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4. Analysis of Usual Consumption of Vitamin D Among Adult Individuals in Italy.

Author

Nuti, Ranuccio, Gennari, Luigi, Cavati, Guido, Caffarelli, Carla, Frediani, Bruno, Gonnelli, Stefano, Catalano, Antonino, Francucci, Cristiano Maria, Laurentaci, Concetta, Letizia Mauro, Giulia, Malavolta, Nazzarena, Mazzantini, Maurizio, Minisola, Giovanni, Russo, Raffaella, Sabatino, Pasquale, Pinto, Monica, Salomone, Sergio, Tei, Luciano, Vescini, Fabio, and Xourafa, Anastasia

Abstract

Background: The condition of vitamin D (25OHD) deficiency represents an important public health problem. In Europe, hypovitaminosis is common not only in the elderly population but also between 50 and 70 years, both in males and females. Data regarding vitamin D intake in the Italian population are very limited. In a recent paper, reporting data collected by a specific Frequency Food Questionnaire (FFQ), we observed in a small group of healthy subjects that the dietary consumption of vitamin D, both in females and males, was far below the average. Methods: With the aim of expanding our preliminary data, we conducted a survey on a large cohort of subjects from different areas of Northern, Central, and Southern Italy. The FFQ contained 11 different questions regarding the amount and type of intake of foods containing ergocalciferol and cholecalciferol. It was submitted to 870 subjects, 627 females and 243 males, with an age range from 40 to 80 years; 31.6% of the studied population was apparently in good health, while 68.4% were affected by different pathologies. Results: The present data confirm previous observations: the global quantity of vitamin D intake in 14 days was 70.8 μg (±1.8 SE, ±54.4 SD) in females and 87.5 μg (±1.9 SE, ±57.1 SD) in males; the mean daily intake of vitamin D in females and males was 5.05 μg (±0.5 SE, ±3.8 SD) and 6.25 μg (±0.21 SE, ±4.1 SD), respectively. In healthy subjects, a gradual decrease was observed in the overall intake of vitamin D in both females and males according to an increase in age bracket, ranging from 74.5 μg and 103.8 μg in the 40–50 age group to 54.5 μg and 87.8 μg in the 71–80 age group, respectively. Conclusions: In conclusion, the present data, collected in a large Italian cohort, underscore that the daily intake of vitamin D is far below the recommended daily average, thereby contributing to the development of potential hypovitaminosis. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Trabecular bone score and phalangeal quantitative ultrasound are associated with muscle strength and fracture risk in hemodialysis patients

Author

Antonino Catalano, Agostino Gaudio, Federica Bellone, Mattia Miriam La Fauci, Anastasia Xourafa, Guido Gembillo, Giorgio Basile, Giuseppe Natale, Giovanni Squadrito, Francesco Corica, Nunziata Morabito, and Domenico Santoro

Subjects
fracture, osteoporosis, hemodialysis, bone mineral density (BMD), trabecular bone score (TBS), chronic kidney disease-mineral bone disorder (CKD-MBD), Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

There is growing interest in the relationship between chronic kidney disease (CKD) and fragility fracture risk. Bone mineral density (BMD) is a major determinant of bone strength, although its role as a predictor of fracture in advanced CKD and hemodialysis is still under debate. We aimed to further investigate surrogates of bone quality and their associations with muscle strength and fracture risk in hemodialysis. Multiple clinical risk factors for fracture and an estimated 10-year probability of fracture, BMD at lumbar spine and femur, trabecular bone score (TBS), X-ray vertebral morphometry, phalangeal bone quantitative ultrasonography (QUS), tibial pulse-echo ultrasonography (PEUS), and handgrip strength were evaluated in a setting of hemodialysis patients in treatment with acetate-free biofiltration (AFB) or bicarbonate hemodialysis. The bone ultrasound measurements, both at phalangeal and tibial sites, were significantly associated with lumbar and femoral DXA values. Handgrip strength was significantly associated with the 10-year probability of fracture (r = −0.57, p < 0.001 for major fractures and r = −0.53, p < 0.001 for hip fracture, respectively), with femur neck, total femur, and L1–L4 BMD values (r = 0.47, p = 0.04; r = 0.48, p = 0.02; r = 0.58, p = 0.007, respectively), with TBS at the lumbar spine (r = 0.71, p < 0.001) and with the phalangeal QUS measure of AD-SoS (r = 0.369, p = 0.023). In the hemodialysis group, 10 participants (24.3%) reported at least one morphometric vertebral fracture (Vfx); conversely, only six participants (15%) showed Vfx in the control group. In the hemodialysis group, participants with Vfx compared with participants without Vfx reported significantly different TBS, bone transmission time (BTT), cortical thickness, and handgrip strength (p < 0.05). At multiple regression analysis, by identifying as dependent variable the 10-year fracture risk for major fracture, after correcting for age, BMI, time since dialysis, AD-SoS, cortical bone thickness, and handgrip strength, only BTT (β = −15.21, SE = 5.91, p = 0.02) and TBS (β = −54.69, SE = 21.88, p = 0.02) turned out as independently associated with fracture risk. In conclusion, hemodialysis patients showed a higher fracture risk and lower surrogate indices of bone strength as TBS and QUS parameters. In this cohort of patients, handgrip strength measurements appeared to be a useful instrument to identify high-fracture-risk subjects.

