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The genetic algorithm-assisted musical composition combines evolutionary computational techniques and artistic composition. In this article, the evolution of musical compositions based on traditional genetic algorithm compositions is combined with interactive genetic algorithm techniques, mainly in model music innovation, using a genetic algorithm to generate an initial population with real number encoding of all individuals. The article focuses on studying the fitness function used to automatically evaluate the automatically generated melodies, perform evolutionary operations on the generated melodies, and generate high-quality model music melodies based on the treatment of evolutionary operations. The evaluation time of the generated melodies by the improved model is reduced from 4 minutes to 0.002 seconds, which makes the composer much more efficient in performing model music composition. The evaluation data of 16 pieces before and after the genetic manipulation were also compared, and it was found that the system evaluated the music after the genetic manipulation significantly higher than the music without the genetic manipulation. The different forms of musical compositions created by the composing system developed based on the technical research of computer genetic algorithm-assisted model music innovation are also a useful supplement to composers’ creations and open a new chapter for the field of artificial intelligence.

The cathode interlayer (CIL) plays a crucial role in organic solar cells (OSCs), which can establish an Ohmic contact between the active layer and the electrode, lower the electron extraction barriers, and minimize the charge carrier recombination. The CIL modification is a useful strategy for improving the performance of OSCs. Herein, an inexpensive water–alcohol‐soluble material known as L‐Arginine (L‐Arg) is introduced as a modifier for the PFN‐Br CIL, leading to successful optimization of the CIL quality. Following L‐Arg modification, the work function of the CIL is lowered and the electron extraction is facilitated. L‐Arg assists in exciton dissociation while suppressing both bimolecular and trap‐assisted recombination processes. The modified CIL establishes superior contact with the metal electrode due to its enhanced hydrophilicity, which helps electron collection. Consequently, the average power conversion efficiency increases from 10.54% in the reference device to 11.17% in the optimally doped device. [ABSTRACT FROM AUTHOR]

Cutaneous adverse events are commonly experienced with use of tyrosine kinase inhibitors in the treatment of leukemia and typically include nonspecific cutaneous eruptions and xerosis. We report the case of a man who experienced an ichthyosiform drug eruption while taking ponatinib, a third-generation tyrosine kinase inhibitor. Disruption of epidermal growth pathways through inhibition of various receptor tyrosine kinases by ponatinib may offer insights into the pathophysiologic mechanisms behind acquired ichthyosis.

A new type of special machine tool for stripper sleeve was developed according to the stripper sleeve process of composite board. In order to ensure the reliability of the mainframe structure and the performance of the linear guide mechanism, the static structural analysis and modal analysis of the mainframe are carried out. The results show that the maximum stress of the supporting beam under the main frame is about 48.18 MPa, the maximum strain is 0.00023, and the maximum stress of the four-legged column is about 5.35 MPa, which is full of strength and stiffness design requirements. The end-cutting mechanism is installed on the beam through the installation plate. The deformation of the beam has a great influence on the operation accuracy of the linear guide mechanism and the cutting accuracy of the end-cutting mechanism. The maximum displacement in the X and Y directions of the installation plate is 0.014 mm, 0.030 mm and 0.197 mm, respectively, which meets the normal use requirements and cutting accuracy requirements of the linear guide mechanism. The first six natural frequencies of the mainframe are 2.963 – 47.137 Hz. In order to make the mainframe have good dynamic characteristics, avoid resonance and meet the end-cutting requirements of the composite board, the motor speed should be controlled between 300 – 493 r / min.