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Expanded polystyrene (EPS) concrete is a low-carbon green building material, which has the properties of thermal insulation, but its strength is not high at present. To improve the strength of EPS concrete, EPS particles were wrapped on the surface by magnesium phosphate cement, ultra-high performance concrete, and waterborne polyurethane, they were used to make concrete after aging, and then the strength and microproperties of concrete were tested. The test results show that the wrapping material form a shell structure on the surface of EPS particles; the hydrophilic property of the wrapped EPS particles and the uniformity of the concrete have been significantly improved; the contact between the wrapped EPS particles and the cement base has become more closer; the cube compressive strength of concrete is increased by 80–110%, the flexural strength of concrete is increased by 40–90%. The research results of this study are of great significance for EPS concrete used as structural material and fabricated lightweight wallboard.

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In this article, a new technology of surface wrapping and strengthening of expandable polystyrene (EPS) beads is proposed. Three wrapping materials including magnesium phosphate cement (MPC), ultra-high performance concrete (UHPC), and water-borne polyurethane (WPU) were evaluated. Four groups of uniaxial compression tests of EPS concrete specimens were conducted: the failure process and the characteristics of the specimens were analyzed; and the complete stress-strain equation is proposed based on these analyses. The research shows that the EPS beads were strengthened by wrapping, and the axial compressive strength of concrete is increased by 50-75%; the concrete with EPS beads wrapped by MPC and WPU has obvious brittleness; the concrete with EPS beads wrapped by UHPC has axial compressive strength close to that of EPS concrete wrapped with MPC and WPU but has a larger ductility coefficient (150%), a larger toughness coefficient (50-90% larger), a higher energy dissipation coefficient (40% larger), and larger residual stress. The proposed stress-strain model is in good agreement with the experimental results, which can accurately describe the stress and deformation characteristics of EPS concrete under uniaxial compression and has good applicability. The discovery of this study provides background knowledge for the structural analysis and design of this kind of concrete; it provides a basis for selecting EPS concrete as structural materials. Beijing major science and technology projects [Z191100008019002]; Science and technology project plan of the Ministry of Housing and Urban-Rural Development of the people's Republic of China "Study on fabricated light steel light concrete structure system" [2016-K5-001] Published version This research was financially supported by the Beijing major science and technology projects (No. Z191100008019002), Science and technology project plan of the Ministry of Housing and Urban-Rural Development of the people's Republic of China "Study on fabricated light steel light concrete structure system" (2016-K5-001).

Xiaohua Chen,1,* Zhenzhen Xiong,2,* Zhixiong Li,3 Yali Yang,4 Zhanying Zheng,5 Yonghong Li,6 Yan Xie,6 Zhe Li7,8 1Department of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 2School of Nursing, Chengdu Medical College, Chengdu, Sichuan 610083, China; 3The Third Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 4The Second Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 5The First Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 6The Sleep Medicine Department, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 7Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 8The Mental Rehabilitation Center, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China *These authors contributed equally tothis work Abstract: The pathophysiology of schizophrenia may involve increased production of inflammatory cytokines by activated microglia. Minocycline can inhibit activated microglia and may improve secondary negative symptoms and/or cognitive functions when used as adjuvant to antipsychotics. Effects on minocycline on primary and enduring negative symptoms in deficit schizophrenia (DS) are unknown. We present a male patient with a 3-year history of DS. He was treated for 12 weeks with risperidone at a maximal dose of 6 mg per day, then for 10 weeks with olanzapine at 20 mg per day. Symptoms did not improve, and body mass index increased from 20.41 to 22.84 kg/m2. Serum levels of several inflammatory cytokines were elevated, so we prescribed minocycline as adjunct to aripiprazole for 12 weeks. Negative symptoms and cognitive impairment improved, and serum levels of inflammatory cytokines decreased. Our case suggests that clinicians may consider minocycline as adjunct therapy to antipsychotics in patients with DS with elevated serum levels of inflammatory cytokines. This highlights the need for further research into possible relationships of minocycline with negative symptoms and cognitive function in patients with DS. Keywords: minocycline, adjunct therapy, deficit schizophrenia