Search

In this manuscript, an independent method is proposed to estimate opening angle of dust torus in AGN, through unique properties of Type-1.9 AGN with double-peaked broad Hα (Type-1.9 DPAGN) coming from central accretion disc. Type-1.9 AGN without broad Hβ can be expected by the commonly accepted unified model of AGN, considering central BLRs seriously obscured by dust torus with its upper boundary in the line of sight. For the unique Type-1.9 DPAGN, accretion disc originations of double-peaked broad Hα can be applied to determine the inclination angle of the central accretion disc, which is well accepted as substitute of the half opening angle of the central dust torus. Then, among low redshift Type-1.9 DPAGN in SDSS, SDSS J1607+3319 at redshift 0.063 is collected, and the half opening angle of the central dust torus is determined to be around 46 ± 4°, after considering the disfavoured BBH system to explain the double-peaked broad Hα through long-term none variabilities and disfavoured local physical conditions to explain the disappearance of broad Hβ through virial BH mass properties. The results indicate that more detailed studying on dust torus of AGN can be appropriately done through Type-1.9 DPAGN in the near future.

In the letter, interesting evidence is reported to support a central tidal disruption event (TDE) in the known AGN NGC 1097. Considering the motivations of TDE as one probable origination of emission materials of double-peaked broad emission lines and also as one probable explanation to changing-look AGN, it is interesting to check whether there are clues to support a TDE in NGC 1097, not only a changing-look AGN but also an AGN with double-peaked broad emission lines. Under the assumption that the onset of broad Hα emission was due to a TDE, the 13 yr-long (1991–2004) variability of double-peaked broad Hα line flux in NGC 1097 can be well predicted by theoretical TDE model, with a (1 − 1.5) M⊙ main-sequence star tidally disrupted by the central BH with TDE model determined mass about (5 − 8) × 107 M⊙. The results provide interesting evidence to not only support TDE-related origin of double-peaked broad line emission materials but also support TDE as an accepted physical explanation to physical properties of changing-look AGN.

In the Letter, an interesting method is proposed to estimate size of narrow emission-lines regions (NLRs) of a type-2 AGN SDSS J083823.91 + 490241.1 (=SDSS J0838) at a redshift of 0.101, by comparing spectroscopic properties through the SDSS fibre (MJD = 51873) (diameter of 3 arcsec) and through the eBOSS fibre (MJD = 55277) (diameter of 2 arcsec). After subtractions of ppxf method determined host galaxy contributions, the narrow emission lines of SDSS J0838 in the SDSS spectrum and in the eBOSS spectrum can be well measured by Gaussian functions, leading more than 90 per cent of [O iii] emissions to be covered by the eBOSS fibre with diameter of 2 arcsec. Meanwhile, both none broad emission components and none-variabilities of ZTF 3 yr-long g-/r-band light curves can be applied to confirm SDSS J0838 as a type-2 AGN, indicating few orientation effects on the projected NLRs size in SDSS J0838. Therefore, upper limit about 1 arcsec (2250 pc) of the NLRs size can be reasonably accepted in SDSS J0838. Combining with the intrinsic reddening corrected [O iii] line luminosity, the upper limit of NLRs size in SDSS J0838 well lies within the 99.9999 per cent confidence bands of the R-L empirical relation for NLRs in AGN.

In the letter, a new candidate for central tidal disruption event (TDE) is reported in SDSS J014124 + 010306 (= SDSS J0141) with broad Mg ii line at redshift $\mathit{ z}$ = 1.06. Based on long-term photometric ugriz-band variabilities from SDSS Stripe82 Data base and PHOTOOBJALL data base, a central TDE is preferred with a 1.3 M⊙ main-sequence star tidally disrupted by central black hole (BH) of (14 ± 2) × 106 M⊙ in SDSS J0141. Moreover, CAR process has been applied to confirm that the probability is only about 0.4 per cent that the long-term variabilities in SDSS J0141 are not related to TDE but from intrinsic active galactic nucleus (AGN) activities. Meanwhile, based on the apparent broad Mg ii emission lines, virial BH mass can be estimated as 245 × 106 M⊙, 18 times larger than the TDE model determined BH mass, providing further clues to support a central TDE in SDSS J0141, similar to the case in the TDE candidate SDSS J0159 with virial BH mass two magnitudes larger than M-sigma relation expected BH mass. Among the reported optical TDE candidates, SDSS J0141 is the candidate at the highest redshift. The results in the letter indicate it should be common to detect TDE candidates in high redshift galaxies with broad Mg ii lines.

