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Abstract Introduction This study aimed to investigate the knowledge, attitude, and practice (KAP) of depression among university students. Methods A cross‐sectional survey was carried out across randomly selected universities in Shandong Province from October 25, 2023, to November 8, 2023. Demographic information and KAP scores were assessed through the administration of questionnaires. The reliability of the questionnaire was confirmed with a Cronbach's alpha coefficient of 0.816 and the Kaiser–Meyer–Olkin measure of 0.894. Results This study included 2448 university students, with 1489 (60.8%) females. The median scores for KAP were 20 (Interquartile Range (IQR): 17–21), 26 (IQR: 23–28), and 35 (IQR: 32–38), respectively. Multivariate regression analysis indicated that being a junior (odds ratio [OR] = 0.720, 95% Confidence Interval (CI): 0.538–0.965, p = .028), senior or above (OR = 0.474, 95% CI: 0.325–0.691, p

BackgroundErythropoietin-producing human hepatocellular (Eph) receptors stand out as the most expansive group of receptor tyrosine kinases (RTKs). Accumulating evidence suggests that within this expansive family, the EphA subset is implicated in driving cancer cell progression, proliferation, invasion, and metastasis, making it a promising target for anticancer treatment. Nonetheless, the extent of EphA family involvement across diverse cancers, along with its intricate interplay with immunity and the tumor microenvironment (TME), remains to be fully illuminated.MethodsThe relationships between EphA gene expression and patient survival, immunological subtypes, and TME characteristics were investigated based on The Cancer Genome Atlas (TCGA) database. The analyses employed various R packages.ResultsA significant difference in expression was identified for most EphA genes when comparing cancer tissues and non-cancer tissues. These genes independently functioned as prognostic factors spanning multiple cancer types. Moreover, a significant correlation surfaced between EphA gene expression and immune subtypes, except for EphA5, EphA6, and EphA8. EphA3 independently influenced the prognosis of papillary renal cell carcinoma (KIRP). This particular gene exhibited links with immune infiltration subtypes and clinicopathologic parameters, holding promise as a valuable biomarker for predicting prognosis and responsiveness to immunotherapy in patients with KIRP.ConclusionBy meticulously scrutinizing the panorama of EphA genes in a spectrum of cancers, this study supplemented a complete map of the effect of EphA family in Pan-cancer and suggested that EphA family may be a potential target for cancer therapy.

Key Clinical Message While adenomyosis is commonly associated with a mild risk of thrombotic complications, the presence of additional thrombophilia factors can increase this risk, particularly in individuals with severe symptoms and elevated CA125 levels.

In the context of high-quality development, scientifically and objectively assessing regional ecosystem health (EH) is important for ecological civilization. However, the commonly used EH assessment framework typically neglects intrinsic connections, mutual adaptability, and coordination among interrelated indicators. The coupling coordination model was utilized to improve the classic pressure–state–response assessment (PSR) model. The carbon footprint, water footprint, landscape pattern, and response status of the Manas River Basin were used to construct a medium-scale regional EH assessment framework linking natural ecosystems with human socioeconomic elements. A quantitative assessment was conducted on the EH conditions of the Manas River Basin from 2000 to 2020. Over the past 21 years, the EH conditions of the Manas River Basin have fluctuated upward. The ecosystem health index (EHI) increased from 0.18 to 0.37. Compared with the conventional PSR model, the coupling coordination pressure–state–response model (CC–PSR) better reflected the fluctuations in EH conditions caused by “pressure”, “state”, and “response” level changes. In the early stage (2000–2006), increasing human activity strongly pressured the regional ecosystem, limiting EH improvements. The increase in “pressure” was reflected in the increasing trends of the water footprint, carbon footprint, and ecological footprint. During the middle to late period (2009–2020), as the “response” level improved, the regional EH condition continued to increase, and the EHI stabilized between 0.29 and 0.38. Ecosystem resilience improvements and human afforestation projects enhanced the “response” level, but their impacts were noticeably delayed. Over the past 21 years, regional landscape diversity, landscape connectance, and landscape contagion have remained high. The well-maintained landscape pattern has laid the foundation for consolidating and improving the regional EH. The EHI is increasing; its fluctuations stem from periodic fluctuations in the regional water yield and carbon sequestration capacity, which are constrained by the basin climate and vegetation coverage. This study provides a scientific model for basin EH assessment.

