39 results on '"Y Y, Che"'
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2. A multicentre, randomized, double-blind, placebo-controlled trial of topical oestradiol gel for endometrial regeneration after induced abortion.
- Author
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Li CY, Teng LR, Jiang XX, Shan L, Wang LQ, Dong XJ, Li QF, Ren CC, Lin Y, Jiang J, Gu XY, Huang W, Li Q, Peng P, Che Y, and Liu XY
- Subjects
- Humans, Female, Double-Blind Method, Adult, Pregnancy, Administration, Topical, Gels, Ultrasonography, Treatment Outcome, Endometrium drug effects, Endometrium diagnostic imaging, Estradiol administration & dosage, Abortion, Induced methods, Regeneration drug effects
- Abstract
Study Question: Is topical oestradiol gel effective in promoting endometrial regeneration after a surgical abortion?, Summary Answer: Topical oestradiol gel is effective in promoting endometrial regeneration after a surgical abortion with few side-effects., What Is Known Already: Oestrogen is effective in promoting endometrial regeneration. Transdermal oestrogen has been widely used in clinical practice for endometrial regeneration after induced abortion, but high-level evidence is limited., Study Design, Size, Duration: We conducted a multicentre, superiority, randomized, double-blind, placebo-controlled trial. Between 9 March 2022 and 21 February 2023, 200 women were assigned in a 1:1 ratio to receive either oestradiol gel (treatment) and or oestradiol gel simulant (control) for 28 days. The participants were scheduled to have their endometrial thickness (mm) measured by ultrasonographic scan at 21-23 days post-abortion. The trial was blinded for participants, investigators, medical staff, and statistical analysts until final unblinding., Participants/materials, Setting, Methods: Participants were women undergoing induced abortion within 10 weeks of gestation. A total of 200 participants were enrolled, with 100 in each group. Eighty-eight (88%) in the treatment group and 82 (82%) in the control group completed the study as per the protocol and were included in the per-protocol set (PPS). The intent-to-treat (ITT) analysis included all participants randomized to the study groups and used inverse probability weighting to account for loss to follow-up., Main Results and the Role of Chance: The ITT analysis showed revealed significantly greater endometrial thickness in the treatment group (mean 8.1 ± 2.5 mm) compared to the control group (mean 6.9 ± 2.1 mm) 21-23 days postabortion (mean difference 1.2 mm, 95% CI 0.7 to 1.9; P < 0.001). The median time to menstrual return was shorter in the treatment group (34 days, inter-quartile range [IQR] 30-38) than in the control group (35 days, IQR 32-42), with a difference of -1 day (95% CI -2.3 to -0.9; P = 0.036). No differences were observed in the timing or volume of bleeding in the first post-abortion cycle. The PPS analysis mirrored the ITT findings. Adverse events were minimal (6% versus 8%), and the blood profile, liver, kidney and coagulation test results were comparable between groups (all P > 0.05)., Limitations, Reasons for Caution: Loss to follow-up was 11% in the treatment group and 15% of controls, with no significant difference (P > 0.05). Inconsistencies in the timing of the ultrasonographic scans may have affected the accuracy of endometrial thickness measurements., Wider Implications of the Findings: Our findings suggest that topical oestrogen supplementation immediately after abortion within the first 10 weeks of gestation improves endometrial regeneration and growth, thereby potentially increasing the chances of a successful subsequent pregnancy. Clinical application of these findings may improve endometrial health management practices and provide a perspective on fertility treatment and women's reproductive health., Study Funding/competing Interest(s): This study was supported by a grant (FW-HKKT2021111501900) from Jianmin Pharmaceutical Group Co., Ltd (JMPG), Wuhan, Hubei, China. Both the oestradiol gel and the simulant were provided by JMPG. The funding source had no role in the study. X.Y.L. reports JMPG grant funding paid to their institutions. All other authors declare no competing interests., Trial Registration Number: CHiCTR2100053565., Trial Registration Date: 24 November 2021., Date of First Patient’s Enrolment: 9 March 2022., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2024
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3. Search for Light Long-Lived Particles in pp Collisions at sqrt[s]=13 TeV Using Displaced Vertices in the ATLAS Inner Detector.
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Aad G, Aakvaag E, Abbott B, Abdelhameed S, Abeling K, Abicht NJ, Abidi SH, Aboelela M, Aboulhorma A, Abramowicz H, Abreu H, Abulaiti Y, Acharya BS, Ackermann A, Adam Bourdarios C, Adamczyk L, Addepalli SV, Addison MJ, Adelman J, Adiguzel A, Adye T, Affolder AA, Afik Y, Agaras MN, Agarwala J, Aggarwal A, Agheorghiesei C, Ahmad A, Ahmadov F, Ahmed WS, Ahuja S, Ai X, Aielli G, Aikot A, Ait Tamlihat M, Aitbenchikh B, Akbiyik M, Åkesson TPA, Akimov AV, Akiyama D, Akolkar NN, Aktas S, Al Khoury K, Alberghi GL, Albert J, Albicocco P, Albouy GL, Alderweireldt S, Alegria ZL, Aleksa M, Aleksandrov IN, Alexa C, Alexopoulos T, Alfonsi F, Algren M, Alhroob M, Ali B, Ali HMJ, Ali S, Alibocus SW, Aliev M, Alimonti G, Alkakhi W, Allaire C, Allbrooke BMM, Allen JF, Allendes Flores CA, Allport PP, Aloisio A, Alonso F, Alpigiani C, Alsolami ZMK, Alvarez Estevez M, Alvarez Fernandez A, Alves Cardoso M, Alviggi MG, Aly M, Amaral Coutinho Y, Ambler A, Amelung C, Amerl M, Ames CG, Amidei D, Amirie KJ, Amor Dos Santos SP, Amos KR, An S, Ananiev V, Anastopoulos C, Andeen T, Anders JK, Anderson AC, Andrean SY, Andreazza A, Angelidakis S, Angerami A, Anisenkov AV, Annovi A, Antel C, Antipov E, Antonelli M, Anulli F, Aoki M, Aoki T, Aparo MA, Aperio Bella L, Appelt C, Apyan A, Arbiol Val SJ, Arcangeletti C, Arce ATH, Arena E, Arguin JF, Argyropoulos S, Arling JH, Arnaez O, Arnold H, Artoni G, Asada H, Asai K, Asai S, Asbah NA, Ashby Pickering RA, Assamagan K, Astalos R, Astrand KSV, Atashi S, Atkin RJ, Atkinson M, Atmani H, Atmasiddha PA, Augsten K, Auricchio S, Auriol AD, Austrup VA, Avolio G, Axiotis K, Azuelos G, Babal D, Bachacou H, Bachas K, Bachiu A, Backman F, Badea A, Baer TM, Bagnaia P, Bahmani M, Bahner D, Bai K, Baines JT, Baines L, Baker OK, Bakos E, Bakshi Gupta D, Balabram Filho LE, Balakrishnan V, Balasubramanian R, Baldin EM, Balek P, Ballabene E, Balli F, Baltes LM, Balunas WK, Balz J, Bamwidhi I, Banas E, Bandieramonte M, Bandyopadhyay A, Bansal S, Barak L, Barakat M, 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- Abstract
A search for long-lived particles (LLPs) using 140 fb^{-1} of pp collision data with sqrt[s]=13 TeV recorded by the ATLAS experiment at the LHC is presented. The search targets LLPs with masses between 5 and 55 GeV that decay hadronically in the ATLAS inner detector. Benchmark models with LLP pair production from exotic decays of the Higgs boson and models featuring long-lived axionlike particles (ALPs) are considered. No significant excess above the expected background is observed. Upper limits are placed on the branching ratio of the Higgs boson to pairs of LLPs, the cross section for ALPs produced in association with a vector boson, and, for the first time, on the branching ratio of the top quark to an ALP and a u/c quark.
- Published
- 2024
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4. Studies of the Energy Dependence of Diboson Polarization Fractions and the Radiation-Amplitude-Zero Effect in WZ Production with the ATLAS Detector.