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupled receptors (GPCRs) dominate, followed by ion channels, transporters, and—to a lesser extent—membrane-bound enzymes. However, various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic antibodies. Antibodies hold the promise of exquisite specificity, as they are able to target even specific conformations of a particular membrane protein, as well as adaptability through engineering into various antibody formats. However, the ease of raising and isolating specific, effective antibodies targeting membrane proteins depends on many factors. In particular, the generation of specific antibodies is easier when targeting larger, simpler, extracellular domains with greater uniqueness of amino acid sequence. The rareness of such ideal conditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complex membrane proteins. Challenges in developing antibodies to complex membrane proteins such as GPCRs, ion channels, transporters, and membrane-bound enzymes can be addressed by the design of the antigen, antibody-generation strategies, lead optimization technologies, and antibody modalities. A better understanding of the membrane proteins being targeted would facilitate mechanism-based drug discovery. This review describes the advantages and challenges of targeting complex membrane proteins with antibodies and discusses the preparation of membrane protein antigens and antibody generation, illustrated by select examples of success.

The fast blue optical transients (FBOTs) are a new population of extragalactic transients of unclear physical origin. A variety of mechanisms have been proposed including failed supernova explosion, shock interaction with a dense medium, young magnetar, accretion onto a compact object, and stellar tidal disruption event, but none is conclusive. Here we report the discovery of a possible X-ray quasi-periodicity signal with a period of $\sim$250 second (at a significance level of 99.76%) in the brightest FBOT AT2018cow through the analysis of XMM-Newton/PN data. The signal is independently detected at the same frequency in the average power density spectrum from data taken from the Swift telescope, with observations covering from 6 to 37 days after the optical discovery, though the significance level is lower (94.26%). This suggests that the QPO frequency may be stable over at least 1.1$\times$ 10$^{4}$ cycles. Assuming the $\sim$250 second QPO to be a scaled-down analogue of that typically seen in stellar mass black holes, a black hole mass of $\sim10^{3}-10^{5}$ solar masses could be inferred. The overall X-ray luminosity evolution could be modeled with the stellar tidal disruption by a black hole of $\sim10^4$ solar masses, providing a viable mechanism to produce AT2018cow. Our findings suggest that other bright FBOTs may also harbor intermediate-mass black holes., 18 pages, 10 figures. Accepted for publication in Research in Astronomy and Astrophysics

Mrk142 is known as the only outlier in R-L space (the correlation between BLR (broad-line region) radii and continuum luminosity) among the low-redshift local reverberation-mapped broad-line active galactic nuclei (BLAGNs) with moderate accretion rates, as its BLR radius is smaller than the expected R-L value. Here, by considering probable optical transient quasi-periodic oscillations (QPOs), a new approach to assessing the BLR radius is presented. Reliable transient QPOs in high-energy emissions from the vicinity of the black hole have been reported in several normal AGNs; however, to date there are few short-term, low-energy optical transient QPOs in normal BLAGNs (i.e. not the QPOs reported in blazars or in AGNs harbouring binary black hole systems). Using the photometric optical light curves, which are well described directly by sinusoidal functions, we report probable short-term optical transient QPOs with periodicities around 14 and 43 d in BLAGN Mrk142, indicating optical QPOs similar to but scaled from those in high-energy bands. By considering the 14-d QPOs related to the reprocessing procedure, a new approach to estimating the BLR radius is possible for Mrk142 through the reverberation mapping technique. The new BLR radius of Mrk142 obeys the R-L relationship well, demonstrating that this relationship is fundamental in local normal BLAGNs without ultra-high accretion rates.