Published
2022
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7. Familiar osteopoikilosis: Case report with differential diagnosis and review of the literature

Author

Agostino Gaudio, Anastasia Xourafa, Rosario Rapisarda, Cristina Gorgone, Maria Gnoli, Elena Pedrini, Luca Sangiorgi, Antonino Catalano, Luca Zanoli, Teresa Mattina, and Pietro Castellino

Subjects
enostoses, LEMD3 gene, osteopoikilosis, sclerosing bone dysplasia, Medicine, Medicine (General), R5-920
Abstract

Abstract Osteopoikilosis (OP) is a rare autosomal dominant sclerosing bone disease, caused by heterozygous mutations in the LEMD3 gene. It is characterised by numerous focal lamellar bone compact deposits in the spongiosa. In this case report, we describe a famliar case of OP and review the literature.

Published
2021
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8. Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register (Internal and Emergency Medicine, (2023), 18, 4, (1049-1063), 10.1007/s11739-023-03254-3)

Author

Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

In this article the names of a few collaborators and some data in Table 5 were missing. It has been corrected. The original article has been corrected.

Published
2023

9. Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Author

Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie–Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria.

Published
2023

10. Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience

Author

Agostino Gaudio, Nancy Morabito, Antonino Catalano, Rosario Rapisarda, Anastasia Xourafa, and Antonino Lasco

Subjects
Osteoporosis, thalassemia major, hypogonadism, marrow expansion, bone turnover, Pediatrics, RJ1-570, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Due to increasing life expectancy in thalassemia major (TM), osteoporosis is emerging as a significant problem. Its aetiology is multifactorial, culminating in increased bone resorption and impaired remodelling. Hypogonadism and marrow expansion seem to play an important role, but iron overload, deferoxamine toxicity, a defective growth hormone-insulin-like growth factor-1 axis and multiple endocrinopathies may represent additional causes of bone damage. Many of these patients, though under appropriate treatment programs, do not achieve normal peak bone mass. The receptor activator of nuclear factor kappa-ß (RANK)/RANK ligand/osteoprotegerin and the Wnt/β-catenin systems work as major mediators of imbalanced bone turnover and bone loss. Additional genetic factors, such as collagen type 1 alpha 1 and vitamin D receptor gene polymorphisms, may exert some influence on the enhanced fracture risk observed in TM. To date, in spite of adequate hormone replacement, chelating therapy and acceptable haemoglobin levels, subjects with TM display impaired bone density and imbalanced bone turnover, thus the puzzle of the pathogenesis of TM-induced osteoporosis remains far from being solved.

Published
2019
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15. A strange case of dyspnoea

Author

Agostino Gaudio, Andrea Ruben Murabito, Anastasia Xourafa, Federica Patanè, Rosario Rapisarda, Sergio Bagnato, and Pietro Castellino

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Acquired neuralgic amyotrophy, described for the first time by Parsonage and Turner, is a rare idiopathic disease that may occur in otherwise normal healthy individuals. It typically begins with sudden, unilateral shoulder pain that may also involve the neck and/or arm. Less frequently, the disease involves nerves other than those of the brachial plexus, such as phrenic nerves, resulting in dyspnoea. The diagnosis is based on the clinical presentation and is generally supported by electroneurography/electromyography. We report the case of a 45-year-old white man who was referred to our clinic for acute dyspnoea preceded by severe neck and right shoulder pain. Corticosteroid therapy ameliorated the clinical picture, but without a complete recovery. Keywords: Dyspnoea, Parsonage-turner syndrome, Neuralgic amyotrophy

Published
2019
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16. Oxidative Stress in Peripheral Arterial Disease (PAD) Mechanism and Biomarkers

Author

Salvatore Santo Signorelli, Salvatore Scuto, Elisa Marino, Anastasia Xourafa, and Agostino Gaudio

Subjects
peripheral arterial disease, pathophysiology, oxidative stress, biomarkers, inflammation, Therapeutics. Pharmacology, RM1-950
Abstract

Hemodynamic dysfunction mainly characterizes pathophysiology of peripheral arterial disease (PAD) leading to chronic ischemia. Hemodynamic dysfunction is the origin of intermittent claudication (chronic PAD) or of critical limb ischemia (very severe PAD). Notably, it is well known that oxidative stress (OxS) plays a pathophysiological role in PAD. The higher production of reactive oxygen species (ROS) from OxS and reduced redox capability are two crucial players in initiating and progressing PAD. A number of biomarkers highlight OxS and monitor it in PAD. The present review summarizes data on OxS, on biomarkers available to mark OxS occurrence and to monitor on PAD progression, as well as to evaluate the effects treatments in PAD patients. In conclusion, by detailing OxS and its biomarkers, we hope to encourage more studies to focus on drugs which combat OxS and inflammation.

