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Background The measurement of exhaled gas nitric oxide (FeNO) has safe, non-invasive, simple, repetitive characteristics which is widely used in the assessment of airway inflammation in asthmatic patients, but the determination of FeNO is affected by a variety of factors, among which living environment factors exposure may have a close relationship to FeNO level, whereas there are few studies on the impact of exposure of living environment factors on the level of FeNO. Objective To analyze the effect of exposure to living environment factors on the level of exhaled nitric oxide (FeNO) in patients with bronchial asthma in non acute attack period, so as to improve the efficacy of clinicians in using FeNO to manage asthma. Methods A total of 109 patients with bronchial asthma in non acute attack period who visited the Respiratory Department Outpatient of the Second Affiliated Hospital of Guangzhou Medical University from July 2018 to June 2020 were included as the study subjects, the data were collected through a questionnaire survey, and the questionnaire information mainly included general information (gender, age, height, body mass) , living environment factors (including smoking history, whether family members smoked at home, allergy history, location of residence, the distance between the residence and the main road with large traffic volume, whether there were factories around the residence, floors of residential buildings, length of residence building, frequency of washing and drying bed sheets, quilt covers/pillow cases, curtain materials at home, potted plants at home, whether the trash can in the home was cleaned regularly, whether kept pets at home, whether there were cockroaches at home and whether kitchen waste was disposed of the same day, whether there were plush toys at home) and the inspection data of FeNO collected. Patients with bronchial asthma were divided into 3 groups according to FeNO level: there were 47 cases in the FeNO low level group (FeNO50 ppb) . Ordinal multiple classification logistic regression analysis was used to explore the environmental factors affecting the FeNO value level measurement. Results There was no significant difference in gender, age, height and body mass among the three groups (P>0.05) . There was no significant difference among the three groups in floors of residential buildings, length of residence, frequency of washing and drying bed sheets, quilt covers/pillow cases, curtain materials at home, potted plants at home, whether the trash can in the home was cleaned regularly, whether there were cockroaches at home and whether kitchen waste was disposed of the same day, whether there were plush toys at home (P>0.05) ; There were statistically significant differences in smoking history, whether family members smoked at home, allergy history, location of residence, the distance between the residence and the main road with large traffic volume, whether there were factories around the residence, and whether there were pets at home (P

Background: Cough is a common symptom during and after COVID-19 infection; however, few studies have described the cough profiles of COVID-19., Objective: The aim of this study was to investigate the prevalence, severity, and associated risk factors of severe and persistent cough in individuals with COVID-19 during the latest wave of the Omicron variant in China., Methods: In this nationwide cross-sectional study, we collected information of the characteristics of cough from individuals with infection of the SARS-CoV-2 Omicron variant using an online questionnaire sent between December 31, 2022, and January 11, 2023., Results: There were 11,718 (n=7978, 68.1% female) nonhospitalized responders, with a median age of 37 (IQR 30-47) years who responded at a median of 16 (IQR 12-20) days from infection onset to the time of the survey. Cough was the most common symptom, occurring in 91.7% of participants, followed by fever, fatigue, and nasal congestion (68.8%-87.4%). The median cough visual analog scale (VAS) score was 70 (IQR 50-80) mm. Being female (odds ratio [OR] 1.31, 95% CI 1.20-1.43), having a COVID-19 vaccination history (OR 1.71, 95% CI 1.37-2.12), current smoking (OR 0.48, 95% CI 0.41-0.58), chronic cough (OR 2.04, 95% CI 1.69-2.45), coronary heart disease (OR 1.71, 95% CI 1.17-2.52), asthma (OR 1.22, 95% CI 1.02-1.46), and gastroesophageal reflux disease (GERD) (OR 1.21, 95% CI 1.01-1.45) were independent factors for severe cough (VAS>70, 37.4%). Among all respondents, 35.0% indicated having a productive cough, which was associated with risk factors of being female (OR 1.44, 95% CI 1.31-1.57), having asthma (OR 1.84, 95% CI 1.52-2.22), chronic cough (OR 1.44, 95% CI 1.19-1.74), and GERD (OR 1.22, 95% CI 1.01-1.47). Persistent cough (>3 weeks) occurred in 13.0% of individuals, which was associated with the risk factors of having diabetes (OR 2.24, 95% CI 1.30-3.85), asthma (OR 1.70, 95% CI 1.11-2.62), and chronic cough (OR 1.97, 95% CI 1.32-2.94)., Conclusions: Cough is the most common symptom in nonhospitalized individuals with Omicron SARS-CoV-2 variant infection. Being female, having asthma, chronic cough, GERD, coronary heart disease, diabetes, and a COVID-19 vaccination history emerged as independent factors associated with severe cough, productive cough, and persistent cough., (©Tingting Xu, Yuehan Chen, Wenzhi Zhan, Kian Fan Chung, Zhongmin Qiu, Kewu Huang, Ruchong Chen, Jiaxing Xie, Gang Wang, Min Zhang, Xuefen Wang, Hongmei Yao, Xiuqing Liao, Yunhui Zhang, Guojun Zhang, Wei Zhang, Dejun Sun, Jia Zhu, Shujuan Jiang, Juntao Feng, Jianping Zhao, Gengyun Sun, Huaqiong Huang, Jianyong Zhang, Lingwei Wang, Feng Wu, Suyun Li, Pusheng Xu, Chunhua Chi, Ping Chen, Mei Jiang, Wen He, Lianrong Huang, Wei Luo, Shiyue Li, Nanshan Zhong, Kefang Lai, China Cough Coalition. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 05.02.2024.)

Platelets-related pathophysiological mechanism and clinical research is one of the research hot topics in chronic obstructive pulmonary disease (COPD) at home and abroad. Increasing evidence has proved the association between thrombocytosis and COPD. Platelets activation interacts with COPD. Antiplatelet therapy has been shown to have significant effects on both short-term and long-term outcomes in COPD. Platelets inhibition may be an emerging therapeutic target for COPD, and antiplatelet therapy is expected to become an inexpensive and effective treatment for COPD. This article reviewed the research progress in platelets and COPD.