Sustainable urban development is one of the most urgent problems worldwide, especially in China, which is in rapid urbanization. Reducing the negative impacts of urbanization and improving the relationship between the two have become research priorities. Using 260 cities in China as the research object, this study evaluated the level and temporal and spatial variation of urbanization and natural ecosystem health, explored the relationships between them, and influence mechanism of urbanization on natural ecosystem health. The results showed that the level of population urbanization, social urbanization, economic urbanization and land urbanization was significantly improved in 2000 compared to 2015, and the spatial distribution was higher in the east of China than in the west. The overall level of ecosystem health improved slightly throughout the same period, and its spatial distribution was higher in the north of China than in the south. In terms of the four dimensions of ecosystem health, the ecosystem services and organization were improved, and the ecological environment and elasticity were decreased. Urbanization mainly affected ecosystem health by changing the demand for the quantity and type of ecosystem services through the growth and aggregation of population. However, under the comprehensive effect of the four dimensions of urbanization on natural ecosystem health, the overall constraint intensity of urbanization on natural ecosystem health was relatively stable. The coupling and coordination level between urbanization and natural ecosystem health showed improvement from 2000 to 2015, and the social and economic factors were highly influential. According to the level of urbanization and natural ecosystem health, all cities were classified, which showed the urban development was mainly the medium-level balanced. On this basis, management suggestions were put forward for each type of city. By analyzing the action process and mechanism between urban development and natural ecosystem health, it provides a theoretical basis for in-depth understanding and coordinating the relationship of the urban ecological economy.

Ecosystem services (ESs) are a multiple whole composed of multiple services and their multiple relations, which can be expressed as tensors (multiple functions of multiple vectors). This study attempts to introduce the concept and method of tensors into ES research to solve problems caused by the multiplicity of ESs, such as multiple descriptions and perceptions of ESs, repeated calculation of ES values, and cascading relationships with the social economy. Taking the Manas River Basin composite ecosystem as an example, we constructed five different types of ES tensors based on different understandings and applications: (1) As multiple vectors, three eigenvectors were extracted from the ES state tensor (ESST), including farmland service (FS), vegetation service (VS) and water service (WS). According to the ES response tensor (ESRT), an increase in FS may lead to a decline in overall services. (2) As multiple functions, the ES value (ESV) of the basin was measured by the ESV metric tensor (ESVMT), with a gross value of 14.8 billion USD and a net value of 10.17 billion USD. From different stakeholders perceptions constructed by the ecosystem services to human well-beings (ES-HW) tensor, the human well-being values (HWV) were ranked as citizens > farmers ≈ herdsmen > public. (3) The HWV output efficiency of different LULC per unit of water use was calculated by a fourth-order mixed tensor constructed by water–LULC–ES–HW multiple cascading relations. Among them, the HWV efficiency of water areas and wetlands was the highest, but the area was the smallest. Cultivated land and unused land had the lowest HWV efficiency and largest area. In general, the ES tensor is the extension and integration of the ES scalars/indicators to the ES vectors/bundles, which can provide tools for the integral expression, objective measurement and multiple perceptions of ESs.

Trichodesmium spp. is a colonial diazotrophic cyanobacterium found in the oligotrophic (sub)tropical oceans, where dissolved inorganic phosphorus (DIP) can be depleted. To cope with low P concentrations, P can be scavenged from the dissolved organic P (DOP) pool. This requires the deployment of multiple enzymes activated by trace metals, potentially enhancing metal requirements under stronger P limitations. To test this, we grew Trichodesmium under trace-metal-controlled conditions, where P was supplied as either DIP or DOP (methylphosphonic acid). Mean steady-state biomass under the DOP treatment was only 40% of that grown under equivalent DIP supply, carbon normalized alkaline phosphorus activity was elevated 4-fold, and the zinc (Zn)–carbon ratio was elevated 3.5-fold. Our finding matches the known, dominant Zn requirement across a diversity of enzymes involved in P stress responses and supports an important interaction in the oceanic cycles of these two nutrients.

