Search

Your search keyword '"Xuan, Mengyang"' showing total 6 results
Start Over Author "Xuan, Mengyang"
6 results on '"Xuan, Mengyang"'

3. Total Synthesis of Jiadifenolide

Author

Paterson, Ian, Xuan, Mengyang, Dalby, Stephen M, Paterson, Ian [0000-0002-8861-9136], and Apollo - University of Cambridge Repository

Subjects
Vinyl Compounds, cyclization, Molecular Structure, terpenoids, neurological agents, Stereoisomerism, General Medicine, samarium, Crystallography, X-Ray, total synthesis, Oxidation-Reduction, Sesquiterpenes, Communications
Abstract

As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.

Published
2014

6. Total Synthesis of Jiadifenolide.

Author

Paterson, Ian, Xuan, Mengyang, and Dalby, Stephen M.

Subjects
*SESQUITERPENES, *SAMARIUM, *RING formation (Chemistry)
Abstract

The stereocontrolled total synthesis of title compound (I), a potent neurotrophic agent, is described. Key is an innovative samarium-mediated cyclization reaction to establish the tricyclic core including two adjacent quaternary stereocenters. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results