In the manuscript, we report evidence on broad [O iii] components apparently obscured in Type-2 active galactic nuclei (AGN) under the framework of the unified model, after checking properties of broad [O iii] emissions in large samples of Type-1 and Type-2 AGN in Sloan Digital Sky Survey DR12. We can well confirm the statistically lower flux ratios of the broad to the core [O iii] components in Type-2 AGN than in Type-1 AGN, which can be naturally explained by stronger obscured broad [O iii] components by central dust torus in Type-2 AGN, unless the unified model for AGN was not appropriate to the narrow emission lines. The results provide further evidence to support broad [O iii] components coming from emission regions nearer to central BHs, and also indicate the core [O iii] component as the better indicator for central activities in Type-2 AGN, due to few effects of obscuration on the core [O iii] component. Considering the broad [O iii] components as signs of central outflows, the results provide evidence for strong central outflows being preferentially obscured in Type-2 AGN. Furthermore, the obscured broad [O iii] component can be applied to explain the different flux ratios of [O iii]λ5007Å/H β between Type-1 and Type-2 AGN in the BPT diagram.

Based on the long-term light curves collected from the Catalina Sky Survey (CSS) (from 2005 to 2013) and the All-Sky Automated Survey for Supernovae (ASAS-SN) (from 2014 to 2018), optical quasi-periodic oscillations (QPOs) about 300 days can be well determined in the well-known blazar PKS~2155-304 through four different methods: the generalized Lomb-Scargle periodogram (GLSP) method, the weighted wavelet Z-transform (WWZ) technique, the epoch-folded method and redfit method. The GLSP determined significance level for the periodicity is higher than 99.9999\% based on a false alarm probability. The redfit provided confidence level for the periodicity is higher than 99\% in ASAS-SN light curve, after considering the effects of red noise. Based on continuous autoregressive (CAR) process created artificial light curves, the probability of detecting fake QPOs is lower than 0.8\%. The determined optical periodicity of 300 days from CSS and ASAS-SN light curves is well consistent with the reported optical periodicity in the literature. Moreover, three possible models are discussed to explain the optical QPOs in PKS 2155-304: the relativistic Frame-dragging effect, the binary black hole (BBH) model and the jet precession model., Comment: 13 pages, 9 figures, accepted to be published in RAA

To search for the possible pathogenic genes for multiple morphological anomalies of sperm flagella (MMAF).We performed whole exome sequencing (WES) of a typical case of MMAF and analyzed its possible pathogenic genes. We examined the semen sample from the patient and identified the ultrastructural characteristics of the sperm flagella under the scanning electron and transmission electron microscopes, and analyzed the expression pattern of cilia and flagela-associated protein 65 (CFAP65) in spermatogenesis by immunofluorescence assay.The MMAF patient was found with a homozygous pathogenic mutation of the CFAP65 gene c.2675GA(p.Trp892*). Scanning electron microscopy showed that the sperm of the patient had typical characteristics of MMAF, that is, without tails or with folded tails, curly tails, short tails or irregular tails. Transmission electron microscopy revealed the loss and disorder of the "9+2" structure in the sperm flagellum, with abnormal assembly of the fibrous sheath, accompanied by loss of central microtubules and dynamin arms. Cellular immunofluorescence assay suggested that the CFAP65 gene was expressed at all levels of mouse germ cells.The CFAP65 gene is involved in the assembly of the sperm flagellum structure, and its mutation can cause the phenotype of MMAF, leading to male infertility.

