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With the sustained growth of economy and significant changes in social demographics, the issue of elderly-related diseases has increasingly drawn attention particularly. Alzheimer's disease (AD),as a representative disease of neurodegenerative diseases has become a major challenge, affecting the health and quality of life among the elderly population severely. In recent years, the incidence, prevalence, and mortality rate of AD increase in China, imposing substantial economic burdens on families, society, and the entire healthcare system. To proactively address this challenge and respond to the national 'Healthy China Action' initiative, leading experts from Renji Hospital, Shanghai Jiao Tong University School of Medicine,and Chinese Center for Disease Control and Prevention Chronic Non-communicable Disease Control Center, Fudan University School of Public Health, Shanghai Mental Health Center, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Fujian Medical University, and other authoritative institutions, have jointly authored the 'China Alzheimer Disease Report 2024'. Building upon previous editions of 2021, 2022, and 2023, this report updates epidemiological data on AD in China, thoroughly analyzes the latest economic burdens of the disease, and comprehensively evaluates the current status of AD diagnosis and treatment services, as well as the allocation of public health resources in our country. The release of the 'China Alzheimer Disease Report 2024' not only reflects China's progress and efforts in AD research and prevention, but also underscores the social heightened concern for elderly health issues. It aims to provide scientific and technical guidance and robust data support for the prevention, diagnosis, and treatment of AD, offering a professional basis for the government and relevant departments to formulate targeted health policies and intervention measures. Furthermore, it serves as a platform for promoting academic exchanges and cooperation in this field domestically and internationally. Through the dissemination and application of this report, we anticipate it will not only serve as a reference for professionals but also enhance public awareness of AD, promote active participation across various sectors of society, and jointly advance the development of elderly health care in China, empowering us towards achieving 'healthy aging'.

ObjectiveTo describe the epidemic characteristics of COVID-19 after policy adjustment from “Category B notifiable disease with category A management” to “Category B notifiable disease with category B management”， and to explore the protective effect of previous infection with SARS-CoV-2 on common symptoms of reinfection.MethodsHealthcare workers infected with SARS-CoV-2 in a grade A tertiary hospital in Shanghai were included in the study from December 4， 2022 to January 11， 2023. Data on demographic characteristics， clinical symptoms， medical history， and COVID-19 vaccination history were collected. We determined the epidemiological curve and characteristics， and then compared the difference in the severity of clinical symptoms between primary and reinfection subjects.ResultsA total of 2 704 cases were included in the study， of which 45 had reinfection， 605 （22.4%）were males， 608 （22.5%）were doctors， 1 275 （47.2%） were nurses， and 2 351 （86.9%） received ≥3 doses of COVID-19 vaccination. The average age of these healthcare workers was （34.9±9.1） years old. The number of cases with mild/moderate illness， asymptomatic infection， fever， headache， dry cough， expectoration， and chest tightness were 2 704 （100.0%）， 92 （3.4%）， 2 385 （88.2%）， 2 066 （76.4%）， 1 642 （60.7%）， 1 807 （66.8%）， and 439 （16.2%）， respectively. Reinfection was a protective factor for fever （OR=0.161， P

Life-purpose orientations can highly influence people's life paths and well-being. However, existing psychological measurements tend to dismiss the need for assessing the individual's life purpose orientations, especially in non-Western cultures. This study sought to develop a new measure to assess purpose orientations specific to the Chinese context. We first built the item pool of Chinese college students' life purpose orientations (Study 1). This was followed by conducting an initial testing of the item pool, and developing a preliminary six-dimension Chinese Life Purpose Orientation Questionnaire (Study 2). Further revision supported a five-dimension questionnaire with adequate validity and reliability (Study 3). The measure's validity and reliability were discussed, and the limitations also were addressed.

Understanding how youth develop a purpose in life could provide guidance for cultivating a positive purpose. This study explored this topic in a Chinese cultural context using in-depth interviews of 41 participants. Furthermore, we identified factors that are particularly important to a beyond-the-self purpose by comparing this with a self-oriented purpose. The findings revealed three pathways to purpose: proactive processes, involving active effort characterized by self-exploration and deepened self-knowledge; transformative processes, characterized by negative or positive major transformative life events; and reactive processes, involving the formation of purpose through external cultural and personal influences. Additionally, the findings indicate that compassion, gratitude, and family support are of particular importance for the development of a beyond-the-self purpose. These findings extend the existing theories and findings of purpose development; consequently, could help develop purpose-fostering interventions that aim to cultivate a positive purpose among youth., Author(s): Tong Wang [sup.1] , Xu Qun You [sup.1] , Ying Li [sup.1] , Xi Ting Huang [sup.2] Author Affiliations: (1) grid.412498.2, 0000 0004 1759 8395, School of Psychology, Shaanxi [...]