Published
2019
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17. Trabecular bone score and phalangeal quantitative ultrasound are associated with muscle strength and fracture risk in hemodialysis patients

Author

Catalano, Antonino, primary, Gaudio, Agostino, additional, Bellone, Federica, additional, La Fauci, Mattia Miriam, additional, Xourafa, Anastasia, additional, Gembillo, Guido, additional, Basile, Giorgio, additional, Natale, Giuseppe, additional, Squadrito, Giovanni, additional, Corica, Francesco, additional, Morabito, Nunziata, additional, and Santoro, Domenico, additional

Published
2022
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18. Special Issue: Metabolic Bone Diseases: Molecular Biology, Pathophysiology and Therapy

Author

Anastasia Xourafa and Agostino Gaudio

Subjects
Inorganic Chemistry, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications
Abstract

Bone is a vital tissue as it carries out various metabolic functions: support of the body, protection of the internal organs, mineral deposit and hematopoietic functions [...]

Published
2023
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19. Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term

Author

Zanoli, Luca, primary, Gaudio, Agostino, additional, Mikhailidis, Dimitri P., additional, Katsiki, Niki, additional, Castellino, Niccolò, additional, Lo Cicero, Lorenzo, additional, Geraci, Giulio, additional, Sessa, Concetto, additional, Fiorito, Letizia, additional, Marino, Francesca, additional, Antonietta Di Rosolini, Maria, additional, Colaci, Michele, additional, Longo, Antonio, additional, Montineri, Arturo, additional, Malatino, Lorenzo, additional, Castellino, Pietro, additional, Aparo, Paola, additional, Arena, Andrea, additional, Barchitta, Martina, additional, Castelletti, Federica, additional, Di Noto, Martina, additional, Di Pino, Antonino, additional, Giarrusso, Ornella, additional, Isaia, Ivan, additional, Lentini, Paolo, additional, Magnano San Lio, Paola, additional, Manuele, Rosa, additional, Marino, Elisa, additional, Morale, Walter, additional, Sciuto, Alice, additional, Scuto, Salvatore Sebastiano, additional, Xourafa, Anastasia, additional, and Zocco, Sabrina, additional

Published
2022
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21. Trabecular bone score and phalangeal quantitative ultrasound are associated with muscle strength and fracture risk in hemodialysis patients

Author

Catalano, Antonino, Gaudio, Agostino, Bellone, Federica, La&nbsp, Fauci, Mattia Miriam, Xourafa, Anastasia, Gembillo, Guido, Basile, Giorgio, Natale, Giuseppe, Squadrito, Giovanni, Corica, Francesco, Morabito, Nunziata, and Santoro, Domenico

Subjects
Bicarbonates, Fractures, Bone, Lumbar Vertebrae, Hand Strength, Bone Density, Renal Dialysis, Endocrinology, Diabetes and Metabolism, Cancellous Bone, Humans, Muscle Strength, Renal Insufficiency, Chronic, Ultrasonography
Abstract

There is growing interest in the relationship between chronic kidney disease (CKD) and fragility fracture risk. Bone mineral density (BMD) is a major determinant of bone strength, although its role as a predictor of fracture in advanced CKD and hemodialysis is still under debate. We aimed to further investigate surrogates of bone quality and their associations with muscle strength and fracture risk in hemodialysis. Multiple clinical risk factors for fracture and an estimated 10-year probability of fracture, BMD at lumbar spine and femur, trabecular bone score (TBS), X-ray vertebral morphometry, phalangeal bone quantitative ultrasonography (QUS), tibial pulse-echo ultrasonography (PEUS), and handgrip strength were evaluated in a setting of hemodialysis patients in treatment with acetate-free biofiltration (AFB) or bicarbonate hemodialysis. The bone ultrasound measurements, both at phalangeal and tibial sites, were significantly associated with lumbar and femoral DXA values. Handgrip strength was significantly associated with the 10-year probability of fracture (r = −0.57, p < 0.001 for major fractures and r = −0.53, p < 0.001 for hip fracture, respectively), with femur neck, total femur, and L1–L4 BMD values (r = 0.47, p = 0.04; r = 0.48, p = 0.02; r = 0.58, p = 0.007, respectively), with TBS at the lumbar spine (r = 0.71, p < 0.001) and with the phalangeal QUS measure of AD-SoS (r = 0.369, p = 0.023). In the hemodialysis group, 10 participants (24.3%) reported at least one morphometric vertebral fracture (Vfx); conversely, only six participants (15%) showed Vfx in the control group. In the hemodialysis group, participants with Vfx compared with participants without Vfx reported significantly different TBS, bone transmission time (BTT), cortical thickness, and handgrip strength (p < 0.05). At multiple regression analysis, by identifying as dependent variable the 10-year fracture risk for major fracture, after correcting for age, BMI, time since dialysis, AD-SoS, cortical bone thickness, and handgrip strength, only BTT (β = −15.21, SE = 5.91, p = 0.02) and TBS (β = −54.69, SE = 21.88, p = 0.02) turned out as independently associated with fracture risk. In conclusion, hemodialysis patients showed a higher fracture risk and lower surrogate indices of bone strength as TBS and QUS parameters. In this cohort of patients, handgrip strength measurements appeared to be a useful instrument to identify high-fracture-risk subjects.

