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Your search keyword '"Xu, Xiang-ying"' showing total 23 results
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23 results on '"Xu, Xiang-ying"'

3. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial

Author

Sun, Ying, Li, Wen-Fei, Chen, Nian-Yong, Zhang, Ning, Hu, Guo-Qing, Xie, Fang-Yun, Sun, Yan, Chen, Xiao-Zhong, Li, Jin-Gao, Zhu, Xiao-Dong, Hu, Chao-Su, Xu, Xiang-Ying, Chen, Yuan-Yuan, Hu, Wei-Han, Guo, Ling, Mo, Hao-Yuan, Chen, Lei, Mao, Yan-Ping, Sun, Rui, Ai, Ping, Liang, Shao-Bo, Long, Guo-Xian, Zheng, Bao-Min, Feng, Xing-Lai, Gong, Xiao-Chang, Li, Ling, Shen, Chun-Ying, Xu, Jian-Yu, Guo, Ying, Chen, Yu-Ming, Zhang, Fan, Lin, Li, Tang, Ling-Long, Liu, Meng-Zhong, and Ma, Jun

Published
2016
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9. Concurrent chemoradiotherapy with/without induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: Long‐term results of phase 3 randomized controlled trial

Author

Li, Wen‐Fei, primary, Chen, Nian‐Yong, additional, Zhang, Ning, additional, Hu, Guo‐Qing, additional, Xie, Fang‐Yun, additional, Sun, Yan, additional, Chen, Xiao‐Zhong, additional, Li, Jin‐Gao, additional, Zhu, Xiao‐Dong, additional, Hu, Chao‐Su, additional, Xu, Xiang‐Ying, additional, Chen, Yuan‐Yuan, additional, Hu, Wei‐Han, additional, Guo, Ling, additional, Mo, Hao‐Yuan, additional, Chen, Lei, additional, Mao, Yan‐Ping, additional, Sun, Rui, additional, Ai, Ping, additional, Liang, Shao‐Bo, additional, Long, Guo‐Xian, additional, Zheng, Bao‐Min, additional, Feng, Xing‐Lai, additional, Gong, Xiao‐Chang, additional, Li, Ling, additional, Shen, Chun‐Ying, additional, Xu, Jian‐Yu, additional, Guo, Ying, additional, Chen, Yu‐Ming, additional, Zhang, Fan, additional, Lin, Li, additional, Tang, Ling‐Long, additional, Liu, Meng‐Zhong, additional, Ma, Jun, additional, and Sun, Ying, additional

Published
2019
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15. Effects of IL-17A on the occurrence of lung adenocarcinoma

Author

Li, Ying, primary, Cao, Zhen Yuan, additional, Sun, Bo, additional, Wang, Guang You, additional, Fu, Zheng, additional, Liu, Yu Mei, additional, Kong, Qing Fei, additional, Wang, Jing Hua, additional, Zhang, Yao, additional, Xu, Xiang Ying, additional, and Li, Hu Lun, additional

Published
2011
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18. Study on the Blend Film Prepared by Chitosan and Gelatin

Author

Wang, An Na, primary, Wu, Li Gen, additional, Li, Xiu Ling, additional, Sun, Yu Dan, additional, Wang, Jie, additional, Wang, Shao Wen, additional, Jia, Ai Xia, additional, Wang, Chao, additional, Zhang, Yuan Yuan, additional, Fu, Qin Qin, additional, and Xu, Xiang Ying, additional

Published
2011
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19. Texture Profile of Gelatin and Tea Polyphenol Mixed Gels

Author

Wang, An Na, primary, Wu, Li Gen, additional, Sun, Yu Dan, additional, Zhang, Yuan Yuan, additional, Xu, Xiang Ying, additional, Li, Xiu Ling, additional, Wang, Jie, additional, Wang, Chao, additional, Fu, Qin Qin, additional, and Jia, Lin Lu, additional

Published
2011
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22. Identification of the Acid-Sensitive Site Critical for Chloral Hydrate (CH) Activation of the Proton-Activated Chloride Channel.

