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635 results on '"Xu, Hong‐Tao"'

3. Application of Microhaplotypes in Sibling Kinship Testing

Author

Xuan TANG, Dan WEN, Chu-dong WANG, Ru-yi XU, Hong-tao JIA, Jie-nan LI, Bai-yi-la ZHALAGA

Subjects
forensic genetics, microhaplotype, sibling, full sibling, half sibling, autosomes, likelihood ratio method, reference sample, Medicine
Abstract

Objective To investigate the efficacy of different numbers of microhaplotype (MH) loci and the introduction of different reference samples on the identification of full sibling, half sibling and differentiation between full sibling and half sibling kinships, and to explore the effect of changing mutation rate on sibling testing. Methods First, a family map involving three generations was established, and four full sibling identification models, five half sibling identification models and five models distinguishing full and half siblings were constructed for different reference samples introduced. Based on the results of the previous study, two sets of nonbinary SNP-MH containing 34 and 54 loci were selected. Based on the above MH loci, 100 000 pairs of full sibling vs. unrelated individuals, 100 000 pairs of half sibling vs. unrelated individuals and 100 000 pairs of full sibling vs. half sibling were simulated based on the corresponding sibling kinship testing models, and the efficacy of each sibling kinship testing model was analyzed by the likelihood ratio algorithm under different thresholds. The mutant rate of 54 MH loci was changed to analyze the effect of mutation rate on sibling identification. Results In the same relationship testing model, the systematic efficacy of sibling testing was positively correlated with the number of MH loci detected. With the same number of MH loci, the efficacy of full sibling testing was better than that of uncle or grandfather when the reference sample introduced was a full sibling of A, but there was no significant difference in the identification efficacy of the four reference samples introduced for full sibling and half sibling differentiation testing. In addition, the mutation rate had a slight effect on the efficacy of sibling kinship testing. Conclusion Increasing the number of MH loci and introducing reference samples of known relatives can increase the efficacy of full sibling testing, half sibling testing, and differentiation between full and half sibling kinships. The level of mutation rate in sibling testing by likelihood ratio method has a slight but insignificant effect on the efficacy.

Published
2023
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32. Thymic lipofibroadenomas: Three case reports

Author

Yang, Mai-Qing, primary, Wang, Zhi-Qiang, additional, Chen, Li-Qian, additional, Gao, Su-Mei, additional, Fu, Xing-Ning, additional, Zhang, Hai-Ning, additional, Zhang, Ke-Xin, additional, and Xu, Hong-Tao, additional

Published
2023
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39. New compounds from Patrinia villosa Juss. and their anti-inflammatory activities.

Author

Huang, Le yi, Sun, Yu zheng, Chen, Qian qian, Bai, Xu lan, Du, Ting ting, Xu, Hong tao, and Chou, Gui xin

Subjects
ANTI-inflammatory agents, IRIDOIDS, MONOTERPENES, X-ray diffraction, NITRIC oxide, AMINOGUANIDINE
Abstract

Five new iridoids, patriscabioins M-Q and a new monoterpene, eldanolide acid, together with three known iridoids, were isolated from the 95% aqueous EtOH extract whole plants of Patrinia villosa Juss. The structures were established by a variety of spectroscopic analysis, such as IR, 1 D and 2 D NMR spectra, MS, ECD and X-ray diffraction data. Bioactivity screening revealed the inhibitory effects on nitric oxide (NO) production of them in lipopolysaccharide-activated RAW264.7 cells with Aminoguanidine Hydrochloride as the positive control. Among them, patriscabioin M (1), patriscabioin N (2), patriscabioin P (4), patriscabioin Q (5), 8,9-didehydro-7-hydroxydolichodia (7) were found to markedly reduce LPS-induced NO production in murine macrophage cells with IC50 values of 18.14, 18.93, 22.00, 13.64, 26.48 μM, respectively. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Research on Remote Upgrade Method of Distributed Load Balancing for Power Monitoring Terminal

Author

Yi-Qin Bao Yi-Qin Bao, Hao Zheng Qiang Zhao, Wen-Bin Xu Hong-Tao Zhang, Hong-Tao Zhang Hao Zheng, Qiang Zhao Yi-Qin Bao, and Zheng-Tang Sun Wen-Bin Xu

Subjects
Upgrade, General Computer Science, Terminal (electronics), Computer science, business.industry, Electrical engineering, Load balancing (electrical power), business, Power (physics)
Abstract

With the increasing application of power monitoring terminal and the increasing demand for its function, it is necessary to upgrade the field embedded software remotely.The existing online upgrade schemes generally deal with the terminals one by one, and there are also distributed upgrade schemes. However, due to the large differences in the communication performance of terminals in different places, there is a problem of load imbalance, resulting in the low efficiency of the whole upgrade. Aiming at the efficiency of remote online upgrade of power monitoring terminal, a distributed load balancing remote upgrade method is proposed. The power monitoring terminal is upgraded at the same time through the cloud platform, and the genetic algorithm is used for load balancing processing, so as to improve the efficiency. The practical results show that this remote upgrade method improves the upgrade efficiency of the terminal by comparing a variety of upgrade schemes, compared with no load balancing method, the average time of upgrading a terminal is reduced by 36%, which achieves good application effect in practical application.

Published
2021

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