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Aad G, Aakvaag E, Abbott B, Abeling K, Abicht NJ, Abidi SH, Aboelela M, Aboulhorma A, Abramowicz H, Abreu H, Abulaiti Y, Acharya BS, Ackermann A, Adam Bourdarios C, Adamczyk L, Addepalli SV, Addison MJ, Adelman J, Adiguzel A, Adye T, Affolder AA, Afik Y, Agaras MN, Agarwala J, Aggarwal A, Agheorghiesei C, Ahmad A, Ahmadov F, Ahmed WS, Ahuja S, Ai X, Aielli G, Aikot A, Ait Tamlihat M, Aitbenchikh B, Aizenberg I, Akbiyik M, Åkesson TPA, Akimov AV, Akiyama D, Akolkar NN, Aktas S, Al Khoury K, Alberghi GL, Albert J, Albicocco P, Albouy GL, Alderweireldt S, Alegria ZL, Aleksa M, Aleksandrov IN, Alexa C, Alexopoulos T, Alfonsi F, Algren M, Alhroob M, Ali B, Ali HMJ, Ali S, Alibocus SW, Aliev M, Alimonti G, Alkakhi W, Allaire C, Allbrooke BMM, Allen JF, Allendes Flores CA, Allport PP, Aloisio A, Alonso F, Alpigiani C, Alvarez Estevez M, Alvarez Fernandez A, Alves Cardoso M, Alviggi MG, Aly M, Amaral Coutinho Y, Ambler A, Amelung C, Amerl M, Ames CG, Amidei D, Amirie KJ, Amor Dos Santos SP, Amos KR, An S, Ananiev V, Anastopoulos C, Andeen T, Anders JK, Andrean SY, Andreazza A, Angelidakis S, Angerami A, Anisenkov AV, Annovi A, Antel C, Anthony MT, Antipov E, Antonelli M, Anulli F, Aoki M, Aoki T, Aparisi Pozo JA, Aparo MA, Aperio Bella L, Appelt C, Apyan A, Arbiol Val SJ, Arcangeletti C, Arce ATH, Arena E, Arguin JF, Argyropoulos S, Arling JH, Arnaez O, Arnold H, Artoni G, Asada H, Asai K, Asai S, Asbah NA, Assamagan K, Astalos R, Astrand KSV, Atashi S, Atkin RJ, Atkinson M, Atmani H, Atmasiddha PA, Augsten K, Auricchio S, Auriol AD, Austrup VA, Avolio G, Axiotis K, Azuelos G, Babal D, Bachacou H, Bachas K, Bachiu A, Backman F, Badea A, Baer TM, Bagnaia P, Bahmani M, Bahner D, Bai K, Baines JT, Baines L, Baker OK, Bakos E, Bakshi Gupta D, Balakrishnan V, Balasubramanian R, Baldin EM, Balek P, Ballabene E, Balli F, Baltes LM, Balunas WK, Balz J, Banas E, Bandieramonte M, Bandyopadhyay A, Bansal S, Barak L, Barakat M, Barberio EL, Barberis D, Barbero M, Barel MZ, Barends KN, Barillari T, Barisits MS, Barklow T, Baron P, Baron Moreno DA, Baroncelli A, Barone G, Barr AJ, Barr JD, Barreiro F, Barreiro Guimarães da Costa J, Barron U, Barros Teixeira MG, Barsov S, Bartels F, Bartoldus R, Barton AE, Bartos P, Basan A, Baselga M, Bassalat A, Basso MJ, Bate R, Bates RL, Batlamous S, Batool B, Battaglia M, Battulga D, Bauce M, Bauer M, Bauer P, Bazzano Hurrell LT, Beacham JB, Beau T, Beaucamp JY, Beauchemin PH, Bechtle P, Beck HP, Becker K, Beddall AJ, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begalli M, Begel M, Behera A, Behr JK, Beirer JF, Beisiegel F, Belfkir M, Bella G, Bellagamba L, Bellerive A, Bellos P, Beloborodov K, Benchekroun D, Bendebba F, Benhammou Y, Benkendorfer KC, Beresford L, Beretta M, Bergeaas Kuutmann E, Berger N, Bergmann B, Beringer J, Bernardi G, Bernius C, Bernlochner FU, Bernon F, Berrocal Guardia A, Berry T, Berta P, Berthold A, Bethke S, Betti A, Bevan AJ, Bhalla NK, Bhamjee M, Bhatta S, Bhattacharya DS, Bhattarai P, Bhide KD, Bhopatkar VS, Bianchi RM, Bianco G, Biebel O, Bielski R, Biglietti M, Billingsley CS, Bindi M, Bingul A, Bini C, Biondini A, Birch-Sykes CJ, Bird GA, Birman M, Biros M, Biryukov S, Bisanz T, Bisceglie E, Biswal JP, Biswas D, Bloch I, Blue A, Blumenschein U, Blumenthal J, Bobrovnikov VS, Boehler M, Boehm B, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bokan P, Bold T, Bomben M, Bona M, Boonekamp M, Booth CD, Borbély AG, Bordulev IS, Borecka-Bielska HM, Borissov G, Bortoletto D, Boscherini D, Bosman M, Bossio Sola JD, Bouaouda K, Bouchhar N, Boudreau J, Bouhova-Thacker EV, Boumediene D, Bouquet R, Boveia A, Boyd J, Boye D, Boyko IR, Bracinik J, Brahimi N, Brandt G, Brandt O, Braren F, Brau B, Brau JE, Brener R, Brenner L, Brenner R, Bressler S, Britton D, Britzger D, Brock I, Brooijmans G, Brost E, Brown LM, Bruce LE, Bruckler TL, Bruckman de Renstrom PA, Brüers B, Bruni A, Bruni G, Bruschi M, Bruscino N, Buanes T, Buat Q, Buchin D, Buckley AG, Bulekov O, Bullard BA, Burdin S, Burgard CD, Burger AM, Burghgrave B, Burlayenko O, Burr JTP, Burton CD, Burzynski JC, Busch EL, Büscher V, Bussey PJ, Butler JM, Buttar CM, Butterworth JM, Buttinger W, Buxo Vazquez CJ, Buzykaev AR, Cabrera Urbán S, Cadamuro L, Caforio D, Cai H, Cai Y, Cai Y, Cairo VMM, Cakir O, Calace N, Calafiura P, Calderini G, Calfayan P, Callea G, Caloba LP, Calvet D, Calvet S, Calvetti M, Camacho Toro R, Camarda S, Camarero Munoz D, Camarri P, Camerlingo MT, Cameron D, Camincher C, Campanelli M, Camplani A, Canale V, Canbay AC, Canonero E, Cantero J, Cao Y, Capocasa F, Capua M, Carbone A, Cardarelli R, Cardenas JCJ, Cardillo F, Carducci G, Carli T, Carlino G, Carlotto JI, Carlson BT, Carlson EM, Carmignani J, Carminati L, Carnelli A, Carnesale M, Caron S, Carquin E, Carrá S, Carratta G, Carroll AM, Carter TM, Casado MP, Caspar M, Castillo FL, Castillo Garcia L, Castillo Gimenez V, Castro NF, Catinaccio A, Catmore JR, Cavaliere T, Cavaliere V, Cavalli N, Cekmecelioglu YC, Celebi E, Cella S, Celli F, Centonze MS, Cepaitis V, Cerny K, Cerqueira AS, Cerri A, Cerrito L, Cerutti F, Cervato B, Cervelli A, Cesarini G, Cetin SA, Chakraborty D, Chan J, Chan WY, Chapman JD, Chapon E, Chargeishvili B, Charlton DG, Chatterjee M, Chauhan C, Che Y, Chekanov S, Chekulaev SV, Chelkov GA, Chen A, Chen B, Chen B, Chen H, Chen H, Chen J, Chen J, Chen M, Chen S, Chen SJ, Chen X, Chen X, Chen Y, Cheng CL, Cheng HC, Cheong S, Cheplakov A, Cheremushkina E, Cherepanova E, Cherkaoui El Moursli R, Cheu E, Cheung K, Chevalier L, Chiarella V, Chiarelli G, Chiedde N, Chiodini G, Chisholm AS, Chitan A, Chitishvili M, Chizhov MV, Choi K, Chou Y, Chow EYS, Chu KL, Chu MC, Chu X, Chudoba J, Chwastowski JJ, Cieri D, Ciesla KM, Cindro V, Ciocio A, Cirotto F, Citron ZH, Citterio M, Ciubotaru DA, Clark A, Clark PJ, Clarry C, Clavijo Columbie JM, Clawson SE, Clement C, Clercx J, Coadou Y, Cobal M, Coccaro A, Barrue RFC, Coelho Lopes De Sa R, Coelli S, Cole B, Collot J, Conde Muiño P, Connell MP, Connell SH, Conroy EI, Conventi F, Cooke HG, Cooper-Sarkar AM, Corchia FA, Cordeiro Oudot Choi A, Corpe LD, Corradi M, Corriveau F, Cortes-Gonzalez A, Costa MJ, Costanza F, Costanzo D, Cote BM, Cowan G, Cranmer K, Cremonini D, Crépé-Renaudin S, Crescioli F, Cristinziani M, Cristoforetti M, Croft V, Crosby JE, Crosetti G, Cueto A, Cui H, Cui Z, Cunningham WR, Curcio F, Curran JR, Czodrowski P, Czurylo MM, De Sousa MJDCS, Da Fonseca Pinto JV, Da Via C, Dabrowski W, Dado T, Dahbi S, Dai T, Dal Santo D, Dallapiccola C, Dam M, D'amen G, D'Amico V, Damp J, Dandoy JR, Danninger M, Dao V, Darbo G, Das SJ, Dattola F, D'Auria S, D'avanzo A, David C, Davidek T, Davis-Purcell B, Dawson I, Day-Hall HA, De K, De Asmundis R, De Biase N, De Castro S, De Groot N, de Jong P, De la Torre H, De Maria A, De Salvo A, De Sanctis U, De Santis F, De Santo A, De Vivie De Regie JB, Dedovich DV, Degens J, Deiana AM, Del Corso F, Del Peso J, Del Rio F, Delagrange L, Deliot F, Delitzsch CM, Della Pietra M, Della Volpe D, Dell'Acqua A, Dell'Asta L, Delmastro M, Delsart PA, Demers S, Demichev M, Denisov SP, D'Eramo L, Derendarz D, Derue F, Dervan P, Desch K, Deutsch C, Di Bello FA, Di Ciaccio A, Di Ciaccio L, Di Domenico A, Di Donato C, Di Girolamo A, Di Gregorio G, Di Luca A, Di Micco B, Di Nardo R, Diamantopoulou M, Dias FA, Vale TDD, Diaz MA, Diaz Capriles FG, Didenko M, Diehl EB, Díez Cornell S, Diez Pardos C, Dimitriadi C, Dimitrievska A, Dingfelder J, Dinu IM, Dittmeier SJ, Dittus F, Divisek M, Djama F, Djobava T, Doglioni C, Dohnalova A, Dolejsi J, Dolezal Z, Dona KM, Donadelli M, Dong B, Donini J, D'Onofrio A, D'Onofrio M, Dopke J, Doria A, Dos Santos Fernandes N, Dougan P, Dova MT, Doyle AT, Draguet MA, Dreyer E, Drivas-Koulouris I, Drnevich M, Drozdova M, Du D, du Pree TA, Dubinin F, Dubovsky M, Duchovni E, Duckeck G, Ducu OA, Duda D, Dudarev A, Duden ER, D'uffizi M, Duflot L, Dührssen M, Duminica I, Dumitriu AE, Dunford M, Dungs S, Dunne K, Duperrin A, Yildiz HD, Düren M, Durglishvili A, Dwyer BL, Dyckes GI, Dyndal M, Dziedzic BS, Earnshaw ZO, Eberwein GH, Eckerova B, Eggebrecht S, Purcino De Souza EE, Ehrke LF, Eigen G, Einsweiler K, Ekelof T, Ekman PA, El Farkh S, El Ghazali Y, El Jarrari H, El Moussaouy A, Ellajosyula V, Ellert M, Ellinghaus F, Ellis N, Elmsheuser J, Elsawy M, Elsing M, Emeliyanov D, Enari Y, Ene I, Epari S, Erland PA, Errenst M, Escalier M, Escobar C, Etzion E, Evans G, Evans H, Evans LS, Ezhilov A, Ezzarqtouni S, Fabbri F, Fabbri L, Facini G, Fadeyev V, Fakhrutdinov RM, Fakoudis D, Falciano S, Falda Ulhoa Coelho LF, Falke PJ, Fallavollita F, Faltova J, Fan C, Fan Y, Fang Y, Fanti M, Faraj M, Farazpay Z, Farbin A, Farilla A, Farooque T, Farrington SM, Fassi F, Fassouliotis D, Faucci Giannelli M, Fawcett WJ, Fayard L, Federic P, Federicova P, Fedin OL, Feickert M, Feligioni L, Fellers DE, Feng C, Feng M, Feng Z, Fenton MJ, Ferencz L, Ferguson RAM, Fernandez Luengo SI, Fernandez Martinez P, Fernoux MJV, Ferrando J, Ferrari A, Ferrari P, Ferrari R, Ferrere D, Ferretti C, Fiedler F, Fiedler P, Filipčič A, Filmer EK, Filthaut F, Fiolhais MCN, Fiorini L, Fisher WC, Fitschen T, Fitzhugh PM, Fleck I, Fleischmann P, Flick T, Flores M, Flores Castillo LR, Flores Sanz De Acedo L, Follega FM, Fomin N, Foo JH, Formica A, Forti AC, Fortin E, Fortman AW, Foti MG, Fountas L, Fournier D, Fox H, Francavilla P, Francescato S, Franchellucci S, Franchini M, Franchino S, Francis D, Franco L, Franco Lima V, Franconi L, Franklin M, Frattari G, Freund