Published
2022

22. Therapeutic Options in the Management of Aromatase Inhibitor-Associated Bone Loss

Author

Anastasia Xourafa, Rosario Rapisarda, Pietro Castellino, and Agostino Gaudio

Subjects
Oncology, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Osteoporosis, Breast Neoplasms, aromatase inhibitors, Fractures, Bone, Breast cancer, breast cancer, Bone Density, Internal medicine, Tumor Microenvironment, medicine, Humans, Immunology and Allergy, Aromatase, bisphosphonates, Aromatase inhibitor, Bone Density Conservation Agents, Diphosphonates, biology, business.industry, Cancer, aromatase inhibitor-associated bone loss, denosumab, medicine.disease, Radiation therapy, Denosumab, biology.protein, Female, business, bone mineral density, cancer treatment-induced bone loss, Tamoxifen, medicine.drug
Abstract

Background: Breast cancer is the most commonly occurring cancer in women worldwide. Early breast cancer is a kind of invasive neoplasm that has not proliferated beyond the breast or the axillary lymph nodes. Current therapeutic strategies for breast cancer mainly include local therapies such as surgery or radiotherapy and systemic therapies like chemotherapy, endocrine, and targeted therapy. Nowadays, the adjuvant treatment for hormone receptor-positive early breast cancer in postmenopausal women remains the main effective systemic therapy which can improve disease- free survival and overall survival; it involves several endocrine treatment regimens, including Selective Estrogen Receptor Modulators (SERMs), Aromatase Inhibitors (AIs), or a combination of them. AIs have been shown to be more effective in preventing recurrence in postmenopausal women with early breast cancer when compared with tamoxifen, thus representing the standard of care for adjuvant endocrine therapy. Although AIs are usually well-tolerated, they can have some side effects. Apart from the appearance of arthralgias or myalgias and cardiovascular events, AI therapies, reducing already low endogenous postmenopausal estradiol levels, cause increased bone loss and increase fracture risk in postmenopausal women. Objectives: The objective of this review is to evaluate the therapeutic options in the management of Aromatase Inhibitor-Associated Bone Loss (AIBL). Methods: We reviewed the current literature dealing with different therapeutic options in the treatment of AIBL. Results: Clinical practice guidelines recommend a careful evaluation of skeletal health in all women with breast cancer before AI therapy initiation. Adequate calcium and vitamin D intake have also been suggested. Pharmacological attempts to minimize AI-related bone loss have focused on the use of antiresorptive agents, such as bisphosphonates and denosumab to protect bone integrity and reduce the risk of fractures. Furthermore, clinical trials have shown that by making the bone microenvironment less susceptible to breast cancer metastasis, these drugs are able to increase disease- free survival. Conclusions: AI, that are the pillar of the systemic treatment for patients with hormone receptor-- positive breast cancer, are associated with different side effects, and in particular, osteoporosis and fractures. Both bisphosphonates and denosumab are able to prevent this negative effect.

Published
2022

24. Anxiety, depression, chronic inflammation and aortic stiffness in Crohn's disease: the brain--gut--vascular axis

Author

Zanoli L., Tuttolomondo A., Inserra G., Cappello M., Granata A., Malatino L., Castellino P., Cottone S., Di Raimondo D., Fatuzzo P., Gaudio A., Geraci G., Lentini P., Mule G., Pellegriti A., Pinto A., Rapisarda F., Rizzo R., Riguccio G., Scrivo B., Torres D., Xourafa A., Zanoli L., Tuttolomondo A., Inserra G., Cappello M., Granata A., Malatino L., Castellino P., Cottone S., Di Raimondo D., Fatuzzo P., Gaudio A., Geraci G., Lentini P., Mule G., Pellegriti A., Pinto A., Rapisarda F., Rizzo R., Riguccio G., Scrivo B., Torres D., and Xourafa A.

