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21 results on '"Xu, Hongshan"'

5. Gradient Hydrogels Spatially Trapped Optical Cell Profiling for Quantitative Blood Cellular Osmotic Analysis

Author

Liu, Yantong, primary, Yu, Le, additional, Chen, Longfei, additional, Chen, Keyu, additional, Xu, Hongshan, additional, Chen, Ming, additional, Yi, Kezhen, additional, Li, Ying, additional, Chen, Ting, additional, Wang, Faxi, additional, Wang, Fang, additional, Zhu, Jiaomeng, additional, Wang, Fubing, additional, Xiao, Xuan, additional, and Yang, Yi, additional

Published
2024
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9. Valve-Adjustable Optofluidic Bio-Imaging Platform for Progressive Stenosis Investigation

Author

Chen, Longfei, primary, Yu, Le, additional, Liu, Yantong, additional, Xu, Hongshan, additional, Li, Wei, additional, Wang, Fang, additional, Zhu, Jiaomeng, additional, Yi, Kezhen, additional, Ma, Linlu, additional, Xiao, Hui, additional, Zhou, Fuling, additional, Chen, Ming, additional, Cheng, Yanxiang, additional, Wang, Fubing, additional, Zhu, Chengliang, additional, Xiao, Xuan, additional, and Yang, Yi, additional

Published
2023
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11. Heterologous prime-boost immunisation with mRNA- and AdC68-based 2019-nCoV variant vaccines induces broad-spectrum immune responses in mice

Author

Li, Xingxing, primary, Liu, Jingjing, additional, Li, Wenjuan, additional, Peng, Qinhua, additional, Li, Miao, additional, Ying, Zhifang, additional, Zhang, Zelun, additional, Liu, Xinyu, additional, Wu, Xiaohong, additional, Zhao, Danhua, additional, Yang, Lihong, additional, Cao, Shouchun, additional, Huang, Yanqiu, additional, Shi, Leitai, additional, Xu, Hongshan, additional, Wang, Yunpeng, additional, Yue, Guangzhi, additional, Suo, Yue, additional, Nie, Jianhui, additional, Huang, Weijin, additional, Li, Jia, additional, and Li, Yuhua, additional

Published
2023
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14. Combining intramuscular and intranasal homologous prime-boost with a chimpanzee adenovirus-based COVID-19 vaccine elicits potent humoral and cellular immune responses in mice

Author

Li, Xingxing, primary, Wang, Ling, additional, Liu, Jingjing, additional, Fang, Enyue, additional, Liu, Xiaohui, additional, Peng, Qinhua, additional, Zhang, Zelun, additional, Li, Miao, additional, Liu, Xinyu, additional, Wu, Xiaohong, additional, Zhao, Danhua, additional, Yang, Lihong, additional, Li, Jia, additional, Cao, Shouchun, additional, Huang, Yanqiu, additional, Shi, Leitai, additional, Xu, Hongshan, additional, Wang, Yunpeng, additional, Suo, Yue, additional, Yue, Guangzhi, additional, Nie, Jianhui, additional, Huang, Weijin, additional, Li, Wenjuan, additional, and Li, Yuhua, additional

Published
2022
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16. Space Time-Based Optofluidic Imaging Analyser for Intelligent Blood Coagulation Diagnosis

Author

Chen, Longfei, primary, Yu, Le, additional, Liu, Yantong, additional, Xu, Hongshan, additional, Ma, Linlu, additional, Tian, Pengfu, additional, Zhu, Jiaomeng, additional, Wang, Fang, additional, Yi, Kezhen, additional, Xiao, Hui, additional, Zhou, Fuling, additional, Yang, Yi, additional, Cheng, Yanxiang, additional, Bai, Long, additional, Wang, Fubing, additional, and Zhu, Yimin, additional

Published
2022
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21. An mRNA vaccine against rabies provides strong and durable protection in mice.

Author

Li M, Fang E, Wang Y, Shi L, Li J, Peng Q, Li X, Zhao D, Liu X, Liu X, Liu J, Xu H, Wang H, Huang Y, Yang R, Yue G, Suo Y, Wu X, Cao S, and Li Y

Subjects
United States, Animals, Humans, Mice, Antibodies, Viral, Antibodies, Neutralizing, Rabies prevention & control, Rabies Vaccines genetics, Rabies virus genetics
Abstract

Introduction: Rabies is a serious public health problem worldwide for which an effective treatment method is lacking but can be prevented by vaccines. Current vaccines are produced in cell or egg cultures, which are both costly and time consuming., Methods: Here, a non-replicating mRNA vaccine (RV021) encoding the rabies virus glycoprotein was developed in vitro , and its immunogenicity and protective efficacy against live virus was evaluated in mice., Results: A two-dose vaccination with 1 μg of RV021 at 7-day intervals induced a protective level of neutralizing antibody that was maintained for at least 260 days. RV021 induced a robust cellular immune response that was significantly superior to that of an inactivated vaccine. Two doses of 1 μg RV021 provided full protection against challenge with CVS of 30~60-fold lethal dose, 50%. Vaccine potency testing (according to the National Institutes of Health) in vivo revealed that the potency of RV021 at 15 μg/dose was 7.5 IU/dose, which is substantially higher than the standard for lot release of rabies vaccines for current human use., Conclusion: The mRNA vaccine RV021 induces a strong protective immune response in mice, providing a new and promising strategy for human rabies prevention and control., Competing Interests: Authors ML and XHL were educated in Vaccines R&D Department, Changchun Institute of Biological Products Co. Ltd. as post-graduate students. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Li, Fang, Wang, Shi, Li, Peng, Li, Zhao, Liu, Liu, Liu, Xu, Wang, Huang, Yang, Yue, Suo, Wu, Cao and Li.)

Published
2023
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