WS, Frid YY, Friend J, Fritzsche N, Froch A, Froidevaux D, Frost JA, Fu Y, Fuenzalida Garrido S, Fujimoto M, Fung KY, De Simas Filho EF, Furukawa M, Fuster J, Gabrielli A, Gabrielli A, Gadow P, Gagliardi G, Gagnon LG, Gaid S, Galantzan S, Gallas EJ, Gallop BJ, Gan KK, Ganguly S, Gao Y, Garay Walls FM, Garcia B, García C, Garcia Alonso A, Garcia Caffaro AG, García Navarro JE, Garcia-Sciveres M, Gardner GL, Gardner RW, Garelli N, Garg D, Garg RB, Gargan JM, Garner CA, Garvey CM, Gaspar P, Gassmann VK, Gaudio G, Gautam V, Gauzzi P, Gavrilenko IL, Gavrilyuk A, Gay C, Gaycken G, Gazis EN, Geanta AA, Gee CM, Gekow A, Gemme C, Genest MH, Gentry AD, George S, George WF, Geralis T, Gessinger-Befurt P, Geyik ME, Ghani M, Ghorbanian K, Ghosal A, Ghosh A, Ghosh A, Giacobbe B, Giagu S, Giani T, Giannetti P, Giannini A, Gibson SM, Gignac M, Gil DT, Gilbert AK, Gilbert BJ, Gillberg D, Gilles G, Ginabat L, Gingrich DM, Giordani MP, Giraud PF, Giugliarelli G, Giugni D, Giuli F, Gkialas I, Gladilin LK, Glasman C, Gledhill GR, Glemža G, Glisic M, Gnesi I, Go Y, Goblirsch-Kolb M, Gocke B, Godin D, Gokturk B, Goldfarb S, Golling T, Gololo MGD, Golubkov D, Gombas JP, Gomes A, Gomes Da Silva G, Gomez Delegido AJ, Gonçalo R, Gonella L, Gongadze A, Gonnella F, Gonski JL, González Andana RY, González de la Hoz S, Gonzalez Lopez R, Gonzalez Renteria C, Gonzalez Rodrigues MV, Gonzalez Suarez R, Gonzalez-Sevilla S, Goossens L, Gorini B, Gorini E, Gorišek A, Gosart TC, Goshaw AT, Gostkin MI, Goswami S, Gottardo CA, Gotz SA, Gouighri M, Goumarre V, Goussiou AG, Govender N, Grabowska-Bold I, Graham K, Gramstad E, Grancagnolo S, Grant CM, Gravila PM, Gravili FG, Gray HM, Greco M, Grefe C, Gregor IM, Greif KT, Grenier P, Grewe SG, Grillo AA, Grimm K, Grinstein S, Grivaz JF, Gross E, Grosse-Knetter J, Grundy JC, Guan L, Gubbels C, Guerrero Rojas JGR, Guerrieri G, Guescini F, Gugel R, Guhit JAM, Guida A, Guilloton E, Guindon S, Guo F, Guo J, Guo L, Guo Y, Gupta R, Gupta R, Gurbuz S, Gurdasani SS, Gustavino G, Guth M, Gutierrez P, Gutierrez Zagazeta LF, Gutsche M, Gutschow C, Gwenlan C, Gwilliam CB, Haaland ES, Haas A, Habedank M, Haber C, Hadavand HK, Hadef A, Hadzic S, Hagan AI, Hahn JJ, Haines EH, Haleem M, Haley J, Hall JJ, Hallewell GD, Halser L, Hamano K, Hamer M, Hamity GN, Hampshire EJ, Han J, Han K, Han L, Han L, Han S, Han YF, Hanagaki K, Hance M, Hangal DA, Hanif H, Hank MD, Hansen JB, Hansen PH, Hara K, Harada D, Harenberg T, Harkusha S, Harris ML, Harris YT, Harrison J, Harrison NM, Harrison PF, Hartman NM, Hartmann NM, Hasan RZ, Hasegawa Y, Hassan S, Hauser R, Hawkes CM, Hawkings RJ, Hayashi Y, Hayashida S, Hayden D, Hayes C, Hayes RL, Hays CP, Hays JM, Hayward HS, He F, He M, He Y, He Y, He Y, Heatley NB, Hedberg V, Heggelund AL, Hehir ND, Heidegger C, Heidegger KK, Heidorn WD, Heilman J, Heim S, Heim T, Heinlein JG, Heinrich JJ, Heinrich L, Hejbal J, Held A, Hellesund S, Helling CM, Hellman S, Henderson RCW, Henkelmann L, Henriques Correia AM, Herde H, Hernández Jiménez Y, Herrmann LM, Herrmann T, Herten G, Hertenberger R, Hervas L, Hesping ME, Hessey NP, Hidaoui M, Hill E, Hillier SJ, Hinds JR, Hinterkeuser F, Hirose M, Hirose S, Hirschbuehl D, Hitchings TG, Hiti B, Hobbs J, Hobincu R, Hod N, Hodgkinson MC, Hodkinson BH, Hoecker A, Hofer DD, Hofer J, Holm T, Holzbock M, Hommels LBAH, Honan BP, Hong J, Hong TM, Hooberman BH, Hopkins WH, Horii Y, Hou S, Howard AS, Howarth J, Hoya J, Hrabovsky M, Hrynevich A, Hryn'ova T, Hsu PJ, Hsu SC, Hsu T, Hu M, Hu Q, Huang S, Huang X, Huang Y, Huang Y, Huang Y, Huang Z, Hubacek Z, Huebner M, Huegging F, Huffman TB, Hugli CA, Huhtinen M, Huiberts SK, Hulsken R, Huseynov N, Huston J, Huth J, Hyneman R, Iacobucci G, Iakovidis G, Ibragimov I, Iconomidou-Fayard L, Iddon JP, Iengo P, Iguchi R, Iizawa T, Ikegami Y, Ilic N, Imam H, Ince Lezki M, Ingebretsen Carlson T, Introzzi G, Iodice M, Ippolito V, Irwin RK, Ishino M, Islam W, Issever C, Istin S, Ito H, Iuppa R, Ivina A, Izen JM, Izzo V, Jacka P, Jackson P, Jaeger BP, Jagfeld CS, Jain G, Jain P, Jakobs K, Jakoubek T, Jamieson J, Janas KW, Javurkova M, Jeanty L, Jejelava J, Jenni P, Jessiman CE, Jia C, Jia J, Jia X, Jia X, Jia Z, Jiang C, Jiggins S, Jimenez Pena J, Jin S, Jinaru A, Jinnouchi O, Johansson P, Johns KA, Johnson JW, Jones DM, Jones E, Jones P, Jones RWL, Jones TJ, Joos HL, Joshi R, Jovicevic J, Ju X, Junggeburth JJ, Junkermann T, Juste Rozas A, Juzek MK, Kabana S, Kaczmarska A, Kado M, Kagan H, Kagan M, Kahn A, Kahn A, Kahra C, Kaji T, Kajomovitz E, Kakati N, Kalaitzidou I, Kalderon CW, Kang NJ, Kar D, Karava K, Kareem MJ, Karentzos E, Karkanias I, Karkout O, Karpov SN, Karpova ZM, Kartvelishvili V, Karyukhin AN, Kasimi E, Katzy J, Kaur S, Kawade K, Kawale MP, Kawamoto C, Kawamoto T, Kay EF, Kaya FI, Kazakos S, Kazanin VF, Ke Y, Keaveney JM, Keeler R, Kehris GV, Keller JS, Kelly AS, Kempster JJ, Kennedy PD, Kepka O, Kerridge BP, Kersten S, Kerševan BP, Keszeghova L, Ketabchi Haghighat S, Khan RA, Khanov A, Kharlamov AG, Kharlamova T, Khoda EE, Kholodenko M, Khoo TJ, Khoriauli G, Khubua J, Khwaira YAR, Kibirige B, Kilgallon A, Kim DW, Kim YK, Kimura N, Kingston MK, Kirchhoff A, Kirfel C, Kirfel F, Kirk J, Kiryunin AE, Kitsaki C, Kivernyk O, Klassen M, Klein C, Klein L, Klein MH, Klein SB, Klein U, Klimek P, Klimentov A, Klioutchnikova T, Kluit P, Kluth S, Kneringer E, Knight TM, Knue A, Kobayashi R, Kobel M, Kobylianskii D, Koch SF, Kocian M, Kodyš P, Koeck DM, Koenig PT, Koffas T, Kolay O, Koletsou I, Komarek T, Köneke K, Kong AXY, Kono T, Konstantinidis N, Kontaxakis P, Konya B, Kopeliansky R, Koperny S, Korcyl K, Kordas K, Korn A, Korn S, Korolkov I, Korotkova N, Kortman B, Kortner O, Kortner S, Kostecka WH, Kostyukhin VV, Kotsokechagia A, Kotwal A, Koulouris A, Kourkoumeli-Charalampidi A, Kourkoumelis C, Kourlitis E, Kovanda O, Kowalewski R, Kozanecki W, Kozhin AS, Kramarenko VA, Kramberger G, Kramer P, Krasny MW, Krasznahorkay A, Kraus JW, Kremer JA, Kresse T, Kretzschmar J, Kreul K, Krieger P, Krishnamurthy S, Krivos M, Krizka K, Kroeninger K, Kroha H, Kroll J, Kroll J, Krowpman KS, Kruchonak U, Krüger H, Krumnack N, Kruse MC, Kuchinskaia O, Kuday S, Kuehn S, Kuesters R, Kuhl T, Kukhtin V, Kulchitsky Y, Kuleshov S, Kumar M, Kumari N, Kumari P, Kupco A, Kupfer T, Kupich A, Kuprash O, Kurashige H, Kurchaninov LL, Kurdysh O, Kurochkin YA, Kurova A, Kuze M, Kvam AK, Kvita J, Kwan T, Kyriacou NG, Laatu LAO, Lacasta C, Lacava F, Lacker H, Lacour D, Lad NN, Ladygin E, Lafarge A, Laforge B, Lagouri T, Lahbabi FZ, Lai S, Lakomiec IK, Lambert JE, Lammers S, Lampl W, Lampoudis C, Lamprinoudis G, Lancaster AN, Lançon E, Landgraf U, Landon MPJ, Lang VS, Langrekken OKB, Lankford AJ, Lanni F, Lantzsch K, Lanza A, Lapertosa A, Laporte JF, Lari T, Lasagni Manghi F, Lassnig M, Latonova V, Laudrain A, Laurier A, Lawlor SD, Lawrence Z, Lazaridou R, Lazzaroni M, Le B, Le Boulicaut EM, Le Pottier LT, Leban B, Lebedev A, LeBlanc M, Ledroit-Guillon F, Lee SC, Lee S, Lee TF, Leeuw LL, Lefebvre HP, Lefebvre M, Leggett C, Lehmann Miotto G, Leigh M, Leight WA, Leinonen W, Leisos A, Leite MAL, Leitgeb CE, Leitner R, Leney KJC, Lenz T, Leone S, Leonidopoulos C, Leopold A, Leroy C, Les R, Lester CG, Levchenko M, Levêque J, Levinson LJ, Levrini G, Lewicki MP, Lewis C, Lewis DJ, Li A, Li B, Li C, Li CQ, Li H, Li H, Li H, Li H, Li H, Li J, Li K, Li L, Li M, Li QY, Li S, Li S, Li T, Li X, Li Z, Li Z, Li Z, Liang S, Liang Z, Liberatore M, Liberti B, Lie K, Lieber Marin J, Lien H, Lin K, Lindley RE, Lindon JH, Lipeles E, 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- Abstract
This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined. A nonzero fraction of events with two longitudinally polarized bosons is measured with an observed significance of 5.3 standard deviations in the region with 100
200 GeV, where p_{T}^{Z} is the transverse momentum of the Z boson. This Letter also reports the first study of the radiation-amplitude-zero effect. Events with two transversely polarized bosons are analyzed for the ΔY(ℓ_{W}Z) and ΔY(WZ) distributions defined respectively as the rapidity difference between the lepton from the W boson decay and the Z boson and the rapidity difference between the W boson and the Z boson. Significant suppression of events near zero is observed in both distributions. Unfolded ΔY(ℓ_{W}Z) and ΔY(WZ) distributions are also measured and compared to theoretical predictions.
- Published
- 2024
- Full Text
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5. Combination of Searches for Higgs Boson Pair Production in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.
