33 results on '"Xue Ying Zhao"'
Search Results
2. Diagnosis and treatment of the blepharochalasis
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Zai-Lin Xiao, Yuan-Ping Zhang, Xue-Ying Zhao, Xu Zha, Guo-Jiu Wu, and Lin-Kun Ma
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blepharochalasis ,pathogenesis ,clinical features ,therapy ,Ophthalmology ,RE1-994 - Abstract
Blepharochalasis is a rare disease that often onsets in childhood or adolescence. It is characterized by non-painful, non-erythemaous eyelid angioedema with intermittent recurrent episodes, resulting in relaxation, atrophy and thinned of eyelid structures. The late complications, attributing to continuous underlying structural destruction, including ptosis, orbital fat prolapse, lacrimal glands prolapse and blepharophimosis etc. The pathogenesis is not clear yet, researchers have indicated that it might be associated with inheritance and endocrine factors. Nevertheless, histopathology examination showed elastic fibers breakdown, IgA deposits and inflammatory cell infiltration. Based on this, it is assumed that the immunologic mechanism and inflammatory reaction play a significant role in the development of the disease. According to the clinical stage, there are two treatment patterns: oral medicine and surgery at present.
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- 2019
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3. Lindenane‐Type Sesquiterpene Dimers Mitigate Lipopolysaccharide‐Induced Inflammation by Inhibiting Toll‐Like Receptor Signaling
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Xue‐Rong Yang, Jing‐Ru Song, Xiao‐Hua Jiang, Fei Dong, Xiao‐Jie Yan, Jian‐Xing Li, Xue‐Ying Zhao, Dian‐Peng Li, and Feng‐Lai Lu
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Molecular Medicine ,Bioengineering ,General Chemistry ,General Medicine ,Molecular Biology ,Biochemistry - Published
- 2023
4. Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle
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Xue-Rong Yang, Naonobu Tanaka, Jing-Ru Song, Feng-Lai Lu, Xiao-Jie Yan, Jian-Xing Li, Xue-Ying Zhao, Yoshiki Kashiwada, and Dian-Peng Li
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Pharmacology ,Complementary and alternative medicine ,Organic Chemistry ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,General Medicine ,Analytical Chemistry - Published
- 2021
5. Concentrations of heavy metals in PM2.5 and health risk assessment around Chinese New Year in Dalian, China
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Gui Guo Jiang, Xiao Liang Zhao, Meng Guo, Bilal Touseef, Zi Ling Song, Yuan Yuan Huang, Bandna Bharti, and Xue Ying Zhao
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QE1-996.5 ,Health risk assessment ,non-cancer risk ,Geology ,Heavy metals ,cancer risk ,Environmental Science (miscellaneous) ,heavy metal concentration ,Geography ,Environmental health ,health risk assessment ,General Earth and Planetary Sciences ,pm2.5 ,China ,spring festival - Abstract
Twelve samples of heavy metals were analyzed by using a 1108A-1 mid-current particle sampler in Dalian, Liaoning Province, for 31 days before and after the spring festival 2019. The results showed that the concentrations of heavy metals were decreased by more than 25% during the spring festival, which was probably due to the shutdown of the factories and the decrease in people’s travel. During the spring festival, the concentration of Ba was increased by 343.39% as compared to the concentration of Ba before the spring festival, which indicated that the fireworks had a great influence on the concentration of Ba. At the same time, this study also evaluated the health risk of heavy metals. For the heavy metals As, Cd, Co, Cr, and Ni, the lifetime cancer risk was found to be 2.13 × 10−4, 2.08 × 10−5, 8.64 × 10−7, 4.39 × 10−4 and 7.93 × 10−7, respectively. The lifetime cancer risk of As, Cd, and Cr exceeds the threshold range of cancer risk (10−6–10−4), indicating that they are carcinogenic to humans. Also, during the spring festival, the non-carcinogenic risk value of V exceeded the limit value of environmental protection agency (EPA), and the lifetime carcinogenic risk value of As, Cd, and Cr exceeded the threshold range of carcinogenic risk; hence, they need to be carefully monitored and controlled.