Background Minimal change disease (MCD) is a common cause of the nephrotic syndrome. Several studies have shown an increased incidence of cancer in patients with MCD. However, there are no reports on the association between MCD and gastrointestinal stromal tumor (GIST). Case presentation We report a case of a 66-year-old female with severe nephrotic syndrome and concomitant duodenal GIST. Immunoglobulin test showed a significant increase of IgE levels. The diagnosis of renal histopathology was MCD with subacute tubulointerstitial injury. The combination of preoperative Imatinib mesylate chemotherapy and tumor excision was accompanied by significant remission of proteinuria, and IgE level decreasing, without immunosuppressivetherapy. Conclusions It is the first case report that MCD was associated with GIST and elevated IgE level. Clinically, in patients with elevated IgE level associated with nephrotic syndrome, the possibility of tumor must be taken into account when allergic factors are excluded.

In this manuscript, an interesting blue Active Galactic Nuclei (AGN) SDSS J154751.94+025550 (=SDSS J1547) is reported with very different line profiles of broad Balmer emission lines: double-peaked broad H$\beta$ but single-peaked broad H$\alpha$. SDSS J1547 is the first AGN with detailed discussions on very different line profiles of the broad Balmer emission lines, besides the simply mentioned different broad lines in the candidate for a binary black hole (BBH) system in SDSS J0159+0105. The very different line profiles of the broad Balmer emission lines can be well explained by different physical conditions to two central BLRs in a central BBH system in SDSS J1547. Furthermore, the long-term light curve from CSS can be well described by a sinusoidal function with a periodicity about 2159days, providing further evidence to support the expected central BBH system in SDSS J1547. Therefore, it is interesting to treat different line profiles of broad Balmer emission lines as intrinsic indicators of central BBH systems in broad line AGN. Under assumptions of BBH systems, 0.125\% of broad line AGN can be expected to have very different line profiles of broad Balmer emission lines. Future study on more broad line AGN with very different line profiles of broad Balmer emission lines could provide further clues on the different line profiles of broad Balmer emission lines as indicator of BBH systems., Comment: 10 pages, 8 figures, 1 table, Accepted to be published in MNRAS

In this Letter, properties of black hole (BH) mass are well checked for the interesting object SDSS J0159, a changing-look AGN and also a host galaxy of a tidal disruption event (TDE). Through spectral absorption features, the stellar velocity dispersion of SDSS J0159 can be well measured as $\sigma\sim81~{\rm km/s}$, leading to SDSS J0159 being an apparent outlier in the \msig space, because of the BH mass estimated through the \msig relation about two magnitudes lower than the reported virial BH mass of about $10^8~{\rm M_\odot}$. After considerations of contributions of stellar debris from the central TDE to broad line emission clouds, the over-estimated virial BH mass could be well explained in SDSS J0159. Therefore, over-estimated virial BH masses through broad line properties in the \msig space could be treated as interesting clues to support central TDEs., Comment: 5 pages, three figures, accepted to be published in MNRAS Letter

In this Letter, we report further evidence to support a tidal disruption event (TDE) in the known changing-look AGN SDSS J0159, through the unique variabilities of asymmetric broad H$\alpha$: broader but redder in 2010 than in 2000. Accepted the broad H$\alpha$ emission regions tightly related to accreting debris in a central TDE, the well-known relativistic accretion disk origination can be applied to well explain the asymmetric broad H$\alpha$ variabilities in SDSS J0159. Moreover, the model determined broad H$\alpha$ emission regions have the sizes not follow the empirical R-L relation valid in normal broad line AGN, but have locations basically similar to the regions of accreting debris from a central TDE in SDSS J0159, indicating tight connections between the broad H$\alpha$ emission materials and central TDE debris. Therefore, explanations of the asymmetric broad H$\alpha$ variabilities through the relativistic accretion disk origination provide further clues to support a central TDE in SDSS J0159., Comment: 5pages, 3 figures and 1 table, accepted to be published in MNRAS Letter