Subjects
medicine.medical_specialty, Physiology, pulse wave velocity, Disease, 030204 cardiovascular system & hematology, Anxiety, Inflammatory bowel disease, 03 medical and health sciences, 0302 clinical medicine, Vascular Stiffness, Crohn Disease, Internal medicine, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, Risk factor, Pulse wave velocity, Depression (differential diagnoses), Aorta, arterial stiffness, inflammation, inflammatory bowel disease, pulse wave velocity, Inflammation, Crohn's disease, business.industry, Depression, medicine.disease, Gastrointestinal Microbiome, Arterial stiffne, arterial stiffness, Cross-Sectional Studies, Arterial stiffness, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Background Patients with Crohn's disease have an increased aortic stiffness, a known cardiovascular risk factor. Anxiety, a key factor of the brain--gut axis in patients with Crohn's disease, is implicated in the pathogenesis and progression of the disease, and is linked with aortic stiffening in other clinical settings. Objectives Considering that depression is frequently linked to anxiety in Crohn's disease, we performed a mediation analysis to reveal the potential link between anxiety, depression and aortic stiffness in these patients. Methods Multicentre observational cross-sectional study of 86 consecutive patients with Crohn's disease and 86 matched control individuals. The connections between anxiety, depression, disease duration, aortic pulse wave velocity (aPWV), brachial and central SBP were tested using partial least squares structural equations modelling. Results In patients with Crohn's disease, anxiety (path coefficient: 0.220, P = 0.01) and disease duration (path coefficient: 0.270, P = 0.02) were associated with aPWV that in turn was associated with brachial SBP (path coefficient: 0.184, P = 0.03). These associations were even stronger in patients with active disease. The connection between anxiety and aPWV was in part mediated by central SBP (indirect effect: 0.090, P = 0.01; indirect-to-total effect ratio: 41%) as well as, in a pilot substudy, by sympathetic hyperactivity. Anxiety and depression were highly correlated in patients with Crohn's disease. Consequently, results were confirmed when anxiety was substituted by depression. Conclusion The connections of anxiety, depression and chronic inflammation with aPWV and SBP could suggest the first evidence of a brain--gut--vascular axis and new potential targets for therapy in patients with Crohn's disease.

Published
2020

26. Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience

Author

Antonino Catalano, Antonino Lasco, Agostino Gaudio, Anastasia Xourafa, Nancy Morabito, and Rosario Rapisarda

Subjects
Peak bone mass, bone turnover, Bone density, Endocrinology, Diabetes and Metabolism, Thalassemia, Osteoporosis, 030209 endocrinology & metabolism, Review, Bioinformatics, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Osteoprotegerin, medicine, Humans, hypogonadism, marrow expansion bone turnover, marrow expansion, lcsh:RC648-665, business.industry, beta-Thalassemia, lcsh:RJ1-570, RANK Ligand, lcsh:Pediatrics, Prognosis, medicine.disease, Deferoxamine, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, thalassemia major, osteoporosis, business, medicine.drug
Abstract

Due to increasing life expectancy in thalassemia major (TM), osteoporosis is emerging as a significant problem. Its aetiology is multifactorial, culminating in increased bone resorption and impaired remodelling. Hypogonadism and marrow expansion seem to play an important role, but iron overload, deferoxamine toxicity, a defective growth hormone-insulin-like growth factor-1 axis and multiple endocrinopathies may represent additional causes of bone damage. Many of these patients, though under appropriate treatment programs, do not achieve normal peak bone mass. The receptor activator of nuclear factor kappa-ß (RANK)/RANK ligand/osteoprotegerin and the Wnt/β-catenin systems work as major mediators of imbalanced bone turnover and bone loss. Additional genetic factors, such as collagen type 1 alpha 1 and vitamin D receptor gene polymorphisms, may exert some influence on the enhanced fracture risk observed in TM. To date, in spite of adequate hormone replacement, chelating therapy and acceptable haemoglobin levels, subjects with TM display impaired bone density and imbalanced bone turnover, thus the puzzle of the pathogenesis of TM-induced osteoporosis remains far from being solved.

Published
2019

28. Hematological Diseases and Osteoporosis

Author

Salvatore Santo Signorelli, Luca Zanoli, Rosario Rapisarda, Anastasia Xourafa, Agostino Gaudio, and Pietro Castellino

Subjects
thalassemia, Osteoporosis, monoclonal gammopathy of undetermined significance (MGUS), 030209 endocrinology & metabolism, Disease, Review, Bioinformatics, Models, Biological, Catalysis, Bone and Bones, Bone remodeling, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, hemophilia, mastocytosis, multiple myeloma, osteoporosis, medicine, Humans, Physical and Theoretical Chemistry, Systemic mastocytosis, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Multiple myeloma, business.industry, Organic Chemistry, General Medicine, Bone fracture, medicine.disease, Hematologic Diseases, Computer Science Applications, lcsh:Biology (General), lcsh:QD1-999, 030220 oncology & carcinogenesis, Secondary osteoporosis, Bone Remodeling, business, Monoclonal gammopathy of undetermined significance
Abstract

Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous hematological diseases that can have a deleterious impact on bone health. In the literature, there is an abundance of evidence of bone involvement in patients affected by multiple myeloma, systemic mastocytosis, thalassemia, and hemophilia; some skeletal disorders are also reported in sickle cell disease. Recently, monoclonal gammopathy of undetermined significance appears to increase fracture risk, predominantly in male subjects. The pathogenetic mechanisms responsible for these bone loss effects have not yet been completely clarified. Many soluble factors, in particular cytokines that regulate bone metabolism, appear to play an important role. An integrated approach to these hematological diseases, with the help of a bone specialist, could reduce the bone fracture rate and improve the quality of life of these patients.