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- 2021
6. Effect of Tong Xie Yao Fang on endogenous metabolites in urine of irritable bowel syndrome model rats
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Jian-Wei Wang, Xue-Ying Zhao, Yue Yin, Miao Zhang, Kai Li, and Fu-Ping Yan
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Male ,medicine.medical_specialty ,Constipation ,Irritable colon ,Endogeny ,Urine ,Irritable Bowel Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Tong Xie Yao Fang ,Internal medicine ,medicine ,Metabolomics ,Animals ,Humans ,Intestinal Mucosa ,Rats, Wistar ,Biochemical markers ,Irritable bowel syndrome ,business.industry ,Gastroenterology ,Endogenous metabolites ,General Medicine ,Basic Study ,medicine.disease ,Rats ,Disease Models, Animal ,Endocrinology ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Biomarkers ,Metabolic Networks and Pathways ,Liver-spleen disharmony ,Drugs, Chinese Herbal - Abstract
BACKGROUND Tong Xie Yao Fang is a representative traditional Chinese prescription for the treatment of liver and spleen deficiency, abdominal pain and diarrhea. It has a unique function in the treatment of gastrointestinal dysfunction including irritable bowel syndrome (IBS), is a common functional bowel disease. Its main symptoms are recurrent abdominal pain, diarrhea, constipation or alternations between diarrhea and constipation. There are obvious differences in metabolites between TCM syndromes. By comparing the body fluid metabolism maps of model animals, metabolomics can discover disease biomarkers, analyze the differences in metabolic pathways and understand the pathological process and the metabolic pathways of substances in the body. Thus, the evaluation of animal models tends to be comprehensive and objective. This may provide further understanding between the interaction between Tong Xie Yao Fang and the IBS model. AIM To evaluate the effect of Tong Xie Yao Fang on IBS rats by using metabolomics method. METHODS Wistar rats were used to establish IBS models, and then randomly divided into four groups: A model control group and three Tong Xie Yao Fang treatment groups (high, medium and low doses). A normal, non-IBS group was established. The rats were treated for 2 wk. On days 0 and 14 of the experimental model, urine was collected for 12 h and was analyzed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Nine potential biomarkers were identified, and six major metabolic pathways were found to be related to IBS. RESULTS In the study of metabonomics, nine potential biomarkers including L-serine, 4-methylgallic acid, L-threonine, succinylacetone, prolyl-hydroxyproline, valyl-serine, acetyl citrate, marmesin rutinoside and 5-hydroxy-L-tryptophan were identified in urine, which were assigned to amino acids, organic acids, succinyl and glycosides. Furthermore, the metabolic pathway of L-serine, L-threonine and 5-hydroxy-L-tryptophan was found in the Kyoto Encyclopedia of Genes and Genomes, which mainly involved the metabolism of cysteine and methionine, vitamin B6 metabolism, serotonin synapse, tryptophan metabolism, sphingolipid metabolism, digestion, absorption of protein and amino acid metabolism. These pathways are related to intestinal dysfunction, inflammatory syndrome, nervous system dysfunction and other diseases. CONCLUSION Tong Xie Yao Fang has pharmacological effects on IBS, and its mechanism may be related to the metabolism of the nine potential biomarkers identified above in urine.
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- 2019
7. Anilido-imine zinc complexes: Efficient catalysts for ring-opening polymerization of L-lactide
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Yao, Wei, Cui, Ning, Xue, Ying-zhao, Liu, Tian-tian, and Wang, Yan
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- 2013
- Full Text
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8. TRIM31 enhances chemoresistance in glioblastoma through activation of the PI3K/Akt signaling pathway
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Bing‑Yu Liu, Zhi‑Ping Dun, Chengwei Wang, Xue‑Ying Zhao, Ming‑De Fan, Yang Jiang, Qi Pang, Rui Zhang, and Jian‑Ni Qi
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0301 basic medicine ,Cancer Research ,03 medical and health sciences ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,Glioma ,medicine ,Viability assay ,Protein kinase B ,PI3K/AKT/mTOR pathway ,PI3K/Akt ,Temozolomide ,Akt/PKB signaling pathway ,Chemistry ,glioblastoma ,apoptosis ,chemoresistance ,Articles ,General Medicine ,tripartite motif-containing 31 ,Cell cycle ,medicine.disease ,030104 developmental biology ,Apoptosis ,030220 oncology & carcinogenesis ,Cancer research ,medicine.drug - Abstract
Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that tripartite motif-containing 31 (TRIM31) was abnormally upregulated in glioma tissues and cell lines compared with normal samples. Furthermore, the role of TRIM31 was assessed by overexpressing and knocking down its expression. Overexpression of TRIM31 increased cell viability, increased TMZ IC50 values and inhibited apoptosis in A172 and U251 cells; whereas overexpression of TRIM31 decreased the expression of the apoptosis-associated protein p53. Knockdown of TRIM31 increased apoptosis in cells treated with TMZ. Additionally, the mechanisms by which TRIM31 affected glioma cells treated with TMZ were determined. Overexpression of TRIM31 increased phosphorylation of AKT and inhibiting the PI3K/AKT signaling pathway abolished the increase in cell viability and decreased phospho-Akt protein expression in TRIM31 overexpressing A172 cells treated with TMZ. Together, the findings suggest that TRIM31 may be a potentially novel target for glioma chemotherapy.
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- 2019
9. Systematic tracking of altered modules identifies the key biomarkers involved in chronic lymphocytic leukemia
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Xue‑Ying Zhao, Xin Lu, Shi‑Feng Kan, Chunfeng Li, and Zhen Wu
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differentially expressed genes ,Cancer Research ,Key genes ,Microarray analysis techniques ,Chronic lymphocytic leukemia ,altered modules ,Cancer ,Articles ,Computational biology ,Disease ,Biology ,medicine.disease ,Differentially expressed genes ,Oncology ,hemic and lymphatic diseases ,Ppi network ,medicine ,chronic lymphocytic leukemia ,protein-protein interaction network ,Gene - Abstract
Key genes in chronic lymphocytic leukemia (CLL) were investigated through systematically tracking the dysregulated modules from protein-protein interaction (PPI) networks. Microarray data of normal subjects and CLL patients recruited from ArrayExpress database were applied to extract differentially expressed genes (DEGs). Additionally, we re-weighted the PPI network of normal and CLL conditions by means of Pearsons correlation coefficient (PCC). Furthermore, clique-merging method was applied to extract the modules and then the altered modules were screened out. The intersection genes were selected from miss and add genes in the altered modules. The common genes were screened from the intersection genes and DEGs in CLL. A total of 734 DEGs were screened by statistical analysis. In this investigation, there were 1,805 and 703 modules in normal as well as disease PPI network. In addition, 875 altered modules were obtained which included 145 miss genes, 353 add genes and 85 intersection genes. Finally, in-depth analysis revealed 9 mutual genes between the intersection genes and DEGs in CLL. Our analysis revealed several key genes associated with CLL by systematically tracking the dysregulated modules, which might be candidate targets for diagnosis and management of CLL.