Background. Herpes zoster (HZ) is an acute inflammatory neurocutaneous disease caused by the reactivation of varicella-zoster virus. It is estimated that the incidence of postherpetic neuralgia following HZ is 10–20%. The leading risk factors of the prognosis are aging and immunity dysfunction. Vitamin C plays a pivoted role in enhancing white blood cell function. Epidemiological evidence and clinical studies have indicated an association between pain and suboptimal vitamin C status. At present, vitamin C has been used as an additional option in the treatment of HZ-associated pain. Despite the current controversy, case reports and randomized controlled studies have indicated that both acute- and postherpetic neuralgia can be dramatically alleviated following intravenous vitamin C infusions. Case Presentation. Two patients (male aged 72 and female 78 years) with HZ did not respond well to antiviral therapy and analgesics. Skin lesions in the right groin and front thigh healed after early antiviral therapy, but the outbreak of pain persisted in the male patient. The female patient presented to our clinic with clusters of rashes in the right forehead with severe edema of her right upper eyelid. Because nerve blockade could not be conducted for both patients, intravenous infusion of vitamin C was applied and resulted in an immediate remission of the breakthrough pain in the male patient and cutaneous lesions in the female patient. Conclusions. The use of vitamin C appears to be an emerging treatment alternative for attenuating HZ and PHN pain. Hence, we recommend the addition of concomitant use of intravenously administered vitamin C into therapeutic strategies in the treatment of HZ-associated pain, especially for therapy-resistant cases. Furthermore, animal studies are required to determine analgesic mechanisms of vitamin C, and more randomized clinical trials are essential to further determine the optimal dose and timing of administration of vitamin C.

Using different kinds of velocity tracers derived from the broad H$\beta$ profile (in the mean or rms spectrum) and the corresponding virial factors $f$, the central supermassive black hole (SMBH) masses ($M_{\rm BH}$) are calculated for a compiled sample of 120 reverberation-mapped (RM) AGNs. For its subsample of RM AGNs with measured stellar velocity dispersion ($\sigma_{\rm \ast}$), the multivariate linear regression technique is used to calibrate the mean value $f$, as well as the variable FWHM-based $f$. It is found that, whether excluding the pseudo-bulges or not, $M_{\rm BH}$ from the H$\beta$ line dispersion in the mean spectrum ($\sigma_{\rm H\beta,mean}$) has the smallest offset rms with respect to the $M_{\rm BH}-\sigma_{\ast}$ relation. For the total sample excluding SDSS-RM AGNs, with respect to $M_{\rm BH}$ from $\sigma_{\rm \ast}$ or that from the H$\beta$ line dispersion in the rms spectrum ($\sigma_{\rm H\beta,rms}$), it is found that we can obtain $M_{\rm BH}$ from the $\sigma_{\rm H\beta,mean}$ with the smallest offset rms of 0.38 dex or 0.23 dex, respectively. It implies that, with respect to the H$\beta$ FWHM, we prefer $\sigma_{\rm H\beta,mean}$ to calculate $M_{\rm BH}$ from the single-epoch spectrum. Using the FWHM-based $f$, we can improve $M_{\rm BH}$ calculation from FWHM(H$\beta$) and the mean $f$, with a decreased offset rms from 0.52 dex to 0.39 dex with respect to $M_{\rm BH}$ from $\sigma_{\rm \ast}$ for the subsample of 36 AGNs with $\sigma_{\rm \ast}$. The value of 0.39 dex is almost the same as that from $\sigma_{\rm H\beta,mean}$ and the mean $f$., Comment: 20 pages, 5 tables, 8 figures, accepted for publication in ApJ

In this paper, we discuss properties of SDSS J1042-0018 which is a broad line active galactic nucleus (AGN) but misclassified as an H ii galaxy in the BPT diagram (SDSS J1042-0018 is called a misclassified broad line AGN). The emission lines around Hα and around Hβ are well described by different model functions, considering broad Balmer lines to be described by Gaussian or Lorentz functions. Different model functions lead to different determined narrow emission line fluxes, but the different narrow emission line flux ratios lead SDSS J1042-0018 as an H ii galaxy in the BPT diagram. In order to explain the unique properties of the misclassified broad line AGN SDSS J1042-0018, two methods are proposed, the star-forming contributions and the compressed narrow emission line regions with high electron densities near to critical densities of forbidden emission lines. Fortunately, the strong star-forming contributions can be preferred in SDSS J1042-0018. The misclassified broad line AGN SDSS J1042-0018, well explained by star-forming contributions, could provide further clues on the applications of BPT diagrams to the normal broad line AGNs.

