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Attempts to determine why some patients respond to electroconvulsive therapy (ECT) are valuable in schizophrenia. Schizophrenia is associated with aberrant dynamic functional architecture, which might impact the efficacy of ECT. We aimed to explore the relationship between pre-treatment temporal variability and ECT acute efficacy. Forty-eight patients with schizophrenia and 30 healthy controls underwent functional magnetic resonance imaging to examine whether patterns of temporary variability of functional architecture differ between high responders (HR) and low responders (LR) at baseline. Compared with LR, HR exhibited significantly abnormal temporal variability in right inferior front gyrus (IFGtriang.R), left temporal pole (TPOsup.L) and right middle temporal gyrus (MTG.R). In the pooled patient group, ∆PANSS was correlated with the temporal variability of these regions. Patients with schizophrenia with a distinct dynamic functional architecture appear to reveal differential response to ECT. Our findings provide not only an understanding of the neural functional architecture patterns that are found in schizophrenia but also the possibility of using these measures as moderators for ECT selection.

Many human activities require high cognitive performance over long periods, while impairments induced by sleep deprivation influence various aspects of cognitive abilities, including working memory (WM), attention, and processing speed. Based on previous research, vagal nerve stimulation can modulate cognitive abilities, attention, and arousal. Two experiments were conducted to assess the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) to relieve the deleterious effects of sleep deprivation. In the first experiment, 35 participants completed N-back tasks at 8:00 a.m. for two consecutive days in a within-subject study. Then, the participants received either taVNS or earlobe stimulation (active control) intervention in two sessions at random orders after 24 h of sustained wakefulness. Then, they completed the N-back tasks again. In the second experiment, 30 participants completed the psychomotor vigilance task (PVT), and 32 completed the N-back tasks at 8:00 a.m. on the first and second days. Then, they received either taVNS or earlobe stimulation at random orders and finished the N-back and PVT tasks immediately after one hour. In Experiment 1, taVNS could significantly improve the accuracy rate of participants in spatial 3-back tasks compared to active control, which was consistent with experiment 2. However, taVNS did not specifically enhance PVT performance. Therefore, taVNS could be a powerful intervention for acute sleep deprivation as it can improve performance on high cognitive load tasks and is easy to administer.

Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key role in both early and advanced stage of atherosclerosis. Previous studies have shown that berberine could inhibit foam cell formation and prevent experimental atherosclerosis. However, its underlying molecular mechanisms have not been fully clarified. In this study, we explored the cholesterol-lowering effects of berberine in macrophage-derived foam cells and investigated its possible mechanisms in prevention and treatment of atherosclerosis. Here, we demonstrated that berberine could inhibit atherosclerosis in apolipoprotein E-deficient mice and induce cholesterol reduction as well as decrease the content of macrophages. Berberine can regulate oxLDL uptake and cholesterol efflux, thus suppresses foam cell formation. Mechanisms study showed that berberine can suppress scavenger receptor expression via inhibiting the activity of AP-1 and upregulate ATP-binding cassette transporter via activating Nrf2/HO-1 signaling in human macrophage. In summary, berberine significantly inhibits atherosclerotic disease development by regulating lipid homeostasis and suppressing macrophage foam cell formation.

The Hard X-ray Modulation Telescope (Insight-HXMT), is China's first X-ray astronomy satellite launched on June 15, 2017. The anti-coincidence CsI detectors of the High Energy X-ray telescope (HE) onboard Insight-HXMT could serve as an all-sky gamma-ray monitor in about 0.2-3 MeV. In its first four years of operation, Insight-HXMT has detected 322 Gamma-Ray Bursts (GRBs) by offline search pipeline including blind search and targeted search. For the GOLDEN sample of Insight-HXMT GRBs, joint analyses were performed with other GRB missions, including Fermi Gamma-ray Burst Monitor (Fermi/GBM), Swift Burst Alert Telescope (Swift/BAT) and Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM). It shows that Insight-HXMT can provide better constraint on GRB spectrum at higher energy band. The properties of Insight-HXMT GRBs are reported in detail, including their trigger time, duration, spectral parameters, peak fluxes of different time scales and fluence. This catalog is an official product of the Insight-HXMT GRB team., 46 pages, 22 figures, accepted by APJS

Myrcene-based vinyl ester resin (VER) monomer was prepared via simple Diels-Alder reaction and ring-opening esterification. The molecular structure and UV curing behaviors of prepared VER monomer were characterized using FTIR analysis method. Moreover, the mechanical properties, thermal stability and hardness of its UV cured product were also investigated. FTIR analysis results demonstrated that the target myrcene-based VER monomer has been successfully synthesized. UV curing behaviors analysis showed that prepared myrcene-based VER monomer could reach ultimate cured level within 50 s. Physical properties study showed that the UV cured product has certain tensile, flexural, impact resistance properties and high hardness. TGA indicated the UV cured product had excellent thermal stability, as it showed high thermal initial decomposition temperature at 359.6 °C .