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- 2018
10. Resonant behavior of multiple wave solutions to a Hirota bilinear equation
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Xue-Ying Zhao, Jun Yu, Li-Na Gao, Xing Lü, and Yao-Yao Zi
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Mathematical analysis ,Bilinear interpolation ,Multivariate polynomials ,01 natural sciences ,Exponential function ,Computational Mathematics ,Superposition principle ,Nonlinear Sciences::Exactly Solvable and Integrable Systems ,Computational Theory and Mathematics ,Modeling and Simulation ,0103 physical sciences ,Traveling wave ,010306 general physics ,010301 acoustics ,Mathematics - Abstract
For the exponential traveling wave solutions to the Hirota bilinear equations, a sufficient and necessary criterion for the existence of linear superposition principle has been given. Motivated by this criterion, we propose a new Hirota bilinear equation via using a multivariate polynomial. Applying the linear superposition principle to this new Hirota bilinear equation, we finally find two types of resonant multiple wave solutions, among which, the resonant three-wave solutions are illustrated with three-dimensional plots.
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- 2016
11. Genetic analysis of 17 Y-STR loci in Han population from Shandong Province in East China
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Teng Ma, Huaigu Zhou, Xue-ying Zhao, Shilin Li, Jing Xu, Mingying Xia, Zhiyi Nie, Liming Li, Li Jin, Ziqin Zhao, Shuping Yang, Fuzhong Xue, Yuan Ping, Lan-Hai Wei, and Sun Hui
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Male ,0301 basic medicine ,China ,congenital, hereditary, and neonatal diseases and abnormalities ,Biology ,Genetic analysis ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Gene Frequency ,Ethnicity ,Genetics ,Humans ,Y-STR ,030216 legal & forensic medicine ,Han population ,Allele frequency ,Chromosomes, Human, Y ,Haplotype ,social sciences ,humanities ,eye diseases ,030104 developmental biology ,Haplotypes ,geographic locations ,Microsatellite Repeats - Abstract
• We report haplotype frequencies on 17 Y-STR loci of the Han population of Shandong Province in East China.
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- 2016
12. Association between polymorphisms of autophagy pathway and responses in non-small cell lung cancer patients treated with platinum-based chemotherapy
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Shi-ming, Wang, Xiao, Song, Xue-ying, Zhao, Hong-yan, Chen, Jiu-cun, Wang, Jun-jie, Wu, Zhi-qiang, Gao, Ji, Qian, Chun-xue, Bai, Qiang, Li, Bao-hui, Han, and Da-ru, Lu
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Adult ,Male ,Polymorphism, Genetic ,Genotype ,Intracellular Signaling Peptides and Proteins ,Vesicular Transport Proteins ,Autophagy-Related Proteins ,Membrane Proteins ,Middle Aged ,Polymorphism, Single Nucleotide ,Carcinoma, Non-Small-Cell Lung ,Ubiquitin-Conjugating Enzymes ,Autophagy ,Autophagy-Related Protein-1 Homolog ,Humans ,Female ,Aged ,Platinum - Abstract
Platinum-based chemotherapy is an important treatment for non-small cell lung cancer. However, the effectiveness of the treatment varies among the patients. We investigated the association between DNA polymorphisms of the autophagy pathway and responses of such treatment among 1004 Chinese patients. Ninety-nine SNPs located on 13 genes of the autophagy pathway were genotyped and assessed for their association with clinical benefit, progression-free survival (PFS) and overall survival (OS). The results showed that rs7953348 (GA) (P=0.017, OR: 0.67, 95%CI: 0.49-0.93) and rs12303764 (AC) (P=0.009, OR: 0.63, 95%CI: 0.45-0.89) at the ULK1 gene, and rs17742719 (CA) (P=0.002, OR: 1.83, 95%CI: 1.26-2.66), rs8003279 (AG) (P=0.006, OR: 1.65, 95%CI: 1.16~2.35) and rs1009647 (GA) (P=0.002, OR: 1.70, 95%CI: 1.22-2.37) at the ATG14 gene were associated with clinical benefit. Polymorphisms at rs7955890 (GA) (P=0.004, HR: 0.63; 95%CI: 0.46-0.86) and rs17032060 (GA) (P=0.006, HR: 0.65, 95%CI: 0.48-0.88) at the DRAM gene, and rs13082005 (GA) (P=0.012, HR: 1.27, 95%CI: 1.05-1.53) at the ATG3 gene were significantly associated with PFS. We also found that rs7953348 (GA) (P=0.011, HR: 0.74, 95%CI: 0.58-0.93) at the ULK1 gene and rs1864183 (GA) (P=0.016, HR: 0.42, 95%CI: 0.21-0.85) at the ATG10 gene were associated with OS. Thus, the study demonstrated that the autophagy pathway might play important role(s) in platinum-based chemotherapy. DNA polymorphisms in its component genes can potentially be predictors for clinical responses of platinum-based chemotherapy among the patients with non-small lung cancer.
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- 2017
13. Comparison on Dam Risk Consequences Comprehensive Evaluation Model
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Xue Ying Zhao, Hao Yao Zheng, Wei Wei Sun, and Lei Li
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Engineering ,Matter element ,business.industry ,Principal component method ,Statistics ,Fuzzy mathematics ,General Engineering ,Correlation method ,business - Abstract
Many evaluation factors are involved in dam risk consequences comprehensive evaluation, which exist plenty of uncertainty and correlation between each other. Combined the five methods, such as linear weighted sum method, fuzzy mathematics method, matter element method, gray correlation method and principal component method with dam risk consequences comprehensive evaluation, establishing five dam risk comprehensive evaluation models, applying to the level evaluation of Changlong Reservoir, Xialan Reservoir, Shibikeng Reservoir, Longshan Reservoir, Lingtan Reservoir successfully.