In this manuscript, we check the well-known correlation between \oiii luminosity and continuum luminosity (\loiiicon) for AGN by a large sample of 1982 SDSS QSOs with $z, Comment: 8 pages, 7 figures, Accepted to be published in MNRAS

Press bending is widely used in Al integral panels for the aerospace industry, which, combined with multi-point dies, is an innovative approach. In the forming process, the fracture on integral panels is a fatal flaw. In this study, it mainly presents a core method on how to predict fracture on stiffeners by a novel method—the multi-point press bending. With the combination of a multi-point press bending experiment and corresponding finite element method (FEM) simulation, a suitable ductile criterion was selected to predict fracture on an aircraft Al stiffener. Using the fracture criterion, the fracture moments and fracture positions on stiffeners were determined in the multi-point press bending process. Due to the rapid reconfigurable characteristic of multi-point die, an optimal deformation path was discussed to reduce the fracture risk on stiffeners. It was identified that the Cockcroft criterion proved to be the most favorable ductile fracture criterion to predict fracture on stiffeners. Moreover, in the multi-point press bending process of the 7B04-T7451 Al stiffener, it is not prone to fracture with the increase of forming steps. Multi-point forming with an equidifferent curvature deformation path reduces the fracture risk of stiffeners much more than that with an equidifferent radius deformation path.

Residual stresses generated during the manufacturing process have direct effects on product life cycle and properties. Thus, it is essential to understand the effects of processing on residual stress distribution. In this paper, a technique for through thickness residual stress measurement was developed and tested experimentally. In this technique, a bent plate slotted in the middle of the concave surface leads to springback of the plate. The residual stress distribution and springback induced by local material removal are theoretically analyzed. This “slotting method” is more convenient than other relaxation methods because it is determined directly from the data and does not require tedious inversion; additionally, it allows the determination of a springback map through thickness residual stress distribution. Here, the research object was a 30-mm-thick aluminum alloy plate that had remaining thickness residual stress induced by bending, and the slotting processes were carried out with FE simulation and experiment, respectively. The simulation results on the residual stress distribution shows consistence with the analytical results. Furthermore, the slotting processes with different groove depths and locations were also investigated. The measured springback data shows minor deviation from the numerical analysis, which verifies that the technique provides a reasonable assessment of the through thickness residual stress distribution and springback.

In this letter, we checked spectral properties of the well-known narrow line Seyfert I Mrk142, in order to try to find effects of narrow line variability on BLR radius of Mrk142 which is an outlier in the R-L plane. Although, no improvement can be found on BLR radius, apparent narrow line variability can be confirmed in Mrk142. Using the public spectra collected from the Lick AGN Monitoring Project, the spectral scaling method based on assumption of constant \oiii line is firstly checked by examining broad and narrow emission line properties. We find that with the application of the spectral scaling method, there is a strong correlation between the \oiii line flux and the \oiii line width, but weaker correlations between the broad H$\alpha$ flux and the broad H$\beta$ flux, and between the broad H$\alpha$ flux and the continuum emission at 5100\AA. The results indicate that the assumption of constant \oiii line is not preferred, and caution should be exercised when applying the spectral scaling calibration method. And then, we can find a strong correlation between the \oiii line flux and the continuum emission at 5100\AA, which indicates apparent short-term variability of the \oiii line in Mrk142 over about two months., Comment: 5 pages, 5 figures, 1 table. Accepted to be published in MNRAS Letter

