36 results on '"Xiong-jing Jiang"'
Search Results
2. Percutaneous Transluminal Renal Angioplasty for Fibromuscular Dysplasia and Prognostic Risk Factors: A Retrospective Chinese Cohort Study
- Author
-
Yi-Ting Lu, Ze-Ming Zhou, Di Zhang, Lin Sun, Xin-Chang Liu, Yan-Kun Yang, Xiong-Jing Jiang, and Xian-Liang Zhou
- Subjects
fibromuscular dysplasia ,percutaneous transluminal renal angioplasty ,hypertension ,stenosis ,prognosis ,risk factor ,Medicine - Abstract
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease involving small-to-medium-sized arteries. The characteristics of Chinese patients with FMD remain unclear. We retrospectively analyzed the data of patients with renal FMD who underwent percutaneous transluminal renal angioplasty (PTRA) for the first time at Fuwai Hospital between 2010 and 2021. The variables were selected through least absolute shrinkage and selection operator regression (LASSO), and logistic regression models were constructed to identify independent risk factors. A total of 116 patients (52 males, median age at diagnosis, 25.0 years) were enrolled. Elevated blood pressure was the leading complaint. After a median follow-up period of 18.0 months (interquartile range: 6.0–48.0 months), hypertension recurred in 34 patients and restenosis in nine patients, among whom four patients underwent secondary intervention and one patient underwent surgical revascularization. Bilateral renal artery involvement (odds ratio [OR]: 2.61, 95% confidence interval [CI]: 1.11–6.15; p = 0.028) and age at hypertension onset (OR: 0.93, 95% CI: 0.88–0.99; p = 0.018) were independent prognostic factors for adverse outcomes. The results indicate that patients with bilateral renal artery involvement and younger age at hypertension onset are more likely to have poorer clinical outcomes after PTRA, and should be more closely monitored.
- Published
- 2022
- Full Text
- View/download PDF
3. Single Nucleotide Polymorphism rs10919543 in FCGR2A/FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
- Author
-
Fang Qin, Hu Wang, Lei Song, Xi-Li Lu, Li-Rui Yang, Er-Peng Liang, Wei Wang, Yu-Bao Zou, Jin Bian, Hai-Ying Wu, Xian-Liang Zhou, Ru-Tai Hui, Hui-Min Zhang, and Xiong-Jing Jiang
- Subjects
FCGR2A ,FCGR3A ,Single Nucleotide Polymorphisms ,Takayasu Arteritis ,Medicine - Abstract
Background: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results: Among the four SNPs, rs10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [CI] = 2.402 − 17.763, P < 0.001) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs10919543 (n = 23, Eos = 0.11 [0.08, 0.17] ×109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] ×109/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
- Published
- 2016
- Full Text
- View/download PDF
4. Consensus of Chinese Specialists on Diagnosis and Treatment of Resistant Hypertension
- Author
-
Ning-Ling Sun, Yong Huo, Ji-Guang Wang, Nan-Fang Li, Jun Tao, Yong Li, Xiao-Wei Yan, Xiong-Jing Jiang, and Xue-Wang Li
- Subjects
Consensus of Chinese Specialists ,Diagnosis and Treatment ,Resistant Hypertension ,Medicine - Published
- 2015
- Full Text
- View/download PDF
5. Clinical Characteristics and Prognosis of End-stage Hypertrophic Cardiomyopathy
- Author
-
Yan Xiao, Kun-Qi Yang, Yan-Kun Yang, Ya-Xin Liu, Tao Tian, Lei Song, Xiong-Jing Jiang, and Xian-Liang Zhou
- Subjects
End-stage ,Hypertrophic Cardiomyopathy ,Left Bundle Branch Block ,Prognosis ,Q wave ,Medicine - Abstract
Background: End-stage hypertrophic cardiomyopathy (HCM) is complicated by substantial adverse events. However, few studies have focused on electrocardiographic features and their prognostic values in HCM. This study aimed to evaluate the clinical manifestations and prognostic value of electrocardiography in patients with end-stage HCM. Methods: End-stage HCM patients were enrolled from a total of 1844 consecutive HCM patients from April 2002 to November 2013 at Fuwai Hospital. Clinical data, including medical history, electrocardiography, and echocardiography, were analyzed. Cox hazards regression analysis was used to assess the risk factors for cardiovascular mortality. Results: End-stage HCM was identified in 99 (5.4%) patients, averaged at 52 ± 16 years old at entry. Atrial fibrillation was observed in 53 patients and mural thrombus in 19 patients. During 3.9 ± 3.0 years of follow-up, embolic stroke, refractory heart failure, and death or transplantation were observed in 20, 39, and 51 patients, respectively. The incidence of annual mortality was 13.2%. Multivariate Cox hazards regression analysis identified New York Heart Association Class (NYHA) III/IV at entry (hazard ratio [HR]: 1.99; 95% confidence interval [CI]: 1.05-3.80; P = 0.036), left bundle branch block (LBBB) (HR: 2.80; 95% CI: 1.47-5.31; P = 0.002), and an abnormal Q wave (HR: 2.21; 95% CI: 1.16-4.23; P = 0.016) as independent predictors of cardiovascular death, in accordance with all-cause death and heart failure-related death. Conclusions: LBBB and an abnormal Q wave are risk factors of cardiovascular mortality in end-stage HCM and provide new evidence for early intervention. Susceptibility of end-stage HCM patients to mural thrombus and embolic events warrants further attention.
- Published
- 2015
- Full Text
- View/download PDF
6. Superselective adrenal arterial embolization for primary aldosteronism without lateralized aldosterone secretion: an efficacy and safety, proof-of-principle study
- Author
-
Jian Qiu, Ning Li, Hong-Liang Xiong, Jiao Yang, Yun-De Li, Chen-Kai Hu, Ze-Qun Lai, Ning-Peng Liang, Hong-Jin Zhang, Xiong-Jing Jiang, and Yi-Fei Dong
- Subjects
Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
7. Prevalence and clinical characteristics of renovascular hypertension associated with fibromuscular dysplasia in China
- Author
-
Yuan-Yuan Kang, Yang Chen, Qi-Hong Wu, Hui Dong, Yu-Bao Zou, Ping-Jin Gao, Jian-Zhong Xu, Xiong-Jing Jiang, and Ji-Guang Wang
- Subjects
Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
8. Characteristics of four-limb blood pressure and brachial-ankle pulse wave velocity in Chinese patients with Takayasu arteritis
- Author
-
Yang Chen, Hui Dong, Hong-Wu Li, Yu-Bao Zou, and Xiong-Jing Jiang
- Subjects
China ,Internal Medicine ,Humans ,Ankle Brachial Index ,Blood Pressure ,General Medicine ,Pulse Wave Analysis ,Cardiology and Cardiovascular Medicine ,Takayasu Arteritis - Abstract
In daily life, many people measure the blood pressure of the arm but measuring the blood pressure of a single arm is inadequate because some hypertension and vascular diseases cannot be detected this way. Synchronous limb blood pressure measurements may be used to close this gap. Measuring synchronous limb blood pressure is very convenient and helps patients understand the value of limb blood pressure and examine many other useful parameters, such as the blood pressure differences between the two arms and two legs, as well as the ankle arm index. These values and derived parameters can also help detect many vascular diseases.Takayasu arteritis is a rare disease in young women. However, the aorta and branches of these patients are narrow or occluded. Patients often experience vague and ambiguous symptoms, such as hypertension or dizziness, so they are likely to be overlooked or misdiagnosed.Our study summarises the results of synchronous limb blood pressure measurements in patients with Takayasu arteritis and compares their results with those of a control population. Synchronous limb blood pressure measurements are easy and convenient and can detect vascular problems, which may improve the ability to diagnose Takayasu arteritis.