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- 2013
14. Sluice Risk Consequences Comprehensive Evaluation Based on Grey Relational Analysis
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Hao Yao Zheng, Jin Bao Sheng, Yin Wang, Xue Ying Zhao, and Xue Hui Peng
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Engineering ,Risk analysis (engineering) ,business.industry ,Order (business) ,Sluice ,General Engineering ,business ,Grey relational analysis ,Civil engineering - Abstract
Many sluices had low standard and poor quantity, which were damaged seriously after several decades use. In sluice safety levels classification standard, there are quantitative indexes and qualitative indexes, which isnt convenient to assess sluice risk consequence objectively. In order to improve the technology of sluice safety comprehensive evaluation and reduce the risk of sluice operating, grey relational analysis method was used to evaluate the sluice according to the specific conditions of the sick-dangerous sluices and some special managing principle. The result is objective and reasonable, so we assess sluice easily, providing a new way for sluices risk consequences comprehensive evaluation.
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- 2013
15. [Application of Ion Torrent PGM™ System in Detection of Fetal DNA in Maternal Plasma]
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Ya-nan, Liu, Xue-ying, Zhao, Yuan, Ping, Qing-wen, Xu, Jiang-ping, Huang, Kai-nan, Zou, and Huai-gu, Zhou
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Male ,Sex Determination Analysis ,Chromosomes, Human, Y ,Polymorphism, Genetic ,Genotype ,DNA ,Fetal Blood ,Polymerase Chain Reaction ,Sensitivity and Specificity ,Haplotypes ,Pregnancy ,Tandem Repeat Sequences ,Humans ,Family ,Female ,Alleles - Abstract
To explore the feasibility of detecting of Y-STR of fetal DNA in maternal plasma using Ion Torrent PGM™ System.A total of 16 fetal DNA samples from maternal plasmas (8 cases from 38 weeks gestational age and 8 ones from 12 weeks) were prepared and a multiplex assay with 7 STR loci (DYS390, DYS391, DYS393, DYS438, DYS437, DYS456, DYS635) was designed for multiplex-PCR amplification. Using Ion Torrent PGM™ System, the results of Y-STR sequences and capillary electrophoresis were obtained and compared.Y-STR specific alleles were detected in the maternal plasma of all the pregnant women having male babies of second and third trimester, which were higher than that detected by capillary electrophoresis. Consistent Y-STR genotypes were observed between fetal DNA from maternal plasma and genomic DNA from the newborn babies.Based on Ion Torrent PGM™ System, the prenatal Y-STR detection method may provide a high-sensitive and high-throughput choice for prenatal STR detection in forensic testing.
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- 2016
16. High Temperature Thermoelectric Property of Sr-Filled Skutterudite SryCo4Sb12
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S.Q. Bai, Xue Ying Zhao, Xinfeng Tang, Xun Shi, Wen Bing Zhang, and Lidong Chen
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Materials science ,Mechanical Engineering ,Analytical chemistry ,Mineralogy ,engineering.material ,Atmospheric temperature range ,Thermal conduction ,Thermoelectric materials ,Thermal conductivity ,Mechanics of Materials ,Electrical resistivity and conductivity ,Seebeck coefficient ,Thermoelectric effect ,engineering ,General Materials Science ,Skutterudite - Abstract
Sr-filled skutterudite compounds SryCo4Sb12 (y=0-0.20) were synthesized by melting method. XRD and EPMA results revealed that the obtained samples are single skutterudite phase with homogeneous chemical composition. The lattice parameters increase linearly with increasing Sr content in the range of y=0-0.20. The thermal conductivity, electrical conductivity and Seebeck coefficient were measured in the temperature range of 300-850K. The measurement of Hall effect was performed by Van de Pauw method at room temperature. The obtained Sr-filled skutterudite exhibits n-type conduction. The absolute value of the Seebeck coefficient of SryCo4Sb12 decreases with the increase of Sr content. The electrical conductivity increases with the increase of Sr content. The lattice thermal conductivity of SryCo4Sb12 is significantly depressed as compared with unfilled CoSb3. The maximum dimensionless thermoelectric figure of merit is 0.7 for Sr0.20Co4Sb12 at 850K. Further optimization of chemical composition would improve the thermoelectric performance.