- Author
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- Abstract
This Letter presents results from a combination of searches for Higgs boson pair production using 126-140 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.4 assuming no Higgs boson pair production. Constraints on the Higgs boson self-coupling modifier κ_{λ}=λ_{HHH}/λ_{HHH}^{SM}, and the quartic HHVV coupling modifier κ_{2V}=g_{HHVV}/g_{HHVV}^{SM}, are derived individually, fixing the other parameter to its SM value. The observed 95% CL intervals are -1.2<κ_{λ}<7.2 and 0.6<κ_{2V}<1.5, respectively, while the expected intervals are -1.6<κ_{λ}<7.2 and 0.4<κ_{2V}<1.6 in the SM case. Constraints obtained for several interaction parameters within Higgs effective field theory are the strongest to date, offering insights into potential deviations from SM predictions.
- Published
- 2024
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6. Combination of Searches for Resonant Higgs Boson Pair Production Using pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.
- Author
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Zormpa O, Zou W, and Zwalinski L
- Abstract
A combination of searches for a new resonance decaying into a Higgs boson pair is presented, using up to 139 fb^{-1} of pp collision data at sqrt[s]=13 TeV recorded with the ATLAS detector at the LHC. The combination includes searches performed in three decay channels: bb[over ¯]bb[over ¯], bb[over ¯]τ^{+}τ^{-}, and bb[over ¯]γγ. No excess above the expected Standard Model background is observed and upper limits are set at the 95% confidence level on the production cross section of Higgs boson pairs originating from the decay of a narrow scalar resonance with mass in the range 251 GeV-5 TeV. The observed (expected) limits are in the range 0.96-600 fb (1.2-390 fb). The limits are interpreted in the type-I two-Higgs-doublet model and the minimal supersymmetric standard model, and constrain parameter space not previously excluded by other searches.
- Published
- 2024
- Full Text
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7. Search for Nearly Mass-Degenerate Higgsinos Using Low-Momentum Mildly Displaced Tracks in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.
- Author
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Aad G, Aakvaag E, Abbott B, Abeling K, Abicht NJ, Abidi SH, Aboelela M, Aboulhorma A, Abramowicz H, Abreu H, Abulaiti Y, Acharya BS, Ackermann A, Adam Bourdarios C, Adamczyk L, Addepalli SV, Addison MJ, Adelman J, Adiguzel A, Adye T, Affolder AA, Afik Y, Agaras MN, Agarwala J, Aggarwal A, Agheorghiesei C, Ahmad A, Ahmadov F, Ahmed WS, Ahuja S, Ai X, Aielli G, Aikot A, Ait Tamlihat M, Aitbenchikh B, Aizenberg I, Akbiyik M, Åkesson TPA, Akimov AV, Akiyama D, Akolkar NN, Aktas S, Al Khoury K, Alberghi GL, Albert J, Albicocco P, Albouy GL, Alderweireldt S, Alegria ZL, Aleksa M, Aleksandrov IN, Alexa C, Alexopoulos T, Alfonsi F, Algren M, Alhroob M, Ali B, Ali HMJ, Ali S, Alibocus SW, Aliev M, Alimonti G, Alkakhi W, Allaire C, Allbrooke BMM, Allen JF, Allendes Flores CA, Allport PP, Aloisio A, Alonso F, Alpigiani C, Alvarez Estevez M, Alvarez Fernandez A, Alves Cardoso M, Alviggi MG, Aly M, Amaral Coutinho Y, Ambler A, Amelung C, Amerl M, Ames CG, Amidei D, Amirie KJ, Amor Dos Santos SP, 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- Abstract
Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1 GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse impact parameter using 140 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV collected by the ATLAS experiment. For the first time since LEP, a range of mass splittings between the lightest charged and neutral Higgsinos from 0.3 to 0.9 GeV is excluded at 95% confidence level, with a maximum reach of approximately 170 GeV in the Higgsino mass.
- Published
- 2024
- Full Text
- View/download PDF
8. [The effect of tumor spread through air spaces on the prognosis of patients with stage Ⅰ non-small cell lung cancer: a meta-analysis].
- Author
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Nurmamat A, Hu Y, Mamatabdulla M, Che Y, Zhang LW, and Zhang HP
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- Humans, Neoplasm Invasiveness pathology, Neoplasm Recurrence, Local surgery, Prognosis, Neoplasm Staging, Retrospective Studies, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms pathology, Carcinoma, Squamous Cell
- Abstract
Objective: To systematically evaluate the effect of tumor spread through air spaces (STAS) on the prognosis of patients with stage Ⅰ non-small cell lung cancer (NSCLC). Methods: PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database and VIP were searched to collect papers related to NSCLC and STAS published from the establishment of aboves databases to November 2022. Papers were screened according to the inclusion and exclusion criteria, and data were extracted. The 5-year overall survival (OS) and relapse-free survival (RFS) of stage Ⅰ NSCLC patients with or without STAS were compared. HR (95%CI ) was used as effective indicator to evaluate the impact of STAS positivity on the prognosis of NSCLC. The quality of each included study was assessed using the Newcast-Ottawa Scale (NOS). Results: A total of 24 papers concerning 29 studies were included according to the inclusion and exclusion criteria, and there was no significant heterogeneity among the included papers(all I
2 <50%). A total of 10 883 patients with stage Ⅰ NSCLC were included in the studies, of which 3 298 (30.3%) were STAS-positive. The 29 studies showed that STAS-positive patients had a higher risk of 5-year recurrence than STAS-negative patients with stage Ⅰ NSCLC [ HR =1.94(95% CI :1.74-2.16)];and a meta-analysis of 17 of the studies showed that that STAS-positive patients had a higher risk of 5-year death [ HR =2.09 (95% CI :1.80-2.43)]. Compared with stage Ⅰ NSCLC patients who underwent other surgeries, STAS-positive patients who underwent sublobar resection had a higher risk of 5-year recurrence than patients with other procedures ( HR =3.44, 95% CI : 2.49-4.76) and a higher risk of 5-year death ( HR =3.40, 95% CI :2.05-5.64); and patients with stage Ⅰ NSCLC who had the pathologic histologic type of squamous carcinoma had a higher risk of 5-year recurrence ( HR =2.48,95% CI :1.71-3.60) and a higher risk of 5-year death ( HR =3.04, 95% CI : 1.90-4.86) than other patients with the type of squamous lung cancer. Conclusion: STAS positivity is a risk factor of poor prognosis in patients with stage Ⅰ NSCLC, especially for patients underwent sublobar resection or with squamous lung cancer.- Published
- 2023
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- View/download PDF
9. [Incidence of unintended pregnancy within 2 years after delivery and its influencing factors in China].
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Yang CX, Zhao XH, Li YY, Zhou YF, Zhang LA, Yuan D, Xia W, Wang JM, Song JD, Lyu W, Luo YF, Jiang LF, Jiang L, Huang XC, Hu XY, Dong XJ, Cheng TY, Zhou YZ, Zhang Y, and Che Y
- Subjects
- China epidemiology, Family Planning Services, Female, Humans, Incidence, Pregnancy, Contraception, Pregnancy, Unplanned
- Abstract
Objective: To investigate the present situation of unintended pregnancy within two years postpartum and its influencing factors in China. Methods: Participants who delivered a live birth at 60 hospitals in 15 provinces in the eastern, central and western regions of China during July 2015 to June 2016 were interviewed by using structured questionnaire. Information on occurrence of unintended pregnancy within 2 years after delivery, postpartum contraceptive use, sexual resumption, breastfeeding, and women's socio-demographic characteristics, and so on, were collected. Life-table analysis, cluster log-rank tests and a 2-level Cox regression model were used for data analysis. Results: A total of 18 045 postpartum women were investigated. The cumulative 1- and 2-year unintended pregnancy rates after delivery were 5.3% (95% CI : 4.5%-6.1%) and 13.1% (95% CI : 11.3%-14.8%), respectively. Cox regression model analysis showed that the risk of unintended pregnancy within 2 years postpartum were increased in younger women, ethnic minorities, women with abortion history, and those who had a vaginal delivery with short lactation time and late postpartum contraceptive initiation (all P <0.01). The risk of postpartum unintended pregnancy was not associated with geographic regions and hospitals where women gave a birth (all P >0.05). Conclusions: In China, the risk of unintended pregnancy within 2 years after delivery is relatively high. Service institutions and service providers should improve the quality of postpartum family planning services, promote the use of high effect contraceptive methods, and educate women to use a method at the time of their sexual resumption or even before.
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- 2021
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10. [Evaluation of screening accuracy on osteoporosis self-assessment tool for Asians and its cut-off value in healthy physical examination population].
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Wang P, Wu H, Che Y, Fan DW, Liu J, and Tao LY
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- Absorptiometry, Photon, Adult, Aged, Asian People, Bone Density, Female, Humans, Male, Middle Aged, Physical Examination, Risk Assessment, Sensitivity and Specificity, Osteoporosis, Self-Assessment
- Abstract
Objective: To explore the screening value of osteoporosis self-assessment tool for Asians (OSTA) and the optimal cut-off value in Chinese healthy physical examination population., Methods: We selected a healthy physical examination population for bone mineral density screening at the Health Examination Center in Peking University Third Hospital from 2013 to 2016. Quantitative ultrasound (QUS) results were used as the gold standard, and T value ≤-2.5 was defined as osteoporosis patients. Diagnostic test methods were used to analyze the sensitivity, specificity, likelihood ratio and area under curve (AUC) of different cut points of OSTA. The screening accuracy of OSTA at different cut points was compared and the optimal cut-point value determined., Results: A total of 5 833 subjects were included in the study, with an average age of (48.3±17.5) years and 2 594 women (44.5%). The QUS test showed 403 patients with osteoporosis (6.9% of the total population), 343 female osteoporosis patients (13.22% of the female population). In the whole age group, AUC at the international routine cut-off value (OSTA ≤-1) screening for osteoporosis was 0.815 (95%CI: 0.804-0.825), and screening accuracy was higher in the women (AUC=0.837, 95%CI: 0.823-0.851) than that in the men (AUC=0.767, 95%CI: 0.752-0.781; P<0.05). In the whole age group, when the optimal cut-off value was 0, its AUC 0.842 (95%CI: 0.832-0.851) was significantly higher than that when the cut-off value was -1 (P<0.01), and net reclassification improvement (NRI) increased by 5.5%. In the 40 to 65-year-old group, when OSTA cut-off value ≤0, the screening accuracy was significantly higher (NRI=19.5%, P=0.003) than that when it was -1., Conclusion: The OSTA screening tool had good osteoporosis screening value in healthy people, and the screening accuracy in women is higher than that in men. Increasing the screening cut-off value of OSTA would be helpful to improve the screening accuracy in the whole and 40 to 65-year-old population. There may be different optimal cut-off values for different age group population.
- Published
- 2019
11. Cohort study to evaluate efficacy, safety and acceptability of a two-rod contraceptive implant during third, fourth and fifth year of product use in China.
