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111 results on '"Xu, Youyi"'

4. A Network Pharmacology Approach to Investigate the Underlying Mechanisms of Alpinia Katsumadai Hayata on Acne Vulgaris

Author

Wang Li, Nie Yang, Chen Huifang, Sun Jun, Hu Mingyue, Xu Youyi, and Chen Shaozhen

Subjects
Environmental sciences, GE1-350
Abstract

The Alpinia katsumadai Hayata Doukou, DK, is a traditional Chinese medicine that has shown superior anti-inflammatory property, which is widely used in the food and commodity industry. A network pharmacology analysis was performed to identify the potential anti-acne compounds, hub therapeutic targets, and the key pathways via TCMSP, BATMAN, CTD, PDB and PubChem databases. Finally, the “compoundtarget- pathway” network was constructed. The study found total 7 active compounds, including quercetin, (2R)-5,7-dihydroxy-2-phenylchroman-4-one, dehydrodiisoeugenol, (2R)-7-hydroxy-5-methoxy-2- phenylchroman-4-one, Pinocembrin, and 1,7-diphenyl-5-hydroxy-6-hepten-3-one alpinolide peroxide. In addition, 30 therapeutic targets, and 4 hub therapeutic targets of the DK were identified. The biological processes were primarily related to inflammatory response, response to oxidative stress, regulation of insulin secretion, etc. Which was significantly associated with ten pathways including the PI3K-Akt signaling pathways, VEGF signaling pathways, etc. Furtherly, the 4 hub targets AKT1, F2, AR, and PTGS2 with higher connectivity in PPI network were verificated though molecular docking, which once again proved that these targets are potential targets of their corresponding chemical molecules. Therefore, DK might have a synergistic effect on the anti-inflammatory effects via the various active compositions, targets and signaling pathways.

Published
2021
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22. A Network Pharmacology Approach to Investigate the Underlying Mechanisms of Alpinia Katsumadai Hayata on Acne Vulgaris

Author

Yang Nie, Huifang Chen, Xu Youyi, Wang Li, Hu Mingyue, Chen Shaozhen, and Sun Jun

Subjects
0301 basic medicine, Pinocembrin, 030102 biochemistry & molecular biology, Protein Data Bank (RCSB PDB), Alpinia, Computational biology, Biology, biology.organism_classification, Environmental sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Network pharmacology, Ppi network, VEGF signaling, GE1-350, Signal transduction, PubChem
Abstract

The Alpinia katsumadai Hayata Doukou, DK, is a traditional Chinese medicine that has shown superior anti-inflammatory property, which is widely used in the food and commodity industry. A network pharmacology analysis was performed to identify the potential anti-acne compounds, hub therapeutic targets, and the key pathways via TCMSP, BATMAN, CTD, PDB and PubChem databases. Finally, the “compoundtarget- pathway” network was constructed. The study found total 7 active compounds, including quercetin, (2R)-5,7-dihydroxy-2-phenylchroman-4-one, dehydrodiisoeugenol, (2R)-7-hydroxy-5-methoxy-2- phenylchroman-4-one, Pinocembrin, and 1,7-diphenyl-5-hydroxy-6-hepten-3-one alpinolide peroxide. In addition, 30 therapeutic targets, and 4 hub therapeutic targets of the DK were identified. The biological processes were primarily related to inflammatory response, response to oxidative stress, regulation of insulin secretion, etc. Which was significantly associated with ten pathways including the PI3K-Akt signaling pathways, VEGF signaling pathways, etc. Furtherly, the 4 hub targets AKT1, F2, AR, and PTGS2 with higher connectivity in PPI network were verificated though molecular docking, which once again proved that these targets are potential targets of their corresponding chemical molecules. Therefore, DK might have a synergistic effect on the anti-inflammatory effects via the various active compositions, targets and signaling pathways.

Published
2021

25. Metal ion permeation properties of silk fibroin/chitosan blend membranes

Author

Jian-Yong Chen, Zhu Baoku, Chun-Hui Du, and Xu Youyi

Subjects
Thermogravimetric analysis, Materials science, Polymers and Plastics, Metal ions in aqueous solution, education, Organic Chemistry, technology, industry, and agriculture, Fibroin, Permeation, Membrane, Polymer chemistry, Materials Chemistry, medicine, Polymer blend, Swelling, medicine.symptom, Fourier transform infrared spectroscopy, Nuclear chemistry
Abstract

Silk fibroin/chitosan (SF/CS) blend membranes were prepared and characterized by infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscopy. It was found that SF and CS were compatible in the blend membranes and that the membranes were dense without microscopic phase separation. Swelling experiments showed that the swelling ratio of the blend membranes increased with CS content and reached the highest value when CS content was 70 wt%. Experiments indicated that the permeability coefficient of K+ through the blend membrane was 2–4 times higher than that of pure CS membrane, and 10 times higher than that of pure SF membrane. The permeation rate of K+ increased linearly with CS content in the blend membrane for the lower concentration feeding solution. For different metal ions, the permeability through SF/CS blend membranes was in the sequence K+ > Ca2+ > Cd2+ > Pb2+ > Cu2+ > Ni2+. Copyright © 2006 Society of Chemical Industry

Published
2006

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