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33 results on '"Xiong, Liangwen"'

1. TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer

Author

Anandhan, Swetha, Herbrich, Shelley, Goswami, Sangeeta, Guan, Baoxiang, Chen, Yulong, Macaluso, Marc Daniel, Jindal, Sonali, Natarajan, Seanu Meena, Andrewes, Samuel W., Xiong, Liangwen, Nagarajan, Ashwat, Basu, Sreyashi, Tang, Derek Ng, Liu, Jielin, Min, Jimin, Maitra, Anirban, and Sharma, Padmanee

Published
2024
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2. Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy

Author

Goswami, Sangeeta, Apostolou, Irina, Zhang, Jan, Skepner, Jill, Anandhan, Swetha, Zhang, Xuejun, Xiong, Liangwen, Trojer, Patrick, Aparicio, Ana, Subudhi, Sumit K., Allison, James P., Zhao, Hao, and Sharma, Padmanee

Subjects
Medical research, Immunotherapy -- Innovations, Transcription factors -- Health aspects, Gene expression -- Health aspects, T cells -- Genetic aspects -- Health aspects, Health care industry
Abstract

Enhancer of zeste homolog 2-mediated (EZH2-mediated) epigenetic regulation of T cell differentiation and Treg function has been described previously; however, the role of EZH2 in T cell-mediated antitumor immunity, especially in the context of immune checkpoint therapy, is not understood. Here, we showed that genetic depletion of EZH2 in Tregs ([FoxP3.sup.cre][EZH2.sup.fl/fl] mice) leads to robust antitumor immunity. In addition, pharmacological inhibition of EZH2 in human T cells using CPI-1205 elicited phenotypic and functional alterations of the Tregs and enhanced cytotoxic activity of Teffs. We observed that ipilimumab (anti-CTLA-4) increased EZH2 expression in peripheral T cells from treated patients. We hypothesized that inhibition of EZH2 expression in T cells would increase the effectiveness of anti-CTLA-4 therapy, which we tested in murine models. Collectively, our data demonstrated that modulating EZH2 expression in T cells can improve antitumor responses elicited by anti-CTLA-4 therapy, which provides a strong rationale for a combination trial of CPI-1205 plus ipilimumab., Introduction Enhancer of zeste homolog 2 (EZH2) is expressed in T cells following its activation via CD28 signaling (1). EZH2 is a catalytic subunit of polycomb repressive complex 2 (PRC2) [...]

Published
2018
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4. Supplementary Data from Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner

Author

Shi, Lewis Zhichang, primary, Goswami, Sangeeta, primary, Fu, Tihui, primary, Guan, Baoxiang, primary, Chen, Jianfeng, primary, Xiong, Liangwen, primary, Zhang, Jan, primary, Ng Tang, Derek, primary, Zhang, Xuejun, primary, Vence, Luis, primary, Blando, Jorge, primary, Allison, James P., primary, Collazo, Renata, primary, Gao, Jianjun, primary, and Sharma, Padmanee, primary

Published
2023
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5. Data from Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner

Author

Shi, Lewis Zhichang, primary, Goswami, Sangeeta, primary, Fu, Tihui, primary, Guan, Baoxiang, primary, Chen, Jianfeng, primary, Xiong, Liangwen, primary, Zhang, Jan, primary, Ng Tang, Derek, primary, Zhang, Xuejun, primary, Vence, Luis, primary, Blando, Jorge, primary, Allison, James P., primary, Collazo, Renata, primary, Gao, Jianjun, primary, and Sharma, Padmanee, primary

Published
2023
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6. Supplementary Table 1 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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7. Supplementary Methods from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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8. Supplementary Table 3 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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9. Supplementary Table 2 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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10. Supplementary Table 4 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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11. Supplementary Table 5 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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12. Supplementary Table 6 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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13. Supplementary Figure 1 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, primary, Yao, Hui, primary, Gao, Jianjun, primary, Xiong, Liangwen, primary, He, Qiuming, primary, Compérat, Eva, primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Doss, Denaha J., primary, Thompson, Erika J., primary, Khayat, David, primary, Wood, Christopher G., primary, Yu, Willie, primary, Teh, Bin T., primary, Weinstein, John, primary, and Tannir, Nizar M., primary

Published
2023
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17. Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by [Ca.sup.2+] x calmodulins

Author

Fallon, Jennifer L., Baker, Mariah R., Xiong, Liangwen, Loy, Ryan E., Yang, Guojun, Dirksen, Robert T., Hamilton, Susan L., and Quiocho, Florante A.

Subjects
Calcium channels -- Structure, Calcium channels -- Research, Calcium channels -- Economic policy, Calmodulin -- Research, Calmodulin -- Structure, Calcium-binding proteins -- Analysis, Crystals -- Structure, Crystals -- Analysis, Science and technology
Abstract

