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16 results on '"Xue, Xinli"'

3. Additional file 1 of Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics

Author

Li, Yuan, Zhang, Ying, Zhou, Xinjin, Xue, Xinli, Wang, Muxi, Kang, Dedong, Zhou, Yali, Hu, Ruimin, Quan, Songxia, Xing, Guolan, and Yang, Jinghua

Abstract

Additional file 1: Supplemental Tables and Figure. Supplemental Figure 1. Representative extracted ion chromatograms of the targeted peptides of internal standard proteins. Supplemental Table 1. List of significantly high normalized abundance proteins in 10 discovery cohort cases and 10 controls microdissected from renal tissues in parallel. Supplemental Table 2. List of potential internal standard proteins identified in 10 discovery cohort cases by high normalized protein abundance and non-significant abundance ratio to 10 controls from microdissected renal tissues. Supplemental Table 3. List of all identified peptides of amyloidogenic proteins and internal standard proteins in 10 discovery cohort cases and 10 controls microdissected from renal tissues in parallel. Supplemental Table 4. Untargeted proteomic diagnostic signature for 10 cases of early-stage renal amyloidosis. Supplemental Table 5. PRM-based targeted proteomic diagnostic signature for 10 cases early-stage renal amyloidosis.

Published
2023
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5. Open Search-Based Proteomics Reveals Widespread Tryptophan Modifications Associated with Hypoxia in Lung Cancer

Author

Chen, Jinfeng, primary, Zhang, Lei, additional, Sun, Zhao, additional, Li, Hongyi, additional, Li, Jingyi, additional, Xue, Xinli, additional, Zhu, Qingqing, additional, Dong, Bowen, additional, Wang, Yuanyuan, additional, Yang, Yang, additional, Dong, Yongqiang, additional, Guo, Guangyu, additional, Jiang, Hongqiang, additional, Zhang, An, additional, Zhang, Guoqing, additional, Hou, Zhichao, additional, Li, Xiangnan, additional, and Yang, Jing-Hua, additional

Published
2022
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8. Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages

Author

Guo, Shuyuan, primary, Lu, Jianhong, additional, Zhuo, Yujuan, additional, Xiao, Mengqing, additional, Xue, Xinli, additional, Zhong, Shanshan, additional, Shen, Xia, additional, Yin, Chunzhao, additional, Li, Luxiao, additional, Chen, Qun, additional, Zhu, Mingjiang, additional, Chen, Buxing, additional, Zhao, Mingming, additional, Zheng, Lemin, additional, Tao, Yongzhen, additional, and Yin, Huiyong, additional

Published
2019
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9. Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics.

Author

Jiang, Yihong, Qi, Jia, Xue, Xinli, Huang, Rong, Zheng, Jun, Liu, Wei, Yin, Huiyong, and Li, Shengxian

Subjects
POLYCYSTIC ovary syndrome, BIOMARKERS, SHOTGUN sequencing, BLOOD lipids, RECEIVER operating characteristic curves
Abstract

Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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10. TiO2 nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight

Author

Chen, Qun, primary, Wang, Ningning, additional, Zhu, Mingjiang, additional, Lu, Jianhong, additional, Zhong, Huiqin, additional, Xue, Xinli, additional, Guo, Shuoyuan, additional, Li, Min, additional, Wei, Xinben, additional, Tao, Yongzhen, additional, and Yin, Huiyong, additional

Published
2018
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14. Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis

Author

Lu, Jianhong, primary, Guo, Shuyuan, additional, Xue, Xinli, additional, Chen, Qun, additional, Ge, Jing, additional, Zhuo, Yujuan, additional, Zhong, Huiqin, additional, Chen, Buxing, additional, Zhao, Mingming, additional, Han, Wei, additional, Suzuki, Takashi, additional, Zhu, Mingjiang, additional, Xia, Lin, additional, Schneider, Claus, additional, Blackwell, Timothy S., additional, Porter, Ned A., additional, Zheng, Lemin, additional, Tsimikas, Sotirios, additional, and Yin, Huiyong, additional

Published
2017
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15. Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?

Author

Li, Shengxian, primary, Chu, Qianqian, additional, Ma, Jing, additional, Sun, Yun, additional, Tao, Tao, additional, Huang, Rong, additional, Liao, Yu, additional, Yue, Jiang, additional, Zheng, Jun, additional, Wang, Lihua, additional, Xue, Xinli, additional, Zhu, Mingjiang, additional, Kang, Xiaonan, additional, Yin, Huiyong, additional, and Liu, Wei, additional

Published
2016
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16. TiO 2 nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight.

Author

Chen Q, Wang N, Zhu M, Lu J, Zhong H, Xue X, Guo S, Li M, Wei X, Tao Y, and Yin H

Subjects
Animals, Cell Membrane drug effects, Cell Membrane genetics, Cyclooxygenase 2 genetics, Gene Expression Regulation drug effects, Humans, Inflammation chemically induced, Macrophages drug effects, Macrophages pathology, Metabolomics, Mice, Mitochondria pathology, Nanoparticles chemistry, Nitric Oxide Synthase Type II genetics, Phagocytosis drug effects, RAW 264.7 Cells, Reactive Oxygen Species metabolism, Titanium administration & dosage, Titanium chemistry, Tumor Necrosis Factor-alpha genetics, Inflammation genetics, Mitochondria drug effects, Nanoparticles administration & dosage, Proteomics
Abstract

Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in food and cosmetics but the health impact of human exposure remains poorly defined. Emerging evidence suggests that TiO 2 NPs may elicit immune responses by acting on macrophages. Our proteomic study showed that treatment of macrophages with TiO 2 NPs led to significant re-organization of cell membrane and activation of inflammation. These observations were further corroborated with transmission electron microscopy (TEM) experiments, which demonstrated that TiO 2 NPs were trapped inside of multi-vesicular bodies (MVB) through endocytotic pathways. TiO 2 NP caused significant mitochondrial dysfunction by increasing levels of mitochondrial reactive oxygen species (ROS), decreasing ATP generation, and decreasing metabolic flux in tricarboxylic acid (TCA) cycle from 13 C-labelled glutamine using GC-MS-based metabolic flux analysis. Further lipidomic analysis showed that TiO 2 NPs significantly decreased levels of cardiolipins, an important class of mitochondrial phospholipids for maintaining proper function of electron transport chains. Furthermore, TiO 2 NP exposure activates inflammatory responses by increasing mRNA levels of TNF-α, iNOS, and COX-2. Consistently, our targeted metabolomic analysis showed significantly increased production of COX-2 metabolites including PGD 2 , PGE 2 , and 15d-PGJ 2 . In addition, TiO 2 NP also caused significant attenuation of phagocytotic function of macrophages. In summary, our studies utilizing multiple powerful omic techniques suggest that human exposure of TiO 2 NPs may have profound impact on macrophage function through activating inflammatory responses and causing mitochondrial dysfunction without physical presence in mitochondria., (Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2018
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