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49. Structural Color Colloidal Photonic Crystals for Biomedical Applications.

Author

Zhang, Wenhui, Hu, Yangnan, Feng, Pan, Li, Zhe, Zhang, Hui, Zhang, Bin, Xu, Dongyu, Qi, Jieyu, Wang, Huan, Xu, Lei, Li, Zhou, Xia, Ming, Li, Jilai, Chai, Renjie, and Tian, Lei

Subjects
PHOTONIC crystals, STRUCTURAL colors, COLLOIDAL crystals, OPTICAL materials, DIELECTRIC materials
Abstract

Photonic crystals are a new class of optical microstructure materials characterized by a dielectric constant that varies periodically with space and features a photonic bandgap. Inspired by natural photonic crystals such as butterfly scales, a series of artificial photonic crystals are developed for use in integrated photonic platforms, biosensing, communication, and other fields. Among them, colloidal photonic crystals (CPCs) have gained widespread attention due to their excellent optical properties and advantages, such as ease of preparation and functionalization. This work reviews the classification and self‐assembly principles of CPCs, details some of the latest biomedical applications of large‐area, high‐quality CPCs prepared using advanced self‐assembly methods, summarizes the existing challenges in CPC construction and application, and anticipates future development directions and optimization strategy. With further advancements, CPCs are expected to play a more critical role in biosensors, drug delivery, cell research, and other fields, bringing significant benefits to biomedical research and clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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50. PEDOT‐Integrated Fish Swim Bladders as Conductive Nerve Conduits.

Author

Zhang, Hui, Xu, Dongyu, Zhang, Bin, Li, Xiaofan, Li, Minli, Zhang, Chen, Wang, Huan, Zhao, Yuanjin, and Chai, Renjie

Subjects
*NERVOUS system regeneration, *FISH locomotion, *NEURAL stimulation, *DORSAL root ganglia, *NERVES, *BLADDER
Abstract

Advanced artificial nerve conduits offer a promising alternative for nerve injury repair. Current research focuses on improving the therapeutic effectiveness of nerve conduits by optimizing scaffold materials and functional components. In this study, a novel poly(3,4‐ethylenedioxythiophene) (PEDOT)‐integrated fish swim bladder (FSB) is presented as a conductive nerve conduit with ordered topology and electrical stimulation to promote nerve regeneration. PEDOT nanomaterials and adhesive peptides (IKVAV) are successfully incorporated onto the decellularized FSB substrate through pre‐coating with polydopamine. The obtained PEDOT/IKVAV‐integrated FSB substrate exhibits outstanding mechanical properties, high electrical conductivity, stability, as well as excellent biocompatibility and bioadhesive properties. In vitro studies confirm that the PEDOT/IKVAV‐integrated FSB can effectively facilitate the growth and directional extension of pheochromocytoma 12 cells and dorsal root ganglion neurites. In addition, in vivo experiments demonstrate that the proposed PEDOT/IKVAV‐integrated FSB conduit can accelerate defective nerve repair and functional restoration. The findings indicate that the FSB‐derived conductive nerve conduits with multiple regenerative inducing signals integration provide a conducive milieu for nerve regeneration, exhibiting great potential for repairing long‐segment neural defects. [ABSTRACT FROM AUTHOR]

Published
2024
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