Novel dimer fatty acids-based vinyl ester resin monomer was prepared via simple ring-opening and esterification reaction with the aid of dimer fatty acids (DA) and glycidyl methacrylate (GMA) as raw material. The effects of different catalyst system, reacting time and reacting temperature on the yield, color, and viscosity of the final product were analyzed. The results of optimal experiments showed that BTEAC catalyst could make the final product with moderate viscosity and lighter color, the optimal BTEAC catalyst addition amount was 0.5wt.%, the optimal reacting temperature and reacting time was 115 °C and 2h, respectively. FTIR and 13C-NMR demonstrated that the target product had been successfully synthesized.

We present high spatial resolution X-ray spectroscopy of supernova remnant Cassiopeia A with the {\sl Chandra} observations. The X-ray emitting region of this remnant was divided into 38 $\times$ 34 pixels with a scale of 10$\arcsec$ $\times$ 10$\arcsec$ each. Spectra of 960 pixels were created and fitted with an absorbed two component non-equilibrium ionization model. With the spectral analysis results we obtained maps of absorbing column density, temperatures, ionization ages, and the abundances for Ne, Mg, Si, S, Ca and Fe. The Si, S and possibly Ca abundance maps show obviously jet structures, while Fe doesn't follow the jet but seems to be distributed perpendicular to it. In the range of about two orders of magnitude, the abundances of Si, S and Ca show tight correlations between each other, suggesting them to be ejecta from explosive O-burning and incomplete Si-burning. Meanwhile, Ne abundance is well correlated with that of Mg, indicating them to be the ashes of explosive C/Ne burning. The Fe abundance is positively correlated with that of Si when Si abundance is lower than 3 solar abundances, but a negative correlation appears when the Si abundance is higher. We suggest that such a two phase correlation is the results of different ways in which Fe is synthesized.

Using the data acquired in the Time To Spill (TTS) mode for long gamma-ray bursts (GRBs) collected by the Burst and Transient Source Experiment on board the Compton Gamma Ray Observatory (BATSE/CGRO), we have carefully measured spectral lags in time between the low (25-55 keV) and high (110-320 keV) energy bands of individual pulses contained in 64 multi-peak GRBs. We find that the temporal lead by higher-energy gamma-ray photons (i.e., positive lags) is the norm in this selected sample set of long GRBs. While relatively few in number, some pulses of several long GRBs do show negative lags. This distribution of spectral lags in long GRBs is in contrast to that in short GRBs. This apparent difference poses challenges and constraints on the physical mechanism(s) of producing long and short GRBs. The relation between the pulse peak count rates and the spectral lags is also examined. Observationally, there seems to be no clear evidence for systematic spectral lag-luminosity connection for pulses within a given long GRB., 20 pages, 4 figures

We present high spatial resolution X-ray spectroscopy of supernova remnant G292.0+1.8 with the {\sl Chandra} observations. The X-ray emitting region of this remnant was divided into 25 $\times$ 25 pixels with a scale of 20$\arcsec$ $\times$ 20$\arcsec$ each. Spectra of 324 pixels were created and fitted with an absorbed one component non-equilibrium ionization model. With the spectral analysis results we obtained maps of absorbing column density, temperature, ionization age, and the abundances for O, Ne, Mg, Si, S, and Fe. The abundances of O, Ne and Mg show tight correlations between each other in the range of about two orders of magnitude, suggesting them all from explosive C/Ne burning. Meanwhile, the abundances of Si and S are also well correlated, indicating them to be the ashes of explosive explosive O-burning or incomplete Si-burbing. The Fe emission lines are not prominent among the whole remnant, and its abundance are significantly deduced, indicating that the reverse shock may have not propagated to the Fe-rich ejecta. Based on relative abundances of O, Ne, Mg, Si and Fe to Si, we suggest a progenitor mass of $25-30 M_{\odot}$ for this remnant., accepted by RAA