- Published
- 2022
9. Case report: Chronic radial artery occlusion treated with paclitaxel-coated balloon via distal transradial access
- Author
-
Ming-hao Liu, Hai-ming Liu, Li-jian Gao, Tao Tian, Ang Li, Qing-kai Wang, Xiong-jing Jiang, Wei-xian Yang, Yong-jian Wu, Bo Xu, Jue Chen, and Jin-qing Yuan
- Subjects
Nephrology ,Surgery - Abstract
A 38-year-old male patient was diagnosed as acute non-ST-segment elevation myocardial infarction on Apr 21st 2021 and he received percutaneous transluminal coronary angioplasty for RCA via transradial artery access. He sought for second percutaneous coronary intervention in our center for frequently exertional angina on Sep 13th 2021. Proximal right radial artery pulsation can not be touched in physical examination, indicating right radial artery occlusion (RAO). Distal transradial access was applied and RAO was confirmed via angiography. With balloon pre-dilation, the guidewire and guiding catheter crossed the occlusion and coronary intervention was successfully completed. A Reewarm 2.5 × 220 mm paclitaxel drug-coated balloon (Endovastec, China) was released at 12 atm in radial arterial lesion with 90 s. Pulsation of radial artery can be well palpated 24 h after PCI. No oral anticoagulant was added. The right radial artery remained patent after 8-month and 14-month follow-up and there was no abnormal sensation or obstacle of right hand.
- Published
- 2023
10. Value of a Machine Learning Approach for Predicting Clinical Outcomes in Young Patients With Hypertension
- Author
-
Xiong-jing Jiang, Jun Cai, Xueyi Wu, Wenjun Ma, Huimin Zhang, Lei Song, Xianliang Zhou, Yubao Zou, Xiaolu Sun, Ying Qin, Haiying Wu, Xinglong Yuan, Wenbing Chang, Kai Liu, Wei Wang, and Shenghan Zhou
- Subjects
Adult ,Adolescent ,Heart Diseases ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Revascularization ,Machine learning ,computer.software_genre ,Models, Biological ,Machine Learning ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal Medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Antihypertensive Agents ,Proportional Hazards Models ,Framingham Risk Score ,business.industry ,Proportional hazards model ,Atrial fibrillation ,Prognosis ,medicine.disease ,Hospitalization ,Treatment Outcome ,Heart failure ,Hypertension ,Kidney Failure, Chronic ,Artificial intelligence ,business ,computer ,Atrial flutter ,Follow-Up Studies ,Forecasting - Abstract
Risk stratification of young patients with hypertension remains challenging. Generally, machine learning (ML) is considered a promising alternative to traditional methods for clinical predictions because it is capable of processing large amounts of complex data. We, therefore, explored the feasibility of an ML approach for predicting outcomes in young patients with hypertension and compared its performance with that of approaches now commonly used in clinical practice. Baseline clinical data and a composite end point—comprising all-cause death, acute myocardial infarction, coronary artery revascularization, new-onset heart failure, new-onset atrial fibrillation/atrial flutter, sustained ventricular tachycardia/ventricular fibrillation, peripheral artery revascularization, new-onset stroke, end-stage renal disease—were evaluated in 508 young patients with hypertension (30.83±6.17 years) who had been treated at a tertiary hospital. Construction of the ML model, which consisted of recursive feature elimination, extreme gradient boosting, and 10-fold cross-validation, was performed at the 33-month follow-up evaluation, and the model’s performance was compared with that of the Cox regression and recalibrated Framingham Risk Score models. An 11-variable combination was considered most valuable for predicting outcomes using the ML approach. The C statistic for identifying patients with composite end points was 0.757 (95% CI, 0.660–0.854) for the ML model, whereas for Cox regression model and the recalibrated Framingham Risk Score model it was 0.723 (95% CI, 0.636–0.810) and 0.529 (95% CI, 0.403–0.655). The ML approach was comparable with Cox regression for determining the clinical prognosis of young patients with hypertension and was better than that of the recalibrated Framingham Risk Score model.
- Published
- 2020
11. Long-term blood pressure outcomes of patients with adrenal venous sampling-proven unilateral primary aldosteronism
- Author
-
Xu, Meng, Wen-Jun, Ma, Xiong-Jing, Jiang, Pei-Pei, Lu, Ying, Zhang, Peng, Fan, Jun, Cai, Hui-Min, Zhang, Lei, Song, Hai-Ying, Wu, Xian-Liang, Zhou, and Ying, Lou
- Subjects
Adrenal Glands ,Hyperaldosteronism ,Humans ,Adrenalectomy ,Blood Pressure ,Aldosterone ,Retrospective Studies - Abstract
Primary aldosteronism (PA) is mainly treated by mineralocorticoid receptor antagonists or laparoscopic adrenalectomy (LA), but the effectiveness of surgical versus medical treatment in patients with adrenal venous sampling (AVS)-proven unilateral PA is unclear. Fifty-one consecutive patients with AVS-proven PA were enrolled. We compared the therapeutic effects between the surgery group (n = 21) and medication group (n = 30) by evaluating the complete control rate (CCR) of hypertension, blood pressure (BP), and number of antihypertensive drugs after a long-term follow-up (12 months). The CCR of hypertension was assessed using a multivariate adjusted Cox proportional hazards regression model. After a mean follow-up of 21.18 ± 5.35 months, the CCR was significantly higher in the surgery than medication group (85.7% vs. 13.3%, respectively; p 0.001). Before adjustment for covariates, the CCR of hypertension in patients who underwent LA was 7.75 times higher than that in patients who underwent medical treatment (95% CI, 2.33-25.78; p = 0.001); significant results were also shown in the adjusted models. Systolic and diastolic BP were also lower in the surgery than medication group (120.3 ± 12.99 vs. 133.54 ± 16.60 and 79.00 ± 7.62 vs. 87.35 ± 12.36 mmHg, respectively; p = 0.01 for both), as was the number of antihypertensive drugs (0.19 ± 0.51 vs. 2.33 ± 0.78, respectively; p 0.001). The rate of hypokalemia was not significantly different between the two groups (0.0% vs. 13.3%, respectively; p = 0.13). In conclusion, AVS plays an essential role in the subtype diagnosis of PA, and surgical candidates with AVS-proven unilateral PA should be highly suggested to undergo LA.