- Author
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Che Y, Taylor D, Luo D, Maldonado LY, Wang M, Wevill S, Vahdat H, Han X, Halpern V, Dorflinger L, and Steiner MJ
- Abstract
Objective: Sino-implant (II) is a contraceptive implant approved for 4 years of use in China. We evaluated the contraceptive efficacy during the third, fourth and fifth year, and assessed additional pharmacokinetics (PK), safety, and acceptability endpoints., Study Design: We enrolled a cohort of 255 current Sino-Implant (II) users entering their third year and a second cohort of 243 users entering their fourth year. We followed these two cohorts for 12 and 24 months, respectively. To characterize PK endpoints (i.e. levonorgestrel (LNG), sex hormone binding globulin and free LNG index) over 5 years, we collected blood samples in a subset of 50 participants we followed during the third, fourth and fifth year. We also enrolled small cohorts (n = 20) of Sino-implant (II) users entering their sixth month and second year and followed them each for up to 6 months. Our primary efficacy measures were the pregnancy Pearl Indices during Year 3 and 4. Secondary objectives included assessments of PK, safety, acceptability and efficacy in the fifth year., Results: We recorded four pregnancies, with a higher pregnancy rate during Year 3 [1.34 (95% CI: 0.28-3.93)] than Year 4 [0.44 (95% CI: 0.01-2.47)] or Year 5 [0.00 (95% CI: 0.00-2.02)]. The overall pregnancy rate for the third, fourth and fifth years of product use was 0.63 per 100 WY; 95% CI: (0.17-1.62). Mean LNG concentrations remained well above 200 pg/mL (Year 3 = 280.9; Year 4 = 233.6; Year 5 = 270.6). Most participants (93.7%) described their bleeding pattern as acceptable., Conclusion: Sino-implant (II) is a highly effective contraceptive method in this population of Chinese women over 5 years., Implications: Sino-implant (II) is a highly effective contraceptive method with an estimated Pearl Index of less than 1% over the third, fourth and fifth years of use in a population of Chinese women of reproductive age., (© 2019 The Authors.)
- Published
- 2019
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12. Osteogenesis-promoting activity of composites SBA-15 mesoporous particles carrying oxytocin in vitro and in vivo.
- Author
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Cheng L, He X, Che Y, Che H, and Qian M
- Subjects
- Alkaline Phosphatase genetics, Alkaline Phosphatase metabolism, Animals, Biomarkers metabolism, Calcification, Physiologic drug effects, Cell Line, Tumor, Cell Proliferation drug effects, Collagen Type I genetics, Collagen Type I metabolism, Delayed-Action Preparations chemistry, Drug Carriers chemistry, Gene Expression, Humans, Osteoblasts cytology, Osteoblasts metabolism, Particle Size, Rabbits, Silicon Dioxide chemistry, Skull drug effects, Skull injuries, Skull metabolism, Delayed-Action Preparations metabolism, Drug Carriers metabolism, Osteoblasts drug effects, Osteogenesis drug effects, Oxytocics pharmacology, Oxytocin pharmacology, Silicon Dioxide metabolism
- Abstract
This study analyzes the performance of SBA-15 mesoporous particles carrying oxytocin (OT) in promoting osteogenesis in vitro and in vivo. The SBA-15 particles synthesized in the previous studies (about 30 μm in diameter and containing 10 nm deep pores) were loaded with the drug oxytocin and cultured with human osteosarcoma MG-63 cell line in vitro. The influence of particles on cell proliferation was studied. The level of the osteogenic marker (alkaline phosphatase and type I collagen) was measured. For in vivo studies, the connectivity defects of rabbit skull were prepared, and SBA-15 suspensions were regularly injected at the defect sites. The changes in the defect site calcium salt deposition were measured, and morphological changes were observed by microscopy. The material had to promote effect on osteogenesis-related indicators such as alkaline phosphatase and collagen I in bone sarcoma cell line MG-63. In vivo, the calcium salt deposition in OT/SBA-15 group was significantly higher than in the blank group. SBA-15 carriers appeared to persist in the region of the defect after the injection and release the drugs slowly, thus playing a more distinct role in promoting bone repair of local bone defects. The results showed that SBA-15 particles with OT could slow the release drugs and could help in promoting osteogenesis.
- Published
- 2017
13. Insights into the potential use of microRNAs as a novel class of biomarkers in esophageal cancer.
- Author
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Wan J, Wu W, Che Y, Kang N, and Zhang R
- Subjects
- Biomarkers, Tumor analysis, Biomarkers, Tumor genetics, Genetic Markers, Humans, Odds Ratio, Predictive Value of Tests, ROC Curve, Saliva chemistry, Sensitivity and Specificity, Esophageal Neoplasms genetics, MicroRNAs analysis
- Abstract
MicroRNAs (abbreviated miRNAs) have been demonstrated to be involved in tumorigenesis and cancer development and proposed as promising biomarkers in cancer diagnosis. Numerous studies have observed the aberrant expression of miRNAs in esophageal cancer. However, there are some discrepant results. Thus, we conducted this meta-analysis to identify the overall accuracy of miRNAs in the diagnosis of esophageal cancer. A comprehensive literature search was conducted in PubMed and other databases using combinations of key words. The summary receiver operator characteristic curves were plotted to assess the overall diagnostic performance of miRNAs. Chi-squared and I(2) tests were used to assess the heterogeneity between studies. Additionally, we conducted subgroup and sensitivity analyses to analyze the potential sources of heterogeneity. In total, 33 studies from 12 articles were available in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR) diagnostic odds ratio, and area under the curve were 0.80, 0.80, 4.0, 0.25, 16, and 0.87, respectively. Subgroup analyses based on the sample types (saliva-, serum- and plasma-based) showed no differences in the diagnostic accuracy of each subgroup. An independent meta-analysis of eight articles was conducted to evaluate the diagnostic accuracy of miRNAs in patients with esophageal squamous cell carcinoma, with a pooled sensitivity of 0.77, specificity of 0.83, PLR of 4.4, NLR of 0.27, diagnostic odds ratio of 16, and area under the curve of 0.87. In conclusion, this meta-analysis demonstrates the feasibility of using miRNAs as non-invasive biomarkers to discriminate esophageal cancer from healthy controls. However, further high-quality studies on more clearly defined esophageal cancer patient are needed to confirm our conclusion., (© 2015 International Society for Diseases of the Esophagus.)
- Published
- 2016
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14. REPLY.
- Author
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Che Y
- Subjects
- Female, Humans, Male, Catheter Ablation methods, Goiter surgery, Thyroid Nodule surgery, Thyroidectomy
- Published
- 2016
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15. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells.
- Author
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Lu Q, Yan S, Sun H, Wang W, Li Y, Yang X, Jiang X, Che Y, and Xi Z
- Subjects
- Apoptosis drug effects, Autophagy drug effects, Carcinoma, Renal Cell genetics, Carcinoma, Renal Cell metabolism, Carcinoma, Renal Cell pathology, Cell Line, Tumor, Drug Interactions, Glycolysis drug effects, HeLa Cells, Humans, Kidney Neoplasms genetics, Kidney Neoplasms metabolism, Kidney Neoplasms pathology, Phosphofructokinase-2 genetics, Phosphofructokinase-2 metabolism, Phosphorylation, Protein Kinase Inhibitors pharmacology, Proto-Oncogene Proteins c-akt metabolism, Transfection, Carcinoma, Renal Cell drug therapy, Fatty Acids, Unsaturated pharmacology, Kidney Neoplasms drug therapy, Proto-Oncogene Proteins c-akt antagonists & inhibitors, Pyrones pharmacology
- Abstract
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In the present study, we observed that rasfonin induced autophagy concomitant with the upregulation of Akt phosphorylation. Both the inhibition of Akt by small molecule inhibitors and genetic modification partially reduced rasfonin-dependent autophagic flux and PARP-1 cleavage. The overexpression of myrAkts (constant active form) promoted rasfonin-induced apoptosis and autophagy in a cell type- and Akt isoform-specific manner. Using quantitative PCR and immunoblotting, we observed that rasfonin increased the expression of glycolytic gene PFKFB3, and this increased expression can be suppressed in the presence of Akt inhibitor. The inhibition of PFKFB3 suppressed rasfonin-activated autophagy with enhanced PARP-1 cleavage. In the case of glucose uptake was disrupted, which mean the glycolytic pathway was fully blocked, the rasfonin-induced autophagy and PARP-1 cleavage were downregulated. Collectively, these results demonstrated that Akt positively regulated rasfonin-enhanced autophagy and caspase-dependent apoptosis primarily through affecting the glycolytic pathway.
- Published
- 2015
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16. Treatment of Benign Thyroid Nodules: Comparison of Surgery with Radiofrequency Ablation.
- Author
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Che Y, Jin S, Shi C, Wang L, Zhang X, Li Y, and Baek JH
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Postoperative Period, Treatment Outcome, Catheter Ablation methods, Goiter surgery, Thyroid Nodule surgery, Thyroidectomy
- Abstract
Background and Purpose: Nodular goiter is one of the most common benign lesions in thyroid nodule. The main treatment of the disease is still the traditional surgical resection, however there are many problems such as general anesthesia, surgical scar, postoperative thyroid or parathyroid function abnormalities, and high nodules recurrence rate in residual gland. The purpose of this study was to compare the efficacy, safety, and cost-effectiveness of 2 treatment methods, surgery and radiofrequency ablation, for the treatment of benign thyroid nodules., Materials and Methods: From May 2012 to September 2013, 200 patients with nodular goiters who underwent surgery (group A) and 200 patients treated by radiofrequency ablation (group B) were enrolled in this study. Inclusion criteria were the following: 1) cosmetic problem, 2) nodule-related symptoms, 3) hyperfunctioning nodules related to thyrotoxicosis, and 4) refusal of surgery (for group B). An internally cooled radiofrequency ablation system and an 18-ga internally cooled electrode were used. We compared the 2 groups in terms of efficacy, safety, and cost-effectiveness during a 1-year follow-up., Results: After radiofrequency ablation, the nodule volume decreased significantly from 5.4 to 0.4 mL (P = .002) at the 12-month follow-up. The incidence of complications was significantly higher from surgery than from radiofrequency ablation (6.0% versus 1.0%, P = .002). Hypothyroidism was detected in 71.5% of patients after surgery but in none following radiofrequency ablation. The rate of residual nodules (11.9% versus 2.9%, P = .004) and hospitalization days was significantly greater after surgery (6.6 versus 2.1 days, P < .001), but the cost difference was not significant., Conclusions: Surgical resection and radiofrequency ablation are both effective treatments of nodular goiter. Compared with surgery, the advantages of radiofrequency ablation include fewer complications, preservation of thyroid function, and fewer hospitalization days. Therefore, radiofrequency ablation should be considered a first-line treatment for benign thyroid nodules., (© 2015 by American Journal of Neuroradiology.)
- Published
- 2015
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17. Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
- Author
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Xiao Z, Li L, Li Y, Zhou W, Cheng J, Liu F, Zheng P, Zhang Y, and Che Y
- Subjects
- Animals, Cell Death drug effects, Cell Line, Tumor, Cell Movement drug effects, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Extracellular Signal-Regulated MAP Kinases metabolism, Female, Humans, Mice, Mice, Nude, Mitogen-Activated Protein Kinase Kinases metabolism, Neoplasm Invasiveness, Pancreatic Neoplasms enzymology, Pancreatic Neoplasms genetics, Pancreatic Neoplasms pathology, Phosphorylation, Proto-Oncogene Proteins metabolism, Proto-Oncogene Proteins c-raf metabolism, Proto-Oncogene Proteins p21(ras), SOS1 Protein metabolism, Signal Transduction drug effects, Time Factors, Tumor Burden drug effects, Xenograft Model Antitumor Assays, ras Proteins metabolism, Antineoplastic Agents pharmacology, Fatty Acids, Unsaturated pharmacology, Mutation, Pancreatic Neoplasms drug therapy, Proto-Oncogene Proteins genetics, Pyrones pharmacology, ras Proteins genetics
- Abstract
Rasfonin is a novel 2-pyrone derivative reported to induce apoptosis in ras-dependent cells. In this study, its effects on ras-mutated pancreatic cancer cells were investigated in vitro and in vivo. Two human pancreatic cancer cell lines Panc-1 (mutated K-ras) and BxPC-3 (wild-type K-ras) were selected to test the effects of rasfonin on cell proliferation, clone formation, migration and invasion in vitro. Immunoblotting was used to detect the expressions of EGFR-Ras-Raf-MEK-ERK signaling pathway proteins. Ras activity was measured using a pull-down ELISA kit and guanine exchange factor (GEF)/GTPase-activating proteins (GAP) activity was measured by [(3)H]-GDP radiometric ligand binding. For an in vivo study, CD1 nude mice bearing Panc-1 cells were treated with rasfonin or Salirasib (FTS). We found that rasfonin suppressed proliferation more strongly in Panc-1 cells (IC50=5.5 μM) than BxPC-3 cells (IC50=10 μM) in vitro. Clone formation, migration and invasion by Panc-1 cells were also reduced by rasfonin. Rasfonin had little effect on the farnesylation of Ras, but it strongly downregulated Ras activity and consequently phosphorylation of c-Raf/MEK/ERK. Further experiments indicated that rasfonin reduced Son of sevenless (Sos1) expression but did not alter GEF and GAP activities. The in vivo experiments also revealed that rasfonin (30 mg/kg) delayed the growth of xenograft tumors originating from Panc-1 cells. Tumor weight was ultimately decreased after 20 days of treatment of rasfonin. Rasfonin is a robust inhibitor of pancreatic cancers with the K-ras mutation. The reduction of Sos1 expression and the consequently depressed Ras-MAPK activity could be important in its anticancer activity.