Accumulating evidence demonstrates that CD8

Post-stretching elongation is a crucial process parameter in stretch bending process because of its significant influence on the forming effects. In this paper, the displacement loading method was presented to control the movement of the jaw in order to avoid the instability of tensile force in mechanical loading method. Typical aluminum hollow profile used in high-speed trains was selected as the research object. Stretch bending process with five levels of post-stretching elongations was carried out by finite element (FE) simulation. The simulation results reveal that an increment of the post-stretching elongation leads to smaller shape error and springback but larger cross-sectional distortion and spatial twist. The forming defects index, which is based on normalizing and weighting four forming defects, was put forward to evaluate comprehensive forming effects. Furthermore, the backtracking method was used to obtain the optimal post-stretching elongation. Experimental validation was conducted on stretch-wrap bending machine. The experiment part meets the processing requirements, thereby validating the reasonability of the optimization method. Measured results showed consistency with numerical analysis which verifies the feasibility of using FE simulation to guide the experiment.

Graphite-like carbon nitride (g-C3N4) photocatalysts with different morphologies have been synthesized using melamine as a precursor using a template-free wet chemical method. The as-prepared g-C3N4 nanorods, g-C3N4 microcones and porous g-C3N4 quadruple prisms were characterized by XRD, FESEM, FT-IR and UV–vis absorption spectrophotometer. These nanostructured g-C3N4 photocatalysts show better photocatalytic activity than bulk g-C3N4 under visible light irradiation in view of degrading Rhodamine B (RhB). The porous g-C3N4 quadruple prisms show the highest photocatalytic efficiency. We deduce that the surface area of the catalysts and their adsorption ability of target molecules play important roles in improving the photocatalytic activity of the g-C3N4 photocatalysts.

Objective To investigate whether apoptosis of renal tubular epithelial cells induced by endoplasmic reticulum stress (ERS) takes a role in the traumatic rhabdomyolysis-induced acute kidney injury (AKI). Methods The model of rhabdomyolysis-induced AKI was reproduced by intramuscular injection of hypertonic glycerol into the hind limbs in male Wistar rats. There were 11 animal groups (each n=3) including control, 1h, 3h, 6h, 12h, 24h, 48h, 72h, 96h, 120h and 168h groups. Serum and renal tissue were collected at various time points. Parameters of renal function and renal pathology were used to evaluate renal injury at various time points. The renal tubular epithelial cell apoptosis was revealed by TUNEL staining at each time point. The expressions of factors, caspase-8, cytochrome C and caspase-9 activity fragments, involved in apoptosis as induced by Fas ligand/receptor interaction and mitochondria were determined by Western blotting at each time point. Furthermore, the expressions of endoplasmic reticulum chaperone protein GRP78 and apoptosis factor caspase-12 activity fragment were also assayed by Western blotting. Results Pathological changes of tubular epithelial cells were detected at 1h, presenting a large area of necrosis at 24h, with the highest number of apoptotic renal tubular epithelial cells. Tubular-interstitial injury reached the peak at 72h. The expression of apoptotic factors (caspase-8, cytochrome C and caspase-9) was elevated reaching the peak at 12h. The change in endoplasmic reticulum stress protein expressions of GRP-78 showed a similar trend as that of caspase-12 (increased at 1h, and reached the peak at 12h). Conclusions Apoptosis of renal tubular epithelial cell is the main pathogenesis of rhabdomyolysis-induced renal injury. In addition to the activation of the death-receptor and the mitochondrial death pathway, endoplasmic reticulum stress also plays an important role in this process. DOI: 10.11855/j.issn.0577-7402.2015.03.05