Two dissimilar cardanol-based unsaturated resin monomers were prepared via simple ring-opening and etherification reaction by utilizing the reactivity between phenolic hydroxyl and epoxy group with the aid of cardanol as raw material. The transformations of different groups were characterized using Fourier transform infrared (FTIR) during the synthesis process, the resin monomers' structure was further analyzed using the 1H-nuclear magnetic resonance (1H-NMR) and gel permeation chromatography (GPC), and the UV curing behaviors of resin monomers were studied by means of FTIR method. In addition, the thermal stability of UV cured resin monomers were also tested by thermogravimetric analysis (TGA). The molecular structure analysis demonstrated that these two target products were successfully synthesized. UV curing behaviors analysis showed that the prepared cardanol-based unsaturated resin monomers could reach ultimate curing level within 30 s. TGA results showed that the molecular structure and the content of double bond had critical influence on their thermal stability. The main initial thermal decomposition temperature of these two cured resin monomers was all above 350 degrees C.

We present high spatial resolution X-ray spectroscopy of Tycho’s supernova remnant (SNR) using observational data from Chandra. The whole remnant was divided into 26 × 27 regions, with each of them covering 20′′ × 20′′. We selected 536 pixels with enough events to generate spectra and fit them with an absorbed two component non-equilibrium ionization model. We obtained maps of absorbing column density, weight-averaged temperature, ionization age and abundances for O, Ne, Mg, Si, S and Fe, with emission used to determine the weight. The abundance maps and the finding that Fe abundance is not correlated with any other element suggest that Fe is located at a smaller radius than other elements, supporting the onion shell model with emission from more massive elements peaking more toward the center. A tight correlation between Si and S abundances support both Si and S coming from explosive O-burning and/or incomplete Si-burning. O and Ne abundances show no correlation with any other element. Considering that O, Ne and Mg are all synthesized in the same process (C/Ne-burning), we suggest that O/Ne/Mg might mix well with other elements during the explosion of the supernova and the expansion of the SNR.

The antioxidant activities of fermented soybean meal (FSM) extract were evaluated by various methods in vitro and in vivo. The antioxidant tests in vitro, included the total phenolic and flavonoid content, reducing activity, 1,1-diphenyl-2-picryl-hy-drazyl (DPPH·) and superoxide anion radical scavenging activity, inhibition of lipid peroxidation in rat liver homogenate and erythrocyte haemolysis in rat blood. For in vivo test, mice were subcutaneously injected with D-galactose (D-gal) for 6 weeks and intragastric administration of fermented soy milk (FSM)extract simultaneously (500, 250 and 125 mg/kg body weight per day, respectively), and then the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), total antioxidant capacity (T-AOC) and MDA were determined. In antioxidant assays in vitro, FSM extract was found to have Fe3+ reducing activity, moderate 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, superoxide anion radical scavenging activity, lipid peroxidation and erythrocyte haemolysis inhibition effect, of which IC50 values were found to be 3.168, 0.321, 7.404, 0.737 and 4.599 mg/ml, respectively. For the antioxidant assays in vivo, administration of FSM extract significantly enhanced the activities of antioxidant enzymes and total antioxidant capacity and decreased the levels of malondialdehyde in both serums and livers of aging mice. Key words: Antioxidant activities, fermented soybean meal (FSM) extract, Bacillus natto.

To study the molluscicidal activity, the influence on glycogen content of Oncomelania hupensis and the acute toxicity to zebra fish of the extract from Phytolacca americana Linn leaf.The different polar factions of the extract of Phytolacca americana Linn leaf were separated by using the systemic solvent segregation method, and then the molluscicidal activity of the fractions was detected according to the Laboratory Final Milluscicides Screening Method issued by WHO. The glycogen content of soft tissues of Oncomelania hupensis treated by the ethyl acetate polar fraction was determined by the anthrone method. Finally, the acute toxicity of the ethyl acetate polar fraction to non-targets was studied with zebra fish.The ethyl acetate polar fraction was the best active components against the snails. Its 48 h LC50 and LC90 were 6.0 mg/100 ml and 26.1 mg/ 100 ml, respectively. The glycogen content of soft tissues of the snails decreased by 20% after treated with the fraction. The fish treated by the concentration of LC50 (48 h) of the ethyl acetate polar fraction survived for 12 h.The Phytolacca americana Linn leaf possesses an adequate molluscicidal activity and a significant acute toxicity to the zebra fish.