The electric power industry is one of the major industries in terms of carbon dioxide (CO2) emissions, and it is necessary to explore low-carbon green power generation models. In recent years, more research has focused on the difference in carbon emissions in fossil energy versus renewable energy but ignored the impact of energy on human well-being. The life cycle assessment (LCA) method is a better method for assessing the impact of the low-carbon model on human well-being. In this paper, the carbon footprints of coal power plants and photovoltaic power (PV) plants generating 1 Kilowatt hour (kWh) of electricity are compared to analyze the degree of carbon emissions at different stages of the two models, and the environmental impact potential of the two models is analyzed using the LCA method. The differences between the two models in terms of human well-being were analyzed through questionnaires and quantified using the hierarchical analysis method. The impact of the different models on human well-being was compared using LCA method. The results of the study were as follows: the total CO2 emissions from coal-fired power generation at the 1 kWh standard were 973.38 g, while the total CO2 emissions from PV power generation were 91.95 g, and the carbon emission intensity of coal-fired power plants was higher than that of PV power plants. The global warming potential and eutrophication potential of coal-fired power plants were higher than those of PV power plants, and the rest of the indicators were lower than those of PV power plants. The composite human well-being index of PV power plants was 0.613 higher than that of coal-fired power plants at 0.561. The per capita income–global warming potential of PV power plants was higher than that of coal-fired power plants, indicating that PV power plants were a low carbon-emission and high well-being model. In conclusion, the PV power plant model is a low-carbon and high human well-being industrial model that is worthy of application in the Qilian Mountains region. The low-carbon industrial model proposed in this study can have a positive effect on regional ecological environmental protection and human well-being enhancement.

A repellent for rats named DC has been successfully synthesized from natural capsaicin and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) via a one-pot procedure. The chemical structure of obtained DC is confirmed by Fourier transform infrared (FTIR), Raman and nuclear magnetic resonance (NMR). Then DC was incorporated into ethylene vinyl acetate copolymer (EVA) by blending, to endow EVA with rat proof property and present the advantage of non-lethal. The influence of DC on the structure and properties of EVA is investigated systematically by theoretical calculations and various measurements. Thermogravimetric analysis (TGA) reveals that the incorporation of 4 wt% DC into EVA can significantly enhance the char residue yield from 2.80 wt% to 6.84 wt%. In addition, limiting oxygen index (LOI) and the char residues analysis suggest that DC could facilitate the formation of char layers, resulting in the improvement of synergistic flame retardancy for EVA/DC compounds. This work provided novel insights into the preparation of highly efficient non-lethal repellent for rats and its potential application for polymer materials.

With the rise of the strategy of Coordinated Development for the Beijing-Tianjin-Hebei Region, it is necessary to evaluate the trade-offs/synergies of the survival environment and human well-being in Hebei, the capital region of China. However, existing methods cannot analyze and express trade-offs/synergies of two or more variables simultaneously. Therefore, this paper proposes a new framework to express the trade-offs/synergies among land-use intensity, ecosystem services, and human well-being. In this paper, we first identified the land-use intensity change and land-use transformation and evaluated ecosystem services and human well-being in Hebei from 2000–2015 under the Millennium Ecosystem Assessment framework. Then, the trade-offs/synergies of the three indicators were determined by GIS-based methods and MATLAB. The results show that land-use intensity and human well-being mainly present a synergistic relationship, while ecosystem services and land-use intensity mainly present a trade-off relationship, and ecosystem services and human well-being also present a trade-off relationship in Hebei during 2000–2015. In addition, some regional solutions to achieve sustainable development were proposed: region 1 needs to adjust land-use structure, region 2 needs to protect the ecological environment to improve the supply of ecosystem services, and region 3 needs to commit to improving the regional comprehensive human well-being. This study not only proposes a new framework for analyzing trade-offs/synergies of land use intensity, ecosystem services, and human well-being, but it also provides regional solutions for Hebei to achieve sustainable development.