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- 2007
17. Role of laparoscopy in the diagnosis and treatment of adnexal masses
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Junji Zhang, Jinhua Leng, Lan Zhu, Feng-zhi Feng, Xue-ying Zhao, Zhu-feng Liu, Dawei Sun, and Jinghe Lang
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Laparoscopic surgery ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Ovary ,General Medicine ,medicine.disease ,Malignancy ,Adnexal mass ,Surgery ,medicine.anatomical_structure ,Laparotomy ,medicine ,Stage (cooking) ,Laparoscopy ,business ,Ovarian cancer - Abstract
Background Laparoscopy has been accepted for years as a management of benign ovarian tumors. The aim of this study was to estimate the feasibility and safety of laparoscopy in diagnosis and management of adnexal masses. Methods A total of 2083 patients with benign adnexal mass were treated by laparoscopy at Peking Union Medical College Hospital from January 2000 to December 2003. Their clinical data were reviewed retrospectively. All the adnexal masses suspicious of malignancy at the time of laparoscopy were sent for frozen section evaluation intraoperatively. The rates of unexpected intracystic vegetation and low malignant potential (LMP) tumor or malignancy were investigated. The sensitivity, specificity, positive predictive value, and negative predictive value of laparoscopic diagnosis for LMP or ovarian malignancies were calculated. The ratios were compared by Chi-square test and the continuous variables were tested using two-tailed t test. Results Of the 2083 patients, 16 had LMP or invasive tumors (0.77%), among which 14 were diagnosed histologically intraoperatively and 2 postoperatively. Fifty-five (2.6%) of the 2083 patients had unexpected intracystic vegetations. Their frozen sections showed benign tumors in 41 (74.5%), LMP tumors in 8 (14.5%), and focal invasive ovarian cancers (stage Ic) in 6 (10.9%). The final pathological diagnosis were benign tumors in 41 (74.5%), LMP tumors 7 (12.7%), and focal invasive ovarian cancers (stage Ic) in 7 (12.7%). Laparoscopy achieved a sensitivity of 87.5%, specificity of 98%, positive predictive value of 25.5%, and negative predictive value of 99.9% in the diagnosis of ovarian malignancies. 2067 cases with benign adnexal masses underwent laparoscopy successfully. No conversion to laparotomy, or intra- and postoperative complications in this series. Of the 16 patients with LMP or invasive ovarian cancer, seven underwent laparoscopic surgery including immediate staging laparoscopy in 3. The mean follow-up was 17.3 months for the 16 patients. Among them, 1 developed a recurrent LMP tumor in the contralateral ovary 36 months after laparoscopic salpingo-oophorectomy, and received subsequent laparoscopic cystectomy and pelvic lymph node sampling; the others had no evidence of recurrent tumor during the follow-up. Conclusion Laparoscopy is feasible for diagnosis of adnexal masses, and the surgery is safe for patients with benign ovarian tumors.
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- 2006
18. Anilido-imine zinc complexes: Efficient catalysts for ring-opening polymerization of L-lactide
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Wang Yan, Liu Tian-tian, Cui Ning, Xue Ying-zhao, and Yao Wei
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chemistry.chemical_compound ,Lactide ,chemistry ,Polymerization ,Benzyl alcohol ,Imine ,Polymer chemistry ,chemistry.chemical_element ,Reactivity (chemistry) ,General Chemistry ,Zinc ,Ring-opening polymerization ,Catalysis - Abstract
A series of anilido-imine zinc complexes ortho-C6H4(CH=NAr)(NAr)ZnEt[Ar=2,6-Me2C6H3(2a); Ar=2,6-Et2C6H3(2b)] was synthesized, characterized and used as catalysts for the ring-opening polymerization of L-lactide in the presence of benzyl alcohol. The effects of the structures of catalysts and reaction conditions on the reactivity were investigated. The polymerization of L-lactide initiated by each of these complexes was found to take place with a controlled manner.
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- 2013
19. Activity and Physico Chemical Properties of Trypsin Inhibitor in Bruchid-Resistant Mung Bean
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Xue-Ying Zhao, Yan-Ping Fan, Yao-Wen Zhang, and Xian-Hong Zhang
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Mung bean ,Chemistry ,Trypsin inhibitor ,Plant Science ,Food science ,Agronomy and Crop Science ,Biotechnology - Published
- 2017
20. Tong Xie Yao Fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P
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Jian-Wei Wang, Lei Zhong, Hai-Xue Kuang, Wen-Jing Zhao, Xue-Ying Zhao, and Yue Yin
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Agonist ,medicine.medical_specialty ,Serotonin ,Time Factors ,medicine.drug_class ,Colon ,Anti-Inflammatory Agents ,Hypothalamus ,Substance P ,Gastroenterology ,Enteric Nervous System ,Irritable Bowel Syndrome ,chemistry.chemical_compound ,Gastrointestinal Agents ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Defecation ,Irritable bowel syndrome ,Gastrointestinal agent ,business.industry ,General Medicine ,Smooth muscle contraction ,Basic Study ,medicine.disease ,Disease Models, Animal ,Endocrinology ,chemistry ,Animals, Newborn ,Enteric nervous system ,business ,Gastrointestinal Motility ,Drugs, Chinese Herbal ,Signal Transduction - Abstract
AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang (TXYF) improves dysfunction in an irritable bowel syndrome (IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats (1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine (5-HT) and substance P (SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral hypersensitivity. RESULTS: Defecation frequency was 1.8 ± 1.03 in normal rats and 4.5 ± 1.58 in IBS model rats (P < 0.001). However, the defecation frequency was significantly decreased (3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time (in seconds) of colon transit function was significantly increased (256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.
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- 2014
21. Clinical study on Shuxuening'Equation missing' <!-- No EquationSource Format='TEX', only image --> combined with antipsychotics in treating chronic schizophreniacombined with antipsychotics in treating chronic schizophrenia
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Fanqiang Meng, Xin Yu, Mei-Lan Zhu, Hong-Wen Zhong, Chun-xiang Tan, Xue-ying Zhao, Yucun Shen, Yuhua Cui, Xu-dong Yang, Ping Liu, Lian-Cheng Zhu, He-Chun Luo, and Jian-cheng Liu
- Subjects
medicine.medical_specialty ,Side effect ,business.industry ,General Medicine ,Antipsychotic treatment ,Placebo ,Disease course ,Clinical study ,Internal medicine ,Brief Psychiatric Rating Scale ,medicine ,Chronic schizophrenia ,Clinical efficacy ,business - Abstract
Objective: To make a preliminary evaluation of the clinical efficacy of Shuxuening (SXN).Methods: One hundred and forty-nine chronic schizophrenic patients were divided randomly into the SXN group and the control group in a double-blind research. SXN was given to the SXN group and placebo to the control group, and patients of both groups went on receiving the previous antipsychotic treatment. Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS) and Treatment Emergent Symptoms Scale (TESS) were used to assess the effects of treatment and side effects of the drug. The evaluation was done before and during the 2nd, 4th, 6th, 10th and 12 th weeks in the course of treatment.Results: SXN was effective by BPRS evaluation (P < 0.05), and even the more effective to negative symptoms than positive symptoms by SANS evaluation (P < 0.05). It was safe and with little side effect. In addition, it was found that the incipience of SXN’ s efficacy was somehow related with the course of disease and the daily dosage used.Conclusion: SXN is worthy of further study n the treatment of chronic schizophrenia.