Published
2020

31. Hematological Diseases and Osteoporosis

Author

Gaudio, Agostino, primary, Xourafa, Anastasia, additional, Rapisarda, Rosario, additional, Zanoli, Luca, additional, Signorelli, Salvatore Santo, additional, and Castellino, Pietro, additional

Published
2020
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32. Sclerostin is a possible candidate marker of arterial stiffness: Results from a cohort study in Catania

Author

Carmelo Erio Fiore, Luca Zanoli, Salvatore Santo Signorelli, Giovanni Tringali, Maria Helga Sidoti, Valerio Fiore, Antonino Catalano, Rosario Rapisarda, Agostino Gaudio, and Anastasia Xourafa

Subjects
Male, Cancer Research, Osteoporosis, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, Biochemistry, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Bayesian multivariate linear regression, Medicine, Ultrasonography, education.field_of_study, Confounding, Middle Aged, Augmentation index, CIMT, Dkk1, Pulse wave velocity, Sclerostin, Carotid Arteries, Oncology, Bone Morphogenetic Proteins, Cardiology, Intercellular Signaling Peptides and Proteins, Molecular Medicine, Female, Cohort study, Genetic Markers, medicine.medical_specialty, Sclerostin, Population, 030209 endocrinology & metabolism, Pulse Wave Analysis, 03 medical and health sciences, Vascular Stiffness, Internal medicine, Genetics, Humans, education, Molecular Biology, Adaptor Proteins, Signal Transducing, Aged, Dkk1, business.industry, CIMT, Augmentation index, Atherosclerosis, medicine.disease, Pulse wave velocity, Endocrinology, chemistry, DKK1, Linear Models, Arterial stiffness, business, Biomarkers
Abstract

Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/β-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/β-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults. To this aim, 67 subjects were recruited in the 'Atherosclerosis and osteoporosis: identification of common pathogenetic factors' investigation. Serum sclerostin levels correlated positively with CIMT (r=0.314, p=0.03) and inversely with the augmentation index, a marker of arterial stiffness (r=-0.286, p

Published
2017
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33. Paget's Disease of Bone and Cardiovascular Risk: A Pilot Study

Author

Antonino Catalano, Agostino Gaudio, Anastasia Xourafa, Luca Zanoli, Pietro Castellino, Salvatore Santo Signorelli, and Rosario Rapisarda

Subjects
cardiovascular risk, medicine.medical_specialty, carotid intima-media thickness, pulse wave velocity, Population, Pilot Projects, Disease, Bone remodeling, medicine.artery, Internal medicine, medicine, Humans, Common carotid artery, education, Pulse wave velocity, Pharmacology, education.field_of_study, business.industry, medicine.disease, Osteitis Deformans, Paget's disease of bone, Cardiovascular Diseases, Heart Disease Risk Factors, Arterial stiffness, Cardiology, Population study, Cardiology and Cardiovascular Medicine, business
Abstract

Background: The association between Paget’s disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. Objective: Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB. Methods: We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of PDB was based on clinical, radiological and biochemical parameters. Results: Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased. Conclusion: These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or the high levels of oxidative stress that characterize this population.

Published
2020

34. Anticoagulants and Osteoporosis

Author

Salvatore Scuto, Michele Giusti, Anastasia Xourafa, Elisa Marino, Salvatore Santo Signorelli, and Agostino Gaudio

Subjects
medicine.medical_specialty, Osteoporosis, MEDLINE, Review, 030204 cardiovascular system & hematology, heparin, Bone tissue, Anticoagulant agents, Fracture, Heparin, Low molecular weight heparins (LMWHs), Warfarin, Catalysis, Bone and Bones, Bone remodeling, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, Fractures, Bone, 0302 clinical medicine, Bone Density, Internal medicine, Medicine, Humans, 030212 general & internal medicine, Physical and Theoretical Chemistry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, low molecular weight heparins (lmwhs), Bone mineral, biology, business.industry, Organic Chemistry, Anticoagulants, General Medicine, Venous Thromboembolism, Heparin, Low-Molecular-Weight, anticoagulant agents, medicine.disease, osteoporosis, Computer Science Applications, warfarin, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, fracture, Osteocalcin, biology.protein, business, medicine.drug
Abstract

Anticoagulant agents are widely used in the treatment of thromboembolic events and in stroke prevention. Data about their effects on bone tissue are in some cases limited or inconsistent (oral anti-vitamin K agents), and in others are sufficiently strong (heparins) to suggest caution in their use in subjects at risk of osteoporosis. This review analyses the effects of this group of drugs on bone metabolism, on bone mineral density, and on fragility fractures. A literature search strategy was developed by an experienced team of specialists by consulting the MEDLINE platform, including published papers and reviews updated to March 2019. Literature supports a detrimental effect of heparin on bone, with an increase in fracture rate. Low molecular weight heparins (LMWHs) seem to be safer than heparin. Although anti-vitamin K agents (VKAs) have a significant impact on bone metabolism, and in particular, on osteocalcin, data on bone mineral density (BMD) and fractures are contrasting. To date, the new direct oral anticoagulants (DOACs) are found to safe for bone health.

Published
2019

35. Bone islands

Author

Gaudio, A, Rapisarda, R, Xourafa, A, Gorgone, C, Mattina, T, and Castellino, P.

