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40 results on '"Xue, Dingwei"'

1. TR4 worsen urosepsis by regulating GSDMD

Author

Wang, Huan, Zhu, Shibin, Zhou, Zhenwei, Wang, Zhenghui, Zhuang, Wei, Xue, Dingwei, Lu, Zeyi, Zheng, Qiming, Ding, Lifeng, Ren, Liangliang, Luo, Wenqing, Wang, Ruyue, Ge, Guangju, Xia, Liqun, Li, Gonghui, and Wu, Haiyang

Published
2024
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8. 基于双目定位和同步触发的城市轨道交通工务综合检测车.

Author

LI Jun, FAN Xiaodong, XUE Dingwei, ZHOU Hang, GAO Tao, CHEN Changbang, and ZHANG Yixia

Abstract

Copyright of Urban Mass Transit is the property of Urban Mass Transit Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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10. Exosome‐derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase‐3‐dependent cleavage

Author

Ding, Lifeng, primary, Zheng, Qiming, additional, Lin, Yudong, additional, Wang, Ruyue, additional, Wang, Huan, additional, Luo, Wenqin, additional, Lu, Zeyi, additional, Xie, Haiyun, additional, Ren, Liangliang, additional, Lu, Haohua, additional, Yu, Chenhao, additional, Zhang, Jixuan, additional, Shen, Danyang, additional, Cheng, Sheng, additional, Xia, Liqun, additional, Li, Gonghui, additional, and Xue, Dingwei, additional

Published
2023
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12. Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway

Author

Ren, Liangliang, Jiang, Minxiao, Xue, Dingwei, Wang, Huan, Lu, Zeyi, Ding, Lifeng, Xie, Haiyun, Wang, Ruyue, Luo, Wenqin, Xu, Li, Wang, Mingchao, Yu, Shicheng, Cheng, Sheng, Xia, Liqun, Yu, Haifeng, Huang, Peng, Xu, Naijin, Li, Gonghui, Ren, Liangliang, Jiang, Minxiao, Xue, Dingwei, Wang, Huan, Lu, Zeyi, Ding, Lifeng, Xie, Haiyun, Wang, Ruyue, Luo, Wenqin, Xu, Li, Wang, Mingchao, Yu, Shicheng, Cheng, Sheng, Xia, Liqun, Yu, Haifeng, Huang, Peng, Xu, Naijin, and Li, Gonghui

Abstract

Bladder cancer is one of the most common and deadly cancer worldwide. Current chemotherapy has shown limited efficacy in improving outcomes for patients. Nitroxoline, an old and widely used oral antibiotic, which was known to treat for urinary tract infection for decades. Recent studies suggested that nitroxoline suppressed the tumor progression and metastasis, especially in bladder cancer. However, the underlying mechanism for anti-tumor activity of nitroxoline remains unclear. Methods: CircRNA microarray was used to explore the nitroxoline-mediated circRNA expression profile of bladder cancer lines. Transwell and wound-healing assay were applied to evaluate the capacity of metastasis. ChIP assay was chosen to prove the binding of promotor and transcription factor. RNA-pulldown assay was performed to explore the sponge of circRNA and microRNA. Results: We first identified the circNDRG1 (has_circ_0085656) as a novel candidate circRNA. Transwell and wound-healing assay demonstrated that circNDRG1 inhibited the metastasis of bladder cancer. ChIP assay showed that circNDRG1 was regulated by the transcription factor EGR1 by binding the promotor of host gene NDRG1. RNA-pulldown assay proved that circNDRG1 sponged miR-520h leading to the overexpression of smad7, which was a negative regulatory protein of EMT. Conclusions: Our research revealed that nitroxoline may suppress metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.

Published
2022

13. Correction to “Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy”

Author

Alifu, Nuernisha, primary, Zebibula, Abudureheman, additional, Qi, Ji, additional, Zhang, Hequn, additional, Sun, Chaowei, additional, Yu, Xiaoming, additional, Xue, Dingwei, additional, Lam, Jacky W. Y., additional, Li, Gonghui, additional, Qian, Jun, additional, and Tang, Ben Zhong, additional

Published
2022
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15. Additional file 2 of N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Author

Chen, Yuanlei, Lu, Zeyi, Qi, Chao, Yu, Chenhao, Li, Yang, Huan, Wang, Wang, Ruyue, Luo, Wenqin, Shen, Danyang, Ding, Lifeng, Ren, Liangliang, Xie, Haiyun, Xue, Dingwei, Wang, Mingchao, Ni, Kangxin, Xia, Liqun, Qian, Jun, and Li, Gonghui

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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16. Additional file 3 of N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Author

Chen, Yuanlei, Lu, Zeyi, Qi, Chao, Yu, Chenhao, Li, Yang, Huan, Wang, Wang, Ruyue, Luo, Wenqin, Shen, Danyang, Ding, Lifeng, Ren, Liangliang, Xie, Haiyun, Xue, Dingwei, Wang, Mingchao, Ni, Kangxin, Xia, Liqun, Qian, Jun, and Li, Gonghui

Abstract

Additional file 3: Table1. TRAF1 intensity of each patients.