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- 1997
22. High Temperature Thermoelectric Property of Sr-Filled Skutterudite SryCo4Sb12
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Xue Ying Zhao, Xun Shi, Li Dong Chen, Sheng Qiang Bai, Wen Bing Zhang, and Xin Feng Tang
- Published
- 2007
23. [Visual and histologic analysis of laparoscopic diagnosis of endometriosis]
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Jin-hua, Leng, Jing-he, Lang, Xue-ying, Zhao, Hua-jun, Li, Li-na, Guo, and Quan-cai, Cui
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Adult ,Uterine Diseases ,Evaluation Studies as Topic ,Biopsy ,Ovary ,Endometriosis ,Humans ,Female ,Laparoscopy ,Prospective Studies ,Sensitivity and Specificity ,Pelvis - Abstract
To determine the characteristics of anatomical distribution of pelvic endometriosis and the correlation between visual and histologic findings of endometriosis at laparoscopy.A prospective study of 62 patients undergoing laparoscopy for the pelvic pain, infertility and/or pelvic masses was carried out. All lesions with the diagnosis of endometriosis laparoscopically were excised and examined pathologically. Normal-appearing peritoneal biopsies were obtained randomly. All lesions were identified by anatomical site and color of the foci. The positive predictive value (PPV), sensitivity, negative predictive value (NPV), and specificity were determined for visually identified endometriosis versus the histologic findings.Totally, 219 peritoneal endometriotic lesions, 54 normal peritoneal biopsies, and 71 ovarian endometriotic cysts were obtained. Peritoneal lesions tended to locate in posterior part of the pelvis (80.8%, 177/219) and in left (58.0%, 127/219) with most in black (39.2%). The PPV was 67.6%; sensitivity, 93.7%; NPV, 81.4%; and specificity, 38.3% for visual versus histologic diagnosis of peritoneal endometriosis. Lesions in black or from sacral ligaments were confirmed histologically in 94.2% and 84.7% respectively, and 80.3% (57/71) of ovarian endometriotic cysts diagnosed by laparoscopy were confirmed histologically with 43.6% in the left, 27.3% in the right; and 29.1% (16/55) in both sides of the ovary. In addition, 18.5% (10/54) of normal-appearing peritoneal biopsy were identified as endometriosis by pathological examination. Laparoscopy was confirmed to be in 100% diagnostic accordance with pathology for patients with endometriosis.Our study showed asymmetrical distribution of pelvic endometriosis. Peritoneal lesions in black or from sacral ligament are more likely to be histologically confirmed, and microscopic lesions are not a rare phenomenon of endometriosis.
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- 2006
24. [Clinical observation on effect of danzhi xiaoyao powder in treating depression]
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He-Chun, Luo, Rui-Qin, Qian, Xue-Ying, Zhao, Juan, Bi, Hongling, Xin, Xuezhu, Jiang, Ke, Xu, and Shaoxiao, Yan
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Adult ,Male ,Psychiatric Status Rating Scales ,Depressive Disorder ,Double-Blind Method ,Maprotiline ,Humans ,Female ,Middle Aged ,Antidepressive Agents ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
To observe the effect and side effect of Danzhi Xiaoyao powder (DXP) in treating depression.A randomized controlled and double-blinded study was conducted in 63 cases of depression by divided them into the western medicine group (WMG, 31 cases) treated with maprotiline, and the Chinese medicine group (CMG, 32 cases) treated with DXP. The effect of therapy was evaluated before and at the 2nd, 4th and 6th week of the treatment with Hamilton's depressive scale (HAMD), self-rating depression scale (SDS), self-rating anxiety scale (SAS) and the scale for TCM syndrome and symptom differentiation (TCM-SSD), and the side-effect of therapy was assessed with Asberg side-effect scale as well.There was no significant difference between the two groups in scores of HAMD, SDS, SAS, and TCM-SSD. The markedly effective rate in CMG was 84% and in WMG 87%, showed no significance between them (P0.05). The scores of HAMD, SDS and SAS of both groups were remarkably lowered after therapy (P0.05). However, the score of Asberg in CMG was lower than that in WMG (P0.05).DXP shows the effect equivalent to that of maprotiline, but with obviously less side-effect.