Published
2019

36. A strange case of dyspnoea

Author

Rosario Rapisarda, Pietro Castellino, Agostino Gaudio, Federica Patanè, Andrea Ruben Murabito, Anastasia Xourafa, and Sergio Bagnato

Subjects
Pulmonary and Respiratory Medicine, Parsonage–Turner syndrome, medicine.medical_specialty, Case Report, Disease, Electromyography, 03 medical and health sciences, 0302 clinical medicine, Electroneuronography, Dyspnoea, medicine, Right shoulder pain, Neuralgic amyotrophy, lcsh:RC705-779, medicine.diagnostic_test, business.industry, Parsonage-turner syndrome, lcsh:Diseases of the respiratory system, medicine.disease, Surgery, 030228 respiratory system, 030220 oncology & carcinogenesis, Presentation (obstetrics), business, Brachial plexus
Abstract

Acquired neuralgic amyotrophy, described for the first time by Parsonage and Turner, is a rare idiopathic disease that may occur in otherwise normal healthy individuals. It typically begins with sudden, unilateral shoulder pain that may also involve the neck and/or arm. Less frequently, the disease involves nerves other than those of the brachial plexus, such as phrenic nerves, resulting in dyspnoea. The diagnosis is based on the clinical presentation and is generally supported by electroneurography/electromyography. We report the case of a 45-year-old white man who was referred to our clinic for acute dyspnoea preceded by severe neck and right shoulder pain. Corticosteroid therapy ameliorated the clinical picture, but without a complete recovery. Keywords: Dyspnoea, Parsonage-turner syndrome, Neuralgic amyotrophy

Published
2019

37. Peripheral artery disease and osteoporosis: Not only age‑related (Review)

Author

Salvatore Santo Signorelli, Rosario Rapisarda, Pietro Castellino, Agostino Gaudio, and Anastasia Xourafa

Subjects
Cancer Research, Hypovitaminosis D, Osteoporosis, Osteoprotegerin, PAD, Sclerostin, Animals, Atherosclerosis, Biomarkers, Humans, Peripheral Arterial Disease, Risk Factors, Signal Transduction, Biochemistry, Molecular Medicine, Molecular Biology, Genetics, Oncology, 030209 endocrinology & metabolism, Disease, Review, sclerostin, 030204 cardiovascular system & hematology, Bioinformatics, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, medicine, Stroke, biology, business.industry, Wnt signaling pathway, Cancer, medicine.disease, Molecular medicine, osteoporosis, RANKL, osteoprotegerin, hypovitaminosis D, biology.protein, business
Abstract

Osteoporosis and atherosclerosis are two chronic degenerative diseases that share several biochemical pathways and risk factors. Previous studies have associated osteoporosis with carotid atherosclerosis, cardiovascular mortality and stroke, but data on the relationship with peripheral artery disease are few and conflicting. The OPG/RANK/RANKL system and Wnt/beta catenin signaling seem to be deeply involved in the pathogenesis of bone alterations and atherosclerotic processes also affect arteries of the lower extremities. Hypovitaminosis D could also play a role in the relationship of these two diseases. New and larger studies are necessary to shed light on this association and to design new drugs able to act in both these chronic degenerative diseases.

Published
2018

38. Anticoagulants and Osteoporosis

Author

Signorelli, Salvatore Santo, primary, Scuto, Salvatore, additional, Marino, Elisa, additional, Giusti, Michele, additional, Xourafa, Anastasia, additional, and Gaudio, Agostino, additional

Published
2019
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42. Pathogenesis of Thalassemia Major-Associated Osteoporosis: Review of the Literature and Our Experience

Author

Anastasia Xourafa, Agostino Gaudio, Antonino Catalano, Rosario Rapisarda, Nancy Morabito, and Antonino Lasco

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Thalassemia, Osteoporosis, medicine.disease, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pediatrics, Perinatology and Child Health, medicine, hypogonadism, marrow expansion bone turnover, osteoporosis, thalassemia major, business, 030217 neurology & neurosurgery, 030215 immunology
Published
2018

43. A rare cause of leg pain

Author

Gaudio, Agostino, Rapisarda, Rosario, Xourafa, Anastasia, Zanoli, Luca, Castellino, Pietro, and Fiore, Carmelo Erio

Subjects
Diabetes and Metabolism, Endocrinology, Sclerosing bone dysplasias, Internal Medicine, Leg pain, Ribbing disease, Endocrinology, Diabetes and Metabolism
Published
2018

44. A strange case of dyspnoea

Author

Gaudio, Agostino, primary, Murabito, Andrea Ruben, additional, Xourafa, Anastasia, additional, Patanè, Federica, additional, Rapisarda, Rosario, additional, Bagnato, Sergio, additional, and Castellino, Pietro, additional

Published
2019
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45. Familiar osteopoikilosis: Case report with differential diagnosis and review of the literature.