Author

Xu XY, Zhang FF, Gan J, Zhang MY, Shen ZS, Guo Q, Teng Y, Ji JW, Cao JL, Tang QY, and Zhang Z

Subjects
Mice, Animals, Male, Humans, Protons, Chlorides metabolism, Mice, Inbred C57BL, Chloral Hydrate pharmacology, Chloride Channels genetics, Chloride Channels metabolism
Abstract

The transmembrane protein TMEM206 was recently identified as the molecular basis of the extracellular proton-activated Cl - channel (PAC), which plays an essential role in neuronal death in ischemia-reperfusion. The PAC channel is activated by extracellular acid, but the proton-sensitive mechanism remains unclear, although different acid-sensitive pockets have been suggested based on the cryo-EM structure of the human PAC (hPAC) channel. In the present study, we firstly identified two acidic amino acid residues that removed the pH-dependent activation of the hPAC channel by neutralization all the conservative negative charged residues located in the extracellular domain of the hPAC channel and some positively charged residues at the hotspot combined with two-electrode voltage-clamp (TEVC) recording in the Xenopus oocytes system. Double-mutant cycle analysis and double cysteine mutant of these two residues proved that these two residues cooperatively form a proton-sensitive site. In addition, we found that chloral hydrate activates the hPAC channel depending on the normal pH sensitivity of the hPAC channel. Furthermore, the PAC channel knock-out (KO) male mice (C57BL/6J) resist chloral hydrate-induced sedation and hypnosis. Our study provides a molecular basis for understanding the proton-dependent activation mechanism of the hPAC channel and a novel drug target of chloral hydrate. SIGNIFICANCE STATEMENT Proton-activated Cl - channel (PAC) channels are widely distributed in the nervous system and play a vital pathophysiological role in ischemia and endosomal acidification. The main discovery of this paper is that we identified the proton activation mechanism of the human proton-activated chloride channel (hPAC). Intriguingly, we also found that anesthetic chloral hydrate can activate the hPAC channel in a pH-dependent manner. We found that the chloral hydrate activates the hPAC channel and needs the integrity of the pH-sensitive site. In addition, the PAC channel knock-out (KO) mice are resistant to chloral hydrate-induced anesthesia. The study on PAC channels' pH activation mechanism enables us to better understand PAC's biophysical mechanism and provides a novel target of chloral hydrate., (Copyright © 2023 the authors.)

Published
2023
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23. [Inverse correlation of S100A4 and E-cad protein expression and their clinical significance in non-small cell lung cancer].

Author

Qi RX and Xu XY

Subjects
Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung pathology, Female, Humans, Immunohistochemistry, Lung Neoplasms pathology, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Prognosis, S100 Calcium-Binding Protein A4, Survival Rate, Cadherins metabolism, Carcinoma, Non-Small-Cell Lung metabolism, Lung Neoplasms metabolism, S100 Proteins metabolism
Abstract

Objective: The purpose of the present study was to explore the relationship between the expression of S100A4 and E-cad protein and some clinicopathological factors such as histological types, TNM stages, lymph node metastasis and prognosis in non-small cell lung cancer (NSCLC), and analyze whether there is a correlation between them., Methods: The expression of S100A4 protein and E-cad protein was detected with immunohistochemical SP technique in 116 non-small-cell lung cancers., Results: The positive immunohistochemical staining for S100A4 protein was observed in 64 out of the 116 patients, with a positive rate of 55.2%. The expression rate of S100A4 protein was associated with age, tumor size, lymph node metastasis and prognosis of NSCLC. The expression of S100A4 protein was not significantly related with histological types, sex and TNM stages. The positive rate of E-cad protein expression was 65.5%. The expression of E-cad protein was associated with TNM staging, lymph node metastasis and prognosis of NSCLC. The expression of E-cad protein had no significant correlation with histological types, patient age and sex. An inverse correlation between the levels of S100A4 and E-cad protein expression was found (P < 0.005)., Conclusion: Expression of S100A4 protein and loss of E-cad protein expression are significantly associated with tumor progression, and may become valuable markers in prediction of biological behavior and tendency of metastasis of non-small-cell lung cancers.

Published
2007

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