- Published
- 2006
25. Role of laparoscopy in the diagnosis and treatment of adnexal masses
- Author
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Jin-hua, Leng, Jing-he, Lang, Jun-ji, Zhang, Feng-zhi, Feng, Zhu-feng, Liu, Da-wei, Sun, Lan, Zhu, and Xue-ying, Zhao
- Subjects
Adult ,Ovarian Neoplasms ,Adolescent ,Humans ,Female ,Laparoscopy ,Middle Aged ,Aged - Abstract
Laparoscopy has been accepted for years as a management of benign ovarian tumors. The aim of this study was to estimate the feasibility and safety of laparoscopy in diagnosis and management of adnexal masses.A total of 2083 patients with benign adnexal mass were treated by laparoscopy at Peking Union Medical College Hospital from January 2000 to December 2003. Their clinical data were reviewed retrospectively. All the adnexal masses suspicious of malignancy at the time of laparoscopy were sent for frozen section evaluation intraoperatively. The rates of unexpected intracystic vegetation and low malignant potential (LMP) tumor or malignancy were investigated. The sensitivity, specificity, positive predictive value, and negative predictive value of laparoscopic diagnosis for LMP or ovarian malignancies were calculated. The ratios were compared by Chi-square test and the continuous variables were tested using two-tailed t test.Of the 2083 patients, 16 had LMP or invasive tumors (0.77%), among which 14 were diagnosed histologically intraoperatively and 2 postoperatively. Fifty-five (2.6%) of the 2083 patients had unexpected intracystic vegetations. Their frozen sections showed benign tumors in 41 (74.5%), LMP tumors in 8 (14.5%), and focal invasive ovarian cancers (stage Ic) in 6 (10.9%). The final pathological diagnosis were benign tumors in 41 (74.5%), LMP tumors 7 (12.7%), and focal invasive ovarian cancers (stage Ic) in 7 (12.7%). Laparoscopy achieved a sensitivity of 87.5%, specificity of 98%, positive predictive value of 25.5%, and negative predictive value of 99.9% in the diagnosis of ovarian malignancies. 2067 cases with benign adnexal masses underwent laparoscopy successfully. No conversion to laparotomy, or intra- and postoperative complications in this series. Of the 16 patients with LMP or invasive ovarian cancer, seven underwent laparoscopic surgery including immediate staging laparoscopy in 3. The mean follow-up was 17.3 months for the 16 patients. Among them, 1 developed a recurrent LMP tumor in the contralateral ovary 36 months after laparoscopic salpingo-oophorectomy, and received subsequent laparoscopic cystectomy and pelvic lymph node sampling; the others had no evidence of recurrent tumor during the follow-up.Laparoscopy is feasible for diagnosis of adnexal masses, and the surgery is safe for patients with benign ovarian tumors.
- Published
- 2006
26. Fabrication of Metal-Organic Framework and Infinite Coordination Polymer Nanosheets by the Spray Technique.
- Author
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Yu-Nong Li, Sha Wang, Yuan Zhou, Xiao-Jue Bai, Guo-Shuai Song, Xue-Ying Zhao, Tie-Qiang Wang, Xuan Qi, Xue-Min Zhang, and Yu Fu
- Published
- 2017
- Full Text
- View/download PDF
27. Preliminary research on treatment of common mental disorders with computer controlled electroacupuncture
- Author
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Yun-Kui Jia, Xue-ying Zhao, Yucun Shen, He-Chun Luo, Fanqiang Meng, Xiu-Qin Feng, and Hua Guo
- Subjects
medicine.medical_specialty ,business.industry ,Electroacupuncture ,medicine.medical_treatment ,Neurosis ,General Medicine ,medicine.disease ,Schizophrenia ,Internal medicine ,Medicine public health ,medicine ,Amitriptyline ,Single episode ,Psychiatry ,business ,Depression (differential diagnoses) ,medicine.drug ,Common mental disorder - Abstract
Electroacupuncture(EA) has proved as effective as amitriptyline in the treatment of depression. The present article compared the therapeutic efficacy of electroacupuncture on common mental disorder and that of computer controlled electroacupuncture (CCEA) treatment of the same disease. The results showed that CCEA treatment had a better effect than EA for the treatment of single episode depression. CCEA treatment was generally superior to EA for the treatment of schizophrenia, depression and neurosis. The mechanism of CCEA for the treatment of common mental disorders was discussed.
- Published
- 1996
28. [Clinical characteristics of abdominal wall endometrioma and its recurrence-related factors]
- Author
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Xue-ying, Zhao, Jing-he, Lang, Jin-hua, Leng, Zhu-feng, Liu, Hua-jun, Li, Da-wei, Sun, and Lan, Zhu
- Subjects
Adult ,Treatment Outcome ,Pregnancy ,Recurrence ,Risk Factors ,Abdominal Wall ,Endometriosis ,Humans ,Female ,Retrospective Studies - Abstract
To analyze the clinical characteristics, and treatment, recurrence-related factors of abdominal wall endometriomas (AWE).Fifty-seven cases of AWE treated at Peking Union Medical College Hospital from 1983 to 2002 were reviewed.The incidence of AWE was 1.04% (57/5478) in patients with endometriosis after surgical treatment. It was 0.046% in patients undergoing cesarean section in the same period. Of 57 cases with AWE, 56 had low-abdominal operation previously and one was primary umbilicus endometrioma. Fifty-five cases of AWE were secondary to cesarean section. The latent period of AWE was positively correlated to patient's age at onset (P0.001). Fifty-five cases received surgical treatment while 2 were given medical treatment. Follow-up duration was 1.1 - 235 months. Five cases recurred and one was transformed to malignancy. The recurrence was correlated to the size and depth of the lesions.AWE could be diagnosed prior to operation according to its typical clinical manifestations. Ultrasonic examination may be valuable for the diagnosis of atypical cases. Surgical treatment is effective. A complete excision with clear margin is very important to prevent recurrence.