To examine the role of glutaminergic neurons in the transmission and integration of the sweat taste information in the brain stem and the amygdala.Conscious Sprague-Dawley rats were subjected to oral sweet taste or water (control) stimulations. The activated neurons were identified by detecting c-Fos expression in taste-related brain areas, and the glutaminergic neurons by detecting vesicular glutamate transpoter-3 (VGLUT3).Compared with control group, the rats with oral sucrose solution stimulation exhibited significantly increased c-Fos-expressing and double-labeled neurons in the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN) and the amygdala.Neurons in the NST, PBN and amygdala are activated after oral sweet taste stimulation. The sweet taste perception at different levels in the CNS is partly mediated by glutamate.

To explore the effect of central serotonin (5-hydroxytryptamine, 5-HT) on gastric motility in rabbit and to analysis its mechanism.Intracerebroventricular (icv) microinjection of drugs were used. The frequency and the amplitude of contractions of gastric motility were recorded.(1) Injection (icv) of 25 microg 5-HT increased the amplitude of contractions and decreased the frequency of gastric motility. (2) The effects of 5-HT were inhibited by injection (icv) of atropine, but intravenous(iv) injection of atropine could only block the increase effect of 5-HT on intragastric pressure. After injection (icv or iv) of phentolamine or propranolol, the effects of 5-HT on gastric motility were not changed markedly. (3) Microinjection (icv) of naloxone or diphenhydramine inhibited the inhibitory effect of 5-HT on the frequency of gastric contractions, and the diphenhydramine reversed the increase effect of 5-HT on intragastric pressure. (4) Vagotomy abolished the effects of 5-HT completely.There may be different nerve mechanisms in regulation of central 5-HT on the frequency and amplitude of contractions of gastric motility. The increase effect of 5-HT on intragastric pressure is medicated by the cholinergic system in brain, and histamine may be one of the important element on the effect of 5-HT. The cholinergic fibers in vagus nerve transmit the effect. The inhibitory effect of 5-HT on the frequency of contractions is also medicated by activating the cholinergic system in brain, enkephalin and histamine are also involved, and it is transmitted via noncholinergic and nonadrenergic fibers in vagus nerve.

In the present study, the responses of inhibitory gustatory neurons in the parabrachial nucleus (PBN) to four basic taste stimuli NaCl, HCl, quinine HCl (QHCl) and sucrose were examined using single-unit recording technique in anesthetized rats. A total of 18 inhibitory taste neurons in the PBN were obtained. Spontaneous firing rates of these inhibitory neurons were 0.2-5.5 Hz with mean firing rate of (2.15+/-0.31) Hz. Most of the neurons responded to more than one of the basic taste qualities. The inhibitory responses to taste occurred quickly and lasted 5-80 s in different PBN neurons. According to the responsive characteristics to the four basic taste stimuli, the neurons could be classified as NaCl-best (n=8), HCl-best (n=3), QHCl-best (n=3), and sucrose-best (n=4). The breadth of tuning of NaCl-best neurons was the highest (0.945). Inhibitory responsive neurons had feeble discrimination among sapid stimuli or aversive stimuli. These results suggest that there exist inhibitory taste neurons in the PBN. These neurons may play some useful roles in precise transmission of taste information and the taste coding for hedonic and aversive tastes.

We present an {\sl XMM-Newton} observation of the eclipsing binary Algol which contains an X-ray dark B8V primary and an X-ray bright K2IV secondary. The observation covered the optical secondary eclipse and captured an X-ray flare that was eclipsed by the B star. The EPIC and RGS spectra of Algol in its quiescent state are described by a two-temperature plasma model. The cool component has a temperature around 6.4$\times 10^{6}$ K while that of the hot component ranges from 2 to 4.0$\times 10^{7}$ K. Coronal abundances of C, N, O, Ne, Mg, Si and Fe were obtained for each component for both the quiescent and the flare phases, with generally upper limits for S and Ar, and C, N, and O for the hot component. F-tests show that the abundances need not to be different between the cool and the hot component and between the quiescent and the flare phase with the exception of Fe. Whereas the Fe abundance of the cool component remains constant at $\sim$0.14, the hot component shows an Fe abundance of $\sim$0.28, which increases to $\sim$0.44 during the flare. This increase is expected from the chromospheric evaporation model. The absorbing column density $N_H$ of the quiescent emission is 2.5$\times10^{20}$ cm$^{-2}$, while that of the flare-only emission is significantly lower and consistent with the column density of the interstellar medium. This observation substantiates earlier suggestions of the presence of X-ray absorbing material in the Algol system., 15 pages, 9 figures, Accpted by RAA