic, Barcelona, Spain. [Miró JM] Servei de Malalties Infeccioses, Hospital Clínic, IDIBAPS, Barcelona, Spain. Universitat de Barcelona, IDIBAPS, Barcelona, Spain. [Pahissa A] Servei de Malalties Infeccioses, Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Planas-Vilà R] Unitat d’Hepatologia, Servei de l’Aparell Digestiu, Hospital Universitari Germans Trias i Pujol, Badalona, Spain [Rafecas A] Servei de Cirurgia, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Spain. [Ribera E] Servei de Malalties Infeccioses, Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Rimola A] Servei d’Hepatologia, Hospital Clínic, IDIBAPS, Barcelona, Spain. Universitat de Barcelona, IDIBAPS, Barcelona, Spain. [Rufí G] Servei de Malalties Infeccioses, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Spain. [Tural C] Unitat Clínica del VIH, Servei de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Vargas V] Servei d’Hepatologia, Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Xiol X] Servei de l’Aparell Digestiu, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Spain, and Departament de Salut

Subjects
Virus Diseases::Coinfection [DISEASES], virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH [ENFERMEDADES], virosis::coinfección [ENFERMEDADES], Other subheadings::/diagnosis [Other subheadings], Otros calificadores::/diagnóstico [Otros calificadores], Hepatitis vírica - Tractament, Hepatitis vírica - Diagnòstic, Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections [DISEASES], Environmental Health::Health::Environmental Illness::Virus Diseases::Hepatitis [PUBLIC HEALTH], Infeccions per VIH - Tractament, salud ambiental::salud::enfermedad ambiental::virosis::hepatitis [SALUD PÚBLICA]
Abstract

VIH; Virus de les Hepatitis; Coinfecció VIH; Virus de las Hepatitis; Coinfección HIV; Hepatitis virus; Coinfection Aquest manual ha estat preparat amb la intenció d'abordar els problemes que planteja el maneig de les persones malaltes amb coinfecció pel virus de la sida i els virus de l'hepatitis. A més, facilita als metges i metgesses assistencials els recursos necessaris per al diagnòstic i la presa de decisions terapèutiques, així com els criteris per ampliar la prevenció en tots aquells grups de població exposats a contraure aquestes infeccions. Este manual ha sido preparado con la intención de abordar los problemas que plantea el manejo de las personas enfermas con coinfección por el virus del sida y los virus de la hepatitis. Además, facilita a los médicos asistenciales los recursos necesarios para el diagnóstico y la toma de decisiones terapéuticas, así como los criterios para ampliar la prevención en todos aquellos grupos de población expuestos a contraer estas infecciones.

Published
2005

46. Corrigendum to “Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study” [J Hepatol 2015;62:92–100]

Author

Castells, Lluis, Rimola, Antoni, Manzardo, Christian, Valdivieso, Andrés, Montero, José Luis, Barcena, Rafael, Abradelo, Manuel, Xiol, Xavier, Aguilera, Victoria, Salcedo, Magdalena, Rodriguez, Manuel, Bernal, Carmen, Suarez, Francisco, Antela, Antonio, Olivares, Sergio, del Campo, Santos, Laguno, Montserrat, Fernandez, José R., de la Rosa, Gloria, Agüero, Fernando, Perez, Iñaki, Gonzàlez-García, Juan, Esteban-Mur, Juan I., and Miro, Jose M.

Published
2016
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50. Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series

Author

Sabaté, Mònica, primary, Ibáñez, Luisa, additional, Pérez, Eulàlia, additional, Vidal, Xavier, additional, Buti, Maria, additional, Xiol, Xavier, additional, Mas, Antoni, additional, Guarner, Carlos, additional, Forné, Montserrat, additional, Solà, Ricard, additional, Castellote, José, additional, Rigau, Joaquim, additional, and Laporte, Joan-Ramon, additional

Published
2011
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