- Published
- 2019
12. GW29-e1740 Time Trends Regarding the Etiology of Renal Artery Stenosis: 18 Years’ Experience from the China Center for Cardiovascular Disease
- Author
-
Runlin Gao, Yubao Zou, Xiong jing Jiang, Meng Peng, Hong liang Xiong, Hui Dong, Lisheng Liu, Wuqiang Che, and Yang Chen
- Subjects
Pediatrics ,medicine.medical_specialty ,Time trends ,business.industry ,Etiology ,Medicine ,Center (algebra and category theory) ,Disease ,Cardiology and Cardiovascular Medicine ,China ,business ,Renal artery stenosis ,medicine.disease - Published
- 2018
13. Stenting for left subclavian artery stenosis in patients scheduled for left internal mammary artery-coronary artery bypass grafting
- Author
-
Wu-qiang, Che, Hui, Dong, Xiong-jing, Jiang, Meng, Peng, Yu-bao, Zou, Hai-yan, Qian, Hui-min, Zhang, Hai-ying, Wu, Yue-jin, Yang, and Run-lin, Gao
- Subjects
Male ,China ,Time Factors ,Myocardial Infarction ,Coronary Artery Disease ,Kaplan-Meier Estimate ,Middle Aged ,Coronary Angiography ,Risk Assessment ,Angina Pectoris ,Stroke ,Subclavian Steal Syndrome ,Treatment Outcome ,Coronary-Subclavian Steal Syndrome ,Recurrence ,Risk Factors ,Humans ,Female ,Stents ,Internal Mammary-Coronary Artery Anastomosis ,Angioplasty, Balloon ,Aged ,Retrospective Studies - Abstract
To evaluate the early and long-term outcomes of stent placement for left subclavian artery stenosis (LSAS) in patients scheduled for left internal mammary artery-coronary artery bypass grafting (LIMA-CABG).Few studies have demonstrated the safety and effectiveness of endovascular therapy for the treatment of LSAS before LIMA-CABG; therefore, use of this therapy requires further exploration and evaluation.Between February 2000 and April 2014, the clinical data of 167 consecutive patients (mean age 64 ± 9 years, 141 males) scheduled for LIMA-CABG with LSAS who were treated by stenting at the Fuwai Hospital were collected and analyzed retrospectively.The technical success rate of the procedure was 97.6% (163/167). The mean stenosis of target lesions decreased from 86.5 ± 9.9% to 7.6 ± 4.6% (P0.001). The incidences of death, stroke, and myocardial infarction, as well as the combined incidence of death, stroke, and myocardial infarction from the time of stenting to 30 days after the stenting procedure were 0.6% (n = 1), 1.8% (n = 3), 0% (n = 0), and 1.8% (n = 3), respectively. The 10-year rate of follow-up was 94.6%. The overall survival rate was 98.8% at 1 year, 97.5% at 2 years, 93.9% at 5 years, and 86.2% at 10 years. A total of 14.1% (23/163) of patients developed in-stent restenosis. Stent restenosis-related angina and myocardial infarction were observed in 13 and 3 patients, respectively. The patency rates of the left subclavian artery were 95.7, 93.8, 86.5, and 75.2% at 1, 2, 5, and 10 years, respectively. The target vessel reconstruction rate was 8.0% (13/163).Stenting of LSAS at experienced medical centers for patients scheduled for LIMA-CABG was safe and effective with a low incidence of complication and in-stent restenosis.
- Published
- 2015
14. Metabolic syndrome is associated with and predicted by resting heart rate: a cross-sectional and longitudinal study
- Author
-
Chun-yu Ruan, Gus Q. Zhang, Xiaoming Zheng, Xiaoxue Liu, Xiong-jing Jiang, Meng Peng, Weiguo Zhang, Yuntao Wu, and Shouling Wu
- Subjects
Gerontology ,Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Longitudinal study ,China ,Time Factors ,Abdominal Fat ,Blood Pressure ,Comorbidity ,Risk Assessment ,Electrocardiography ,Heart Rate ,Predictive Value of Tests ,Risk Factors ,Diabetes mellitus ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Longitudinal Studies ,Risk factor ,Adiposity ,Aged ,Metabolic Syndrome ,business.industry ,Incidence (epidemiology) ,Incidence ,Middle Aged ,medicine.disease ,Impaired fasting glucose ,Lipids ,Cross-Sectional Studies ,Logistic Models ,Obesity, Abdominal ,Cohort ,Hypertension ,Cardiology ,Linear Models ,Female ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,Biomarkers - Abstract
Objective Although higher resting heart rate (RHR) has emerged as a predictor for lifespan, the underlying mechanisms remain obscure. The present study investigates whether a positive relationship exists between RHR and metabolic syndrome (MetS) and whether RHR predicts future MetS. Methods A cohort of 89 860 participants were surveyed during 2006–2007 in Kailuan/Tangshan, China. MetS was diagnosed when a participant presented at least three of the following: abdominal adiposity, low high density lipoprotein-cholesterol, high triglycerides, hypertension or impaired fasting glucose. RHR was derived from ECG recordings and subjects were stratified based on RHR. Some participants without MetS at baseline were followed-up for 4 years. Results At baseline, 23 150 participants (25.76%) had MetS. There was a positive association between RHR and MetS. The OR of having MetS was 1.49 (95% CI 1.32 to 1.69) in subjects with RHR at 95–104 compared with those at 55–64 beats per minute (bpm) (reference), after adjusting for variables including age, sex, education, cigarette smoking, alcohol drinking, physical activities, body mass index, hypertension, diabetes, hyperlipidaemia, inflammatory biomarkers and renal function. More importantly, when 43 725 individuals from the original study without MetS at baseline were followed-up, higher RHR was found to predict greater risk of MetS incidence. The OR of developing MetS 4 years later was 1.41 (95% CI 1.21 to 1.65) in subjects with RHR at 95–104 bpm compared with reference, after all adjustments. Conclusions Our cross-sectional and longitudinal findings provide evidence that RHR is an independent risk factor for existing MetS and a powerful predictor for future incidence of MetS.