Terrain has been one of very significant impact factors of air pollution formation and distribution. The relationship between air-pollution and terrain has been studied for a long time. It is still a very hot topic, especially in the context of global environmental deterioration, being represented by severe haze, acid rain, local area air pollution and greenhouse gas emission as well. It is significant to obtain deeper insight into this relationship. This paper overviewed the mechanism of air-pollution terrain nexus, summarised some methods for modelling, monitoring and predicting the air pollutants distribution, flow and settling that influenced by terrain. The limitation and challenges of related studies were discussed. In conclusions, this paper aims at reviewing the nexus of terrain and air pollutions and the methods in this field, trying to highlight the current challenges.

Pressure humanity is facing from environment-related problems has been increasing in the past decades. A comprehensive and effective approach for environment protection management has been the top priority. Water footprint (WF) provides a good methodology to assess the environment related problem and address the challenges. In the last several years the Web of Science has witnessed that WF-related publications have significantly increased. The research in WF has become mature and linked with a growing number of topics. The “WF-Energy”, “WF-Carbon Emissions (CE)” (mainly CO2) and “WF-Nitrogen Emissions (NE)” (mainly NOx) were selected and proposed as recent hot topics. This paper analyses current and future development trends in WF.

Studying the characteristics, trends, and evolution of carbon emissions in agricultural related sectors is of great significance for rational formulation of carbon emission reduction policies. However, as an important carbon emission reduction policy, carbon tax has been controversial over whether or not it should be levied on China. Based on this consideration, this paper takes China’s agricultural related sectors as an example and analyzes the degree of carbon tax on macro-environment, macroeconomy, and agricultural sectors during the period 2020–2050 by constructing a 3EAD-CGE (economy-energy-environmental-agricultural-dynamics Computable General Equilibrium) model. The results show that: (1) carbon tax has a time effect, specifically, the short-term effect is better than the long-term. (2) If the incremental rate of carbon tax is carried out alone, it will exert a great influence on the macroeconomy as well as on most of the agricultural related sectors. (3) If a carbon tax is introduced at the same time as indirect taxes are cut (proportionally), the policy will exert a negative impact on agriculture-related sectors that are subsidized. However, the policy will have a positive impact on those nonsubsidized sectors. Finally, based on the results, we put forward some suggestions that are more suitable for the introduction of a carbon tax in China’s agricultural-related sectors.

Inner Mongolia is among the most important regions in terms of contribution to the socio-economic development of China. Furthermore, its grassland is a major ecological barrier for Northern China. The present study evaluates the changes in ecosystem services availability and human wellbeing based on a survey on864 herdsmen of the grassland and 20 governmental officials. The survey provided the following results: (1) The supporting and provisioning services of the grassland have recently declined, thus affecting the herdsmen's wellbeing. The intensity of grazing, coal exploitation and tourism development heavily limits the availability of ecosystem services, among which provisioning ones are perceived as the most important. Below a certain threshold, grazing and mining are likely to promote the improvement of herdsmen's wellbeing, while trespassing that point, the enhancement of the herdsmen's living standards is curbed. (2) The herdsmen's cultural exchange, health conditions and social relations are better now than before; however, the threats on herdsmen's health and safety have increased. (3) A better income is among the most urgent herdsmen's needs. Livestock revenues did not increase at the same rate as the damage to the grassland and human risk exposure did. (4) The governmental ecological compensation policy did not entirely solve the problem of grassland desertification and environmental degradation, although it is also true that the degree of implementation and effectiveness of government policies is related to the still insufficient herdsmen's understanding and acceptance of these policies.