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218 results on '"Xu, Pingwei"'

20. In vitro vascularized liver tumor model based on a microfluidic inverse opal scaffold for immune cell recruitment investigation.

Author

Xu, Pingwei, Chi, Junjie, Wang, Xiaochen, Zhu, Meng, Chen, Kai, Fan, Qihui, Ye, Fangfu, and Shao, Changmin

Subjects
*LIVER tumors, *CHEMOKINE receptors, *OPALS, *LIVER cancer, *TISSUE scaffolds, *HEPATOCELLULAR carcinoma, *CRITICAL currents, *LIVER, *DENDRITIC cells
Abstract

Liver cancer, characterized as a kind of malignant tumor within the digestive system, poses great health harm, and immune escape stands out as an important reason for its occurrence and development. Chemokines, pivotal in guiding immune cells' migration, is necessary to initiate and deliver an effective anti-tumor immune response. Therefore, understanding the chemotactic environment and identifying chemokines that regulate recruitment of immune cells to the tumor microenvironment (TME) are critical to improve current immunotherapy interventions. Herein, we report a well-defined inverse opal scaffold generated with a microfluidic emulsion template for the construction of a vascularized liver tumor model, offering insights into immune cells' recruitment. Due to the excellent 3D porous morphology of the inverse opal scaffold, human hepatocellular carcinoma cells can aggregate in the pores of the scaffold to form uniform multicellular tumor spheroids. More attractively, the vascularized liver tumor model can be achieved by constructing a 3D co-culture system involving endothelial cells and hepatocellular carcinoma cells. The results demonstrate that the 3D co-cultured tumor cells increase the neutrophil chemokines remarkably and recruit neutrophils to tumor tissues, then promote tumor progression. This approach opens a feasible avenue for realizing a vascularized liver tumor model with a reliable immune microenvironment close to that of a solid tumor of liver cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Supplementary Figures from Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells

Author

Ma, Jingwei, primary, Wei, Keke, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Li, Fei, primary, Zhang, Tianzhen, primary, Liu, Junwei, primary, Xu, Pingwei, primary, Yu, Yuandong, primary, Sun, Weiwei, primary, Zhu, LiYan, primary, Chen, Jie, primary, Zhou, Li, primary, Liang, Xiaoyu, primary, Lv, Jiadi, primary, Fiskesund, Roland, primary, Liu, Yuying, primary, and Huang, Bo, primary

Published
2023
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38. Data from Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells

Author

Ma, Jingwei, primary, Wei, Keke, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Li, Fei, primary, Zhang, Tianzhen, primary, Liu, Junwei, primary, Xu, Pingwei, primary, Yu, Yuandong, primary, Sun, Weiwei, primary, Zhu, LiYan, primary, Chen, Jie, primary, Zhou, Li, primary, Liang, Xiaoyu, primary, Lv, Jiadi, primary, Fiskesund, Roland, primary, Liu, Yuying, primary, and Huang, Bo, primary

Published
2023
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39. Data from Circulating Tumor Microparticles Promote Lung Metastasis by Reprogramming Inflammatory and Mechanical Niches via a Macrophage-Dependent Pathway

Author

Zhang, Huafeng, primary, Yu, Yuandong, primary, Zhou, Li, primary, Ma, Jingwei, primary, Tang, Ke, primary, Xu, Pingwei, primary, Ji, Tiantian, primary, Liang, Xiaoyu, primary, Lv, Jiadi, primary, Dong, Wenqian, primary, Zhang, Tianzhen, primary, Chen, Degao, primary, Xie, Jing, primary, Liu, Yuying, primary, and Huang, Bo, primary

Published
2023
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40. Supplementary data from Circulating Tumor Microparticles Promote Lung Metastasis by Reprogramming Inflammatory and Mechanical Niches via a Macrophage-Dependent Pathway

Author

Zhang, Huafeng, primary, Yu, Yuandong, primary, Zhou, Li, primary, Ma, Jingwei, primary, Tang, Ke, primary, Xu, Pingwei, primary, Ji, Tiantian, primary, Liang, Xiaoyu, primary, Lv, Jiadi, primary, Dong, Wenqian, primary, Zhang, Tianzhen, primary, Chen, Degao, primary, Xie, Jing, primary, Liu, Yuying, primary, and Huang, Bo, primary

Published
2023
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41. Supplementary Figure S1 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

Author

Li, Yong, primary, Luo, Shunqun, primary, Ma, Ruihua, primary, Liu, Jing, primary, Xu, Pingwei, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Ma, Jingwei, primary, Zhang, Yi, primary, Liang, Xiaoyu, primary, Sun, Yanling, primary, Ji, Tiantian, primary, Wang, Ning, primary, and Huang, Bo, primary

Published
2023
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42. Supplementary Table S1 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

Author

Li, Yong, primary, Luo, Shunqun, primary, Ma, Ruihua, primary, Liu, Jing, primary, Xu, Pingwei, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Ma, Jingwei, primary, Zhang, Yi, primary, Liang, Xiaoyu, primary, Sun, Yanling, primary, Ji, Tiantian, primary, Wang, Ning, primary, and Huang, Bo, primary

Published
2023
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43. Supplementary Methods from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

Author

Li, Yong, primary, Luo, Shunqun, primary, Ma, Ruihua, primary, Liu, Jing, primary, Xu, Pingwei, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Ma, Jingwei, primary, Zhang, Yi, primary, Liang, Xiaoyu, primary, Sun, Yanling, primary, Ji, Tiantian, primary, Wang, Ning, primary, and Huang, Bo, primary

Published
2023
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44. Supplementary Figure Legends from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

Author

Li, Yong, primary, Luo, Shunqun, primary, Ma, Ruihua, primary, Liu, Jing, primary, Xu, Pingwei, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Ma, Jingwei, primary, Zhang, Yi, primary, Liang, Xiaoyu, primary, Sun, Yanling, primary, Ji, Tiantian, primary, Wang, Ning, primary, and Huang, Bo, primary

Published
2023
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45. Data from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

Author

Li, Yong, primary, Luo, Shunqun, primary, Ma, Ruihua, primary, Liu, Jing, primary, Xu, Pingwei, primary, Zhang, Huafeng, primary, Tang, Ke, primary, Ma, Jingwei, primary, Zhang, Yi, primary, Liang, Xiaoyu, primary, Sun, Yanling, primary, Ji, Tiantian, primary, Wang, Ning, primary, and Huang, Bo, primary

Published
2023
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