- Published
- 2014
15. Quantification of glyceryl trinitrate effect through analysis of the synthesised ascending aortic pressure waveform
- Author
-
Michael F. O'Rourke, X C Zhang, Xiong-jing Jiang, L S Liu, W Q L Jin, P C Tai, C W Li, and S Z Liu
- Subjects
Male ,Vasodilator Agents ,Diastole ,Hemodynamics ,Blood Pressure ,Cardiovascular Medicine ,Nitroglycerin ,Heart Rate ,medicine.artery ,Ascending aorta ,Heart rate ,medicine ,Humans ,Aorta ,Dose-Response Relationship, Drug ,business.industry ,Pulse (signal processing) ,Middle Aged ,Blood pressure ,Anesthesia ,Cuff ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology - Abstract
To establish through analysis of the radial pressure pulse waveform the dose dependent effects of glyceryl trinitrate (GTN) on properties of different blood vessels.Radial pulse waveform was measured in randomised order before, during a five hour application of a GTN patch delivering 0.104-0.625 mg/h, and for two hours after patch removal. The radial pressure waveform (Millar applanation tonometer) was convolved into an ascending aortic wave using a generalised transfer function (SphygmoCor process) enabling measurement of aortic systolic, diastolic, pulse, mean, and augmented pressure and left ventricular ejection duration in addition to standard brachial cuff pressures.Fu Wai and Ren Ming hospitals in Beijing, China.46 recumbent hospitalised patients aged 56 (9) years, awaiting electrophysiological or other diagnostic studies, fasting, and with other treatments suspended.Conventional brachial pressure measures and data from the synthesised aortic pulse.There was no consistent change in heart rate or brachial pressures except for a decrease in systolic and pulse pressures (p0.01) at dose0.416 mg/h. In contrast, there were substantial and significant (p0.0001) decreases in aortic systolic, pulse, and augmented pressures at all doses, mean pressure (p0.001) at doses0.416 mg/h, and ejection duration (p0.001) at doses0.208 mg/h.Pulse waveform analysis exposes dose dependent effects of GTN on the aortic waveform, suggesting muscular conduit arterial dilatation with reduced wave reflection at the lowest dose, arteriolar dilatation and decreased peripheral resistance at the highest dose, and venous dilatation at the intermediate dose.
- Published
- 2002
16. [Safety and feasibility of carotid artery stenting in patients with coexisting carotid and coronary artery disease]
- Author
-
Hui, Dong, Xiong-jing, Jiang, Ting, Guan, Hui-min, Zhang, Si-yong, Teng, Meng, Peng, Wei, Ji, Yue-jin, Yang, and Run-lin, Gao
- Subjects
Male ,Carotid Arteries ,Humans ,Carotid Stenosis ,Female ,Stents ,Coronary Artery Disease ,Middle Aged ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
To evaluate the safety and feasibility of carotid artery stenting (CAS) for treating patients with coexisting carotid and coronary artery disease.The clinical data of 237 consecutive patients [(66.1 ± 7.7) years old, 79.7% male] with coexisting carotid and coronary artery disease undergoing CAS in Fuwai hospital from January 2005 to June 2010. The patients were analyzed retrospectively.Indication for CAS was defined as carotid artery diameter reduction of60% (symptomatic) or80% (asymptomatic) with suitable carotid artery anatomy for stenting. Thirty-day rates of stroke, death and myocardial infarction after CAS were assessed.All patients suffered from coronary artery disease, of whom 87(36.7%) had unstable angina pectoris and 82(34.6%) had recent myocardial infarction (30 days). The procedural success rate of CAS was 99.2 % (235/237). Cerebral protection devices were used in 234 patients (99.6%). Among them, 36(15.2%) patients received simultaneous bilateral CAS and 79(33.3%) patients underwent simultaneous percutaneous intervention of other non-coronary arteries.Within 30 days after CAS, 127(53.6%) patients underwent coronary revascularization, including 118(49.6%) coronary artery bypass grafting and 9 (3.8%) percutaneous coronary intervention. The rate of major stroke, minor stroke, death and myocardial infarction from time of CAS to 30 days was 2.1% (5/237), 3.0% (7/237),0.4% (1/237) and 0.4% (1/237) respectively.Data from this study indicate that CAS is safe and feasible for treating patients with coexisting carotid and coronary artery disease with a low incidence of periprocedural complication rate.
- Published
- 2013
17. [Catheter-based renal sympathetic denervation: current status and challenges]
- Author
-
Run-lin, Gao and Xiong-jing, Jiang
- Subjects
Humans ,Sympathectomy ,Kidney ,Catheterization - Published
- 2013
18. RE-EVALUATION OF NITRATE TOLERANCE: A STUDY OF CENTRAL AORTIC PULSE WAVEFORM ANALYSIS
- Author
-
Michael F. O'Rourke, Xiong jing Jiang, Meng Peng, Yi-Shi Li, Hui Dong, Audrey Adji, Wei Ji, and Lisheng Liu
- Subjects
medicine.medical_specialty ,chemistry.chemical_compound ,Pulse waveform ,Nitrate ,chemistry ,business.industry ,Internal medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
19. [Clinical analysis of simultaneous bilateral carotid stenting for treating patients with bilateral atherosclerotic carotid stenosis]
- Author
-
Hui, Dong, Xiong-jing, Jiang, Meng, Peng, Wei, Ji, Si-yong, Teng, Hai-ying, Wu, Rui-tai, Hui, and Yue-jin, Yang
- Subjects
Adult ,Male ,Carotid Arteries ,Treatment Outcome ,Humans ,Carotid Stenosis ,Female ,Stents ,Middle Aged ,Angioplasty, Balloon ,Aged ,Retrospective Studies - Abstract
To evaluate the safety and feasibility of simultaneous bilateral carotid stenting for treating patients with bilateral atherosclerotic carotid stenosis.The clinical data of 39 consecutive patients with bilateral atherosclerotic carotid stenosis undergoing simultaneous bilateral carotid artery stenting in Fuwai hospital from January 2005 to December 2009 were collected and analyzed retrospectively. The reduction of the angiographic diameter stenosis after stenting and clinical outcomes of 30 days after stenting including hyperperfusion syndrome, hemodynamic depression, stroke, myocardial infarction and death were assessed.The patients were 43 - 78 (65.9 ± 8.5) years old, and there were 25 (64.1%) male. Carotid stenting procedure success rate was 100%. Distal embolic protection devices were used in all patients, and 20 (51.3%) out of 39 patients underwent coronary artery bypass surgery after carotid stenting. The angiographic diameter stenosis reduced from (87.0 ± 5.8)% to (10.2 ± 5.6)% after stenting (P0.01). Up to 30 days after carotid artery stenting, the incidence of hyperperfusion syndrome, hemodynamic depression, minor stroke, major stroke, myocardial infarction and death was 2.6% (1/39), 28.2% (11/39), 5.1% (2/29), 0, 2.6% (1/39), 2.6% (1/39), respectively.The data show that simultaneous bilateral carotid stenting is a technically feasible and safe alternative for patients with severe bilateral atherosclerotic carotid stenosis.
