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Your search keyword '"Xu, Liu‐Yue"' showing total 6 results
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6 results on '"Xu, Liu‐Yue"'

2. Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199

Author

Ren, Wen-xiang, primary, Guo, Hao, additional, Lin, Sheng-yan, additional, Chen, Si-yi, additional, Long, Yao-ying, additional, Xu, Liu-yue, additional, Wu, Di, additional, Cao, Yu-lin, additional, Qu, Jiao, additional, Yang, Bian-lei, additional, Xu, Hong-pei, additional, Li, He, additional, Yu, Ya-li, additional, Zhang, An-yuan, additional, Wang, Shan, additional, Zhang, Yi-cheng, additional, Zhou, Ke-shu, additional, Chen, Zhi-chao, additional, and Li, Qiu-bai, additional

Published
2023
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3. Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner

Author

Yang, Bian-lei, Long, Yao-ying, Lei, Qian, Gao, Fei, Ren, Wen-xiang, Cao, Yu-lin, Wu, Di, Xu, Liu-yue, Qu, Jiao, Li, He, Yu, Ya-li, Zhang, An-yuan, Wang, Shan, Wang, Hong-xiang, Chen, Zhi-chao, and Li, Qiu-bai

Abstract

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have obvious advantages over MSC therapy. But the strong procoagulant properties of MSC-EVs pose a potential risk of thromboembolism, an issue that remains insufficiently explored. In this study, we systematically investigated the procoagulant activity of large EVs derived from human umbilical cord MSCs (UC-EVs) both in vitro and in vivo. UC-EVs were isolated from cell culture supernatants. Mice were injected with UC-EVs (0.125, 0.25, 0.5, 1, 2, 4 μg/g body weight) in 100 μL PBS via the tail vein. Behavior and mortality were monitored for 30 min after injection. We showed that these UC-EVs activated coagulation in a dose- and tissue factor-dependent manner. UC-EVs-induced coagulation in vitro could be inhibited by addition of tissue factor pathway inhibitor. Notably, intravenous administration of high doses of the UC-EVs (1 μg/g body weight or higher) led to rapid mortality due to multiple thrombus formations in lung tissue, platelets, and fibrinogen depletion, and prolonged prothrombin and activated partial thromboplastin times. Importantly, we demonstrated that pulmonary thromboembolism induced by the UC-EVs could be prevented by either reducing the infusion rate or by pre-injection of heparin, a known anticoagulant. In conclusion, this study elucidates the procoagulant characteristics and mechanisms of large UC-EVs, details the associated coagulation risk during intravenous delivery, sets a safe upper limit for intravenous dose, and offers effective strategies to prevent such mortal risks when high doses of large UC-EVs are needed for optimal therapeutic effects, with implications for the development and application of large UC-EV-based as well as other MSC-EV-based therapies.

Published
2024
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4. Determination of Organophosphorus Pesticide Residues in Winter Bamboo Shoots by Homogenate Extraction Coupled with Gas Chromatography-Flame Photometric Detector

Author

Feng Qi, Zhu Miao-Qin, Xu Liu-Yue, and Zhu Yu-Xin

Subjects
chemistry.chemical_compound, Chromatography, Bamboo shoots, Chemistry, Detector, Extraction (chemistry), General Medicine, Gas chromatography, Acetonitrile, Organophosphorus pesticides
Abstract

Excessive use of organophosphorus pesticides (OPPs) in fruits and vegetables may affect human health. In this paper, a simple, rapid and effective method for the determination of five OPPs in winter bamboo shoots by gas chromatography-flame photometric detector (GC-FPD) was developed. Three extractants and three extraction methods were examined respectively. The results showed that the recovery rate was higher when the samples were extracted by acetonitrile and treated with homogenate extraction method. Under the optimized conditions, recoveries ranged from 82.12% to 91.48% with the relative standard deviation (RSD) of 1.51-4.20% and the limit of detection (LOD) of 0.005-0.02 μg/mL. Results showed that using acetonitrile as extractants and homogenate extraction in sample preparation is an effective method in determination of pesticide residues in winter bamboo shoots.

Published
2020

6. Illness uncertainty, self‐perceived burden and quality of life in patients with chronic myeloid leukaemia: A cross‐sectional study.

Author

Zhang, Nan, Tang, Xiao‐Qiong, Lu, Kai, Dong, Qian, Kong, Ling‐Na, Jiang, Tian‐Tian, and Xu, Liu‐Yue

Subjects
ACADEMIC medical centers, CHRONIC myeloid leukemia, SELF-perception, CROSS-sectional method, RESEARCH methodology, SELF-evaluation, UNCERTAINTY, ATTITUDES toward illness, PATIENTS' attitudes, SURVEYS, PSYCHOLOGICAL tests, QUALITY of life, QUESTIONNAIRES, FACTOR analysis, DESCRIPTIVE statistics, RESEARCH funding, STATISTICAL sampling, PSYCHOLOGY of the sick
Abstract

Aims and objectives: To investigate the relationship between illness uncertainty, self‐perceived burden and quality of life and explore the mediating role of self‐perceived burden between illness uncertainty and quality of life in patients with chronic myeloid leukaemia. Background: Patients with chronic myeloid leukaemia need long‐term, potentially lifelong therapy to control the disease, which affects their quality of life. There is a need for exploring potentially changeable factors to develop interventions. Little is known about the effects of illness uncertainty and self‐perceived burden on quality of life in this population. Design: A cross‐sectional study. Methods: A convenience sample of 248 patients with chronic myeloid leukaemia was recruited from four university hospitals from February to August 2020. Participants were assessed with the Mishel Uncertainty in Illness Scale, Self‐Perceived Burden Scale, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. The STROBE checklist was used to report the results. Results: Illness uncertainty and self‐perceived burden were negatively associated with quality of life in patients with chronic myeloid leukaemia. Self‐perceived burden partially mediated the relationship between illness uncertainty and quality of life. The indirect effect was −0.101, accounting for 22.9% of the total effect. Conclusion: The findings revealed the relationship between illness uncertainty, self‐perceived burden and quality of life in patients with chronic myeloid leukaemia. Self‐perceived burden exerted a mediating role between illness uncertainty and quality of life in this population. Relevance to clinical practice: This study alerts healthcare providers to pay attention to patients' illness uncertainty and self‐perceived burden, which can contribute to develop effective interventions to improve the quality of life among patients with chronic myeloid leukaemia in the clinical practice. [ABSTRACT FROM AUTHOR]

Published
2022
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