Voltage-dependent calcium channels (Car) open in response to changes in membrane potential, but their activity is modulated by [Ca.sup.2+] binding to calmodulin (CAM). Structural studies of this family of channels have focused on CaM bound to the IQ motif; however, the minimal differences between structures cannot adequately describe CaM's role in the regulation of these channels. We report a unique crystal structure of a 77-residue fragment of the [Ca.sub.v]1.2 [[alpha].sub.1] subunit carboxyl terminus, which includes a tandem of the pre-IQ and IQ domains, in complex with [Ca.sup.2+].CaM in 2 distinct binding modes. The structure of the [Ca.sub.v]1.2 fragment is an unusual dimer of 2 coiled-coiled pre-IQ regions bridged by 2 [Ca.sup.2+].CaMs interacting with the pre-IQ regions and a canonical [Ca.sub.v]1-IQ-[Ca.sup.2+]-CaM complex. Native [Ca.sub.v]1.2 channels are shown to be a mixture of monomers/dimers and a point mutation in the pre-IQ region predicted to abolish the coiled-coil structure significantly reduces [Ca.sup.2+]-dependent inactivation of heterologously expressed [Ca.sub.v]1.2 channels. structure | function | voltage-gated calcium channel

Published
2009

18. Combinatorial biomarkers to predict responses to immune checkpoint therapy in metastatic urothelial cancer.

Author

Goswami, Sangeeta, primary, Chen, Yulong, additional, Anandhan, Swetha, additional, Szabo, Peter M, additional, Basu, Sreyashi, additional, Blando, Jorge M, additional, Liu, Wenbin, additional, Zhang, Jan, additional, Natarajan, Seanu, additional, Xiong, Liangwen, additional, Guan, Baoxiang, additional, Singh, Shalini, additional, Saci, Abdel, additional, Allison, James Patrick, additional, Galsky, Matt D., additional, and Sharma, Padmanee, additional

Published
2021
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19. ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC

Author

Goswami, Sangeeta, primary, Chen, Yulong, additional, Anandhan, Swetha, additional, Szabo, Peter M., additional, Basu, Sreyashi, additional, Blando, Jorge M., additional, Liu, Wenbin, additional, Zhang, Jan, additional, Natarajan, Seanu Meena, additional, Xiong, Liangwen, additional, Guan, Baoxiang, additional, Yadav, Shalini Singh, additional, Saci, Abdel, additional, Allison, James P., additional, Galsky, Matthew D., additional, and Sharma, Padmanee, additional

Published
2020
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20. Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner

Author

Shi, Lewis Zhichang, primary, Goswami, Sangeeta, additional, Fu, Tihui, additional, Guan, Baoxiang, additional, Chen, Jianfeng, additional, Xiong, Liangwen, additional, Zhang, Jan, additional, Ng Tang, Derek, additional, Zhang, Xuejun, additional, Vence, Luis, additional, Blando, Jorge, additional, Allison, James P., additional, Collazo, Renata, additional, Gao, Jianjun, additional, and Sharma, Padmanee, additional

Published
2019
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21. Antidepressant Effects of Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex of Parkinson's Disease Patients With Depression: A Meta-Analysis

Author

Zhou, Liang, primary, Guo, Zhiwei, additional, Xing, Guoqiang, additional, Peng, Haitao, additional, Cai, Mengjie, additional, Chen, Huaping, additional, McClure, Morgan A., additional, He, Lin, additional, Xiong, Liangwen, additional, He, Bin, additional, Du, Fei, additional, and Mu, Qiwen, additional

Published
2019
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23. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

Author

Gao, Jianjun, primary, Shi, Lewis Zhichang, additional, Zhao, Hao, additional, Chen, Jianfeng, additional, Xiong, Liangwen, additional, He, Qiuming, additional, Chen, Tenghui, additional, Roszik, Jason, additional, Bernatchez, Chantale, additional, Woodman, Scott E., additional, Chen, Pei-Ling, additional, Hwu, Patrick, additional, Allison, James P., additional, Futreal, Andrew, additional, Wargo, Jennifer A., additional, and Sharma, Padmanee, additional

Published
2016
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25. Molecular profiling of renal medullary carcinoma to reveal frequent alterations in chromatin remodeling genes and to identify EZH2 as a relevant therapeutic target.

Author

Gao, Jianjun, primary, Malouf, Gabriel G., additional, Su, Xiaoping, additional, Yao, Hui, additional, Rao, Priya, additional, He, Rong, additional, Xiong, Liangwen, additional, Karam, Jose A., additional, Matin, Surena F., additional, Mouawad, Roger, additional, Comperat, Eva, additional, Khayat, David, additional, Wood, Christopher G., additional, and Tannir, Nizar M., additional

Published
2016
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27. Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

Author

Malouf, Gabriel G., primary, Su, Xiaoping, additional, Yao, Hui, additional, Gao, Jianjun, additional, Xiong, Liangwen, additional, He, Qiuming, additional, Compérat, Eva, additional, Couturier, Jérôme, additional, Molinié, Vincent, additional, Escudier, Bernard, additional, Camparo, Philippe, additional, Doss, Denaha J., additional, Thompson, Erika J., additional, Khayat, David, additional, Wood, Christopher G., additional, Yu, Willie, additional, Teh, Bin T., additional, Weinstein, John, additional, and Tannir, Nizar M., additional

Published
2014
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33. ARID1Amutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC

Author

Goswami, Sangeeta, Chen, Yulong, Anandhan, Swetha, Szabo, Peter M., Basu, Sreyashi, Blando, Jorge M., Liu, Wenbin, Zhang, Jan, Natarajan, Seanu Meena, Xiong, Liangwen, Guan, Baoxiang, Yadav, Shalini Singh, Saci, Abdel, Allison, James P., Galsky, Matthew D., and Sharma, Padmanee

Abstract

A combination of ARID1Amutation and CXCL13 expression in baseline tumor tissues improves predictive capability for patients with mUCC receiving ICT.

Published
2020
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