- Published
- 2014
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18. The roles of mesenchymal stem cells in gastric lesion and regeneration: applications in gastric diseases.
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Gong Y, Song L, Yang C, Che Y, Chen Q, and Wu B
- Subjects
- Humans, Precancerous Conditions pathology, Stomach Neoplasms pathology, Stomach Ulcer pathology, Mesenchymal Stem Cells physiology, Precancerous Conditions physiopathology, Regeneration physiology, Stomach Neoplasms physiopathology, Stomach Ulcer physiopathology
- Abstract
In recent years, many studies have focused on the roles of mesenchymal stem cells (MSCs) due to their contribution to tissue regeneration and tumorigenesis. However, the full profile of the roles of MSCs in gastric diseases has not been established. In this review, we aim to provide an overview on the roles of MSCs on cell lesion and regeneration in gastric diseases, including gastric ulcer, premalignant conditions and cancer. We will also discuss the mechanisms underlying the behaviors of MSCs in these diseases.
- Published
- 2013
19. TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7.
- Author
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Min S, Li L, Zhang M, Zhang Y, Liang X, Xie Y, He Q, Li Y, Sun J, Liu Q, Jiang X, Zhang Y, Che Y, and Yang R
- Subjects
- Adaptor Proteins, Signal Transducing, Animals, Base Sequence, Cell Communication, Cell Differentiation, Cell Line, Tumor, Dendritic Cells drug effects, Dendritic Cells pathology, Gene Expression Regulation, Neoplastic, Humans, Intracellular Signaling Peptides and Proteins genetics, Intracellular Signaling Peptides and Proteins metabolism, MAP Kinase Signaling System, Macrophages drug effects, Macrophages metabolism, Macrophages pathology, Mice, MicroRNAs metabolism, Mitogen-Activated Protein Kinases metabolism, Molecular Sequence Data, Monocytes drug effects, Monocytes metabolism, Monocytes pathology, Oligonucleotide Array Sequence Analysis, Signal Transduction, Th1 Cells drug effects, Th1 Cells pathology, Th17 Cells drug effects, Th17 Cells pathology, Transforming Growth Factor beta metabolism, Dendritic Cells metabolism, MicroRNAs genetics, Mitogen-Activated Protein Kinases genetics, Th1 Cells metabolism, Th17 Cells metabolism, Transforming Growth Factor beta pharmacology
- Abstract
The alterations induced in dendritic cells (DCs) in the cancer microenvironment have not been extensively explored. We found that the tumor-associated factor TGF-β may selectively upregulate the expression of miR-27a via the SP1 transcription factor. Importantly, miR-27a altered the activity of NF-κB and MAPKs (mitogen-activated protein kinases) p38, JNK (c-Jun N-terminal kinases) and ERK (extracellular signal-regulated kinase 1/2). It influences the production of proinflammatory cytokines by targeting TAB3, p38 MAPK, MAP2K4 and MAP2K7. As a consequence, miR-27a hampered the DC-mediated differentiation of Th1 and Th17 cells in vitro and in vivo, but it promoted the DC-mediated accumulation of Tr1 (CD4(+)IL-10(+)) and Treg (CD4(+)CD25(+)Foxp3(+)) cells in vivo. The repeated infusion of miR-27a-engineered DCs into tumor tissues accelerated tumor growth, indicating that miR-27a is a potential target for tumor immunotherapy.
- Published
- 2012
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20. Global mapping of H3K4me3 and H3K27me3 reveals chromatin state-based regulation of human monocyte-derived dendritic cells in different environments.
- Author
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Huang Y, Min S, Lui Y, Sun J, Su X, Liu Y, Zhang Y, Han D, Che Y, Zhao C, Ma B, and Yang R
- Subjects
- Cell Differentiation, Cellular Microenvironment, Chromatin genetics, Computational Biology, Dendritic Cells cytology, Dendritic Cells drug effects, Gene Silencing, Histocompatibility Antigens genetics, Histocompatibility Antigens immunology, Histocompatibility Antigens metabolism, Histone-Lysine N-Methyltransferase genetics, Histone-Lysine N-Methyltransferase immunology, Histone-Lysine N-Methyltransferase metabolism, Histones genetics, Histones immunology, Humans, Lipopolysaccharides immunology, Lipopolysaccharides pharmacology, Methylation, Monocytes cytology, RNA, Small Interfering genetics, RNA, Small Interfering metabolism, Transfection, Transforming Growth Factor beta, Chromatin metabolism, Chromosome Mapping methods, Dendritic Cells immunology, Epigenesis, Genetic, Histones metabolism
- Abstract
Depending on the environment, dendritic cells (DCs) may become active or tolerogenic, but little is known about whether heritable epigenetic modifications are involved in these processes. Here, we have found that epigenetic histone modifications can regulate the differentiation of human monocyte-derived DCs (moDCs) into either activated or tolerized DCs. The inhibition or silencing of methyltransferases or methylation-associated factors affects the expression of multiple genes. Genome mapping of transforming growth factor (TGF-β)- or lipopolysaccharide (LPS)-associated H3K4 trimethylation (H3K4me3) and H3K27 trimethylation (H3K27me3) demonstrated the presence of histone modification of gene expression in human TGF-β- or LPS-conditioned moDCs. Although the upregulated or downregulated genes were not always associated with H3K4me3 and/or H3K27me3 modifications in TGF-β-conditioned (tolerized) or LPS-conditioned (activated) moDCs, some of these genes may be regulated by the increased and/or decreased H3K4me3 or H3K27me3 levels or by the alteration of these epigenetic marks, especially in TGF-β-conditioned moDCs. Thus, our results suggested that the differentiation and function of moDCs in tumor and inflammation environments are associated with the modification of the H3K4me3 and K3K27me3 epigenetic marks.
- Published
- 2012
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21. Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers.
- Author
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Chen Y, Guo H, Du Z, Liu XZ, Che Y, and Ye X
- Subjects
- Animals, Antineoplastic Agents isolation & purification, Blotting, Western, Caspases metabolism, Cell Cycle, Cell Line, Tumor, Drug Screening Assays, Antitumor, Enzyme Activation, HeLa Cells, Humans, Mice, Mice, Inbred C57BL, Antineoplastic Agents pharmacology, Apoptosis drug effects, Cell Proliferation drug effects, Cordyceps metabolism, Ecology
- Abstract
Objectives: This study aims to identify new anti-cancer agents from Cordyceps-colonizing fungi, using an ecology-based approach. It also aims to explore their anti-cell proliferative mechanisms, and to evaluate their anti-tumour effects in vivo., Materials and Methods: Extracts from Cordyceps-colonizing fungi were tested on HeLa cells, and active extracts were separated to obtain anti-tumour metabolites; their structures were elucidated by mass and nuclear magnetic resonance spectroscopy. Cell cycle analysis was evaluated using flow cytometry. Tumour formation assays were performed using C57BL/6J mice., Results: Based on ecological considerations, the selected extracts were subjected to initial anti-tumour screening. Bioassay-guided fractionation of the active extract afforded two new epipolythiodioxopiperazines, named gliocladicillins A (1) and B (2). (A) 1 and B (2) inhibited growth of HeLa, HepG2 and MCF-7 tumour cells. Further study demonstrated that both preparations arrested the cell cycle at G(2)/M phase in a dose-dependent manner, and induced apoptosis through up-regulation of expression of p53, p21, and cyclin B, and activation of caspases-8, -9 and -3. These data imply that gliocladicillins A (1) and B (2) induce tumour cell apoptosis through both extrinsic and intrinsic pathways. In addition, in vivo studies showed that they displayed significant inhibitory effects on cell population growth of melanoma B16 cells implanted into immunodeficient mice., Conclusions: Gliocladicillins A (1) and B (2) are effective anti-tumour agents in vitro and in vivo and should be further evaluated for their potential in clinical use.
- Published
- 2009
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22. Splenic irradiation-induced Sweet's syndrome associated with preceding myelofibrosis.
- Author
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Che Y, Tanioka M, Matsumura Y, and Miyachi Y
- Subjects
- Aged, Granulocyte Colony-Stimulating Factor administration & dosage, Granulocyte Colony-Stimulating Factor adverse effects, Humans, Male, Sweet Syndrome drug therapy, Treatment Outcome, Primary Myelofibrosis complications, Spleen radiation effects, Sweet Syndrome complications
- Published
- 2008
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23. RhoA, encoding a Rho GTPase, is associated with smoking initiation.
- Author
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Chen X, Che Y, Zhang L, Putman AH, Damaj I, Martin BR, Kendler KS, and Miles MF
- Subjects
- Animals, Case-Control Studies, Gene Expression Profiling, Haplotypes, Humans, Mice, Nerve Tissue Proteins genetics, Nerve Tissue Proteins metabolism, Neuronal Plasticity genetics, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Reference Values, Tyrosine 3-Monooxygenase genetics, Tyrosine 3-Monooxygenase metabolism, Ventral Tegmental Area metabolism, rhoA GTP-Binding Protein metabolism, Smoking genetics, Tobacco Use Disorder genetics, rhoA GTP-Binding Protein genetics
- Abstract
We used microarray analysis of acute nicotine responses in mouse brain to choose rationale candidates for human association studies on tobacco smoking and nicotine dependence (ND). Microarray studies on the time-course of acute response to nicotine in mouse brain identified 95 genes regulated in ventral tegmental area. Among these, 30 genes were part of a gene network, with functions relevant to neural plasticity. On this basis and their known roles in drug abuse or synaptic plasticity, we chose the genes RhoA and Ywhag as candidates for human association studies. A synteny search identified human orthologs and we investigated their role in tobacco smoking and ND in a human case-control association study. We genotyped five and three single nucleotide polymorphisms from the RhoA and Ywhag genes, respectively. Both single marker and haplotype analyses were negative for the Ywhag gene. For the RhoA gene, rs2878298 showed highly significant genotypic association with both smoking initiation (SI) and ND (P = 0.00005 for SI and P = 0.0007 for ND). In the allelic analyses, rs2878298 was only significant for SI. In the multimarker haplotype analyses, significant association with SI was found for the RhoA gene (empirical global P values ranged from 9 x 10(-5) to 10(-5)). In all multimarker combinations analyzed, with or without inclusion of the single most significant marker rs2878298, identical risk and protective haplotypes were identified. Our results indicated that the RhoA gene is likely involved in initiation of tobacco smoking and ND. Replication and future model system studies will be needed to validate the role of RhoA gene in SI and ND.