- Published
- 2012
20. Genetic diagnosis of Liddle's syndrome by mutation analysis of SCNN1B and SCNN1G in a Chinese family
- Author
-
Lin-ping, Wang, Ling-gen, Gao, Xian-liang, Zhou, Hai-ying, Wu, Lin, Zhang, Dan, Wen, Yue-hua, Li, Ya-xin, Liu, Tao, Tian, Xiao-han, Fan, Xiong-Jing, Jiang, Hui-min, Zhang, and Ru-tai, Hui
- Subjects
Male ,Liddle Syndrome ,Adolescent ,DNA Mutational Analysis ,Mutation, Missense ,Humans ,Female ,Epithelial Sodium Channels ,Pedigree - Abstract
Liddle's syndrome is a rare autosomal-dominant monogenic form of salt-sensitive hypertension. This study aimed to screen the gene mutation in β and γ subunits of the epithelial sodium channel (ENaC) of a Chinese family with Liddle's syndrome, an autosomal dominant form of hypertension.DNA samples from the proband with early-onset, treatment-resistant hypertension and suppressed plasma renin activity were initially screened for mutations in the C-terminal exons of the ENaC β or γ subunit genes, using amplification by polymerase chain reaction and direct DNA sequencing. We also screened the C-terminus of SCNN1B and SCNN1G in family members, and screened for the mutation in 150 controls.Genetic analysis of the β ENaC gene revealed a missense mutation of CCC to TCC at codon 616 in the proband, her mother and her grandmother. One hundred and fifty randomly selected controls had not the mutation, indicating that this is not a common genetic polymorphism. There was no mutation of the γ ENaC gene in any of the individuals examined.Through direct DNA sequencing analysis, we established the diagnosis of Liddle's syndrome for the proband and her families, and provided tailored therapies to this abnormality. These results provide further evidence that Pro616Ser is a critical amino acid that has a key role in the inhibition of sodium channel activity.
- Published
- 2012
21. Comparison of the safety of simultaneous bilateral carotid artery stenting versus unilateral carotid artery stenting: 30-day and 6-month results
- Author
-
Hui, Dong, Xiong-jing, Jiang, Meng, Peng, Wei, Ji, Hai-ying, Wu, Ru-tai, Hui, Bo, Xu, Yue-jin, Yang, and Run-lin, Gao
- Subjects
Male ,Postoperative Complications ,Time Factors ,Hemodynamics ,Humans ,Carotid Stenosis ,Female ,Stents ,Middle Aged ,Angioplasty, Balloon ,Aged ,Retrospective Studies - Abstract
Severe bilateral carotid stenosis caused by atherosclerosis has not been unusual in the elderly. Such patients have high stroke risk. Many studies show that carotid artery stenting (CAS) is an alternative to treat unilateral carotid stenosis. However, the optimal procedural strategy of bilateral carotid stenosis remains unclear. The purpose of our study was to evaluate the safety of simultaneous bilateral carotid artery stenting (SBCAS) compared with unilateral carotid artery stenting (UCAS).In this single-center retrospective study, we analyzed 234 consecutive patients who underwent carotid stenting from January 2005 to December 2009. Thirty-nine patients (16.7%) of them underwent SBCAS, and the others (n = 195) underwent UCAS. Indication for CAS was defined as carotid artery diameter reduction60% (symptomatic) or80% (asymptomatic). Six-month and 30-day hemodynamic depression (HD), hyperperfusion syndrome (HPS), stroke, death and myocardial infarction (MI) after carotid stenting were assessed.SBCAS group had no more HD and HPS compared with UCAS group at 30 days (HD: 28.2% vs. 20.0%, P = 0.396; HPS: 2.6% vs. 2.1%, P = 0.262). Moreover, there was no statistically significant difference between SBCAS group and UCAS group in major stroke, death, MI and their combinations within 30 days (major stroke: 0 vs. 3.6%, P = 0.604; death: 2.6% vs. 1.5%, P = 0.520; MI: 2.6% vs. 0.5%, P = 0.306; and their combinations: 5.1% vs. 4.6%, P = 1.000) and 6 months (major stroke: 0 vs. 3.6%, P = 0.604; death: 5.1% vs. 2.1%, P = 0.262; MI: 5.1% vs.1.0%, P = 0.130 and their combinations: 7.7% vs. 5.1%, P = 0.459).The patients undergoing SBCAS had no more events than those undergoing UCAS in 30-day and 6-month follow-up. Our finding suggests that SBCAS appears to be as safe as UCAS.
- Published
- 2012
22. Role of plasma C-reactive protein and white blood cell count in predicting in-hospital clinical events of acute type A aortic dissection
- Author
-
Dan, Wen, Hai-ying, Wu, Xiong-jing, Jiang, Hui-min, Zhang, Xian-liang, Zhou, Jian-jun, Li, and Ru-tai, Hui
- Subjects
Adult ,Male ,Aortic Dissection ,Leukocyte Count ,C-Reactive Protein ,Logistic Models ,Aortic Aneurysm, Thoracic ,Humans ,Female ,Middle Aged - Abstract
A few recent studies have reported that inflammation is associated with the prognosis of acute aortic dissection (AD). There is, however, no systemic investigation regarding the role of plasma C-reactive protein (CRP) and white blood cell (WBC) levels in predicting in-hospital clinical events of acute type A AD.The levels of high-sensitivity CRP and WBC counts were systemically determined after admission in 36 patients with acute type A AD. The variations of plasma CRP and WBC levels in different time windows (admission, 1, 2, 3, 4, 6, 8 days) in patients with acute type A AD were analyzed between patients with events and without events.During hospitalization, five patients died, and increased levels of CRP and WBC were found in patients died with acute type A AD compared with patients survived (P0.01, respectively). Medical treatment may significantly decrease inflammatory response in survived patients with acute type A AD. Additionally, patients with complication of pleural effusion showed higher CRP and WBC levels (P = 0.046, P = 0.018, respectively). Lower WBC levels were found in survived patients treated medically (P = 0.001). Moreover, mean CRP and WBC levels had positive correlations with aortic diameter (r = 0.364, P = 0.000; r = 0.333, P = 0.000, respectively) and age (r = 0.270, P = 0.000, respectively), while negative correlations with the time from onset of symptoms to hospital admission (r = -0.229, P = 0.000, r = -0.200, P = 0.002, respectively). Univariate analysis showed that age ≥ 65 years, CRP ≥ 12.05 mg/L, WBC ≥ 12.16 × 10(9)/L, aortic diameter ≥ 48 mm, pleural effusion and diastolic blood pressure ≥ 105 mmHg were associated with hospital mortality. While CRP ≥ 12.05 mg/L, WBC ≥ 12.16 × 10(9)/L, aortic diameter ≥ 48 mm were strongly associated with hospital mortality in multiple Logistic regression analysis.The results suggested that CRP and WBC were preferred markers for predicting the clinical events in patients with acute type A AD, especially death during hospitalization. Therefore, further study enrolling larger cohort, prospective study would be warranted.
