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328 results on '"Xu, Kai-Lin"'

6. Impact of prophylactic/preemptive donor lymphocyte infusion and intensified conditioning for relapsed/refractory leukemia: a real-world study

Author

Wang, Yu, Liu, Qi-Fa, Wu, De-Pei, Wang, Jing-Bo, Zhang, Xi, Wang, Heng-Xiang, Gao, Feng, Wang, Shun-Qing, Sun, Zi-Min, Ouyang, Jian, Xu, Kai-Lin, Gao, Su-Jun, Xu, Lan-Ping, Yan, Chen-Hua, and Huang, Xiao-Jun

Abstract

Prophylactic/preemptive donor lymphocyte infusion (p/pDLI) and intensified conditioning have shown promising results in experimental studies of refractory/relapsed acute leukemia (RRAL), but real-world data remain scarce. We conducted a multicenter, population-based analysis of 932 consecutive patients. The three-year leukemia-free survival (LFS) rates were 56% for patients receiving both p/pDLI and intensified myeloablative conditioning (MAC) (intenseMAC) and 30% for those who received neither therapy per landmark analysis. Multivariable analyses were run separately for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), and p/pDLI treatment was linked to significantly higher LFS than non-DLI for both AML and ALL patients without increasing the nonrelapse mortality. IntenseMAC was associated with significantly lower relapse and higher LFS than nonintensified MAC despite higher nonrelapse mortality rates in ALL, while there was no impact of intenseMAC observed in AML. p/pDLI achieved superior outcomes in both matched-sibling donor (MSD) and haploidentical donor transplantation, while intenseMAC only influenced MSD outcomes. Data suggest that RRAL patients receiving “total therapy” by way of p/pDLI and intensified conditioning treatment have an improved chance for LFS, with p/pDLI being safer with a more extensive impact relative to intenseMAC. Patients with RRAL can tolerate both interventions and achieve a reasonable outcome.

Published
2024
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24. Treatment outcome of 301 aplastic anemia patients in China: a 10-year follow-up and real-world data from single institute experience

Author

Zhang, Xiao-tian, primary, Wang, Xue, additional, Cao, Jiang, additional, Chen, Wei, additional, Qi, Kun-ming, additional, Qi, Na, additional, Liang, Fei, additional, Dong, Xue-yan, additional, Tang, Guo-feng, additional, Li, De-peng, additional, Sang, Wei, additional, Li, Zhen-yu, additional, Cheng, Hai, additional, and Xu, Kai-lin, additional

Published
2021
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32. Oral arsenic plus retinoic acid versus intravenous arsenic plus retinoic acid for non-high-risk acute promyelocytic leukaemia: a non-inferiority, randomised phase 3 trial

Author

Zhu, Hong-Hu, primary, Wu, De-Pei, additional, Du, Xin, additional, Zhang, Xi, additional, Liu, Lin, additional, Ma, Jun, additional, Shao, Zong-Hong, additional, Ren, Han-Yun, additional, Hu, Jian-Da, additional, Xu, Kai-Lin, additional, Wang, Jing-Wen, additional, Song, Yong-Ping, additional, Fang, Mei-Yun, additional, Li, Juan, additional, Yan, Xiao-Yan, additional, and Huang, Xiao-Jun, additional

Published
2018
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36. Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase‐3‐mediated cleavage of the AML1‐ETO oncoprotein

Author

Cao, Jiang, primary, Feng, Hao, additional, Ding, Ning‐Ning, additional, Wu, Qing‐yun, additional, Chen, Chong, additional, Niu, Ming‐Shan, additional, Chen, Wei, additional, Qiu, Ting‐Ting, additional, Zhu, Hong‐Hu, additional, and Xu, Kai‐Lin, additional

Published
2016
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40. Dihydroartemisinin‑induced apoptosis in human acute monocytic leukemia cells.

Author

Cao, Jia-Tian, Mo, Hui-Min, Wang, Yue, Zhao, Kai, Zhang, Tian-Tian, Wang, Chang-Qian, Xu, Kai-Lin, and Han, Zhi-Hua

Subjects
LEUKEMIA treatment, LEUKEMIA genetics, ARTEMISININ derivatives, GENE expression, APOPTOSIS, CANCER cells
Abstract

