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To evaluate the effectiveness of the integrated schistosomiasis control measures in Changzhou City from 2015 to 2020, so as to provide insights into the formulation of the strategy used to consolidate the schistosomiasis elimination achievements.The annual schistosomiasis control working report and integrated schistosomiasis control data were collected in Changzhou City from 2015 to 2020, and the prevalence ofDuring the period from 2015 to 2020, a total of 112 061 person-time individuals received serological tests forChangzhou City is now at the post-elimination surveillance stage; however, there are still factors affecting schistosomiasis transmission. The schistosomiasis surveillance system remains to be improved to consolidate the schistosomiasis elimination achievements in Changzhou City.

We investigate the effect of long non-coding RNA H19 in acute myocardial infarction (AMI) and the underlying mechanism.C57BL/6 mice were subjected to AMI and injected with lentivirus pcDNA-H19. After AMI procedures for 3 weeks, cardiac function was detected by echocardiography. The infarct size was stained by triphenyltetrazolium chloride. H19 expression in mice was measured by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Protein expressions of LC3, Beclin-1, and ATG-7 in mice were measured by Western blot.Our results indicated that H19 expression was significantly downregulated in the infarcted myocardium. Overexpression of H19 after injection with pcDNA-H19 in mice could reduce infarct size and improve cardiac function through upregulating the ratio of LC3-II/I and expressions of Beclin-1 and ATG-7.Overexpression of H19 could protect AMI in mice via activating autophagy.

To identify key genes and novel potential therapeutic targets for contused spin cord injury through analyzing microarray data.Gene expression data set GSE2599 was downloaded from Gene Expression Omnibus, including 3 rat spinal cord injury (SCI) samples and 3 healthy controls. Data pre-treatment and differential analyses were performed with packages of R. Cluster analysis was done with gene expression values to globally present the difference between the two states. Functional enrichment analysis was performed for all the DEGs with DAVID tools. The most up- and down-regulated genes were picked out and their interactors were predicted with String. Pathway enrichment analysis was done with GENECODIS for all the genes in the network.A total of 227 DEGs were screened out, 132 up-regulated genes and 145 down-regulated genes. Response to wounding, response to organic substance and defense response was the top 3 significant functional terms. APOBEC1 was the most up-regulated gene while HPD was the most down-regulated one. Their interactors were obtained and network was constructed. Pathway enrichment analysis revealed that tyrosine metabolism and other metabolism-related pathways were significantly over-represented.A range of DEGs were revealed in present study, which could deepen the understandings about the mechanisms of SCI and guide future researches on treatment development.