- Published
- 2011
23. [Comparative study of ambulatory blood pressure between renovascular hypertensive and essential hypertensive patients]
- Author
-
Pan-Pan, Chen, Xiong-Jing, Jiang, and Jian-Feng, Huang
- Subjects
Adult ,Male ,Young Adult ,Hypertension, Renovascular ,Adolescent ,Hypertension ,Humans ,Blood Pressure ,Female ,Blood Pressure Monitoring, Ambulatory ,Middle Aged ,Aged ,Circadian Rhythm - Abstract
To compare 24 h ambulatory blood pressure changes between patients with renovascular hypertension and essential hypertension.The 24 h ambulatory blood pressure of patients with age and gender matched renovascular hypertension (RVH, n = 51) was compared with that of patients with essential hypertension (EH, n = 51).The 24 h, daytime and nighttime systolic blood pressures (SBP), diastolic blood pressures (DBP) and pulse pressures (PP) in RVH were significantly higher than in EH (all P0.05), especially the nocturnal SBP (P0.05). The SBP and DBP loads in RVH were 58.96% and 35.98% respectively, while blood pressure loads were around 20.00% in EH (P0.05). In patients with RVH, The nocturnal blood pressure fall was 5.39%, and only 27.50% patients were dippers, while the nocturnal blood pressure fall was 10.36% and 60.8% patients were dippers in EH.RVH patients have higher dynamic BP, PP, BP loads and blunted diurnal rhythm compared to those with EH.
- Published
- 2011
24. Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate
- Author
-
Li-wei, Liu, Hong, Liu, Guo-Liang, Chen, Yi-ling, Huang, Lu-lu, Han, Zhi-min, Xu, Xiong-jing, Jiang, and Yi-shi, Li
- Subjects
Adult ,Male ,Polymorphism, Genetic ,Genotype ,Heart Rate ,Hypertension ,Humans ,Female ,Middle Aged ,Peptidyl-Dipeptidase A ,Antihypertensive Agents ,Aged ,Metoprolol - Abstract
Genetic factors can influence antihypertensive response to metoprolol, and many studies focused on the relationship between the genotype in beta1-adrenergic receptor and blood pressure (BP), little was known about the association of angiotensin-converting enzyme (ACE) genotype with the therapeutic result of metoprolol. The present study aimed to investigate whether the ACE gene insertion (I)/deletion (D) polymorphism is related to the response to metoprolol in Chinese Han hypertensive patients.Ninety-six patients with essential hypertension received metoprolol (100 mg once daily) as monotherapy for 8 weeks. Twenty-four hours ambulatory blood pressure monitoring and dynamic electrocardiogram were performed before and after treatment. Genotyping analysis was performed using PCR. The association of the ACE gene I/D polymorphism with variations in BP and heart rate (HR) was observed after the 8-week treatment.The patients with ACE gene II polymorphism showed greater reduction in 24-hour average HR than those with ID or DD polymorphisms (P = 0.045), no effect of this genotype on the reduction in seating HR or in BP was observed. After adjusting for age, gender, body mass index, BP and HR at baseline, the ACE gene I/D polymorphism was still an independent predictor for variations in 24-hour average HR.The II polymorphism in ACE gene could be a candidate predictor for greater reduction in 24-hour average HR in Chinese Han hypertensive patients treated by metoprolol. Greater benefits would be obtained by patients with II polymorphism from the treatment with metoprolol. Larger studies are warranted to validate this finding.
- Published
- 2010
25. [Current status of renal artery stenting]
- Author
-
Xiong-jing, Jiang and Run-lin, Gao
- Subjects
Humans ,Stents ,Renal Artery Obstruction - Published
- 2010
26. Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial
- Author
-
Vlado Perkovic, Nicole Li, Xue Qun Yu, Xiong Jing Jiang, Yang Feng Wu, Bai Ling Chen, Ji Hong Hu, Bruce Neal, and Lian Cheng Zhao
- Subjects
Male ,Rural Population ,medicine.medical_specialty ,China ,Physiology ,Sodium ,chemistry.chemical_element ,Blood Pressure ,law.invention ,chemistry.chemical_compound ,Randomized controlled trial ,Double-Blind Method ,law ,Risk Factors ,Internal medicine ,Internal Medicine ,Medicine ,Humans ,Ankle Brachial Index ,Aged ,business.industry ,Vascular disease ,Salt substitute ,Hemodynamics ,Sodium, Dietary ,Diet, Sodium-Restricted ,Middle Aged ,medicine.disease ,Surgery ,Pulse pressure ,Blood pressure ,Treatment Outcome ,chemistry ,Cardiovascular Diseases ,Regional Blood Flow ,Arterial stiffness ,Cardiology ,Aortic pressure ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Reduced-sodium, increased-potassium salt substitutes lower blood pressure but may also have direct effects on vascular structure and arterial function. This study aimed to test the effects of long-term salt substitution on indices of these outcomes. The China Salt Substitute Study was a randomized, controlled trial designed to establish the effects of salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with regular salt (100% sodium chloride) on blood pressure among 600 high-risk individuals living in six rural areas in northern China over a 12-month intervention period. Data on central aortic blood pressure, aortic pressure augmentation (AUG), augmentation index (AIx), the differences of the peak of first and baseline waves (P(1)-P(0)) and pulse wave reflection time (RT) were collected at randomization and at the completion of follow-up in 187 participants using the Sphygmocor pulse wave analysis system. Mean baseline blood pressure was 150.1/91.4 mm Hg, mean age was 58.4 years, 41% were male and three quarters had a history of vascular disease. After 12 months of intervention, there were significant net reductions in peripheral (7.4 mm Hg, P=0.009) and central (6.9 mm Hg, P=0.011) systolic blood pressure levels and central pulse pressure (4.5 mm Hg, P=0.012) and correspondingly there was a significant net reduction in P(1)-P(0) (3.0 mm Hg, P=0.007), borderline significant net reduction in AUG (1.5 mm Hg, P=0.074) and significant net increase in RT (2.59 ms, P=0.001). There were no detectable reductions in peripheral (2.8 mm Hg, P=0.14) or central (2.4 mm Hg, P=0.13) diastolic blood pressure levels or AIx (0.06%, P=0.96). In conclusion, over the 12-month study period the salt substitute significantly reduced not only peripheral and central systolic blood pressure but also reduced arterial stiffness.
- Published
- 2009
27. [Outcome of patients with coronary artery disease underwent carotid artery stenting before coronary artery bypass surgery.]
- Author
-
Xiong-Jing, Jiang, Qian, Yang, Yue-Jin, Yang, Hai-Ying, Wu, Hui-Min, Zhang, Bo, Xu, Ru-Tai, Hui, and Run-Lin, Gao
- Subjects
Cohort Studies ,Carotid Arteries ,Treatment Outcome ,Humans ,Stents ,Coronary Artery Disease ,Prospective Studies ,Coronary Artery Bypass - Abstract
To evaluate the safety and efficacy of carotid artery stenting before open heart surgery.Patients with heart disease and severe carotid artery stenosis received carotid stenting before open heart surgery were included in this prospective cohort study. The incidence of stroke, myocardial infarction and death from carotid stenting to 30 days after cardiac surgery was assessed.A total of 42 patients were enrolled. The carotid stenting procedural success rate was 100%. Distal embolic protection devices were used in 97.6% patients (41/42). Thirty-six (85.7%) patients received bypass surgery, 5 patients received bypass and valve replacement surgery (11.9%) and 1 patient received valve replacement surgery (2.4%) post carotid stenting. The incidence of stroke, myocardial infarction and death from carotid stenting to 30 days after cardiac surgery was 2.4% (1/42), 0% and 0% respectively.Our data from this small cohort study showed that carotid artery stenting before open heart surgery was safe and effective for patients with heart disease and severe carotid artery stenosis.
