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Two analogous M4L4-type tetrahedral cages (smaller: MOC-19; larger: MOC-22) were synthesized and investigated for their interactions with the anticancer drug 5-fluoracil (5-FU) by NMR spectroscopy, high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), and molecular simulation. The cage's size and window are of importance for the host-guest binding, and consequently the smaller MOC-19 with a more suitable size of cavity window was found to have much stronger hydrogen-bond interactions with 5-FU. The porous nanoparticles of MOC-19 exhibited outstanding behavior for the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution. [ABSTRACT FROM AUTHOR]

An M4L4 type metal-organic cage (MOC-19) has been synthesized from the one-pot reaction of tri(pyridinylmethylene)phenylbenzeneamine (TPBA) with hydrated Zn(ClO4)2 under mild conditions and characterized by single-crystal X-Ray diffraction. Iodine capture studies show that the porous crystals of MOC-19 exhibit a versatile behavior to accumulate iodine species not only in vapor (for I2) but also in solution (for I2 and I3−), and anion-exchange experiments indicate the capacity to extract IO3− anions from aqueous solution. Enrichment of iodine species from KI/I2 aqueous solution proceeds facilely, revealing a pseudo-second-order kinetics of I3− adsorption. Furthermore, the electrical conductivity of MOC-19 single crystals could be significantly altered by I2 inclusion. [ABSTRACT FROM AUTHOR]

Two analogous M 4 L 4 -type tetrahedral cages (smaller: MOC-19; larger: MOC-22) were synthesized and investigated for their interactions with the anticancer drug 5-fluoracil (5-FU) by NMR spectroscopy, high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), and molecular simulation. The cage's size and window are of importance for the host-guest binding, and consequently the smaller MOC-19 with a more suitable size of cavity window was found to have much stronger hydrogen-bond interactions with 5-FU. The porous nanoparticles of MOC-19 exhibited outstanding behavior for the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

An M(4) L4 type metal-organic cage (MOC-19) has been synthesized from the one-pot reaction of tri(pyridinylmethylene)phenylbenzeneamine (TPBA) with hydrated Zn(ClO4 )2 under mild conditions and characterized by single-crystal X-Ray diffraction. Iodine capture studies show that the porous crystals of MOC-19 exhibit a versatile behavior to accumulate iodine species not only in vapor (for I2 ) but also in solution (for I2 and I3 (-) ), and anion-exchange experiments indicate the capacity to extract IO3 (-) anions from aqueous solution. Enrichment of iodine species from KI/I2 aqueous solution proceeds facilely, revealing a pseudo-second-order kinetics of I3 (-) adsorption. Furthermore, the electrical conductivity of MOC-19 single crystals could be significantly altered by I2 inclusion., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)