- Published
- 2007
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24. Morphological alteration and biological properties of hepatocytes not related to tumorigenesis following transfection with HCV core protein.
- Author
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Gu J, Wang L, Che Y, Liu L, Jiang L, Dong S, Li W, and Li Q
- Subjects
- Cell Proliferation, Humans, Transfection, Carcinoma, Hepatocellular etiology, Hepatitis C complications, Hepatocytes pathology, Liver Neoplasms etiology, Viral Core Proteins physiology
- Abstract
The hepatitis C virus (HCV) core protein is supposed to play a critical role in HCV-mediated human liver disease with its capabilities to regulate the growth rate of hepatocytes and to partially contribute to the pathogenesis of hepatocellular carcinoma in association with cellular oncogenes. In this study, to analyse the possible pathological mechanism of the HCV core protein, human primary embryo hepatocytes transfected with HCV core were monitored by immunofluorescence, reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot. The morphological changes and biological properties of the transfected hepatocytes were also studied. The results showed that the HCV core gene integrated in the cellular genome and the protein expressed in the transfected hepatocyte, could be detected following serial passage at both the mRNA and protein level. The proliferation assays indicated that hepatocytes transfected with the HCV core gene alone did not exhibit any tumorigenic tendency. Meanwhile, the morphological alterations of these cells demonstrated obvious changes in size, and large vacuolar degeneration. In conclusion, the hepatocytes transfected with the HCV core gene revealed that the core protein expressed induced pathological changes of degeneration, probably related indirectly to tumorigenicity.
- Published
- 2005
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25. Identification of a novel human sand family protein in human fibroblasts induced by herpes simplex virus 1 binding.
- Author
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Dong S, Dong C, Liu L, Che Y, Sun M, Hu F, Li J, and Li Q
- Subjects
- Amino Acid Sequence, Animals, Cells, Cultured, Fibroblasts chemistry, Fibroblasts virology, Herpesvirus 1, Human metabolism, Humans, Intracellular Signaling Peptides and Proteins, Mice, Molecular Sequence Data, Phylogeny, Protein Biosynthesis, Proteins classification, Sequence Alignment, Transfection, Herpesvirus 1, Human physiology, Proteins genetics
- Abstract
Studies on interaction between Herpes simplex virus 1 (HSV-1) and human fibroblasts KMB-17 have demonstrated that HSV-1 binding to the cell surface could induce a specific gene response. In this study, the HSV-1 stimulation-related gene 1 (HSRG1), a new so far unknown gene function of cellular response induced by a specific stimulation with HSV-1, was cloned from the cDNA library established from mRNA of early gene response of KMB-17 cells. The gene product consisted of 547 amino acids and had a significant homology, in six eukaryotic species. On the basis of its structure it was identified as a member of the SAND protein family. The HSRG1 protein was fused with glutathione S-transferase (GST) and expressed in Escherichia coli DHPalpha strain under the control of T7 promoter. An antibody to HSRG1 raised in mice was used to detect expression of the HSRG1 protein in KMB-17 cells stimulated by HSV-1 by an immunoprecipitation assay. It was found that the HSRG1 protein was induced in these cells by HSV-1 at high level.
- Published
- 2003
26. Infertility in Shanghai: prevalence, treatment seeking and impact.
- Author
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Che Y and Cleland J
- Subjects
- Adult, China epidemiology, Female, Humans, Infertility etiology, Infertility therapy, Male, Patient Acceptance of Health Care, Pregnancy, Prevalence, Infertility epidemiology
- Abstract
To assess the level of treatment seeking and impact on marriage of infertility among newly married couples of Shanghai, China, a total of 7872 newly married couples, enrolled between 1987 and 1988, were followed-up for 5 years. The prevalence of infertility (no fertile conception after 24 months of unprotected intercourse) was found to be 5.1%. Couples' age at marriage, education, prior induced abortion, miscarriage, use of IUD or hormonal contraceptives and medical problems of both partners were associated significantly with infertility. About 57% of infertile couples sought infertility treatment and subsequently had a higher probability of childbirth (42%) than non-seekers (28%). Husband's education, induced abortion and both partner's previous medical problems were associated significantly with infertility treatment seeking. Moreover, infertile couples were 2.2 times more likely to divorce than their counterparts (95% CI 1.52-3.18). We conclude that infertility in Shanghai is modest, but a substantial number of infertile couples would not like to seek infertility treatment. Further research is needed on this subject.
- Published
- 2002
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27. Detection of Campylobacter jejuni in poultry samples using an enzyme-linked immunoassay coupled with an enzyme electrode.
- Author
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Che Y, Li Y, and Slavik M
- Subjects
- Animals, Food Microbiology, Humans, Immunomagnetic Separation, Monophenol Monooxygenase, Biosensing Techniques methods, Campylobacter jejuni isolation & purification, Immunoenzyme Techniques methods, Poultry microbiology
- Abstract
An enzyme-linked immunoassay coupled with a tyrosinase modified enzyme electrode was used for rapid detection of Campylobacter jejuni. The immunomagnetic separation (IMS) method was investigated to achieve optimal isolation of C. jejuni cells. Eight types of beads with three different sizes and function groups were coated with anti-C. jejuni to isolate C. jejuni from the sample solution. Bead size and coating methods were found to be major factors that influenced the capture efficacy. Streptavidin-labeled beads (2.8 microm) provided the greatest capture ability. Three blocking reagents were tested to minimize non-specific binding. Bovine serum albumin (BSA) showed the best blocking capability. Two IMS formats were tested. Competitive immunoassay cut the detection time to 1.5 h, but the detection limit was relatively high (10(6) CFU/ml). This system was evaluated using C. jejuni pure culture and poultry samples inoculated with C. jejuni. This detection method for C. jejuni could be completed within 2.5 h and had a detection limit of 2.1 x 10(4) CFU/ml. No significant difference was found between pure culture samples and poultry samples (P>0.01). A linear relationship was found between C. jejuni cell numbers and the peak current ratio in a range of 10(2)-10(7) CFU/ml (R(2)=0.94).
- Published
- 2001
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28. Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure.
- Author
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Che Y, Yu YM, Han PL, and Lee JK
- Subjects
- Animals, Antibody Specificity, Behavior, Animal, Cell Death physiology, Excitatory Amino Acid Agonists, Gliosis metabolism, Immunohistochemistry, Kainic Acid, Male, Mice, Mice, Inbred BALB C, Mitogen-Activated Protein Kinases analysis, Mitogen-Activated Protein Kinases immunology, Neurons cytology, Status Epilepticus chemically induced, p38 Mitogen-Activated Protein Kinases, Astrocytes enzymology, Hippocampus cytology, Mitogen-Activated Protein Kinases biosynthesis, Status Epilepticus metabolism
- Abstract
Activation of p38 mitogen-activated protein kinase (p38 MAPK) has been implicated in pathological changes in inflammatory and apoptotic processes in various cell types including neurons. Here we report the delayed induction of p38 MAPKs in the brain of mice following kainic acid (KA)-induced seizure. The immunoreactivities of p38alpha and p38beta MAPKs were markedly increased in the brain 4 days after KA administration, especially in the areas undergoing selective neuronal loss. In particular, p38beta was dramatically increased in reactive astrocytes of CA3 and CA1 regions of hippocampus with its enriched localization in the nucleus of astrocytes. The induction of p38beta was sustained for more than 10 days after KA-treatment. Pre-administration of the selective neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI), which suppressed the delayed neuronal death as well as astrogliosis in hippocampus of seizure-experienced animals, dramatically repressed the delayed induction of p38beta MAPK in astrocytes. The repression was reversed by the co-injection with L-arginine (L-arg), a substrate for NOS, which coincided with the aggravation of neuronal death. Together, these data suggested a role of p38 MAPK signal pathway in delayed neuronal death and/or in reactive gliosis in mice with KA-induced seizure.
- Published
- 2001
- Full Text
- View/download PDF
29. Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
- Author
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Che Y, Piao CS, Han PL, and Lee JK
- Subjects
- Animals, Arginine pharmacology, Astrocytes drug effects, Astrocytes pathology, Crystallins drug effects, Drug Interactions physiology, Enzyme Inhibitors pharmacology, Excitatory Amino Acid Agonists pharmacology, Gliosis pathology, Gliosis physiopathology, Hippocampus pathology, Hippocampus physiopathology, Immunohistochemistry, Indazoles pharmacology, Kainic Acid pharmacology, Male, Mice, Mice, Inbred BALB C, Molecular Chaperones, Neoplasm Proteins drug effects, Nerve Degeneration pathology, Nerve Degeneration physiopathology, Neuroprotective Agents pharmacology, Nitric Oxide metabolism, Nitric Oxide Synthase antagonists & inhibitors, Nitric Oxide Synthase metabolism, Oxidative Stress drug effects, Oxidative Stress physiology, Seizures chemically induced, Seizures pathology, Astrocytes metabolism, Crystallins metabolism, Gliosis metabolism, Heat-Shock Proteins, Hippocampus metabolism, Neoplasm Proteins metabolism, Nerve Degeneration metabolism, Seizures physiopathology
- Abstract
Small heat shock proteins have been implicated in playing a role in various cellular processes, including stress-induced cell death. In kainic acid (KA)-treated rat brain, the immunoreactivity of heat-shock protein 27 (HSP27) was markedly increased in glia cells of the limbic system. In the present study, we demonstrated that alpha B-crystallin, a member of the small heat-shock protein family, was strongly induced in reactive astrocytes in hippocampus after KA-induced seizure. The induction was localized mainly in the CA3 region of hippocampus, where massive neuronal loss occurred. We also demonstrated that the delayed induction of alpha B-crystallin and HSP27 immunoreactivities in the hippocampus of epileptic animals was repressed to the levels seen in control animals with preadministration of the selective nNOS inhibitor 7-nitroindazole (7-NI). This repression was reversed by coinjection of L-arginine, a substrate of NOS. Together, these data suggest a role for alpha B-crystallin and HSP27 in reactive gliosis and/or in delayed neuronal death proceeded after KA-induced seizure., (Copyright 2001 Wiley-Liss, Inc.)
- Published
- 2001
- Full Text
- View/download PDF
30. [Latest advances in pharmacological study of banxia xiexintang decoction].