- Published
- 2008
28. [Outcome of endovascular therapy of iliac, superficial femoral and popliteal arteries in 136 patients]
- Author
-
Xiong-Jing, Jiang, Hui-Min, Zhang, and Qian, Yang
- Subjects
Adult ,Aged, 80 and over ,Male ,Arterial Occlusive Diseases ,Middle Aged ,Iliac Artery ,Femoral Artery ,Lower Extremity ,Humans ,Female ,Popliteal Artery ,Stents ,Angioplasty, Balloon ,Aged ,Follow-Up Studies - Abstract
To evaluate the effect and clinical outcome of balloon angioplasty or selected stent implantation in patients with severe lower limb artery disease.A total of 136 consecutive patients who had severe claudication or chronic limb ischemia due to atherosclerotic stenosis or occlusion of the iliac (n = 81), superficial femoral (n = 43) and popliteal (n = 12) arteries underwent balloon angioplasty initially and selected stent implantation was followed in cases of dissection or more than 30% residual stenosis after balloon angioplasty (n = 99). Restenosis and clinical outcomes were assessed at 6 months and 12 months.Baseline mean (+/- SD) lesion length ranged from 1.5 cm - 18.0 cm [(6.2 +/- 2.9) cm] and stenosis ranged from 70% - 100% (88.6% +/- 7.5%). The mean length of treated segments was 2.0 cm - 19.0 cm [(7.3 +/- 3.2) cm], and residual stenosis after procedure was 0% - 30% (8.7% +/- 5.1%). There were two procedure-related thrombosis complications and patients recovered post related treatments. At 6 months, the rates of restenosis were 7.3% in iliac lesions, 19.4% in femoropopliteal lesions and 12.3% in all lesions, 10.2% in the stent group and 17.8% in the balloon angioplasty group, respectively (P0.05) and revascularization was performed in 10 patients; at 12 months, the rates of restenosis were 12.5% in iliac lesions, 29.9% in femoropopliteal lesions and 19.6% in all lesions, 16.1% in the stent group and 28.9% in the balloon angioplasty group (P0.05), respectively. Six-minute walk distance was significantly longer and ankle brachial index (ABI) was significantly higher at 6 months and 12 months in the stent group compared to balloon angioplasty group (all P0.001). All patients are alive and 3 acute myocardial infarction and 2 minor stroke were observed during 12 months follow-up.Endovascular therapy in the iliac, superficial femoral and popliteal artery was safe and effective. The rate of restenosis in the stent group was comparable to that in balloon angioplasty group during 12 months follow up. Stent implantation is superior to balloon angioplasty in terms of six-minute maximal walk capacity and ABI during 12 months follow up.
- Published
- 2008
29. [Comparison of pulmonary perfusion imaging with pulmonary angiography in diagnosis of pulmonary involvement in Takayasu's arteritis]
- Author
-
Min-fu, Yang, Zuo-xiang, He, Shi-guo, Li, and Xiong-jing, Jiang
- Subjects
Adult ,Male ,Adolescent ,Middle Aged ,Pulmonary Artery ,Takayasu Arteritis ,Radiography ,Young Adult ,Humans ,Female ,Radionuclide Angiography ,Lung ,Technetium Tc 99m Aggregated Albumin ,Retrospective Studies - Abstract
To compare the diagnostic value of (99)Tc(m)-MAA pulmonary perfusion imaging with that of pulmonary angiography for pulmonary involvement in Takayasu's arteritis.Twenty-one patients (19 women, 2 men), with diagnosed Takayasu's arteritis and underwent both (99)Tc(m)-MAA pulmonary perfusion imaging and pulmonary angiography, were retrospectively analyzed.Out of the 21 patients, pulmonary angiography detected 11 patients with pulmonary artery involvement whereas 13 patients were revealed perfusion defects by pulmonary perfusion imaging. The agreement of diagnosis by pulmonary perfusion imaging with that by pulmonary angiography existed in 19 patients (90.5%, Kappa = 0.81, P0.0001). There were 331 pulmonary segments consistently diagnosed by pulmonary perfusion imaging and pulmonary angiography in 378 pulmonary segments (87.5%, Kappa = 0.74, P0.0001).Pulmonary perfusion imaging is highly accorded with pulmonary angiography in detecting the pulmonary involvement in Takayasu's arteritis. Therefore, pulmonary perfusion imaging could be used as a non-invasive screening test for the pulmonary artery involvement in Takayasu's arteritis.
- Published
- 2006
30. [Effects of renal artery stenting on renal function of patients with ischaemic nephropathy]
- Author
-
Xiong-jing, Jiang, Hai-ying, Wu, Hui-min, Zhang, Guang-hua, Ming, De-yu, Zhang, Guo-zhang, Liu, Ru-tai, Hui, and Li-sheng, Liu
- Subjects
Male ,Arteriosclerosis ,Humans ,Female ,Stents ,Renal Insufficiency ,Middle Aged ,Kidney ,Kidney Function Tests ,Renal Artery Obstruction ,Angioplasty, Balloon ,Aged - Abstract
To evaluate the effects of stent revascularization on renal function of patients with atherosclerotic renal artery stenosis with renal insufficiency.Percutaneous transluminal renal angioplasty with stent (PTRAS) was performed on 27 consecutive patients with severe atherosclerotic renal artery stenosis for preservation of renal function, and follow-up was conducted for 6 approximately 48 months.Technically PTRAS was successfully performed in all 27 patients. The creatinine value was 155 micromol/L +/- 31 micromol/L before operation, and increased to 189 micromol/L +/- 38 micromol/L (P0.001), then decreased to 145 micrommol/L +/- 22 micrommol/L, 143 micromol/L +/- 22 micromol/L, 143 micromol/L +/- 24 micromol/L, and 139 micromol/L +/- 10 micromol/L, 6, 12, 24, and 36 months after the PTRAS respectively (all P0.05). The severe complications related to the procedure mainly included 7 cases of acute renal failure, 4 cases being reversible. One case died of cardiac infarction with underlying coronary heart disease 9 months after and 1 case died heart failure due to valvular disease of heart 25 months after.Renal artery stent revascularization is effective for preservation of renal function in patients with ischaemic nephropathy effect on. However, complications related to the procedure frequently occurred. The long-term efficacy is to be investigated further.