Author

Gaudio, Agostino, Xourafa, Anastasia, Rapisarda, Rosario, Gorgone, Cristina, Gnoli, Maria, Pedrini, Elena, Sangiorgi, Luca, Catalano, Antonino, Zanoli, Luca, Mattina, Teresa, and Castellino, Pietro

Subjects
COMPACT bone, DIFFERENTIAL diagnosis, BONE diseases, GENETIC mutation
Abstract

Osteopoikilosis (OP) is a rare autosomal dominant sclerosing bone disease, caused by heterozygous mutations in the LEMD3 gene. It is characterised by numerous focal lamellar bone compact deposits in the spongiosa. In this case report, we describe a famliar case of OP and review the literature. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Quantitative ultrasound and DXA measurements in aromatase inhibitor-treated breast cancer women receiving denosumab

Author

Rita Maria Agostino, Marco Atteritano, Anastasia Xourafa, Antonino Lasco, G. Natale, Elisabetta Morini, Agostino Gaudio, Giorgio Basile, Antonino Catalano, and Nunziata Morabito

Subjects
medicine.medical_specialty, Bone turnover, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Urology, 030209 endocrinology & metabolism, Breast Neoplasms, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Breast cancer, Absorptiometry, Photon, Bone Density, medicine, Bone mineral density, Humans, 030212 general & internal medicine, Prospective Studies, Aromatase, Osteoporosis, Postmenopausal, Femoral neck, Ultrasonography, Aromatase inhibitor, biology, Bone Density Conservation Agents, business.industry, Aromatase Inhibitors, Ultrasound, Middle Aged, medicine.disease, Quantitative ultrasound, Postmenopause, Denosumab, medicine.anatomical_structure, Aromatase inhibitors, biology.protein, Female, Radiology, Bone Remodeling, business, medicine.drug
Abstract

Denosumab has been proven to reduce fracture risk in breast cancer (BC) women under aromatase inhibitors (AIs). Quantitative ultrasound (QUS) provides information on the structure and elastic properties of bone. Our aim was to assess bone health by phalangeal QUS and by dual-energy X-ray absorptiometry (DXA), and to evaluate bone turnover in AIs-treated BC women receiving denosumab. 35 Postmenopausal BC women on AIs were recruited (mean age 61.2 ± 4.5 years) and treated with denosumab 60 mg administered subcutaneously every 6 months. Phalangeal QUS parameters [Amplitude Dependent Speed of Sound (AD-SoS), Ultrasound Bone Profile Index (UBPI), Bone Transmission Time (BTT)] and DXA at lumbar spine and femoral neck were performed. Serum C-telopeptide of type 1 collagen (CTX) and bone-specific alkaline phosphatase (BSAP) were also measured. The main outcomes were compared with a control group not receiving denosumab (n = 39). In patients treated with denosumab, differently from controls, QUS and DXA measurements improved after 24 months, and a reduction of CTX and BSAP was detected at 12 and 24 months in comparison to baseline (P

Published
2017

49. Bone health assessment by quantitative ultrasound and dual-energy x-ray absorptiometry in postmenopausal women with breast cancer receiving aromatase inhibitors

Author

Antonino Catalano, Elisabetta Morini, Giuseppe Natale, Marco Atteritano, Agostino Gaudio, Giorgio Basile, Anastasia Xourafa, Antonino Lasco, Rita Maria Agostino, Nunziata Morabito, and Vincenzo Adamo

Subjects
medicine.medical_specialty, FRAX, Bone density, General Mathematics, Urology, 030209 endocrinology & metabolism, Breast Neoplasms, Lumbar vertebrae, Bone remodeling, 03 medical and health sciences, Finger Phalanges, 0302 clinical medicine, Breast cancer, Absorptiometry, Photon, Bone Density, Risk Factors, medicine, Humans, Prospective Studies, Prospective cohort study, Dual-energy X-ray absorptiometry, Osteoporosis, Postmenopausal, Femoral neck, Aged, Ultrasonography, Gynecology, Lumbar Vertebrae, medicine.diagnostic_test, business.industry, Aromatase Inhibitors, Femur Neck, Applied Mathematics, Obstetrics and Gynecology, Middle Aged, medicine.disease, Postmenopause, medicine.anatomical_structure, Medicine (all), quantitative ultrasound, dual-energy x-ray absorptiometry, breast cancer, aromatase inhibitors, 030220 oncology & carcinogenesis, Case-Control Studies, Female, Bone Remodeling, business
Abstract

OBJECTIVE Phalangeal quantitative ultrasound (QUS) measurements provide surrogate information on bone quality. The aim of the present study was to assess bone status by phalangeal QUS and by dual-energy x-ray absorptiometry (DXA), and to evaluate bone turnover in breast cancer (BC) women receiving aromatase inhibitors (AIs). METHODS Sixty postmenopausal BC women and 42 matched controls were recruited (mean age 61.64 ± 8.33 y). Amplitude-dependent speed of sound (AD-SoS), bone transmission time (BTT), Ultrasound Bone Profile Index, as QUS parameters, L1-L4 and femoral neck BMD by DXA were assessed at baseline and after 18 months; serum bone-specific alkaline phosphatase (BSAP) and C-telopeptide of type 1 collagen were measured at baseline, 9 and 18 months. RESULTS FRAX (without BMD) derived 10-years probability of major fractures and hip fractures were significantly associated with AD-SoS (r = -0.381, P =

Published
2017

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