Published
2022
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17. Additional file 2 of circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA

Author

Ding, Lifeng, Wang, Ruyue, Zheng, Qiming, Shen, Danyang, Wang, Huan, Lu, Zeyi, Luo, Wenqin, Xie, Haiyun, Ren, Liangliang, Jiang, Minxiao, Yu, Chenhao, Zhou, Zhenwei, Lin, Yudong, Lu, Haohua, Xue, Dingwei, Su, Wenjing, Xia, Liqun, Neuhaus, Jochen, Cheng, Sheng, and Li, Gonghui

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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18. Additional file 4 of circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA

Author

Ding, Lifeng, Wang, Ruyue, Zheng, Qiming, Shen, Danyang, Wang, Huan, Lu, Zeyi, Luo, Wenqin, Xie, Haiyun, Ren, Liangliang, Jiang, Minxiao, Yu, Chenhao, Zhou, Zhenwei, Lin, Yudong, Lu, Haohua, Xue, Dingwei, Su, Wenjing, Xia, Liqun, Neuhaus, Jochen, Cheng, Sheng, and Li, Gonghui

Subjects
Data_FILES
Abstract

Additional file 4.

Published
2022
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21. Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway

Author

Ren, Liangliang, primary, Jiang, Minxiao, additional, Xue, Dingwei, additional, Wang, Huan, additional, Lu, Zeyi, additional, Ding, Lifeng, additional, Xie, Haiyun, additional, Wang, Ruyue, additional, Luo, Wenqin, additional, Xu, Li, additional, Wang, Mingchao, additional, Yu, Shicheng, additional, Cheng, Sheng, additional, Xia, Liqun, additional, Yu, Haifeng, additional, Huang, Peng, additional, Xu, Naijin, additional, and Li, Gonghui, additional

Published
2022
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25. Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine

Author

Feng, Zhe, Bai, Siyi, Qi, Ji, Sun, Chaowei, Zhang, Yuhuang, Yu, Xiaoming, Ni, Huwei, Wu, Di, Fan, Xiaoxiao, Xue, Dingwei, Liu, Shunjie, Chen, Ming, Gong, Junyi, Wei, Peifa, He, Mubin, Lam, Wing Yip, Li, Xinjian, Tang, Benzhong, Gao, Lixia, Qian, Jun, Feng, Zhe, Bai, Siyi, Qi, Ji, Sun, Chaowei, Zhang, Yuhuang, Yu, Xiaoming, Ni, Huwei, Wu, Di, Fan, Xiaoxiao, Xue, Dingwei, Liu, Shunjie, Chen, Ming, Gong, Junyi, Wei, Peifa, He, Mubin, Lam, Wing Yip, Li, Xinjian, Tang, Benzhong, Gao, Lixia, and Qian, Jun

Abstract

Superb reliability and biocompatibility equip aggregation-induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, a kind of PEGylated AIE (OTPA-BBT) dots with strong absorption and extremely high second near-infrared region (NIR-II) PLQY of 13.6% is designed, and a long-aliphatic-chain design blueprint contributing to their excretion from an animal's body is proposed. Assisted by the OTPA-BBT dots with bright fluorescence beyond 1100 nm and even 1500 nm (NIR-IIb), large-depth cerebral vasculature (beyond 600 µm) as well as real-time blood flow are monitored through a thinned skull, and noninvasive NIR-IIb imaging with rich high-spatial-frequency information gives a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA-BBT dots from the body is demonstrated, which provides influential evidence of biosafety. © 2021 Wiley-VCH GmbH

Published
2021

26. Biologically Excretable Aggregation‐Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine

Author

Feng, Zhe, primary, Bai, Siyi, additional, Qi, Ji, additional, Sun, Chaowei, additional, Zhang, Yuhuang, additional, Yu, Xiaoming, additional, Ni, Huwei, additional, Wu, Di, additional, Fan, Xiaoxiao, additional, Xue, Dingwei, additional, Liu, Shunjie, additional, Chen, Ming, additional, Gong, Junyi, additional, Wei, Peifa, additional, He, Mubin, additional, Lam, Jacky W. Y., additional, Li, Xinjian, additional, Tang, Ben Zhong, additional, Gao, Lixia, additional, and Qian, Jun, additional

Published
2021
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28. Oncometabolite L‐2‐hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma

Author

Wang, Huan, primary, Wang, Liya, additional, Zheng, Qiming, additional, Lu, Zeyi, additional, Chen, Yuanlei, additional, Shen, Danyang, additional, Xue, Dingwei, additional, Jiang, Minxiao, additional, Ding, Lifeng, additional, Zhang, Jie, additional, Wu, Haiyang, additional, Xia, Liqun, additional, Qian, Jun, additional, Li, Gonghui, additional, and Lu, Jieyang, additional

Published
2021
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30. Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

Author

Feng, Zhe, primary, Bai, Siyi, additional, Qi, Ji, additional, Sun, Chaowei, additional, Zhang, Yuhuang, additional, Yu, Xiaoming, additional, Ni, Huwei, additional, Wu, Di, additional, Fan, Xiaoxiao, additional, Xue, Dingwei, additional, Liu, Shunjie, additional, Chen, Ming, additional, Gong, Junyi, additional, Wei, Peifa, additional, He, Mubin, additional, Lam, Jacky W. Y., additional, Li, Xinjian, additional, Tang, Ben Zhong, additional, Gao, Lixia, additional, and Qian, Jun, additional

Published
2020
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31. N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma.