- Published
- 2005
31. [The comparison of the effect of enalapril and indapamide on the peripheral blood pressure and central blood pressure through pulse wave analysis]
- Author
-
Xiong-jing, Jiang, Qiu-ying, Li, Yu-qing, Zhang, Guo-zhang, Liu, and Li-sheng, Liu
- Subjects
Adult ,Male ,Double-Blind Method ,Enalapril ,Hypertension ,Indapamide ,Humans ,Angiotensin-Converting Enzyme Inhibitors ,Blood Pressure ,Female ,Middle Aged ,Antihypertensive Agents ,Aged - Abstract
The purpose of this study was to evaluate the effects of the angiotensin-converting enzyme (ACE) inhibitor enalapril and diuretic indapamide on the peripheral blood pressure and the central blood pressure in Chinese patients with essential hypertension.This study was a double blind, randomized study. Informed consent were given by all patients. After 2 weeks of placebo run-in period, 105 patients with mild or moderate essential hypertension were randomized to receive either enalapril (10 mg per day) or indapamide (2.5 mg per day) for 8 weeks. Radial pulse wave recordings were performed in all the patients before the active treatments were given and at the end of the study. Only those patients who have finished 8 weeks of active treatment in both groups were included into the final analysis.One hundred one patients (51 in enalapril group and 50 in indapamide group) completed the study. No significant difference (all P values0.05) was found in baseline data between the two groups. After 8 weeks of treatment, all the parameters of pulse wave (except heart rates in both groups and augmentation index in indapamide group) decreased significantly. Comparison of the 2 groups showed that there were no significant differences (all P values0.05) in all the parameters of pulse wave except that the central systolic blood pressure, augmentation and augmentation index were significantly lower in enalapril group than in indapamide group. In enalapril group, the reduced values of systolic blood pressure and pulse pressure in central aorta were significantly larger than those in brachial artery. However, the difference was not observed in indapamide group.Enalapril and indapamide are both similarly effective in reducing peripheral arterial blood pressure. Moreover, enalapril is more effective in reducing central systolic pressure and augmentation index than indapamide. The difference is probably due to the reduction of wave reflection caused by enalapril.
- Published
- 2005
32. [Clinical results of stent revascularization as treatment for renal artery stenosis during 6 months of follow-up]
- Author
-
Xiong-jing, Jiang, Hai-ying, Wu, Guang-hua, Ming, Lei-li, Wang, De-yu, Zheng, Guo-zhang, Liu, Ru-tai, Hui, and Li-sheng, Liu
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Middle Aged ,Kidney Function Tests ,Renal Artery Obstruction ,Young Adult ,Renal Artery ,Treatment Outcome ,Humans ,Female ,Stents ,Aged ,Follow-Up Studies - Abstract
To evaluate the safety and midterm efficacy of stent revascularization as treatment for renal artery stenosis.Percutaneous transluminal renal angioplasty with stent (PTRA) was performed because of poorly controlled hypertension or preservation of renal function in 150 consecutive patients with severe renal artery stenosis, caused by atheroma (96 patients), arteritis (44 patients) and fibromuscular dysplasia (10 patients). All of them subsequently underwent 6-month clinical follow-up to observe the effect of the procedure on renal function, blood pressure control, number of antihypertensive medications.Angiographic success was obtained in 148 (98.7%) of 150 patients after PTRA. At 6 months, both systolic and diastolic blood pressures significantly decreased (from 169.6 to 142.7 mm Hg and from 97.3 to 83.3 mm Hg, respectively; P0.001), and less antihypertensive medication was taken (from 2.7 to 1.9). The blood pressure became normal without taking any antihypertensive medications in 48 of 150 patients (32.0%), and the blood pressure control was more facile in 78 patients (52.0%), however, there were no improvement in 22 patients (16.0%). Creatinine level decreased in 34 patients (22.7%), remained stable in 112 patients (74.6%), and increased in 4 (2.7%). There was no statistical significance. No deaths occurred during 6-months follow-up.Renal artery stent revascularization had a beneficial effect on blood pressure control and a nondeleterious effect on renal function during 6-months follow-up. The long-term efficacy should be investigated. The procedure is safe in usual.
- Published
- 2005
33. Clinical outcomes of selective stenting as treatment for renovascular hypertension caused by aortoarteritis
- Author
-
Ru-Tai Hui, Hai-Ying Wu, Yuejin Yang, Bo Xu, Run-lin Gao, Xiong-Jing Jiang, Hui-Ming Zhang, and Qian Yang
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Renovascular hypertension - Published
- 2009
34. AS-51: Benefits from Carotid Stenting before Open Heart Surgery: A Single-Center Experience with 76 Patients
- Author
-
Xiong Jing Jiang, Yue Jin Yang, Run Ling Gao, Qian Yang, and Hai Ying Wu
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Medicine ,Carotid stenting ,Cardiology and Cardiovascular Medicine ,business ,Single Center ,Surgery - Published
- 2009
35. Can lercanidipine improve renal function in patients with atherosclerotic renal artery stenosis undergoing renal artery intervention?
- Author
-
Meng Peng, Xiong-jing Jiang, Hui Dong, Yu-bao Zou, Hui-min Zhang, Hai-ying Wu, and Yuejin Yang
- Subjects
- *
KIDNEY disease treatments , *RENAL artery obstruction , *ATHEROSCLEROSIS , *ARTERIAL stenosis , *CREATININE - Abstract
Objective: To investigate the renal-protective effect of lercanidipine in patients undergoing renal artery intervention. Methods: A prospective, single-center, cohort study was conducted and patients, 30–75 years of age, with atherosclerotic renal artery stenosis were consecutively enrolled between September 2011 and October 2012. Lercanidipine (10–20 mg/day) was regularly taken after the intervention. Follow up visits were performed at 3 and 6 months after the intervention. Serum creatinine, clinical blood pressure, 24 hour ambulatory blood pressure, pulse wave velocity, and 24 hour urine protein were assessed. Adverse events were recorded. Results: In total, 55 patients (mean age 63.5 ± 8.9 years) were enrolled and 52 completed the study. Renal function, estimated glomerular filtration rate (eGFR) and 24 hour urine protein at 3 months after the intervention were not statistically different compared with the baseline. At 6 months after the intervention eGFR significantly increased versus baseline (78 ± 23 ml/min/1.73 m2 vs 71 ± 21 ml/min/1.73 m2, p = 0.021); 24 hour urine protein decreased significantly (0.02 g [IQR, 0.01–0.1] vs 0.03 g [IQR, 0.01–0.28], p = 0.042). Blood pressure control improved at 3 months and 6 months after the intervention. The need for antihypertensive drugs decreased; clinical systolic blood pressure, diastolic blood pressure and 24 hour average systolic blood pressure and diastolic blood pressure decreased. The pulse wave velocity decreased after 3 and 6 months. At the end of follow-up, none of the following adverse events occurred: death, dialysis, myocardial infarction or stroke. Mild lower extremity edema occurred in only one patient. No other side effects occurred. Conclusions: This study showed that lercanidipine can improve renal function in patients undergoing renal artery intervention. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
36. Sildenafil/Nitrate Interaction
- Author
-
O’Rourke, Michael, primary and Xiong-Jing, Jiang, additional
- Published
- 2000
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.