- Published
- 2004
29. [Sentinel lymph notes in female reproductive tract cancer]
- Author
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Jing-he, Lang and Xue-ying, Zhao
- Subjects
Vaginal Neoplasms ,Vulvar Neoplasms ,Genital Neoplasms, Female ,Sentinel Lymph Node Biopsy ,Lymphatic Metastasis ,Humans ,Lymph Node Excision ,Uterine Cervical Neoplasms ,Female ,Lymph Nodes ,Radionuclide Imaging ,Endometrial Neoplasms - Abstract
To reduce extensive radical procedures and decrease morbidity in gynecologic malignancies, much effort is being focused on implementing less aggressive interventions. Two different approaches such as lymphatic mapping and lymphoscintigraphy are currently used to identify sentinel lymph nodes. In vulvar and cervical carcinomas, metastatic spread of disease commonly follows stepwise progressive drainage. Thus, sentinel lymph node identification may significantly reduce the number of patients undergoing unnecessary, extensive lymphadenectomy in the absence of metastatic disease. The addition of novel techniques, such as histopathologic ultrastaging, step sectioning, and immunohistochemistry staining, will help increase the accuracy and rate of detection of the disease. Any definitive statements can be made to the validity of sentinel lymphadenectomy until we got data with long-term follow-up.
- Published
- 2003
30. Clinical research on the therapeutic effect of the electro-acupuncture treatment in patients with depression
- Author
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Xue-ying Zhao, Yun-Kui Jia, Fanqiang Meng, and He-Chun Luo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Side effect ,Electroacupuncture ,medicine.medical_treatment ,Amitriptyline ,Antidepressive Agents, Tricyclic ,Placebo ,law.invention ,Randomized controlled trial ,Double-Blind Method ,law ,medicine ,Humans ,Psychiatry ,Depressive Disorder ,General Neuroscience ,Therapeutic effect ,Infant, Newborn ,Hamilton Rating Scale for Depression ,General Medicine ,Combined Modality Therapy ,Psychiatry and Mental health ,Treatment Outcome ,Neurology ,Anesthesia ,Clinical Global Impression ,Female ,Neurology (clinical) ,Psychology ,medicine.drug - Abstract
Electroacupuncture (EA) stimulation has been found to influence the brain (norepinephrine metabolism in experimental animals). Preliminary clinical research has shown that EA treatment is as effective as amitriptyline for patients with depression. In this study, two consecutive clinical studies on the treatment of depression with EA are conducted. The first study was double blind placebo controlled, in which 29 depressed inpatients were recruited. Patients were randomly divided into three groups: EA + placebo; amitriptyline; and EA + amitriptyline. They received EA and/or amitriptyline treatment for 6 weeks. The Hamilton Rating Scale for Depression, Clinical Global Impression and ASBERG scales for the side effect of antidepressants were used to evaluate the therapeutic efficacy and side effects. Based on the results and research protocol of the first study, a multi-centered collaborative study was conducted, in which 241 inpatients with depression were recruited. Patients were randomly divided into two treatment groups: the EA + placebo and the amitriptyline groups. The results from both studies showed that the therapeutic efficacy of EA was equal to that of amitriptyline for depressive disorders (P > 0.05). Electro-acupuncture had a better therapeutic effect for anxiety somatization and cognitive process disturbance of depressed patients than amitriptyline (P < 0.05). Moreover, the side effects of EA were much less than that of amitriptyline (P < 0.001). The article suggested that EA treatment was an effective therapeutic method for depressive disorders. Particularly, it was a treatment of choice for depressed patients who were unable to comply with the classic tricyclic antidepressants because of their anticholinergic side effects. The possible mechanism of EA treatment is discussed.
- Published
- 1999
31. Adsorption geometry of glycine on Cu(001) determined with low-energy electron diffraction and scanning tunnelling microscopy
- Author
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Si-Ping, Ge, primary, Xue-Ying, Zhao, additional, Zheng, Gai, additional, Ru-Guang, Zhao, additional, and Wei-Sheng, Yang, additional
- Published
- 2002
- Full Text
- View/download PDF
32. Adsorption of L-Phenylalanine on Cu(001)
- Author
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Hao, Wang, primary, Xue-Ying, Zhao, additional, Ru-Guang, Zhao, additional, and Wei-Sheng, Yang, additional
- Published
- 2001
- Full Text
- View/download PDF
33. Tong Xie Yao Fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P.
- Author
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Yin Y, Zhong L, Wang JW, Zhao XY, Zhao WJ, and Kuang HX
- Subjects
- Animals, Animals, Newborn, Colon innervation, Colon metabolism, Colon physiopathology, Defecation drug effects, Disease Models, Animal, Enteric Nervous System drug effects, Enteric Nervous System metabolism, Enteric Nervous System physiopathology, Gastrointestinal Motility drug effects, Hypothalamus drug effects, Hypothalamus metabolism, Hypothalamus physiopathology, Irritable Bowel Syndrome genetics, Irritable Bowel Syndrome metabolism, Irritable Bowel Syndrome physiopathology, Rats, Wistar, Signal Transduction drug effects, Substance P genetics, Time Factors, Anti-Inflammatory Agents pharmacology, Colon drug effects, Drugs, Chinese Herbal pharmacology, Gastrointestinal Agents pharmacology, Irritable Bowel Syndrome drug therapy, Serotonin metabolism, Substance P metabolism
- Abstract
Aim: To investigate whether the Chinese medicine Tong Xie Yao Fang (TXYF) improves dysfunction in an irritable bowel syndrome (IBS) rat model., Methods: Thirty baby rats for IBS modeling were separated from mother rats (1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine (5-HT) and substance P (SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral hypersensitivity., Results: Defecation frequency was 1.8 ± 1.03 in normal rats and 4.5 ± 1.58 in IBS model rats (P < 0.001). However, the defecation frequency was significantly decreased (3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time (in seconds) of colon transit function was significantly increased (256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation., Conclusion: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.
- Published
- 2015
- Full Text
- View/download PDF
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