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C46H60N6O2Se2, triclinic, P1‾$\overline{1}$ (no. 2), a = 10.4701(7) Å, b = 10.6331(7) Å, c = 20.4665(14) Å, α = 92.079(2)°, β = 97.937(2)°, γ = 95.848(2)°, V = 2242.0(3) Å3, Z = 2, Rgt(F) = 0.0487, wRref(F2) = 0.1183, T = 293(2) K.

To study the effect of Scutellaria baicalensis extract on Mycobacterium abscessus, the standard strain of M. abscessus ATCC19977 and clinical isolates were used as the test bacteria. The minimum inhibitory concentration (MIC) of S. baicalensis extract against M. abscessus was determined by the Alarmar-Blue method; the minimum bactericidal concentration (MBC) was determined by plate coating method; crystal violet staining method and scanning electron microscope assay were used to analyze the effect of S. baicalensis extract on the biomass formation and morphological structure of M. abscessus; RT-qPCR was further used to investigate the effect of S. baicalensis extract on the gene expression which involves in mycolic acid synthesis. The inhibitory effects of S. baicalensis extract against M. abscessus standard strain ATCC 19977 and 8 clinical isolates were evaluated, the results showed that the MIC90 was 50~100 mg/mL, and the MBC was 50~200 mg/mL. The biofilm formation of M. abscessus was significantly decreased after adding S. baicalensis extract(P<0.05), and S. baicalensis extract disrupted the biofilm formation. The expression of genes related to mycolic acid synthesis was significantly decreased in the S. baicalensis extract treatment group (P<0.01). S. baicalensis extract inhibits planktonic M. abscessus growth, meanwhile, it reduces the bacterial adhesion and aggregation onM. abscessus biofilm formation. [ABSTRACT FROM AUTHOR]

In recent years, some isoquinoline derivatives have been also found to be used as solid-state fluorescence sensors for pressure, organic steam, and acid gas [[8]], [[9]], [[10]]. In the title compound, the pyridine ring and benzene ring in isoquinoline unit are not completely coplanar because of the existence of the piperidine and hexyloxy groups, a finding which is similar to previous reports in [[8]]. Thus, the synthesis and crystal structures of novel isoquinoline derivatives have received increasing attention [[12]]. [Extracted from the article]

In recent years, some isoquinoline derivatives have been also found to be used as solid-state fluorescence sensors for pressure, organic steam, and acid gas [[8]], [[9]], [[10]]. In the title compound, the pyridine ring and benzene ring in isoquinoline unit are not completely coplanar because of the existence of the piperidine and hexyloxy groups, a finding which is similar to previous reports in [[8]]. Thus, the synthesis and crystal structures of novel isoquinoline derivatives have received increasing attention [[12]]. [Extracted from the article]

Although titanium implants have been applied in dental clinics to replace lost teeth and to restore masticatory function for decades, strategies to design the surface of the transmucosal sites of implants to achieve ideal and predictable biological sealing following implantation remain to be optimized. In this study, we hypothesized that gingival epithelial cell (GEC) adhesion and new tissue attachment to titanium sheets/implants could be promoted by the release of plasmid pLAMA3-CM (encoding a motif of the C-terminal globular domain of LAMA3) from a titanium surface. To test this hypothesis, a chitosan/collagen (Chi/Col) coating was immobilized on the surfaces of titanium substrates with nanotube topography (NT-Ti) through cathodic electrophoretic deposition; it was found that pLAMA3-CM could be released from the coating in a highly sustained manner. After culturing on titanium with nanotube topography coated by Chi/Col with the plasmid pLAMA3-CM (Chi/Col/pLAMA3-CM-Ti), human GECs (hGECs) were found to effectively uptake the incorporated plasmids, which resulted in improved attachment, as evidenced by morphological and immunofluorescence analyses. In addition, Chi/Col/pLAMA3-CM-Ti induced better biological sealing at transmucosal sites following immediate implantation into Sprague-Dawley rats. Our findings indicate that the modification of titanium implants by plasmid-mediated pLAMA3-CM gene transfection points to a practical strategy for optimizing biological sealing around the transmucosal sites of implants. [ABSTRACT FROM AUTHOR]