In this letter, we firstly report one unique object SDSS J0832+0643 with particular features of narrow balmer emission lines: double-peaked narrow H\alpha but single-peaked narrow H\beta. The particular features can not be expected by currently proposed kinematic models for double-peaked narrow emission lines, because the proposed kinematic models lead to similar line profiles of narrow balmer emission lines. However, due to radiative transfer effects, the non-kinematic model can be naturally applied to well explain the particular features of narrow balmer emission lines: larger optical depth in H\alpha than 10 leads to observed double-peaked narrow H\alpha, but smaller optical depth in H\beta around 2 leads to observed single-peaked narrow H\beta. Therefore, SDSS J0832+0643 can be used as strong evidence to support the non-kinematic model for double-peaked narrow emission lines., Comment: 5 pages, 1 table, 4 figures, accepted and to be published in MNRAS Letter

This paper proposed the Weighted Least Square method (WLS method) to identify the output filter of three-phase PWM converter, which incorporates the signal processing as well as mathematical techniques into conventional Least Square method. It sets different weights to different measurements according to the phase where it locates, based on the discovery of the correlation between accuracy and phase of current. The algorithm is tested in both simulation and experimental environment, and the results validate that proposed method gives accurate estimation in steady state, and can response within 10ms in when grid voltage drops. This method can work under both balanced and unbalanced operating conditions, therefore provides a powerful tool for various control strategies to better understand the operating conditions. Compared with the invasive method, which intentionally inject a series of white noise in the system, proposed WLS method does not bring any turbulence, while compared with conventional Least Square method, it possesses better stability as well as higher accuracy.

Objective To explore predictors of the 6-month clinical outcome of thalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage (THD) could improve its prognosis. Methods A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score (GCS) on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset. Univariate analysis and multivariate logistic regression analysis were performed to determine predictors of a poor outcome. Results Conservative treatment was performed for five patients (9.3%), external ventricular drainage (EVD) for 20 patients (37.0%), THD for four patients (7.4%), and EVD combined with THD for 25 patients (46.3%). At six months after onset, 21 (38.9%) patients achieved a favorable outcome, while 33 (61.1%) had a poor outcome. In the univariate analysis, predictors of poor 6-month outcome were lower GCS on admission (P = 0.001), larger hematoma volume (P < 0.001), midline shift (P = 0.035), acute hydrocephalus (P = 0.039), and no THD (P = 0.037). The independent predictors of poor outcome, according to the multivariate logistic regression analysis, were no THD and larger hematoma volume. Conclusions Minimally invasive THD, which removes most of the hematoma within a few days, with limited damage to perihematomal brain tissue, improved the 6-month outcome of thalamic hemorrhage. Thus, THD can be widely applied to treat patients with thalamic hemorrhage.

We present a new catalog of narrow-line Seyfert 1 (NLSy1) galaxies from the Sloan Digital Sky Survey Data Release 12 (SDSS DR12). This was obtained by a systematic analysis through modeling of the continuum and emission lines of the spectra of all the 68,859 SDSS DR12 objects that are classified as "QSO" by the SDSS spectroscopic pipeline with z < 0.8 and a median signal-to-noise ratio (S/N) > 2 per pixel. This catalog contains a total of 11,101 objects, which is about 5 times larger than the previously known NLSy1 galaxies. Their monochromatic continuum luminosity at 5100 A is found to be strongly correlated with H-beta, H-alpha, and [O III] emission line luminosities. The optical Fe II strength in NLSy1 galaxies is about two times larger than the broad- line Seyfert 1 (BLSy1) galaxies. About 5% of the catalog sources are detected in the FIRST survey. The Eddington ratio (XEdd) of NLSy1 galaxies has an average of log XEdd of -0.34, much higher than -1.03 found for BLSy1 galaxies. Their black hole masses (MBH) have an average of log MBH of 6.9 Msun, which is less than BLSy1 galaxies, which have an average of log MBH of 8.0 Msun. The MBH of NLSy1 galaxies is found to be correlated with their host galaxy velocity dispersion. Our analysis suggests that geometrical effects playing an important role in defining NLSy1 galaxies and their MBH deficit is perhaps due to their lower inclination compared to BLSy1 galaxies., ApJS, 229:39 (16pp), 2017 April