- Author
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Zhang S, Wu CF, Chen LJ, and Che Y
- Subjects
- Adjuvants, Immunologic pharmacology, Animals, Drugs, Chinese Herbal isolation & purification, Gastric Mucosa pathology, Helicobacter pylori drug effects, Humans, Phytotherapy, Drugs, Chinese Herbal pharmacology, Gastrointestinal Agents pharmacology, Plant Extracts pharmacology, Plants, Medicinal chemistry, Stomach Ulcer drug therapy
- Published
- 2001
31. Induced abortion and prematurity in a subsequent pregnancy: a study from Shanghai.
- Author
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Che Y, Zhou W, Gao E, and Olsen J
- Abstract
To evaluate the impact of a first trimester induced abortion on the risks of low birth weight (LBW) and preterm birth in a subsequent pregnancy we conducted a pregnancy-based cohort study in Shanghai, China with recruitment from 15 general hospitals (or maternity and infant health institutes) from November 1993 to March 1998. Pregnant women with a history of induced abortion entered the abortion cohort and a reference cohort was established among women without such a history. All the subjects were enrolled before 64 days of gestation and interviewed five times until 42 days after delivery. Only singleton live births were analysed in this study. A total of 2953 pregnant women were enrolled and 2707 gave birth to live singletons. The overall incidence of LBW was 1.7%, 2.0% in the abortion cohort and 1.4% in the reference cohort. After controlling the potential confounders using logistic regression, the adjusted odds ratios were 1.7 (95% CI: 0.8-3.3) for LBW, 2.0 (95% CI: 0.9-4.7) for term LBW and 1.0 (95% CI: 0.6-1.5) for preterm birth, following an induced abortion pregnancy. Birth weight in the abortion cohort was 38.5 g higher than that of the reference cohort after adjustment for calendar year at recruitment, couples' occupation, education, age, infant sex, maternal body mass index at recruitment, contraceptive use and gestation age. Previous first trimester induced abortion did not significantly increase the risk of LBW or preterm birth. The study was performed in a low-risk population and results may not be applicable to other settings.
- Published
- 2001
- Full Text
- View/download PDF
32. Pseudodestruxins A and B: new cyclic depsipeptides from the coprophilous fungus Nigrosabulum globosum.
- Author
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Che Y, Swenson DC, Gloer JB, Koster B, and Malloch D
- Subjects
- Amino Acids analysis, Anti-Bacterial Agents, Anti-Infective Agents pharmacology, Bacteria drug effects, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Crystallography, X-Ray, Hydrolysis, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Spectrometry, Mass, Fast Atom Bombardment, Anti-Infective Agents isolation & purification, Ascomycota chemistry, Depsipeptides, Fungal Proteins, Peptides, Cyclic chemical synthesis, Peptides, Cyclic pharmacology
- Abstract
Pseudodestruxins A (1) and B (2), two new cyclic peptides, have been isolated from cultures of the coprophilous fungus Nigrosabulum globosum. The structure of pseudodestruxin A (1) was elucidated using 2D NMR techniques and confirmed by single-crystal X-ray diffraction analysis. The structure of 2 was assigned by comparing its NMR and FABMS data with those of compound 1. The known compounds ascochlorin and 5-chlorocollectorin B were also isolated from N. globosum. Although 1 and 2 display antibacterial effects, ascochlorin was found to be responsible for the antifungal activity of the crude extract.
- Published
- 2001
- Full Text
- View/download PDF
33. [Investigation on genotype constitution of different Plasmodium vivax isolates and its geographical distribution in China].
- Author
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Huang TY, Huang YM, Wang XL, Li XM, Zhang ZX, Wang SQ, Wang GZ, Pan B, Huang Z, Fu WZ, Liu H, Gao Q, Zhang S, Shang L, Xu G, Sheng Y, Liu T, Li P, Zeng F, and Che Y
- Subjects
- Animals, China epidemiology, Genetic Variation, Genotype, Geography, Humans, Malaria, Vivax parasitology, Plasmodium vivax isolation & purification, Polymerase Chain Reaction, Malaria, Vivax epidemiology, Plasmodium vivax genetics, Protozoan Proteins genetics
- Abstract
Objective: To investigate the population constitution and geographical distribution of Plasmodium vivax in China using molecular technique., Methods: Blood-spot filter paper samples with related epidemiological data were collected from vivax malaria patients living in malarious area of 10 provinces (autonomous region) in China. Semi-nested- or nested-allelic-specific PCR genotyping method was used to identify CSP genotypes, families and types of Plasmodium vivax of each isolate from these patients., Results: Of 384 field isolates of Plasmodium vivax, 258 temperate zone family strains were identified, including 14 allelic variant genotypes spreading among 10 sampling provinces; allelic variants sized less than 731 bp were only seen in 5 provinces in southern China; 79 tropical zone family strains including 5 genotypes were also distributed in 5 provinces of southern China south to 25 degrees N. lat; and 14 PV Type-2 strains including 2 genotypes were found in some areas of Hainan and Yunnan Provinces. In addition, 33 isolates from genotype-mixed infections were revealed., Conclusion: At present, area north to 25 degrees N. lat. of the country is the sole area prevalent for Plasmodium vivax family strains of temperate zone; there is overlapping distribution of P. v. of temperate zone family and tropical zone family of this parasite in the southern China south to 25 degrees N. lat; where the most complex isolate constitution is in Yunnan and Hainan Provinces, and PV Type-2 strains have been found in some areas of the two provinces. Besides, there were 2 groups of genotype with distinct geographic distribution feature within the temperate zone family.
- Published
- 2001
34. Single-pulse ultraviolet laser recording of periodically poled structures in polymer thin films.
- Author
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Sugihara O, Nakanishi M, Che Y, Egami C, Kawata Y, and Okamoto N
- Abstract
A simple fabrication technique for nonlinear polymeric optical waveguide patterns is introduced based on the two-beam interference method. We determined that the second-order nonlinearity of poled polymer films is erased by single-pulse ultraviolet (UV) laser irradiation. The erasure mechanism for second-order nonlinearity is discussed. To form a periodic structure in an optical polymer waveguide, two types of optical configuration of two-beam interference were arranged, and a single-pulse UV laser was exposed directly onto poled films. We prove that this method provides a simple way to fabricate volume-type and ridge-type periodically poled structures, i.e., chi(2) gratings, from the submicrometer to the millimeter range.
- Published
- 2000
- Full Text
- View/download PDF
35. Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain.
- Author
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Lee SH, Park J, Che Y, Han PL, and Lee JK
- Subjects
- Animals, Brain cytology, Brain physiology, Brain Mapping, Female, Immunohistochemistry, Male, Mice, Mice, Inbred BALB C, Neurons cytology, p38 Mitogen-Activated Protein Kinases, Brain metabolism, Mitogen-Activated Protein Kinases immunology, Neurons metabolism, Protein Isoforms metabolism
- Abstract
To understand the roles of p38 mitogen-activated protein kinase (p38 MAPK) isoforms in adult mouse brain, in vivo activities and detailed expression patterns of two p38 isoforms, p38alpha and p38beta, were examined by using biochemical and immunohistochemical analyses. The result indicated that the activity of both p38alpha and p38b MAPKs in normal adult mouse brain was remarkably high, and the nuclear pool of the p38 isoforms was primarily responsible for most of the constitutive p38 MAPK activity in brain. Both p38alpha and p38beta were highly expressed in brain areas including cerebral cortex, hippocampus, cerebellum, and few nuclei of the brainstem. At the subcellular level, p38alpha was distributed in dendrites and in cytoplasmic and nuclear regions of cell body of neurons, which is in contrast to p38beta, since p38beta was preferentially expressed in nucleus of neurons. These results suggest that the p38 pathway may play an important role, not only in inflammation and neuronal cell death as previously suggested, but also in normal physiology of adult mouse brain., (Copyright 2000 Wiley-Liss, Inc.)
- Published
- 2000
- Full Text
- View/download PDF
36. [Studies on identification of circumsporozoite protein genotyping of Plasmodium vivax].
- Author
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Huang TY, Wang XL, Li XM, Huang YM, Zeng FX, Che Y, Zhang SM, Fu WZ, Zhang ZX, Zhang GS, Cai XZ, Wang SQ, and Wang GZ
- Subjects
- Animals, China, Genotype, Humans, Plasmodium vivax classification, Polymerase Chain Reaction, DNA, Protozoan analysis, Malaria, Vivax parasitology, Plasmodium vivax genetics, Protozoan Proteins genetics
- Abstract
Objective: To develop a new method of genotyping circumsporozoite protein (CSP) gene for identification of field isolates of Plasmodium vivax., Methods: Improved Chelex-100 ion-exchange method was used to extract DNA from blood filter paper samples, nested PCR and allele-specific PCR techniques, agarose gel electrophoresis analysis and dot/southern blotting-probe hybridization were employed for amplification, resolution and identification of the diagnostic fragments., Results: Using the nest-allele-specific PCR assay reported here, small amounts of DNA extracted from a piece of blood filter paper sample were amplified which produced three different size ranges of diagnostic bands: 650-770 bp PV-species-specific band, 170-230 bp diagnostic band for temperate zone family and 588 bp band for PV type-2. The sizes and patterns of the bands produced by the reference strains were consistent with those of designed target sequences. Of 59 examined isolates from 6 provinces of China, 42 temperate zone family strains, 15 tropical zone family strains and two PV type-2 strains were identified., Conclusion: 1, Three genotype strains of P. vivax mentioned above could be identified by this method with only two rounds of PCR and without probe hybridization. 2, The preliminary results showed that PV type-1 including temperate zone family strains and tropical zone family strains as well as PV type-2 strains are present in China. In addition, another CSP genotype with both sequence characteristics of temperate zone and tropical zone family might also be present in China.
- Published
- 2000
37. Induced abortion and duration of third stage labour in a subsequent pregnancy.
- Author
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Zhou W, Gao E, Che Y, and Olsen J
- Abstract
We set out to evaluate the impact of first trimester induced abortion on the duration of third stage labour and related complications in a subsequent pregnancy. The study was conducted in Shanghai city at 15 general hospitals (or maternity and infant health institutes) from November 1993 to March 1998. We identified all nulliparae who came for antenatal care within the first 63 days of pregnancy (2953); the women were divided into two cohorts according to their previous history of first trimester induced abortion. After enrollment, the women were interviewed five times from recruitment until 42 days after delivery. We included in the study all 1363 women who had a singleton vaginal live birth. Of these women, 703 were primigravida (non-exposed), 534 had had one previous first trimester induced abortion, and 126 women had had two or more first trimester induced abortions. The duration of third stage labour in minutes was longer in women with one or more previous induced abortions (mean=7.32 minutes) compared with primigravid women (mean=6.79 minutes). Prolonged third stage labour (>30 minutes) following one or more induced abortions was seen for 3.4% versus 1.0% in primigravid women. After adjusting for a number of potential confounders, women with one or more previous first trimester induced abortions had an odds ratio of prolonged third stage labour of 2.59 (95%C.I.=1.06-6.37) compared with primigravida, especially after an interpregnancy interval of more than 6 months (OR=3.24, 95%C.I.=1.29-8.13). The odds ratio of prolonged third stage labour was 3.14 (95%C.I.=1.22-8.09) if gestational age at the time of the induced abortion exceeded 49 days. Women with a first trimester induced abortion had no significantly increased risk of postpartum haemorrhage or retained placenta. It was concluded that a history of one or more first trimester induced abortions was related to an increased risk of prolonged third stage labour in the following pregnancy, particularly if the induced abortion was performed after 49 days of gestation.
- Published
- 1999
- Full Text
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38. Low-power phase conjugation in push-pull azobenzene compounds.
- Author
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Fei H, Wei Z, Yang Q, Che Y, Shen Y, Fu X, and Qiu L
- Abstract
Push-pull azobenzene compounds were synthesized by the diazocoupling reaction, and low-power phase conjugation of azobenzene-compound-doped poly(methyl methacrylate) films was studied with a He-Ne laser at 632.8 nm. It is shown that this kind of polymer has appreciable third-order optical nonlinearity, with a chi((3)) of approximately 10(-4) esu in the tail of absorption.
- Published
- 1995
- Full Text
- View/download PDF
39. Biphoton holographic storage in Methyl Orange and Ethyl Orange dyes: erratum.
- Author
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Fei H, Wei Z, Wu P, Han L, Zhao Y, and Che Y
- Published
- 1994
- Full Text
- View/download PDF
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