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The performance of the oxygen reduction reaction (ORR) can be enhanced through the utilization of multi-heteroatom doped, porous, and layered electrocatalysts. Nitrogen-doped graphene-like porous carbon (Cu–Fe–CN) was synthesized via a simple and cost-effective NaCl template method using maltose, FeCl3·6H2O, and CuCl2·H2O as precursors. This material exhibits excellent electrocatalytic activity towards the ORR. During the electrocatalysis process, the maltose-derived graphene-like porous carbon possesses abundant pores that facilitate rapid mass and electron transfer. Additionally, the incorporation of polyatomic dopants and the construction of the porous carbon framework result in an abundance of active sites. The optimized Cu–Fe–CN electrocatalyst exhibited a more positive half-wave potential (E1/2 = 0.87 V) in alkaline media, surpassing that of the commercial Pt/C (E1/2 = 0.84 V), and demonstrated exceptional durability. The average discharge voltage of Al–air batteries with the Cu–Fe–CN catalyst is always higher than that of Al–air batteries with the commercial Pt/C catalyst, at the same current density. The present study showcases a convenient approach for fabricating porous low-metal catalysts for the ORR, highlighting their immense potential in ORR catalysis and aluminum–air batteries. [ABSTRACT FROM AUTHOR]

Objective: Total hip arthroplasty (THA) effectively treats end‐stage hemophilic hip arthropathy. Given hemophilia's unique characteristics, perioperative bleeding remains a significant risk for patients undergoing THA. Tranexamic acid (TXA), an efficient antifibrinolytic agent, may benefit the outcomes of THA for patients with hemophilia (PWH). This study aims to explore the clinical efficacy of intra‐articular injection of TXA in treating perioperative bleeding in PWH and assess its additional clinical benefits. Methods: The retrospective study comprised data of PWH who received THA from January 2015 to December 2021 in the research center. A total of 59 individuals were included in the study, divided into a TXA group (n = 31) and a non‐TXA group (n = 28). We compared various parameters, including total blood loss (TBL), visible blood loss (VBL), occult blood loss (OBL), intraoperative coagulation factor VIII (FVIII) consumption, perioperative total FVIII consumption, hemoglobin (HB), erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), length of hospital stay, hospitalization costs, length of surgery, total protein, activated partial thromboplastin time (APTT), D‐dimer, rate of joint swelling, hip joint range of motion (ROM), visual analogue scale (VAS), and Harris hip joint function scale (HHS) between the two groups. Follow‐up assessments were conducted for up to 24 months. A Student's t test was utilized for the statistical analysis. Results: This study demonstrated that intra‐articular TXA effectively reduced TBL (1248.19 ± 439.88 mL, p < 0.001), VBL (490.32 ± 344.34 mL, p = 0.003), and OBL (757.87 ± 381.48 mL, p = 0.004) in PWH who underwent THA. TXA demonstrated effectiveness in reducing VAS scores on POD1, POD7, and POD14 and joint swelling rates on POD1, POD7, POD14, and at discharge (p < 0.05). Additionally, the TXA group achieved higher HHS ratings at all follow‐up time points (p < 0.05), showing superior hip joint mobility, lower postoperative inflammation levels, reduced factor VIII consumption during surgery, and less postoperative nutritional loss. No statistically significant differences were observed between the two groups in terms of hospital stay, hospitalization costs, surgery duration, and coagulation indicators. Conclusion: Intra‐articular injection of TXA reduces perioperative bleeding in PWH undergoing THA while also improving joint mobility, post‐operative rehabilitation, and quality of life. This may provide value for the future application of TXA in PWH. [ABSTRACT FROM AUTHOR]