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Your search keyword '"Xu, Chun-Miao"' showing total 14 results
Start Over Author "Xu, Chun-Miao"
14 results on '"Xu, Chun-Miao"'

3. Continuous magnetic separation microfluidic chip for tumor cell in vivo detection.

Author

Tang, Man, Feng, Jiao, Xia, Hou-Fu, Xu, Chun-Miao, Wu, Ling-Ling, Wu, Min, Hong, Shao-Li, Chen, Gang, and Zhang, Zhi-Ling

Subjects
MAGNETIC separation, BLOOD circulation, IMMUNOMAGNETIC separation, METASTASIS, BLOOD cells
Abstract

Continuously recording the dynamic changes of circulating tumor cells (CTCs) is crucial for tumor metastasis. This paper creates a continuous magnetic separation microfluidic chip that enables rapid and continuous in vivo cell detection. The chip shows its potential to study tumor cell circulation in the blood, offering a new platform for studying the cellular mechanism of tumor metastasis. [ABSTRACT FROM AUTHOR]

Published
2023
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13. One-to-Many Single Entity Electrochemistry Biosensing for Ultrasensitive Detection of microRNA

Author

Bai, Yi-Yan, Wu, Zhen, Xu, Chun-Miao, Zhang, Li, Feng, Jiao, Pang, Dai-Wen, and Zhang, Zhi-Ling

Abstract

Single-entity electrochemistry (SEEC), a promising method for biosensing, has an intrinsic limitation on sensitivity since at most one colliding entity can be successfully triggered by one target. Here, we take advantage of one-to-many (1:n) signal amplification to develop a new single-entity electrochemistry biosensing (SEECBS), integrating satellite magnetic nanoparticle (MN)-DNA-Pt nanoparticle (NP) conjugates, duplex-specific nuclease (DSN) assisted Pt NPs releasing with stabilization, and effective collision of small sized and nearly naked Pt NPs. Compared with conventional SEECBS, the 1:nSEECBS can successfully enrich ∼2 nM Pt NPs by adding 50 aM microRNA (miRNA), in other words, ∼4 × 107Pt NPs can be triggered by one target. The proposed SEECBS allows the detection of 47 aM miRNA-21, nearly 6 orders of magnitude lower than the previous work, and discrimination of nontarget miRNAs containing even single-nucleotide mismatch. Besides, this method has also been successfully demonstrated for quantification of miRNA in different cell lines. Therefore, the proposed method holds great potential for the application of SEECBS in early diagnosis and prognosis monitoring of cancer.

Published
2020
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