Author

Chen, Yuanlei, Lu, Zeyi, Qi, Chao, Yu, Chenhao, Li, Yang, Huan, Wang, Wang, Ruyue, Luo, Wenqin, Shen, Danyang, Ding, Lifeng, Ren, Liangliang, Xie, Haiyun, Xue, Dingwei, Wang, Mingchao, Ni, Kangxin, Xia, Liqun, Qian, Jun, and Li, Gonghui

Subjects
RENAL cell carcinoma, SUNITINIB, TUMOR necrosis factors, CELL death, ADENO-associated virus, PLANT gene silencing, RNA sequencing
Abstract

Background: Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms in renal cell carcinoma are still unclear. Methods: RNA sequencing and m6A sequencing were used to screen for functional genes involved in sunitinib resistance. In vitro and in vivo experiments were carried out and patient samples and clinical information were obtained for clinical analysis. Results: We identified a tumor necrosis factor receptor-associated factor, TRAF1, that was significantly increased in sunitinib-resistant cells, resistant cell-derived xenograft (CDX-R) models and clinical patients with sunitinib resistance. Silencing TRAF1 increased sunitinib-induced apoptotic and antiangiogenic effects. Mechanistically, the upregulated level of TRAF1 in sunitinib-resistant cells was derived from increased TRAF1 RNA stability, which was caused by an increased level of N6-methyladenosine (m6A) in a METTL14-dependent manner. Moreover, in vivo adeno-associated virus 9 (AAV9) -mediated transduction of TRAF1 suppressed the sunitinib-induced apoptotic and antiangiogenic effects in the CDX models, whereas knockdown of TRAF1 effectively resensitized the sunitinib-resistant CDXs to sunitinib treatment. Conclusions: Overexpression of TRAF1 promotes sunitinib resistance by modulating apoptotic and angiogenic pathways in a METTL14-dependent manner. Targeting TRAF1 and its pathways may be a novel pharmaceutical intervention for sunitinib-treated patients. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence

Author

Yang, Yanqing, primary, Fan, Xiaoxiao, additional, Li, Ling, additional, Yang, Yuming, additional, Nuernisha, Alifu, additional, Xue, Dingwei, additional, He, Chao, additional, Qian, Jun, additional, Hu, Qinglian, additional, Chen, Hao, additional, Liu, Jie, additional, and Huang, Wei, additional

Published
2020
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37. Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

Author

Alifu, Nuernisha, primary, Zebibula, Abudureheman, additional, Qi, Ji, additional, Zhang, Hequn, additional, Sun, Chaowei, additional, Yu, Xiaoming, additional, Xue, Dingwei, additional, Lam, Jacky W. Y., additional, Li, Gonghui, additional, Qian, Jun, additional, and Tang, Ben Zhong, additional

Published
2018
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40. Development and verification of a nomogram for prediction of recurrence‐free survival in clear cell renal cell carcinoma.

Author

Chen, Yuanlei, Jiang, Shangjun, Lu, Zeyi, Xue, Dingwei, Xia, Liqun, Lu, Jieyang, Wang, Huan, Xu, Liwei, Li, Liyang, and Li, Gonghui

Subjects
RECEIVER operating characteristic curves, RENAL cell carcinoma, BIOMARKERS, NOMOGRAPHY (Mathematics)
Abstract

Nowadays, gene expression profiling has been widely used in screening out prognostic biomarkers in numerous kinds of carcinoma. Our studies attempt to construct a clinical nomogram which combines risk gene signature and clinical features for individual recurrent risk assessment and offer personalized managements for clear cell renal cell carcinoma. A total of 580 differentially expressed genes (DEGs) were identified via microarray. Functional analysis revealed that DEGs are of fundamental importance in ccRCC progression and metastasis. In our study, 338 ccRCC patients were retrospectively analysed and a risk gene signature which composed of 5 genes was obtained from a LASSO Cox regression model. Further analysis revealed that identified risk gene signature could usefully distinguish the patients with poor prognosis in training cohort (hazard ratio [HR] = 3.554, 95% confidence interval [CI] 2.261‐7.472, P <.0001, n = 107). Moreover, the prognostic value of this gene‐signature was independent of clinical features (P =.002). The efficacy of risk gene signature was verified in both internal and external cohorts. The area under receiver operating characteristic curve of this signature was 0.770, 0.765 and 0.774 in the training, testing and external validation cohorts, respectively. Finally, a nomogram was developed for clinicians and did well in the calibration plots. This nomogram based on risk gene signature and clinical features might provide a practical way for recurrence prediction and facilitating personalized managements of ccRCC patients after surgery. [ABSTRACT FROM AUTHOR]

Published
2020
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