Dihydroartemisinin (DHA) is a derivative of artemisinin. The present study aimed to investigate whether DHA induces apoptosis in the THP‑1 human acute monocytic leukemia cell line (AMoL), and to identify the relative molecular mechanisms. The results of the present study demonstrated that the viability of THP‑1 cells were inhibited by DHA in a dose‑ and time‑dependent manner, which was accompanied by morphological characteristics associated with apoptosis. After 24 h of 200 μM DHA treatment, the proportion of apoptotic cells was significantly increased compared with the untreated controls (P<0.01). In addition, DHA downregulated the levels of B‑cell lymphoma (Bcl)‑2, protein kinase B (Akt)1, Akt2 and Akt3 gene expression, and increased the expression of the Bcl‑2‑associated X protein apoptosis regulator. The protein expression of phospho‑Akt and phospho‑extracellular signal‑regulated kinase (ERK) was also decreased, and the protein expression level of cleaved caspase‑3 was increased following treatment with DHA. Therefore, DHA may induce apoptosis in the AMoL THP‑1 cell line via currently unknown underlying molecular mechanisms, including the downregulation of ERK and Akt, and the activation of caspase‑3. [ABSTRACT FROM AUTHOR]

Published
2018
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43. The KOJACH food frequency questionnaire for Chaoshan, China: development and description

Author

Ke, Li, Toshiro, Takezaki, Feng-Yan, Song, Ping, Yu, Xu-Kai, Lin, He-Lin, Yang, Xiao-Ling, Deng, Yu-Qi, Zhang, Lai-Wen, Lv, Xin-En, Huang, and Kazuo, Tajima

Subjects
Adult, Male, Rural Population, China, Urban Population, Reproducibility of Results, Feeding Behavior, Middle Aged, Diet Surveys, Diet Records, Diet, Nutrition Assessment, Surveys and Questionnaires, Humans, Regression Analysis, Female, Life Style
Abstract

This paper aims to develop a data-based Semi-Quantitative Food Frequency Questionnaire (SQFFQ) covering both urban and rural areas in the Chaoshan region of Guangdong Province, China, for the investigation of relationships between food intake and lifestyle-related diseases among middle-aged Chinese. We recruited 417 subjects from the general population and performed an assessment of the diet, using a 3-day weighed dietary record survey. We employed contribution analysis (CA) and multiple regression analysis (MRA) to select food items covering up to a 90% contribution and a 0.90 R2, respectively. The total number of food items consumed was 523 (443 in the urban and 417 in the rural population) and the intake of 29 nutrients was calculated according to the actual consumption by foods/recipes. The CA selected 233, 194 and 183 foods/recipes for the combined, the urban and the rural areas, respectively, and then 196, 157 and 160 were chosen by the MRA. Finally, 125 foods/recipes were selected for the final questionnaire. The frequencies were classified into eight categories and standard portion sizes were also calculated. For adoption of the area-specific SQFFQ, Validity and reproducibility tests are now planned to determine how the combined SQFFQ performs in actual assessment of disease risk and benefit.

Published
2006

44. Development of a semi-quantitative food frequency questionnaire for middle-aged inhabitants in the Chaoshan area, China

Author

Xiao-Ling Deng, Xin-En Huang, Lai-Wen Lv, Yu-Qi Zhang, Tajima Kazuo, Feng-Yan Song, Ping Yu, He-Lin Yang, Takezaki Toshiro, Ke Li, and Xu-Kai Lin

Subjects
Male, Food intake, China, Population, Body Mass Index, Food Preferences, Clinical Research, Reference Values, Environmental health, Surveys and Questionnaires, Humans, Food science, education, education.field_of_study, Gastroenterology, Food frequency questionnaire, Regression analysis, General Medicine, Middle Aged, Geography, Female, Rural area, Rural population, Semi quantitative, Nutritive Value
Abstract

AIM: This paper aims to develop a data-based semi-quantitative food frequency questionnaire (SQFFQ) covering both urban and rural areas in the Chaoshan region of Guang-dong Province, China, for the investigation of relationships between food intake and lifestyle-related diseases among middle-aged Chinese. METHODS: We recruited 417 subjects from the general population and performed an assessment of the diet, using a 3-d weighed dietary record survey. We employed contribution analysis (CA) and multiple regression analysis (MRA) to select food items covering up to a 90% contribution and a 0.90 R2, respectively. The total number of food items consumed was 523 (443 in the urban and 417 in the rural population) and the intake of 29 nutrients was calculated according to the actual consumption by foods/ recipes. RESULTS: The CA selected 233, 194, and 183 foods/recipes for the combined, the urban and the rural areas, respectively, and then 196, 157, and 160 were chosen by the MRA. Finally, 125 foods/recipes were selected for the final questionnaire. The frequencies were classified into eight categories and standard portion sizes were also calculated. CONCLUSION: For adoption of the area-specific SQFFQ, validity and reproducibility tests are now planned to determine how the combined SQFFQ performs in actual assessment of disease risk and benefit.

Published
2005

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